{"id":"https://openalex.org/W4283743435","doi":"https://doi.org/10.3390/ijms23137249","title":"Detection of Human Papillomavirus in Squamous Lesions of the Conjunctiva Using RNA and DNA In-Situ Hybridization","display_name":"Detection of Human Papillomavirus in Squamous Lesions of the Conjunctiva Using RNA and DNA In-Situ Hybridization","publication_year":2022,"publication_date":"2022-06-29","ids":{"openalex":"https://openalex.org/W4283743435","doi":"https://doi.org/10.3390/ijms23137249","pmid":"https://pubmed.ncbi.nlm.nih.gov/35806252","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9266440"},"language":"en","primary_location":{"id":"doi:10.3390/ijms23137249","doi":"https://doi.org/10.3390/ijms23137249","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms23137249","pdf_url":"https://www.mdpi.com/1422-0067/23/13/7249/pdf?version=1656686770","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/23/13/7249/pdf?version=1656686770","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012567800","display_name":"Cornelia Peterson","orcid":"https://orcid.org/0000-0001-6550-1883","observed_orcids":["https://orcid.org/0000-0001-6550-1883"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cornelia Peterson","raw_affiliation_strings":["Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA"],"raw_orcid":"https://orcid.org/0000-0001-6550-1883","affiliations":[{"raw_affiliation_string":"Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078396857","display_name":"Rupin N. Parikh","orcid":"https://orcid.org/0000-0002-2716-107X","observed_orcids":["https://orcid.org/0000-0002-2716-107X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rupin N. Parikh","raw_affiliation_strings":["Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA","Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007058609","display_name":"Meleha T. Ahmad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meleha T. Ahmad","raw_affiliation_strings":["Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105989077","display_name":"Ashley A. Campbell","orcid":"https://orcid.org/0009-0006-5420-3411","observed_orcids":["https://orcid.org/0009-0006-5420-3411"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashley A. Campbell","raw_affiliation_strings":["Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025812003","display_name":"Yassine J. Daoud","orcid":"https://orcid.org/0000-0002-8046-4045","observed_orcids":["https://orcid.org/0000-0002-8046-4045"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yassine Daoud","raw_affiliation_strings":["Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010577206","display_name":"Nicholas R. Mahoney","orcid":"https://orcid.org/0000-0001-7175-0413","observed_orcids":["https://orcid.org/0000-0001-7175-0413"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas Mahoney","raw_affiliation_strings":["Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053030738","display_name":"Sepideh Siadati","orcid":"https://orcid.org/0000-0003-1787-9915","observed_orcids":["https://orcid.org/0000-0003-1787-9915"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sepideh Siadati","raw_affiliation_strings":["Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019028542","display_name":"Charles G. Eberhart","orcid":"https://orcid.org/0000-0002-2910-9427","observed_orcids":["https://orcid.org/0000-0002-2910-9427"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Charles G. Eberhart","raw_affiliation_strings":["Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA","Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5019028542"],"corresponding_institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"],"apc_list":{"value":2300,"currency":"CHF","value_usd":2408},"apc_paid":{"value":2300,"currency":"CHF","value_usd":2408},"fwci":0.8667,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.68914749,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"23","issue":"13","first_page":"7249","last_page":"7249"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-papillomavirus","display_name":"human papillomavirus","score":0.996999979019165},{"id":"https://openalex.org/keywords/conjunctival-papilloma","display_name":"conjunctival papilloma","score":0.8899999856948853},{"id":"https://openalex.org/keywords/conjunctival-intraepithelial-neoplasia","display_name":"conjunctival intraepithelial neoplasia","score":0.9959999918937683},{"id":"https://openalex.org/keywords/conjunctival-squamous-cell-carcinoma","display_name":"conjunctival squamous cell carcinoma","score":0.9649999737739563},{"id":"https://openalex.org/keywords/rna-in-situ-hybridization","display_name":"RNA in situ hybridization","score":0.8450000286102295},{"id":"https://openalex.org/keywords/dna-in-situ-hybridization","display_name":"DNA in situ hybridization","score":0.9980000257492065},{"id":"https://openalex.org/keywords/low-risk-hpv","display_name":"low-risk HPV","score":0.8450000286102295},{"id":"https://openalex.org/keywords/high-risk-hpv","display_name":"high-risk HPV","score":0.9539999961853027},{"id":"https://openalex.org/keywords/reactive-atypia","display_name":"reactive