{"id":"https://openalex.org/W4283753408","doi":"https://doi.org/10.1093/humrep/deac104.031","title":"O-031 Activation of NLRP3 inflammasome enhances neutrophil extracellular traps in women with stage III/IV endometriosis: convergence of multiple signaling portray association between genetics and lesion type","display_name":"O-031 Activation of NLRP3 inflammasome enhances neutrophil extracellular traps in women with stage III/IV endometriosis: convergence of multiple signaling portray association between genetics and lesion type","publication_year":2022,"publication_date":"2022-06-29","ids":{"openalex":"https://openalex.org/W4283753408","doi":"https://doi.org/10.1093/humrep/deac104.031"},"language":"en","primary_location":{"id":"doi:10.1093/humrep/deac104.031","doi":"https://doi.org/10.1093/humrep/deac104.031","is_oa":false,"landing_page_url":"https://doi.org/10.1093/humrep/deac104.031","pdf_url":null,"source":{"id":"https://openalex.org/S127900037","display_name":"Human Reproduction","issn_l":"0268-1161","issn":["0268-1161","1460-2350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Reproduction","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034872746","display_name":"Baidyanath Chakravarty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127825","display_name":"Institute of Reproductive Medicine","ror":"https://ror.org/03jgxy838","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210127825"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"B Chakravarty","raw_affiliation_strings":["Institute of Reproductive Medicine, Department of Assisted Reproduction, Kolkata , India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Reproductive Medicine, Department of Assisted Reproduction, Kolkata , India","institution_ids":["https://openalex.org/I4210127825"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038817855","display_name":"Shovandeb Kalapahar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127825","display_name":"Institute of Reproductive Medicine","ror":"https://ror.org/03jgxy838","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210127825"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"S Kalapahar","raw_affiliation_strings":["Institute of Reproductive Medicine, Department of Assisted Reproduction, Kolkata , India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Reproductive Medicine, Department of Assisted Reproduction, Kolkata , India","institution_ids":["https://openalex.org/I4210127825"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043525401","display_name":"Sunita Sharma","orcid":"https://orcid.org/0000-0003-2402-3891","observed_orcids":["https://orcid.org/0000-0003-2402-3891"]},"institutions":[{"id":"https://openalex.org/I4210127825","display_name":"Institute of Reproductive Medicine","ror":"https://ror.org/03jgxy838","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210127825"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"S Sharma","raw_affiliation_strings":["Institute of Reproductive Medicine, Department of Assisted Reproduction, Kolkata , India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Reproductive Medicine, Department of Assisted Reproduction, Kolkata , India","institution_ids":["https://openalex.org/I4210127825"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074488642","display_name":"Ratna Chattopadhyay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127825","display_name":"Institute of Reproductive Medicine","ror":"https://ror.org/03jgxy838","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210127825"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"R Chattopadhyay","raw_affiliation_strings":["Institute of Reproductive Medicine, Department of Assisted Reproduction, Kolkata , India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Reproductive Medicine, Department of Assisted Reproduction, Kolkata , India","institution_ids":["https://openalex.org/I4210127825"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101499668","display_name":"S. Ghosh","orcid":"https://orcid.org/0000-0002-0834-5391","observed_orcids":["https://orcid.org/0000-0002-0834-5391"]},"institutions":[{"id":"https://openalex.org/I4210127825","display_name":"Institute of Reproductive Medicine","ror":"https://ror.org/03jgxy838","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210127825"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"S Ghosh","raw_affiliation_strings":["Institute of Reproductive Medicine, Department of Assisted Reproduction, Kolkata , India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Reproductive Medicine, Department of Assisted Reproduction, Kolkata , India","institution_ids":["https://openalex.org/I4210127825"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061232509","display_name":"Manojit