{"id":"https://openalex.org/W4283744568","doi":"https://doi.org/10.1177/10547738221107081","title":"Biomarkers of Neuroinflammation in Traumatic Brain Injury","display_name":"Biomarkers of Neuroinflammation in Traumatic Brain Injury","publication_year":2022,"publication_date":"2022-06-29","ids":{"openalex":"https://openalex.org/W4283744568","doi":"https://doi.org/10.1177/10547738221107081","pmid":"https://pubmed.ncbi.nlm.nih.gov/35770330"},"language":"en","primary_location":{"id":"doi:10.1177/10547738221107081","doi":"https://doi.org/10.1177/10547738221107081","is_oa":false,"landing_page_url":"https://doi.org/10.1177/10547738221107081","pdf_url":null,"source":{"id":"https://openalex.org/S153670922","display_name":"Clinical Nursing Research","issn_l":"1054-7738","issn":["1054-7738","1552-3799"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Nursing Research","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017061851","display_name":"Kathryn S. Gerber","orcid":"https://orcid.org/0000-0003-0581-9536","observed_orcids":["https://orcid.org/0000-0003-0581-9536"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kathryn S. Gerber","raw_affiliation_strings":["University of Miami School of Nursing and Health Studies, Coral Gables, FL, USA"],"raw_orcid":"https://orcid.org/0000-0003-0581-9536","affiliations":[{"raw_affiliation_string":"University of Miami School of Nursing and Health Studies, Coral Gables, FL, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079286282","display_name":"Gemayaret Alvarez","orcid":"https://orcid.org/0000-0003-2769-8691","observed_orcids":["https://orcid.org/0000-0003-2769-8691"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gema Alvarez","raw_affiliation_strings":["University of Miami Miller School of Medicine, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Miami Miller School of Medicine, FL, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009172489","display_name":"Arsham Alamian","orcid":"https://orcid.org/0000-0002-3355-286X","observed_orcids":["https://orcid.org/0000-0002-3355-286X"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arsham Alamian","raw_affiliation_strings":["University of Miami School of Nursing and Health Studies, Coral Gables, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Miami School of Nursing and Health Studies, Coral Gables, FL, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034152550","display_name":"Victoria Behar\u2010Zusman","orcid":"https://orcid.org/0000-0002-8732-0116","observed_orcids":["https://orcid.org/0000-0002-8732-0116"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victoria Behar-Zusman","raw_affiliation_strings":["University of Miami School of Nursing and Health Studies, Coral Gables, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Miami School of Nursing and Health Studies, Coral Gables, FL, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041635920","display_name":"Charles A. Downs","orcid":"https://orcid.org/0000-0003-4859-7929","observed_orcids":["https://orcid.org/0000-0003-4859-7929"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles A. Downs","raw_affiliation_strings":["University of Miami School of Nursing and Health Studies, Coral Gables, FL, USA"],"raw_orcid":"https://orcid.org/0000-0003-4859-7929","affiliations":[{"raw_affiliation_string":"University of Miami School of Nursing and Health Studies, Coral Gables, FL, USA","institution_ids":["https://openalex.org/I145608581"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5017061851"],"corresponding_institution_ids":["https://openalex.org/I145608581"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":0.3255,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.35255784,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"31","issue":"7","first_page":"1203","last_page":"1218"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.023900000378489494,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":1.0},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.9850000143051147},{"id":"https://openalex.org/keywords/inflammasome","display_name":"inflammasome","score":0.9509999752044678},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":1.0},{"id":"https://openalex.org/keywords/neuropeptides","display_name":"neuropeptides","score":0.9980000257492065},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.9409999847412109},{"id":"https://openalex.org/keywords/exosomes","display_name":"exosomes","score":1.0}],"concepts":[{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.9248871207237244},{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.7413794994354248},{"id":"https://openalex.org/C2781145037","wikidata":"https://www.wikidata.org/wiki/Q5011772","display_name":"CINAHL","level":3,"score":0.6972188949584961},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6665768623352051},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5132637023925781},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.4845980405807495},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4278605580329895},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.4199548065662384},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.35595548152923584},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.35416778922080994},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.3313352167606354},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.235537588596344},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2009832262992859},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.18225759267807007},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.1189010739326477},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07084581255912781},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000070642","descriptor_name":"Brain Injuries, Traumatic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000090862","descriptor_name":"Neuroinflammatory Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1177/10547738221107081","doi":"https://doi.org/10.1177/10547738221107081","is_oa":false,"landing_page_url":"https://doi.org/10.1177/10547738221107081","pdf_url":null,"source":{"id":"https://openalex.org/S153670922","display_name":"Clinical Nursing