atypia","score":0.925000011920929},{"id":"https://openalex.org/keywords/dysplasia","display_name":"dysplasia","score":0.890999972820282},{"id":"https://openalex.org/keywords/atopy","display_name":"atopy","score":0.8100000023841858}],"concepts":[{"id":"https://openalex.org/C81439078","wikidata":"https://www.wikidata.org/wiki/Q2304142","display_name":"In situ hybridization","level":4,"score":0.8585312366485596},{"id":"https://openalex.org/C2777661416","wikidata":"https://www.wikidata.org/wiki/Q1035645","display_name":"Carcinoma in situ","level":3,"score":0.7402721047401428},{"id":"https://openalex.org/C2781283455","wikidata":"https://www.wikidata.org/wiki/Q1960558","display_name":"Atypia","level":2,"score":0.6869374513626099},{"id":"https://openalex.org/C2775984611","wikidata":"https://www.wikidata.org/wiki/Q273554","display_name":"Conjunctiva","level":2,"score":0.6623069047927856},{"id":"https://openalex.org/C2775894508","wikidata":"https://www.wikidata.org/wiki/Q1128996","display_name":"Dysplasia","level":2,"score":0.5964547395706177},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5310471653938293},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5117123126983643},{"id":"https://openalex.org/C2778580637","wikidata":"https://www.wikidata.org/wiki/Q184627","display_name":"HPV infection","level":4,"score":0.497805118560791},{"id":"https://openalex.org/C2777822432","wikidata":"https://www.wikidata.org/wiki/Q216681","display_name":"In situ","level":2,"score":0.47360706329345703},{"id":"https://openalex.org/C2776350393","wikidata":"https://www.wikidata.org/wiki/Q912796","display_name":"Papilloma","level":2,"score":0.468310683965683},{"id":"https://openalex.org/C130197536","wikidata":"https://www.wikidata.org/wiki/Q418436","display_name":"Hybridization probe","level":3,"score":0.4353146553039551},{"id":"https://openalex.org/C2779534503","wikidata":"https://www.wikidata.org/wiki/Q6058399","display_name":"Intraepithelial neoplasia","level":4,"score":0.41089940071105957},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.387246698141098},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3665693402290344},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.3389394283294678},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3092226982116699},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.20547443628311157},{"id":"https://openalex.org/C2778220009","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical cancer","level":3,"score":0.1276010274887085},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12005794048309326},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1010591983795166},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08556431531906128},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.08062723278999329},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D002278","descriptor_name":"Carcinoma in Situ","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003228","descriptor_name":"Conjunctiva","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003230","descriptor_name":"Conjunctival Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D003230","descriptor_name":"Conjunctival Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010212","descriptor_name":"Papilloma","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D010212","descriptor_name":"Papilloma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027383","descriptor_name":"Papillomaviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D030361","descriptor_name":"Papillomavirus Infections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D052685","descriptor_name":"Alphapapillomavirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3390/ijms23137249","doi":"https://doi.org/10.3390/ijms23137249","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms23137249","pdf_url":"https://www.mdpi.com/1422-0067/23/13/7249/pdf?version=1656686770","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9266440","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9266440","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:35806252","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35806252","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:c4ac7ba32b8a4f1db66c07afad71b181","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/c4ac7ba32b8a4f1db66c07afad71b181","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 23, Iss 7249, p 7249 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ijms23137249","doi":"https://doi.org/10.3390/ijms23137249","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms23137249","pdf_url":"https://www.mdpi.com/1422-0067/23/13/7249/pdf?version=1656686770","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G9000890202","display_name":"Training Veterinarians for Careers in Biomedical