Chakraborty","orcid":"https://orcid.org/0009-0009-6420-8058","observed_orcids":["https://orcid.org/0009-0009-6420-8058"]},"institutions":[{"id":"https://openalex.org/I4210127825","display_name":"Institute of Reproductive Medicine","ror":"https://ror.org/03jgxy838","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210127825"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"M Chakraborty","raw_affiliation_strings":["Institute of Reproductive Medicine, Department of Assisted Reproduction, Kolkata , India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Reproductive Medicine, Department of Assisted Reproduction, Kolkata , India","institution_ids":["https://openalex.org/I4210127825"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044954815","display_name":"Rituparna Chakraborty","orcid":"https://orcid.org/0000-0002-2273-5820","observed_orcids":["https://orcid.org/0000-0002-2273-5820"]},"institutions":[{"id":"https://openalex.org/I4210093039","display_name":"Melaka Manipal Medical College","ror":"https://ror.org/00g2cf802","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210093039"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"R Chakraborty","raw_affiliation_strings":["Melaka Manipal Medical College, Department of Microbiology, Manipal , India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Melaka Manipal Medical College, Department of Microbiology, Manipal , India","institution_ids":["https://openalex.org/I4210093039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069761987","display_name":"Ujjal Bose","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093039","display_name":"Melaka Manipal Medical College","ror":"https://ror.org/00g2cf802","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210093039"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"U Bose","raw_affiliation_strings":["Melaka Manipal Medical College, Department of Pharmacology, Manipal , India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Melaka Manipal Medical College, Department of Pharmacology, Manipal , India","institution_ids":["https://openalex.org/I4210093039"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021013614","display_name":"Pratip Chakraborty","orcid":"https://orcid.org/0000-0001-5835-8214","observed_orcids":["https://orcid.org/0000-0001-5835-8214"]},"institutions":[{"id":"https://openalex.org/I4210127825","display_name":"Institute of Reproductive Medicine","ror":"https://ror.org/03jgxy838","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210127825"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"P Chakraborty","raw_affiliation_strings":["Institute of Reproductive Medicine, Department of Assisted Reproduction, Kolkata , India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Reproductive Medicine, Department of Assisted Reproduction, Kolkata , India","institution_ids":["https://openalex.org/I4210127825"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3752,"currency":"EUR","value_usd":3953},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"37","issue":"Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10935","display_name":"Endometriosis Research and Treatment","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10935","display_name":"Endometriosis Research and Treatment","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.025200000032782555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":0.8960000276565552},{"id":"https://openalex.org/keywords/neutrophil-extracellular-traps","display_name":"neutrophil extracellular traps","score":0.9940000176429749},{"id":"https://openalex.org/keywords/netosis","display_name":"NETosis","score":0.8519999980926514},{"id":"https://openalex.org/keywords/endometriosis","display_name":"endometriosis","score":0.921999990940094},{"id":"https://openalex.org/keywords/deep-endometriosis","display_name":"deep infiltrating endometriosis","score":0.9639999866485596},{"id":"https://openalex.org/keywords/inflammasome-activation","display_name":"inflammasome activation","score":0.7570000290870667},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.47999998927116394},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.5839999914169312},{"id":"https://openalex.org/keywords/il-18","display_name":"IL-18","score":0.6499999761581421},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.5550000071525574},{"id":"https://openalex.org/keywords/il-13","display_name":"IL-13","score":0.45399999618530273},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.6399999856948853},{"id":"https://openalex.org/keywords/il-5","display_name":"IL-5","score":0.7179999947547913},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.6919999718666077},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7770000100135803},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.6669999957084656},{"id":"https://openalex.org/keywords/eutopic-endometrium","display_name":"eutopic