{"id":"https://openalex.org/W4283699548","doi":"https://doi.org/10.3389/fcvm.2022.900810","title":"Dominant Myocardial Fibrosis and Complex Immune Microenvironment Jointly Shape the Pathogenesis of Arrhythmogenic Right Ventricular Cardiomyopathy","display_name":"Dominant Myocardial Fibrosis and Complex Immune Microenvironment Jointly Shape the Pathogenesis of Arrhythmogenic Right Ventricular Cardiomyopathy","publication_year":2022,"publication_date":"2022-06-29","ids":{"openalex":"https://openalex.org/W4283699548","doi":"https://doi.org/10.3389/fcvm.2022.900810","pmid":"https://pubmed.ncbi.nlm.nih.gov/35845067","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9278650"},"language":"en","primary_location":{"id":"doi:10.3389/fcvm.2022.900810","doi":"https://doi.org/10.3389/fcvm.2022.900810","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcvm.2022.900810","pdf_url":null,"source":{"id":"https://openalex.org/S2595413687","display_name":"Frontiers in Cardiovascular Medicine","issn_l":"2297-055X","issn":["2297-055X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cardiovascular Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fcvm.2022.900810","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021245150","display_name":"Wenzhao Lu","orcid":"https://orcid.org/0000-0002-8621-1858","observed_orcids":["https://orcid.org/0000-0002-8621-1858"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210161896","display_name":"Fu Wai Hospital","ror":"https://ror.org/0590dnz19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161896"]},{"id":"https://openalex.org/I4391767941","display_name":"State Key Laboratory of Cardiovascular Disease","ror":"https://ror.org/00t7sjs72","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210087153","https://openalex.org/I4391767941"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenzhao Lu","raw_affiliation_strings":["State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Arrhythmia Center, Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Arrhythmia Center, Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210161896","https://openalex.org/I4391767941"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yao Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210161896","display_name":"Fu Wai Hospital","ror":"https://ror.org/0590dnz19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161896"]},{"id":"https://openalex.org/I4391767941","display_name":"State Key Laboratory of Cardiovascular Disease","ror":"https://ror.org/00t7sjs72","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210087153","https://openalex.org/I4391767941"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yao Li","raw_affiliation_strings":["State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Arrhythmia Center, Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Arrhythmia Center, Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210161896","https://openalex.org/I4391767941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100642678","display_name":"Yan Dai","orcid":"https://orcid.org/0009-0007-4533-8813","observed_orcids":["https://orcid.org/0009-0007-4533-8813"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210161896","display_name":"Fu Wai Hospital","ror":"https://ror.org/0590dnz19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161896"]},{"id":"https://openalex.org/I4391767941","display_name":"State Key Laboratory of Cardiovascular Disease","ror":"https://ror.org/00t7sjs72","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210087153","https://openalex.org/I4391767941"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Dai","raw_affiliation_strings":["State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Arrhythmia Center, Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Arrhythmia Center, Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210161896","https://openalex.org/I4391767941"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101543289","display_name":"Keping Chen","orcid":"https://orcid.org/0000-0001-9954-9770","observed_orcids":["https://orcid.org/0000-0001-9954-9770"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210161896","display_name":"Fu Wai Hospital","ror":"https://ror.org/0590dnz19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161896"]},{"id":"https://openalex.org/I4391767941","display_name":"State Key Laboratory of Cardiovascular Disease","ror":"https://ror.org/00t7sjs72","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210087153","https://openalex.org/I4391767941"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Keping Chen","raw_affiliation_strings":["State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Arrhythmia Center, Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Arrhythmia