{"id":"https://openalex.org/W4283706846","doi":"https://doi.org/10.3233/jad-220481","title":"3-Hydroxyacyl-CoA and Alcohol Dehydrogenase Activities of Mitochondrial Type 10 17\u03b2-Hydroxysteroid Dehydrogenase in Neurodegeneration Study","display_name":"3-Hydroxyacyl-CoA and Alcohol Dehydrogenase Activities of Mitochondrial Type 10 17\u03b2-Hydroxysteroid Dehydrogenase in Neurodegeneration Study","publication_year":2022,"publication_date":"2022-06-28","ids":{"openalex":"https://openalex.org/W4283706846","doi":"https://doi.org/10.3233/jad-220481","pmid":"https://pubmed.ncbi.nlm.nih.gov/35786658","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9484088"},"language":"en","primary_location":{"id":"doi:10.3233/jad-220481","doi":"https://doi.org/10.3233/jad-220481","is_oa":true,"landing_page_url":"https://doi.org/10.3233/jad-220481","pdf_url":"https://content.iospress.com:443/download/journal-of-alzheimers-disease/jad220481?id=journal-of-alzheimers-disease%2Fjad220481","source":{"id":"https://openalex.org/S25155249","display_name":"Journal of Alzheimer s Disease","issn_l":"1387-2877","issn":["1387-2877","1875-8908"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer\u2019s Disease","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://content.iospress.com:443/download/journal-of-alzheimers-disease/jad220481?id=journal-of-alzheimers-disease%2Fjad220481","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101671468","display_name":"Xue\u2010Ying He","orcid":"https://orcid.org/0009-0006-2672-7066","observed_orcids":["https://orcid.org/0009-0006-2672-7066"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Xue-Ying He","raw_affiliation_strings":["Department of Molecular Biology, NYS Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, NYS Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089582930","display_name":"Carl Dobkin","orcid":"https://orcid.org/0000-0003-0855-9960","observed_orcids":["https://orcid.org/0000-0003-0855-9960"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carl Dobkin","raw_affiliation_strings":["Department of Human Genetics, NYS Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, NYS Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113444733","display_name":"William Ted Brown","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"W.Ted Brown","raw_affiliation_strings":["Central Clinical School, University of Sydney, Sydney, Australia","Department of Human Genetics, NYS Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Clinical School, University of Sydney, Sydney, Australia","institution_ids":["https://openalex.org/I129604602"]},{"raw_affiliation_string":"Department of Human Genetics, NYS Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024216177","display_name":"Song\u2010Yu Yang","orcid":"https://orcid.org/0000-0001-7995-2984","observed_orcids":["https://orcid.org/0000-0001-7995-2984"]},"institutions":[{"id":"https://openalex.org/I121847817","display_name":"The Graduate Center, CUNY","ror":"https://ror.org/00awd9g61","country_code":"US","type":"education","lineage":["https://openalex.org/I121847817"]},{"id":"https://openalex.org/I174216632","display_name":"City University of New York","ror":"https://ror.org/00453a208","country_code":"US","type":"education","lineage":["https://openalex.org/I174216632"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Song-Yu Yang","raw_affiliation_strings":["Department of Molecular Biology, NYS Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA","Ph.D. Program in Biology-Neuroscience, Graduate Center of the City University of New York, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, NYS Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA","institution_ids":[]},{"raw_affiliation_string":"Ph.D. Program in Biology-Neuroscience, Graduate Center of the City University of New York, New York, NY, USA","institution_ids":["https://openalex.org/I121847817","https://openalex.org/I174216632"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5024216177","https://openalex.org/A5101671468"],"corresponding_institution_ids":["https://openalex.org/I121847817","https://openalex.org/I174216632"],"apc_list":null,"apc_paid":null,"fwci":0.3452,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.45176034,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"88","issue":"4","first_page":"1487","last_page":"1497"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9291999936103821,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9291999936103821,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.020400000736117363,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13736","display_name":"Steroid Chemistry and Biochemistry","score":0.011599999852478504,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.6745675802230835},{"id":"https://openalex.org/C2777344606","wikidata":"https://www.wikidata.org/wiki/Q410754","display_name":"Alcohol dehydrogenase","level":3,"score":0.6564201712608337},{"id":"https://openalex.org/C2776317432","wikidata":"https://www.wikidata.org/wiki/Q412547","display_name":"Dehydrogenase","level":3,"score":0.5143221616744995},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4058331847190857},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3632301092147827},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3168576955795288},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2845802903175354},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23896360397338867},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.16119793057441711}],"mesh":[{"descriptor_ui":"D000426","descriptor_name":"Alcohol Dehydrogenase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003065","descriptor_name":"Coenzyme A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015067","descriptor_name":"17-Hydroxysteroid Dehydrogenases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015094","descriptor_name":"3-Hydroxyacyl CoA Dehydrogenases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3233/jad-220481","doi":"https://doi.org/10.3233/jad-220481","is_oa":true,"landing_page_url":"https://doi.org/10.3233/jad-220481","pdf_url":"https://content.iospress.com:443/download/journal-of-alzheimers-disease/jad220481?id=journal-of-alzheimers-disease%2Fjad220481","source":{"id":"https://openalex.org/S25155249","display_name":"Journal