Research","issn_l":"1054-7738","issn":["1054-7738","1552-3799"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Nursing Research","raw_type":"journal-article"},{"id":"pmid:35770330","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35770330","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical nursing research","raw_type":"Journal Article"},{"id":"pmh:oai:RePEc:sae:clnure:v:31:y:2022:i:7:p:1203-1218","doi":null,"is_oa":false,"landing_page_url":"https://journals.sagepub.com/doi/10.1177/10547738221107081","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9907000064849854}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":94,"referenced_works":["https://openalex.org/W587925266","https://openalex.org/W941967958","https://openalex.org/W1603121691","https://openalex.org/W1816716886","https://openalex.org/W1964249139","https://openalex.org/W1967164782","https://openalex.org/W1970240791","https://openalex.org/W1980541833","https://openalex.org/W1982938288","https://openalex.org/W1985050143","https://openalex.org/W2000727518","https://openalex.org/W2007012993","https://openalex.org/W2011398156","https://openalex.org/W2016285277","https://openalex.org/W2023819682","https://openalex.org/W2031848915","https://openalex.org/W2032514423","https://openalex.org/W2045557070","https://openalex.org/W2046208657","https://openalex.org/W2061324452","https://openalex.org/W2067693365","https://openalex.org/W2068710494","https://openalex.org/W2071539925","https://openalex.org/W2074059782","https://openalex.org/W2078515727","https://openalex.org/W2083996703","https://openalex.org/W2085684925","https://openalex.org/W2097692982","https://openalex.org/W2100115921","https://openalex.org/W2102738791","https://openalex.org/W2110744130","https://openalex.org/W2113297034","https://openalex.org/W2118046722","https://openalex.org/W2118820183","https://openalex.org/W2142514031","https://openalex.org/W2142529576","https://openalex.org/W2183966404","https://openalex.org/W2276813124","https://openalex.org/W2280580125","https://openalex.org/W2315662306","https://openalex.org/W2319601484","https://openalex.org/W2411723293","https://openalex.org/W2472846991","https://openalex.org/W2487395313","https://openalex.org/W2515462226","https://openalex.org/W2555637551","https://openalex.org/W2587029358","https://openalex.org/W2590515666","https://openalex.org/W2606481147","https://openalex.org/W2741811224","https://openalex.org/W2750121529","https://openalex.org/W2802945225","https://openalex.org/W2806176415","https://openalex.org/W2885731210","https://openalex.org/W2888742576","https://openalex.org/W2891402596","https://openalex.org/W2899615612","https://openalex.org/W2899914781","https://openalex.org/W2900232443","https://openalex.org/W2903495971","https://openalex.org/W2922493891","https://openalex.org/W2937406181","https://openalex.org/W2945404218","https://openalex.org/W2948548647","https://openalex.org/W2969572670","https://openalex.org/W2969662882","https://openalex.org/W2979985810","https://openalex.org/W2987460475","https://openalex.org/W2999148389","https://openalex.org/W3004566999","https://openalex.org/W3005543322","https://openalex.org/W3013857818","https://openalex.org/W3014364481","https://openalex.org/W3014891772","https://openalex.org/W3029043315","https://openalex.org/W3032076365","https://openalex.org/W3037900192","https://openalex.org/W3045232717","https://openalex.org/W3080545619","https://openalex.org/W3082869775","https://openalex.org/W3093445331","https://openalex.org/W3112642835","https://openalex.org/W3119532665","https://openalex.org/W3126902774","https://openalex.org/W3127616767","https://openalex.org/W3141323775","https://openalex.org/W3154383788","https://openalex.org/W3176801337","https://openalex.org/W3197337762","https://openalex.org/W3201344397","https://openalex.org/W3212204510","https://openalex.org/W3217283025","https://openalex.org/W4238356733","https://openalex.org/W4301463908"],"related_works":["https://openalex.org/W7148692531","https://openalex.org/W3106244383","https://openalex.org/W7217297925","https://openalex.org/W4394954706","https://openalex.org/W4403948639","https://openalex.org/W3093450130","https://openalex.org/W3014364481","https://openalex.org/W3028597724","https://openalex.org/W4405475426","https://openalex.org/W4394738352"],"abstract_inverted_index":{"Traumatic":[0],"brain":[1,16],"injury":[2],"(TBI)":[3],"is":[4,34],"characterized":[5],"by":[6],"neuroinflammation":[7,23,41,134],"and":[8,14,24,37,46,58,97,116,118,127,129,151],"structural":[9],"damage":[10],"leading":[11],"to":[12,35,43,147,153],"symptoms":[13],"altered":[15],"function.":[17],"Biomarkers":[18,122],"are":[19],"useful":[20],"in":[21,124,135],"understanding":[22,132,142],"correlations":[25],"with":[26],"TBI":[27,45,158],"sequalae.":[28,48],"The":[29],"purpose":[30],"of":[31,40,60,64,133,143,157],"this":[32],"paper":[33],"identify":[36],"discuss":[38],"biomarkers":[39,106],"used":[42,70,75],"study":[44],"its":[47],"A":[49,62],"systematic":[50,138],"review":[51,139],"was":[52],"conducted":[53],"using":[54],"PubMed,":[55],"CINAHL,":[56],"Embase,":[57],"Web":[59],"Science.":[61],"total":[63],"350":[65],"articles":[66],"met":[67],"criteria;":[68],"70":[69],"biomarkers.":[71],"PRISMA":[72],"criteria":[73],"were":[74,107],"for":[76],"Quality":[77],"Assessment.":[78],"Articles":[79],"included":[80],"reviews":[81],"(":[82,87,92,101],"n":[83,88,93,102],"=":[84,89,94,103],"17),":[85],"case-control":[86],"25),":[90],"cross-sectional":[91],"25)":[95],"studies,":[96],"randomized":[98],"controlled":[99],"trials":[100],"3).":[104],"Twenty-seven":[105],"identified,":[108],"including":[109],"inflammasomes,":[110],"cytokines,":[111],"neuropeptides,":[112],"complement":[113],"complexes,":[114],"miRNA":[115],"exosomes,":[117],"glial":[119],"cell-specific":[120],"proteins.":[121],"aid":[123],"predicting":[125],"morbidity":[126],"mortality":[128],"advance":[130],"our":[131,141],"TBI.":[136],"This":[137],"advances":[140],"the":[144],"neuroinflammatory":[145],"response":[146],"better":[148],"enable":[149],"nurses":[150],"clinicians":[152],"provide":[154],"informed":[155],"care":[156],"patients.":[159]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-07-02T00:00:00"}
