{"id":"https://openalex.org/W4283704341","doi":"https://doi.org/10.1155/2022/1399697","title":"Mechanism of Targeting the Hedgehog Signaling Pathway against Chemotherapeutic Resistance in Multiple Myeloma","display_name":"Mechanism of Targeting the Hedgehog Signaling Pathway against Chemotherapeutic Resistance in Multiple Myeloma","publication_year":2022,"publication_date":"2022-06-29","ids":{"openalex":"https://openalex.org/W4283704341","doi":"https://doi.org/10.1155/2022/1399697","pmid":"https://pubmed.ncbi.nlm.nih.gov/35813864","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9259296"},"language":"en","primary_location":{"id":"doi:10.1155/2022/1399697","doi":"https://doi.org/10.1155/2022/1399697","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2022/1399697","pdf_url":"https://downloads.hindawi.com/journals/jo/2022/1399697.pdf","source":{"id":"https://openalex.org/S207014961","display_name":"Journal of Oncology","issn_l":"1687-8450","issn":["1687-8450","1687-8469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/jo/2022/1399697.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056541945","display_name":"Yuefeng Zhang","orcid":"https://orcid.org/0000-0002-1891-0040","observed_orcids":["https://orcid.org/0000-0002-1891-0040"]},"institutions":[{"id":"https://openalex.org/I4210148790","display_name":"Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine","ror":"https://ror.org/05pwsw714","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210148790"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yuefeng Zhang","raw_affiliation_strings":["Department of Hematology, First People\u2019s Hospital of Linping District, Hangzhou 311100, Zhejiang, China"],"raw_orcid":"https://orcid.org/0000-0002-1891-0040","affiliations":[{"raw_affiliation_string":"Department of Hematology, First People\u2019s Hospital of Linping District, Hangzhou 311100, Zhejiang, China","institution_ids":["https://openalex.org/I4210148790"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007061533","display_name":"Guoli Yao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148790","display_name":"Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine","ror":"https://ror.org/05pwsw714","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210148790"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guoli Yao","raw_affiliation_strings":["Department of Hematology, First People\u2019s Hospital of Linping District, Hangzhou 311100, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, First People\u2019s Hospital of Linping District, Hangzhou 311100, Zhejiang, China","institution_ids":["https://openalex.org/I4210148790"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004144742","display_name":"Xinxin Yang","orcid":"https://orcid.org/0000-0002-2024-4307","observed_orcids":["https://orcid.org/0000-0002-2024-4307"]},"institutions":[{"id":"https://openalex.org/I4210148790","display_name":"Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine","ror":"https://ror.org/05pwsw714","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210148790"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinxin Yang","raw_affiliation_strings":["Department of Hematology, First People\u2019s Hospital of Linping District, Hangzhou 311100, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, First People\u2019s Hospital of Linping District, Hangzhou 311100, Zhejiang, China","institution_ids":["https://openalex.org/I4210148790"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007388157","display_name":"Tao Qiu","orcid":"https://orcid.org/0000-0002-1410-7795","observed_orcids":["https://orcid.org/0000-0002-1410-7795"]},"institutions":[{"id":"https://openalex.org/I4210148790","display_name":"Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine","ror":"https://ror.org/05pwsw714","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210148790"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao Qiu","raw_affiliation_strings":["Department of Hematology, First People\u2019s Hospital of Linping District, Hangzhou 311100, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, First People\u2019s Hospital of Linping District, Hangzhou 311100, Zhejiang, China","institution_ids":["https://openalex.org/I4210148790"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100371274","display_name":"Sheng