Center, Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210161896","https://openalex.org/I4391767941"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5101543289"],"corresponding_institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210161896","https://openalex.org/I4391767941"],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":2.6327,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.91358434,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"9","issue":null,"first_page":"900810","last_page":"900810"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11922","display_name":"Cardiovascular Effects of Exercise","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11922","display_name":"Cardiovascular Effects of Exercise","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arrhythmogenic-right-ventricular-cardiomyopathy","display_name":"arrhythmogenic right ventricular cardiomyopathy","score":1.0},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.9279999732971191},{"id":"https://openalex.org/keywords/immune-infiltration","display_name":"immune cell infiltration","score":0.9950000047683716},{"id":"https://openalex.org/keywords/t-cell-subsets","display_name":"T cell subsets","score":0.7609999775886536},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.921999990940094},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.5839999914169312},{"id":"https://openalex.org/keywords/hub-genes","display_name":"hub genes","score":0.7620000243186951},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.30799999833106995}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6592369675636292},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.4867992103099823},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4585345685482025},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.45821279287338257},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.4477508068084717},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4425089955329895},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.43866589665412903},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.41333144903182983},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3668854236602783},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31916260719299316},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.19475498795509338},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14176875352859497}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fcvm.2022.900810","doi":"https://doi.org/10.3389/fcvm.2022.900810","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcvm.2022.900810","pdf_url":null,"source":{"id":"https://openalex.org/S2595413687","display_name":"Frontiers in Cardiovascular Medicine","issn_l":"2297-055X","issn":["2297-055X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cardiovascular Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9278650","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9278650","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Cardiovasc Med","raw_type":"Text"},{"id":"pmid:35845067","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35845067","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cardiovascular medicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:dd73aca31daf4b08807522fcc6abdbbb","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/dd73aca31daf4b08807522fcc6abdbbb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cardiovascular Medicine, Vol 9 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fcvm.2022.900810","doi":"https://doi.org/10.3389/fcvm.2022.900810","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcvm.2022.900810","pdf_url":null,"source":{"id":"https://openalex.org/S2595413687","display_name":"Frontiers in Cardiovascular Medicine","issn_l":"2297-055X","issn":["2297-055X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cardiovascular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W1925728463","https://openalex.org/W1966327575","https://openalex.org/W1969814796","https://openalex.org/W1970727687","https://openalex.org/W1978162436","https://openalex.org/W2003045329","https://openalex.org/W2010186048","https://openalex.org/W2022229270","https://openalex.org/W2025826819","https://openalex.org/W2047141937","https://openalex.org/W2064871215","https://openalex.org/W2071596061","https://openalex.org/W2071765960","https://openalex.org/W2073621589","https://openalex.org/W2078780781","https://openalex.org/W2083163701","https://openalex.org/W2085822999","https://openalex.org/W2101304778","https://openalex.org/W2102118247","https://openalex.org/W2113808060","https://openalex.org/W2123879591","https://openalex.org/W2127904701","https://openalex.org/W2138839726","https://openalex.org/W2143540084","https://openalex.org/W2147207765","https://openalex.org/W2148056172","https://openalex.org/W2149967999","https://openalex.org/W2150550128","https://openalex.org/W2151873763","https://openalex.org/W2153948