{"id":"https://openalex.org/W4283708230","doi":"https://doi.org/10.1111/tid.13885","title":"Safety and value of pretransplant antibiotic allergy delabeling in a quaternary transplant center","display_name":"Safety and value of pretransplant antibiotic allergy delabeling in a quaternary transplant center","publication_year":2022,"publication_date":"2022-06-29","ids":{"openalex":"https://openalex.org/W4283708230","doi":"https://doi.org/10.1111/tid.13885","pmid":"https://pubmed.ncbi.nlm.nih.gov/35765165","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9588656"},"language":"en","primary_location":{"id":"doi:10.1111/tid.13885","doi":"https://doi.org/10.1111/tid.13885","is_oa":false,"landing_page_url":"https://doi.org/10.1111/tid.13885","pdf_url":null,"source":{"id":"https://openalex.org/S14534568","display_name":"Transplant Infectious Disease","issn_l":"1398-2273","issn":["1398-2273","1399-3062"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplant Infectious Disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9588656","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070410429","display_name":"Chelsea A. Gorsline","orcid":"https://orcid.org/0000-0002-1068-2493","observed_orcids":["https://orcid.org/0000-0002-1068-2493"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chelsea A. Gorsline","raw_affiliation_strings":["Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA"],"raw_orcid":"https://orcid.org/0000-0002-1068-2493","affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023525049","display_name":"Abaseen K. Afghan","orcid":"https://orcid.org/0000-0002-4407-8243","observed_orcids":["https://orcid.org/0000-0002-4407-8243"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abaseen K. Afghan","raw_affiliation_strings":["Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018729944","display_name":"Cosby A. Stone","orcid":"https://orcid.org/0000-0002-1888-4188","observed_orcids":["https://orcid.org/0000-0002-1888-4188"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cosby A. Stone","raw_affiliation_strings":["Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA"],"raw_orcid":"https://orcid.org/0000-0002-1888-4188","affiliations":[{"raw_affiliation_string":"Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080985934","display_name":"Elizabeth Jane Phillips","orcid":"https://orcid.org/0000-0002-7623-3383","observed_orcids":["https://orcid.org/0000-0002-7623-3383"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth J. Phillips","raw_affiliation_strings":["Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA"],"raw_orcid":"https://orcid.org/0000-0002-7623-3383","affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023992625","display_name":"Gowri Satyanarayana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gowri Satyanarayana","raw_affiliation_strings":["Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA","institution_ids":["https://openalex.org/I901861585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5070410429"],"corresponding_institution_ids":["https://openalex.org/I901861585"],"apc_list":{"value":3450,"currency":"USD","value_usd":3450},"apc_paid":null,"fwci":2.423,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.8944591,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"24","issue":"5","first_page":"e13885","last_page":"e13885"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":0.4259999990463257,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":0.4259999990463257,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.35839998722076416,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11080","display_name":"Surgical site infection prevention","score":0.033399999141693115,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pretransplant-evaluation","display_name":"pre-transplant evaluation","score":0.8370000123977661},{"id":"https://openalex.org/keywords/solid-organ-transplantation","display_name":"solid organ transplantation","score":0.8830000162124634},{"id":"https://openalex.org/keywords/stem-cell-transplantation","display_name":"stem cell transplantation","score":0.9629999995231628},{"id":"https://openalex.org/keywords/sulfonamide-allergy","display_name":"sulfonamide allergy","score":0.6629999876022339},{"id":"https://openalex.org/keywords/antibiotic-stewardship","display_name":"antibiotic stewardship","score":0.7549999952316284},{"id":"https://openalex.org/keywords/cost-reduction","display_name":"cost reduction","score":0.6610000133514404},{"id":"https://openalex.org/keywords/prophylaxis","display_name":"prophylaxis","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9510830044746399},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.768609881401062},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.6125697493553162},{"id":"https://openalex.org/C2776040555","wikidata":"https://www.wikidata.org/wiki/Q19903321","display_name":"Antimicrobial stewardship","level":4,"score":0.5685365200042725},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.45709624886512756},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3796348571777344},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.26557624340057373},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.14999768137931824},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000073602","descriptor_name":"Antimicrobial Stewardship","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004342","descriptor_name":"Drug Hypersensitivity","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/tid.13885","doi":"https://doi.org/10.1111/tid.13885","is_oa":false,"landing_page_url":"https://doi.org/10.1111/tid.13885","pdf_url":null,"source":{"id":"https://openalex.org/S14534568","display_name":"Transplant Infectious Disease","issn_l":"1398-2273","issn":["1398-2273","1399-3062"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplant Infectious Disease","raw_type":"journal-article"},{"id":"pmid:35765165","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35765165","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplant infectious disease : an official journal of the Transplantation Society","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9588656","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9588656","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Transpl Infect Dis","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9588656","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9588656","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Transpl Infect Dis","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G129402337","display_name":null,"funder_award_id":"K12 HS026395","funder_id":"https://openalex.org/F4320332177","funder_display_name":"Agency for Healthcare Research and Quality"},{"id":"https://openalex.org/G1991070941","display_name":null,"funder_award_id":"R13 AR078623","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G3355698053","display_name":"Improving Prediction of Drug Action","funder_award_id":"P50GM115305","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5774467610","display_name":"Stevens-Johnson syndrome/toxic epidermal necrolysis 2021: Collaboration, Innovation and Community","funder_award_id":"1r13ar078623-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5970016102","display_name":"Genetic risk and long-term outcomes associated with Drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in survivors","funder_award_id":"R01HG010863","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G9000871931","display_name":"Immune Tolerance Network","funder_award_id":"UM1AI109565","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000875372","display_name":"Immune-mediated adverse drug reactions to HIV and TB treatments in South Africa: predict, prevent and improve long-term outcomes (IMARI SA study)","funder_award_id":"R01AI152183","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000908289","display_name":"NATIENS: A Phase III Randomized Double Blinded Study to Determine the Mechanisms and Optimal Management of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis","funder_award_id":"U01AI154659","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332177","display_name":"Agency for Healthcare Research and Quality","ror":"https://ror.org/03jmfdf59"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1489456801","https://openalex.org/W2078897207","https://openalex.org/W2286634806","https://openalex.org/W2292993343","https://openalex.org/W2337544276","https://openalex.org/W2750513024","https://openalex.org/W2789603460","https://openalex.org/W2949742803","https://openalex.org/W2961830492","https://openalex.org/W2974905787","https://openalex.org/W3006754325","https://openalex.org/W3012112115","https://openalex.org/W3047330221","https://openalex.org/W3091971071","https://openalex.org/W3177423627","https://openalex.org/W3202507808","https://openalex.org/W4211095142"],"related_works":["https://openalex.org/W4306682097","https://openalex.org/W4411887425","https://openalex.org/W4414124303","https://openalex.org/W3041225443","https://openalex.org/W7133296340","https://openalex.org/W4306734268","https://openalex.org/W2982118391","https://openalex.org/W4389030986","https://openalex.org/W4416812353","https://openalex.org/W2980718227"],"abstract_inverted_index":{"BACKGROUND:":[0],"Self-reported":[1],"antibiotic":[2,7,22,46,55,76,101,128,153,161,172,245],"allergies,":[3],"also":[4],"known":[5],"as":[6],"allergy":[8,23,47,77,102,129,154,208,246],"labels,":[9],"are":[10,230],"common":[11],"and":[12,32,38,59,85,116,136,156,219,238],"may":[13,33],"lead":[14,26],"to":[15,27,169,188,197,211],"worse":[16],"patient":[17,191],"outcomes.":[18],"Within":[19],"immunocompromized":[20],"patients,":[21],"labels":[24],"can":[25],"inappropriate":[28],"use":[29,199],"of":[30,54,61,97,148,179,186,200,216,235,243],"antimicrobials":[31],"limit":[34],"options":[35,40],"for":[36,107,141,203,232,240],"prophylactic":[37],"therapeutic":[39],"in":[41,64,80,120,139,192,223],"the":[42,81,159,170,193,198,224,233],"posttransplant":[43,89,194],"period.":[44,227],"While":[45],"delabeling":[48,78,130,155,182,209,236,247],"is":[49,67,213,215],"considered":[50,222],"an":[51,75,100],"important":[52],"aspect":[53],"stewardship":[56],"protocols,":[57],"evidence":[58],"awareness":[60],"its":[62,86],"application":[63],"transplant":[65,212],"recipients":[66],"limited.":[68],"METHODS:":[69],"We":[70],"describe":[71],"our":[72,132],"experience":[73],"with":[74,99],"intervention":[79],"pretransplant":[82,127,152,225,244],"evaluation":[83,106,226],"period":[84,195],"impact":[87],"on":[88],"antimicrobial":[90],"utilization.":[91],"This":[92],"was":[93],"a":[94],"retrospective":[95],"analysis":[96,122],"patients":[98,150],"label":[103],"who":[104,125],"underwent":[105,151],"solid":[108],"organ":[109],"or":[110],"stem":[111],"cell":[112],"transplantation":[113],"between":[114],"2015":[115],"2020.":[117],"Patients":[118],"included":[119],"this":[121],"were":[123,137,164],"those":[124],"completed":[126],"through":[131],"Drug":[133],"Allergy":[134],"Clinic":[135],"retained":[138],"care":[140],"6":[142,174],"months":[143,175],"after":[144],"transplant.":[145],"RESULTS:":[146],"Twenty-six":[147],"27":[149],"safely":[157],"received":[158],"delabeled":[160,171],"posttransplant.":[162,176],"There":[163],"no":[165],"reported":[166],"side":[167],"effects":[168],"within":[173],"Specific":[177],"examination":[178],"sulfonamide":[180],"(sulfa)-antibiotic":[181],"showed":[183],"cost":[184],"savings":[185],"$254":[187],"$2910":[189],"per":[190],"compared":[196],"alternative":[201],"antibiotics":[202],"prophylaxis":[204],"protocol.":[205],"CONCLUSION:":[206],"Antibiotic":[207],"prior":[210],"safe,":[214],"high":[217],"value,":[218],"should":[220],"be":[221],"More":[228],"resources":[229],"needed":[231],"development":[234],"guidelines":[237],"support":[239],"broad":[241],"implementation":[242],"programs.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-06-30T00:00:00"}