endometrium","score":0.7829999923706055},{"id":"https://openalex.org/keywords/male-subfertility","display_name":"male subfertility","score":0.5669999718666077},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.33000001311302185}],"concepts":[{"id":"https://openalex.org/C2779522080","wikidata":"https://www.wikidata.org/wiki/Q205764","display_name":"Endometriosis","level":2,"score":0.9003332853317261},{"id":"https://openalex.org/C134897094","wikidata":"https://www.wikidata.org/wiki/Q7003141","display_name":"Neutrophil extracellular traps","level":3,"score":0.6053177118301392},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5784172415733337},{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.5206091403961182},{"id":"https://openalex.org/C2779742232","wikidata":"https://www.wikidata.org/wiki/Q839508","display_name":"Endometrium","level":2,"score":0.45992311835289},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.4455721974372864},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3955976665019989},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3722640573978424},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36978858709335327},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.22866979241371155}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/humrep/deac104.031","doi":"https://doi.org/10.1093/humrep/deac104.031","is_oa":false,"landing_page_url":"https://doi.org/10.1093/humrep/deac104.031","pdf_url":null,"source":{"id":"https://openalex.org/S127900037","display_name":"Human Reproduction","issn_l":"0268-1161","issn":["0268-1161","1460-2350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Reproduction","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4391520254","https://openalex.org/W4312066333","https://openalex.org/W4281860113","https://openalex.org/W2027627062","https://openalex.org/W2792308735","https://openalex.org/W4310702112","https://openalex.org/W3201086755","https://openalex.org/W4226089601","https://openalex.org/W7221497004","https://openalex.org/W3138598865"],"abstract_inverted_index":{"Abstract":[0],"Study":[1,151],"question":[2],"Do":[3],"NOD-like":[4],"receptor":[5],"pyrin-containing":[6],"3":[7],"(NLRP3)":[8],"signaling":[9],"affect":[10],"neutrophil":[11],"extracellular":[12,94],"traps":[13],"(NET)-osis":[14],"in":[15,42,46,82,87,105,123,276,299,339,355,364,374,408,412,429,481,527,547,559,572,602,620],"women":[16,157,204,214,560],"with":[17,113,160,451,478,489],"stage":[18],"III/IV":[19],"endometriosis?":[20],"Summary":[21],"answer":[22],"Inflammasome":[23],"activation":[24,388],"whether":[25],"due":[26],"to":[27,100,145,190,293,416,432,499,529,544,590,613,617],"pathogen":[28],"(disease":[29],"itself)":[30],"or":[31,210],"damage-associated":[32],"molecular":[33],"pattern":[34],"(through":[35],"NET)":[36],"might":[37],"be":[38,545],"one":[39],"mechanism":[40],"involved":[41],"establishing":[43],"perturbed":[44],"endometrium":[45,84,576,622],"endometriosis.":[47,108,482,608],"What":[48],"is":[49,53,98,566],"known":[50],"already":[51],"Endometriosis":[52],"characterized":[54],"by":[55,211,248,266,284,289,343,391,443,553],"number":[56,634],"of":[57,70,132,142,148,173,180,195,253,314,320,359,386,398,422,508,510,517,534,555,561,583,594,607,629],"processes":[58],"like":[59],"vascularization,":[60],"hypernociception,":[61],"and":[62,75,116,170,239,261,268,279,286,295,311,345,361,464,471,532,558,605],"fibrosis,":[63],"cardinal":[64],"cause":[65],"being":[66],"inflammation.":[67],"Recently,":[68],"expression":[69,263,358,370,397],"inflammasome":[71,512,596,626],"components,":[72],"including":[73],"NLRP3":[74,360,387,452,511,595],"apoptosis":[76],"signal-regulating":[77],"kinase":[78],"has":[79],"been":[80],"demonstrated":[81],"human":[83,575],"cueing":[85,498],"involvement":[86],"uterine":[88,181],"innate":[89],"immunity.":[90],"Moreover,":[91,420,483],"a":[92,129,425,505,520,599],"novel":[93],"killing":[95],"mechanism,":[96],"NET,":[97],"documented":[99,371],"reflect":[101],"an":[102],"inflammatory":[103,115,121],"status":[104],"deep":[106],"infiltrating":[107],"Since,":[109],"endometriosis":[110,124,161,340,377,430,556],"demonstrates":[111],"similarities":[112],"chronic":[114],"autoimmune":[117],"disorders;":[118],"we":[119],"postulated":[120],"responses":[122],"may":[125,514],"become":[126],"modulated":[127],"through":[128],"feed-forward":[130],"loop":[131],"NET-induced":[133],"specific":[134],"cytokine":[135],"production":[136,298,516],"thus":[137],"providing":[138],"insights":[139],"against":[140],"potentiality":[141],"endometriotic":[143],"cells":[144],"limit":[146],"progression":[147],"the":[149,230,312,382,567,578,584,603,615,621,625,630],"disease.":[150],"design,":[152],"size,":[153],"duration":[154],"Twenty-two":[155],"consented":[156],"(24-39":[158],"years)":[159],"(Group":[162,176,208,218