of Alzheimer s Disease","issn_l":"1387-2877","issn":["1387-2877","1875-8908"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer\u2019s Disease","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9484088","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9484088","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Alzheimers Dis","raw_type":"Text"},{"id":"pmid:35786658","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35786658","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer's disease : JAD","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3233/jad-220481","doi":"https://doi.org/10.3233/jad-220481","is_oa":true,"landing_page_url":"https://doi.org/10.3233/jad-220481","pdf_url":"https://content.iospress.com:443/download/journal-of-alzheimers-disease/jad220481?id=journal-of-alzheimers-disease%2Fjad220481","source":{"id":"https://openalex.org/S25155249","display_name":"Journal of Alzheimer s Disease","issn_l":"1387-2877","issn":["1387-2877","1875-8908"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer\u2019s Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320319226","display_name":"Office for People With Developmental Disabilities","ror":"https://ror.org/00b6kjb41"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4283706846.pdf","grobid_xml":"https://content.openalex.org/works/W4283706846.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1485838909","https://openalex.org/W1505108252","https://openalex.org/W1579505662","https://openalex.org/W1966530439","https://openalex.org/W1969547229","https://openalex.org/W1971097859","https://openalex.org/W1980214458","https://openalex.org/W1986826429","https://openalex.org/W1987307328","https://openalex.org/W1993558908","https://openalex.org/W1995705046","https://openalex.org/W1998262675","https://openalex.org/W1998879475","https://openalex.org/W2022574700","https://openalex.org/W2025383063","https://openalex.org/W2030564045","https://openalex.org/W2031370072","https://openalex.org/W2039615989","https://openalex.org/W2040271350","https://openalex.org/W2041720829","https://openalex.org/W2055348534","https://openalex.org/W2074154331","https://openalex.org/W2077017147","https://openalex.org/W2090085493","https://openalex.org/W2091085285","https://openalex.org/W2091579589","https://openalex.org/W2100240547","https://openalex.org/W2106662259","https://openalex.org/W2117037463","https://openalex.org/W2126886556","https://openalex.org/W2133662632","https://openalex.org/W2138765938","https://openalex.org/W2151952542","https://openalex.org/W2163757074","https://openalex.org/W2184763224","https://openalex.org/W2204366321","https://openalex.org/W2204392591","https://openalex.org/W2208687042","https://openalex.org/W2288795473","https://openalex.org/W2293722429","https://openalex.org/W2751029985","https://openalex.org/W2789058915","https://openalex.org/W2898565901","https://openalex.org/W2900633866","https://openalex.org/W2902738161","https://openalex.org/W2947017842","https://openalex.org/W2981654653","https://openalex.org/W3003370225","https://openalex.org/W3017202199","https://openalex.org/W3044771426","https://openalex.org/W4255440993"],"related_works":["https://openalex.org/W4225429046","https://openalex.org/W2789058915","https://openalex.org/W4393168026","https://openalex.org/W4412907457","https://openalex.org/W2041720829","https://openalex.org/W4389917563","https://openalex.org/W1987307328","https://openalex.org/W448192093","https://openalex.org/W3017202199","https://openalex.org/W2039615989"],"abstract_inverted_index":{"BACKGROUND:":[0],"Mitochondrial":[1],"17\u03b2-hydroxysteroid":[2],"dehydrogenase":[3,24,88,99,131],"type":[4],"10":[5],"(17\u03b2-HSD10)":[6],"is":[7],"necessary":[8],"for":[9,33,120],"brain":[10],"cognitive":[11],"function,":[12],"but":[13,92],"its":[14,97,128],"studies":[15,181],"were":[16,61],"confounded":[17],"by":[18,73],"reports":[19,53,145],"of":[20,45,90,96,106,136,166,190],"A\u03b2-peptide":[21,29],"binding":[22,30],"alcohol":[23,130],"(ABAD),":[25],"formerly":[26],"endoplasmic":[27],"reticulum-associated":[28],"protein":[31],"(ERAB),":[32],"two":[34],"decades":[35],"so":[36],"long":[37],"as":[38,41,117],"ABAD":[39,52,137,144,167],"serves":[40],"the":[42,87,93,134,139],"alternative":[43],"term":[44],"17\u03b2-HSD10.":[46],"OBJECTIVE:":[47],"To":[48],"determine":[49],"whether":[50],"those":[51,105],"are":[54,101],"true":[55],"or":[56],"false,":[57],"even":[58],"if":[59],"they":[60],"published":[62],"in":[63,113,143,176,182],"prestigious":[64],"journals.":[65],"METHODS:":[66],"6xHis-tagged":[67],"17\u03b2-HSD10":[68,171],"was":[69,110,124],"prepared":[70],"and":[71,108,156,179],"characterized":[72],"well-established":[74],"experimental":[75,140],"procedures.":[76],"RESULTS:":[77],"The":[78],"N-terminal":[79],"6xHis":[80],"tag":[81],"did":[82],"not":[83,111,159],"significantly":[84],"interfere":[85],"with":[86],"activities":[89,132],"17\u03b2-HSD10,":[91],"kinetic":[94],"constants":[95],"3-hydroxyacyl-CoA":[98],"activity":[100],"drastically":[102],"distinct":[103],"from":[104],"ABAD,":[107],"it":[109,123],"involved":[112],"ketone":[114],"body":[115],"metabolism":[116,178],"previously":[118],"reported":[119],"ABAD.":[121],"Furthermore,":[122],"impossible":[125],"to":[126,162,187],"measure":[127],"generalized":[129],"underlying":[133],"concept":[135],"because":[138],"procedures":[141],"described":[142],"violated":[146],"basic":[147],"chemical":[148],"and/or":[149],"biochemical":[150],"principles.":[151],"More":[152],"incredibly,":[153],"both":[154],"authors":[155],"journals":[157],"had":[158],"yet":[160],"agreed":[161],"make":[163],"any":[164],"corrigenda":[165],"reports.":[168],"CONCLUSION:":[169],"Brain":[170],"plays":[172],"a":[173],"key":[174],"role":[175],"neurosteroid":[177],"further":[180],"this":[183],"area":[184],"may":[185],"lead":[186],"potential":[188],"treatments":[189],"neurodegeneration":[191],"including":[192],"AD.":[193]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-06-30T00:00:00"}