Research","funder_award_id":"T32OD011089","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4283743435.pdf","grobid_xml":"https://content.openalex.org/works/W4283743435.grobid-xml"},"referenced_works_count":91,"referenced_works":["https://openalex.org/W45243890","https://openalex.org/W1565778062","https://openalex.org/W1576348771","https://openalex.org/W1909524983","https://openalex.org/W1960895270","https://openalex.org/W1965457809","https://openalex.org/W1968317563","https://openalex.org/W1970798368","https://openalex.org/W1980284988","https://openalex.org/W1983019576","https://openalex.org/W1985393369","https://openalex.org/W1995177877","https://openalex.org/W2009377629","https://openalex.org/W2013776790","https://openalex.org/W2034848002","https://openalex.org/W2036641307","https://openalex.org/W2038224867","https://openalex.org/W2041460032","https://openalex.org/W2048761637","https://openalex.org/W2048969068","https://openalex.org/W2057993707","https://openalex.org/W2059109849","https://openalex.org/W2060480439","https://openalex.org/W2060565056","https://openalex.org/W2062277174","https://openalex.org/W2062331789","https://openalex.org/W2062649734","https://openalex.org/W2065150919","https://openalex.org/W2071420551","https://openalex.org/W2073474887","https://openalex.org/W2076197926","https://openalex.org/W2076654028","https://openalex.org/W2091365166","https://openalex.org/W2100512746","https://openalex.org/W2104573099","https://openalex.org/W2113447715","https://openalex.org/W2119229039","https://openalex.org/W2122096644","https://openalex.org/W2126401000","https://openalex.org/W2126930654","https://openalex.org/W2127433490","https://openalex.org/W2165078045","https://openalex.org/W2166191901","https://openalex.org/W2190002176","https://openalex.org/W2260911333","https://openalex.org/W2278571014","https://openalex.org/W2281986318","https://openalex.org/W2318969565","https://openalex.org/W2329640948","https://openalex.org/W2335162820","https://openalex.org/W2427020577","https://openalex.org/W2588612043","https://openalex.org/W2592644763","https://openalex.org/W2625292978","https://openalex.org/W2752179323","https://openalex.org/W2787896722","https://openalex.org/W2791179780","https://openalex.org/W2791812741","https://openalex.org/W2799721388","https://openalex.org/W2805252396","https://openalex.org/W2805606782","https://openalex.org/W2911372338","https://openalex.org/W2916866853","https://openalex.org/W2925189784","https://openalex.org/W2946856333","https://openalex.org/W2947819018","https://openalex.org/W2949642869","https://openalex.org/W2950781942","https://openalex.org/W2951711842","https://openalex.org/W2960651781","https://openalex.org/W2971752113","https://openalex.org/W2972191622","https://openalex.org/W2972571479","https://openalex.org/W2981747653","https://openalex.org/W2989150632","https://openalex.org/W2997051888","https://openalex.org/W3030106787","https://openalex.org/W3033090694","https://openalex.org/W3080889714","https://openalex.org/W3094012162","https://openalex.org/W3104775752","https://openalex.org/W3109394523","https://openalex.org/W3116467957","https://openalex.org/W3119331860","https://openalex.org/W3133593664","https://openalex.org/W3172807922","https://openalex.org/W3186343739","https://openalex.org/W3192333041","https://openalex.org/W3204539462","https://openalex.org/W6759715342","https://openalex.org/W6788305633"],"related_works":["https://openalex.org/W3041737112","https://openalex.org/W2166191901","https://openalex.org/W2026386639","https://openalex.org/W4245790204","https://openalex.org/W3042048864","https://openalex.org/W2048368633","https://openalex.org/W2013974324","https://openalex.org/W2418133588","https://openalex.org/W1979619990","https://openalex.org/W162146259"],"abstract_inverted_index":{"In-situ":[0],"hybridization":[1,103,119,154],"provides":[2],"a":[3,157],"convenient":[4],"and":[5,31,110,133,170,177,188],"reliable":[6],"method":[7],"to":[8,75,121],"detect":[9,122],"human":[10],"papillomavirus":[11],"(HPV)":[12],"infection":[13,124,163,187],"in":[14,28,37,63,104,125,136,164,190],"formalin-fixed":[15],"paraffin-embedded":[16],"tissue.":[17],"Cases":[18],"of":[19,82,107,113,127,144,167],"conjunctival":[20,22,26,64],"papillomas,":[21],"intraepithelial":[23],"neoplasia":[24],"(CIN),":[25],"carcinoma":[27,35],"situ":[29],"(cCIS),":[30],"invasive":[32],"squamous":[33,165],"cell":[34],"(SCC),":[36],"which":[38],"low-risk":[39],"(LR)":[40],"and/or":[41],"high-risk":[42],"(HR)":[43],"HPV":[44,58,92,97,123,146,162,186],"types":[45,59],"were":[46,54,60,88],"evaluated":[47],"by":[48,93,100],"RNA":[49,72,101,152],"or":[50,85,192],"DNA":[51,79,117],"in-situ":[52,102,118,153],"hybridization,":[53],"retrospectively":[55],"identified.":[56],"LR":[57,91,145],"frequently":[61],"detected":[62,99],"papillomas":[65,137,191],"(25/30,":[66],"83%),":[67],"including":[68],"17/18":[69],"(94%)":[70],"with":[71,78,141],"probes,":[73],"compared":[74],"8/12":[76],"(75%)":[77],"probes.":[80],"None":[81],"the":[83,128,142,168,172],"CIN/cCIS":[84,108,129],"SCC":[86,114],"cases":[87,109],"positive":[89],"for":[90,160],"either":[94],"method.":[95],"HR":[96],"was":[98,138,181],"1/16":[105],"(6%)":[106],"2/4":[111],"(50%)":[112],"cases,":[115],"while":[116],"failed":[120],"any":[126],"lesions.":[130,194],"Reactive":[131],"atypia":[132,176],"dysplasia":[134],"observed":[135],"generally":[139],"associated":[140],"detection":[143],"types.":[147],"Collectively,":[148],"our":[149],"findings":[150],"indicate":[151],"may":[155],"provide":[156],"high-sensitivity":[158],"approach":[159],"identifying":[161],"lesions":[166],"conjunctiva":[169],"facilitate":[171],"distinction":[173],"between":[174,185],"reactive":[175],"true":[178],"dysplasia.":[179],"There":[180],"no":[182],"clear":[183],"association":[184],"atopy":[189],"dysplastic":[193]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-07-02T00:00:00"}