Wang","orcid":"https://orcid.org/0000-0002-4797-5310","observed_orcids":["https://orcid.org/0000-0002-4797-5310"]},"institutions":[{"id":"https://openalex.org/I4210148790","display_name":"Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine","ror":"https://ror.org/05pwsw714","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210148790"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sheng Wang","raw_affiliation_strings":["Department of Hematology, First People\u2019s Hospital of Linping District, Hangzhou 311100, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, First People\u2019s Hospital of Linping District, Hangzhou 311100, Zhejiang, China","institution_ids":["https://openalex.org/I4210148790"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5056541945"],"corresponding_institution_ids":["https://openalex.org/I4210148790"],"apc_list":{"value":2550,"currency":"USD","value_usd":2550},"apc_paid":{"value":2550,"currency":"USD","value_usd":2550},"fwci":0.4082,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.49635896,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"2022","issue":null,"first_page":"1","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.05220000073313713,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hedgehog-signaling","display_name":"Hedgehog signaling","score":0.9919999837875366},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.996999979019165},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.7950000166893005},{"id":"https://openalex.org/keywords/azithromycin-resistance","display_name":"azithromycin resistance","score":0.9789999723434448},{"id":"https://openalex.org/keywords/ptch1","display_name":"PTCH1","score":0.9200000166893005},{"id":"https://openalex.org/keywords/gli1","display_name":"Gli1","score":0.8870000243186951},{"id":"https://openalex.org/keywords/gli2","display_name":"GLI2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hes1","display_name":"Hes1","score":0.9860000014305115},{"id":"https://openalex.org/keywords/sonic-hedgehog","display_name":"Sonic hedgehog","score":0.9350000023841858},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9409999847412109},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9909999966621399},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.75},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7200000286102295}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8858212232589722},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.7426997423171997},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.6876686811447144},{"id":"https://openalex.org/C88498014","wikidata":"https://www.wikidata.org/wiki/Q14859918","display_name":"Hedgehog signaling pathway","level":3,"score":0.621516227722168},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5459020733833313},{"id":"https://openalex.org/C2778539099","wikidata":"https://www.wikidata.org/wiki/Q6120","display_name":"Hedgehog","level":3,"score":0.5286558270454407},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4008130431175232},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33557918667793274},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26849278807640076},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1799357831478119},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08557498455047607},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1155/2022/1399697","doi":"https://doi.org/10.1155/2022/1399697","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2022/1399697","pdf_url":"https://downloads.hindawi.com/journals/jo/2022/1399697.pdf","source":{"id":"https://openalex.org/S207014961","display_name":"Journal of Oncology","issn_l":"1687-8450","issn":["1687-8450","1687-8469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9259296","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9259296","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Oncol","raw_type":"Text"},{"id":"pmid:35813864","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35813864","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of oncology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:d6131070efc3408dbd41a6b74a267834","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d6131070efc3408dbd41a6b74a267834","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Oncology, Vol 2022 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1155/2022/1399697","doi":"https://doi.org/10.1155/2022/1399697","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2022/1399697","pdf_url":"https://downloads.hindawi.com/journals/jo/2022/1399697.pdf","source":{"id":"https://openalex.org/S207014961","display_name":"Journal of