],"A)":[163,209],"(Stages":[164],"III\u2013IV)":[165],"(based":[166],"on":[167],"ASRM-2018":[168],"guidelines)":[169],"age-matched":[171],"counterpart/s":[172],"male":[174],"sub-fertility":[175],"B;":[177],"control),":[178],"free":[179],"abnormalities":[182],"(n":[183],"=":[184,454,460,467,474,493],"18)":[185],"were":[186,201,401],"recruited":[187],"between":[188,449,525],"January":[189],"December":[191],"2021":[192],"from":[193,203,213,273,376],"Institute":[194],"Reproductive":[196],"Medicine,":[197],"Kolkata.":[198],"Eutopic":[199],"endometrium,":[200],"collected":[202,222],"undergoing":[205,215],"diagnostic":[206],"laparoscopy":[207],"curettage":[212],"endometrial":[216,535],"ablation":[217],"B).":[219],"Serum":[220],"was":[221,246,264,291,305,323,353,389],"during":[223],"window-of-implantation":[224],"(LH":[225],"+":[226],"7)":[227],"for":[228,539],"both":[229],"group/s.":[231],"Participants/materials,":[232],"setting,":[233],"methods":[234],"Pro-(IFN-g,":[235],"TNF-a,":[236,336],"IL-6,":[237,337],"TGF-b)":[238,338],"anti-inflammatory":[240,618],"(IL-10,":[241],"IL-13,":[242],"IL-4,":[243],"IL-5)":[244],"cytokines":[245],"evaluated":[247],"western":[249],"blot.":[250],"Expression":[251],"level":[252],"inflammasome-related":[254],"proteins":[255],"(NLRP3,":[256],"ASC,":[257],"CASPASE1,":[258],"PYCARD,":[259],"IL-1-b)":[260],"mRNA":[262,357,396],"estimated":[265],"western-blot":[267,344],"quantitative-real-time":[269],"PCR":[270],"(qRT-PCR)":[271],"respectively":[272],"tissue":[274],"biopsies":[275,375],"Group":[277,365],"A":[278,347,414],"B.":[280],"SYTOX\u00ae":[281],"green":[282],"assay":[283],"flow-cytometry":[285],"neutrophil-elastase":[287],"activity":[288],"immunofluorescence":[290],"done":[292],"quantify":[294],"characterize":[296],"NET":[297],"blood":[300],"monocytes.":[301],"P":[302],"<":[303,331,351,394,406,439,496],"0.05":[304],"considered":[306],"statistically":[307],"significant.":[308],"Main":[309],"results":[310],"role":[313,593],"chance":[315],"The":[316,384,586],"mean":[317],"(\u00b1SD)":[318],"age":[319],"study":[321,549,588],"population":[322],"31.6\u00b15.2":[324],"years.":[325],"Hyperestrogenic":[326],"milieu":[327,619],"possibly":[328],"stimulated":[329],"(p":[330,350,393,405],"0.001)":[332,352],"pro-inflammatory":[333],"molecules":[334],"(IFN-g,":[335],"as":[341,598,627],"observed":[342,354],"qRT-PCR.":[346],"significant":[348],"up-regulation":[349],"relative":[356],"PYCARD":[362,458],"gene":[363],"A.":[366],"However,":[367],"caspase":[368],"1":[369],"non-significant":[372],"variation":[373],"patients.":[378],"Western":[379],"blot":[380],"corroborated":[381],"finding/s.":[383],"outcome":[385],"supported":[390],"increased":[392],"0.002)":[395],"IL-1b.":[399],"NETs":[400,423,571],"detected":[402],"significantly":[403,426],"higher":[404,427],"0.01)":[407,470,477,497],"54.54%":[409],"(12/22)":[410],"patients":[411],"group":[413,433],"compared":[415,431],"control":[417],"(16.66%;":[418],"(3/18)).":[419],"quantification":[421],"showed":[424],"amount":[428],"B":[434],"(0.097":[435],"vs.":[436],"0.02,":[437],"p":[438,495],"0.03).":[440],"Spermann-rank":[441],"correlation":[442,448],"SPSS":[444],"version22":[445],"revealed":[446],"positive":[447],"IL-1b":[450,472],"(r":[453,459,466,473,492],"0.56,":[455],"p<":[456,462,469,476],"0.001),":[457],"0.11,":[461],"0.01);":[463],"caspase1":[465],"0.16,":[468],"0.47,":[475],"NET-positive":[479,490],"cell/s":[480,491],"posterior":[484],"cul-de-sac":[485],"lesions":[486],"correlated":[487],"positively":[488],"0.29;":[494],"possible":[500],"prognostic":[501],"marker/s.":[502],"In":[503],"summary,":[504],"coordinated-fashioned":[506],"action":[507],"components":[509],"machinery":[513],"regulate":[515],"NET/s":[518],"forming":[519],"complex":[521,597],"network":[522],"allowing":[523],"communication":[524],"cell-types":[526],"order":[528],"maintain":[530],"viability":[531],"development":[533,604],"lesion/s.":[536],"Limitations,":[537],"reasons":[538],"caution":[540],"Our":[541],"findings":[542,585],"need":[543],"replicated":[546],"larger":[548],"cohort/s,":[550],"especially":[551],"stratified":[552],"severity":[554],"sub-groups":[557],"different":[562],"ethnicities.":[563],"Another":[564],"limitation":[565],"missing":[568],"information":[569],"about":[570],"normal":[573],"functioning":[574],"throughout":[577],"menstrual":[579],"cycle.":[580],"Wider":[581],"implications":[582],"proposed":[587],"aims":[589],"understand":[591],"potential":[592],"\u201cdouble-edged":[600],"sword\u201d":[601],"pathophysiology":[606],"Therapeutic":[609],"alternatives":[610],"that":[611],"aim":[612],"re-balance":[614],"pro-":[616],"should":[623],"consider":[624],"part":[628],"equation.":[631],"Trial":[632],"registration":[633],"Not":[635],"applicable":[636]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2022-07-02T00:00:00"}