838","https://openalex.org/W2167196315","https://openalex.org/W2170939446","https://openalex.org/W2238998036","https://openalex.org/W2282085803","https://openalex.org/W2288411839","https://openalex.org/W2568946517","https://openalex.org/W2596139865","https://openalex.org/W2604561621","https://openalex.org/W2608650231","https://openalex.org/W2621850935","https://openalex.org/W2743241869","https://openalex.org/W2782454362","https://openalex.org/W2789580833","https://openalex.org/W2792342950","https://openalex.org/W2887947508","https://openalex.org/W2904851070","https://openalex.org/W2905562353","https://openalex.org/W2928665623","https://openalex.org/W2941565518","https://openalex.org/W2949273159","https://openalex.org/W2954229637","https://openalex.org/W2974365689","https://openalex.org/W3013733909","https://openalex.org/W3033126525","https://openalex.org/W3034875393","https://openalex.org/W3096818982","https://openalex.org/W3107527779","https://openalex.org/W3110500961","https://openalex.org/W3168163181","https://openalex.org/W3168775597","https://openalex.org/W3210024567","https://openalex.org/W3214158946","https://openalex.org/W4200591494","https://openalex.org/W4207035974","https://openalex.org/W7097432222","https://openalex.org/W7098958697"],"related_works":["https://openalex.org/W7163221199","https://openalex.org/W7220459251","https://openalex.org/W4296117380","https://openalex.org/W4417162975","https://openalex.org/W2904962923","https://openalex.org/W2153948838","https://openalex.org/W2763299385","https://openalex.org/W4399155317","https://openalex.org/W7005729972","https://openalex.org/W6959000027"],"abstract_inverted_index":{"Background:":[0],"integrated":[1],"bioinformatics":[2],"analysis.":[3],"Methods:":[4],"RNA-sequencing":[5],"datasets":[6],"of":[7,91,217,230,269],"GSE107475,":[8],"GSE107311,":[9],"GSE107156,":[10],"and":[11,23,30,43,47,55,161,181,194,205,211,221,288],"GSE107125":[12],"were":[13,51,86,166,213],"obtained":[14],"from":[15,27],"the":[16,39,92,100,214,227,237,252,266,277],"Gene":[17],"Expression":[18],"Omnibus":[19],"database,":[20],"including":[21,188],"right":[22],"left":[24],"ventricular":[25],"myocardium":[26,268],"ARVC":[28,40,79,110,170,218,243,258],"patients":[29],"normal":[31,113],"controls.":[32,114],"Weighted":[33],"gene":[34],"co-expression":[35],"network":[36,241],"analysis":[37,50,60,72,90],"identified":[38],"hub":[41,80,84,93,174,186,219,223,244],"modules":[42,81],"genes.":[44],"Functional":[45,88],"enrichment":[46,59,89],"protein-protein":[48],"interaction":[49,240],"performed":[52,74],"by":[53,75],"Metascape":[54],"STRING.":[56],"Single-sample":[57],"gene-set":[58],"(ssGSEA)":[61],"was":[62,73,99,119,176,246],"applied":[63],"to":[64,297],"assess":[65],"immune":[66,117,179,202,262,289],"cell":[67,165,203,274,290],"infiltration.":[68,291],"Transcription":[69],"regulator":[70],"(TF)":[71],"TRRUST.":[76],"Results:":[77],"Three":[78],"with":[82,185],"25":[83],"genes":[85,94,187,220,245],"identified.":[87],"indicated":[95],"that":[96,121],"myocardial":[97,105,285],"fibrosis":[98,106,206,250,286],"dominant":[101,253],"pathogenic":[102,254],"process.":[103],"Higher":[104],"activity":[107,207,287],"existed":[108,200],"in":[109,112,169,178,208,233,256,265,271],"than":[111],"A":[115,196,260,280],"complex":[116,261],"microenvironment":[118,263],"discovered":[120],"type":[122,127],"2":[123],"T":[124,129,133,144,159,164,273],"helper":[125,130],"cell,":[126,131,134,137,140,145,150,153,156,160],"1":[128],"regulatory":[132],"plasmacytoid":[135],"dendritic":[136],"neutrophil,":[138],"mast":[139],"central":[141],"memory":[142,154],"CD4":[143],"macrophage,":[146],"CD56dim":[147],"natural":[148,157],"killer":[149,158],"myeloid-derived":[151],"suppressor":[152],"B":[155],"activated":[162],"CD8":[163],"highly":[167],"infiltrated":[168],"myocardium.":[171],"The":[172],"immune-related":[173,222],"module":[175,224],"enriched":[177],"processes":[180],"inflammatory":[182],"disease":[183],"pathways,":[184],"CD74,":[189],"HLA-DRA,":[190],"ITGAM,":[191],"CTSS,":[192],"CYBB,":[193],"IRF8.":[195],"positive":[197],"linear":[198],"correlation":[199],"between":[201,284],"infiltration":[204],"ARVC.":[209],"NFKB1":[210],"RELA":[212],"shared":[215],"TFs":[216],"genes,":[225],"indicating":[226],"critical":[228],"role":[229],"NF\u03baB":[231,292],"signaling":[232,293],"both":[234,298],"mechanisms.":[235,299],"Finally,":[236],"potential":[238],"lncRNA-miRNA-mRNA":[239],"for":[242],"constructed.":[247],"Conclusion:":[248],"Myocardial":[249],"is":[251],"process":[255],"end-stage":[257],"patients.":[259],"exists":[264,283],"diseased":[267],"ARVC,":[270],"which":[272],"subsets":[275],"are":[276],"primary":[278],"category.":[279],"tight":[281],"relationship":[282],"pathway":[294],"possibly":[295],"contributes":[296]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-06-30T00:00:00"}