Oncology","issn_l":"1687-8450","issn":["1687-8450","1687-8469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G544051967","display_name":null,"funder_award_id":"2017B27","funder_id":"https://openalex.org/F4320329364","funder_display_name":"Zhejiang Medical Association"},{"id":"https://openalex.org/G5950835721","display_name":null,"funder_award_id":"2017ZYC-A43","funder_id":"https://openalex.org/F4320329364","funder_display_name":"Zhejiang Medical Association"}],"funders":[{"id":"https://openalex.org/F4320329364","display_name":"Zhejiang Medical Association","ror":"https://ror.org/00kv1td69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4283704341.pdf","grobid_xml":"https://content.openalex.org/works/W4283704341.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1999549312","https://openalex.org/W2554199252","https://openalex.org/W2611520057","https://openalex.org/W2619737660","https://openalex.org/W2724424633","https://openalex.org/W2799637892","https://openalex.org/W2819082975","https://openalex.org/W2889850156","https://openalex.org/W2906937763","https://openalex.org/W2910087950","https://openalex.org/W2913434193","https://openalex.org/W2942050688","https://openalex.org/W2944512335","https://openalex.org/W2954953185","https://openalex.org/W2978712187","https://openalex.org/W2988166391","https://openalex.org/W3001436247","https://openalex.org/W3004087209","https://openalex.org/W3011596369","https://openalex.org/W3016698942","https://openalex.org/W3021912665","https://openalex.org/W3024238537","https://openalex.org/W3042678088","https://openalex.org/W3044411258","https://openalex.org/W3087673370","https://openalex.org/W3134103265","https://openalex.org/W3154166441","https://openalex.org/W3162216898","https://openalex.org/W3200752197"],"related_works":["https://openalex.org/W3024238537","https://openalex.org/W2552211862","https://openalex.org/W2171874387","https://openalex.org/W2978712187","https://openalex.org/W3181483659","https://openalex.org/W2578050598","https://openalex.org/W2973018202","https://openalex.org/W3001436247","https://openalex.org/W3032156608","https://openalex.org/W2057940494"],"abstract_inverted_index":{"Objective.":[0],"The":[1,23,76],"aim":[2],"of":[3,78,88,134,143,158,185,194],"this":[4],"study":[5],"was":[6,30,43,47,83,113,160,217],"to":[7,49,239],"explore":[8],"the":[9,12,33,51,86,128,131,141,148,155,170,173,182,192,221,228],"relationship":[10],"between":[11],"Hedgehog":[13,52,222,229],"signaling":[14,53,223,230],"pathway":[15,224,231],"and":[16,45,71,85,105,117,138,140,145,189,191,196,226],"drug":[17,241],"resistance":[18,242],"in":[19,80,110,147,243],"multiple":[20,215,244],"myeloma.":[21,245],"Methods.":[22],"human":[24],"myeloma":[25,216],"cell":[26,39,178],"line":[27,40],"RPMI":[28,41,59,63],"8266":[29],"taken":[31],"as":[32,235],"research":[34],"object.":[35],"An":[36],"azithromycin":[37],"(AZM)-resistant":[38],"8226/R":[42,64,73],"constructed,":[44],"GENT61":[46],"used":[48,234],"block":[50],"pathway.":[54],"Cells":[55],"were":[56,123,151,198,205],"rolled":[57],"into":[58],"8226/S":[60,68],"(S":[61],"group),":[62,66,70],"(R":[65],"GENT61+RPMI":[67,72],"(GENT61+S":[69],"(GENT61+R":[74],"group).":[75],"proliferation":[77,179],"cells":[79],"each":[81,111],"group":[82,112,150,175],"assessed,":[84],"expression":[87,132,156,183,203],"patched":[89],"homolog":[90],"1":[91,97,103],"(PTCH1),":[92],"zinc":[93],"finger-containing":[94],"transcription":[95],"factors":[96],"(GLI1),":[98],"GLI2,":[99,136,187],"hair-division":[100],"associated":[101,219],"enhancer":[102],"(Hes1),":[104],"sonic":[106],"hedgehog":[107],"factor":[108,121],"(SHH)":[109],"detected.":[114],"Interleukin":[115],"(IL)-6":[116],"vascular":[118],"endothelial":[119],"growth":[120],"(VEGF)":[122],"measured.":[124],"Results.":[125],"Compared":[126,168],"with":[127,169,220],"S":[129],"group,":[130,172],"levels":[133,184,204],"PTCH1,":[135,186],"Hes1,":[137,188],"SHH":[139],"contents":[142,193],"IL-6":[144,195],"VEGF":[146,197],"R":[149,171],"greatly":[152,176,206],"increased,":[153],"while":[154,201],"level":[157],"GLI1":[159,202],"notably":[161,199],"decreased":[162],"(":[163,208],"P":[164,209],"<":[165,210],"0.05":[166,211],").":[167,212],"GENT61+R":[174],"increased":[177,207],"inhibition.":[180],"However,":[181],"SHH,":[190],"decreased,":[200],"Conclusion.":[213],"AZM-resistant":[214],"closely":[218],"activation,":[225],"blocking":[227],"can":[232],"be":[233],"a":[236],"therapeutic":[237],"target":[238],"improve":[240]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2022-06-30T00:00:00"}
