{"id":"https://openalex.org/W4283699427","doi":"https://doi.org/10.3390/jof8070677","title":"Novel ABC Transporter Associated with Fluconazole Resistance in Aging of Cryptococcus neoformans","display_name":"Novel ABC Transporter Associated with Fluconazole Resistance in Aging of Cryptococcus neoformans","publication_year":2022,"publication_date":"2022-06-28","ids":{"openalex":"https://openalex.org/W4283699427","doi":"https://doi.org/10.3390/jof8070677","pmid":"https://pubmed.ncbi.nlm.nih.gov/35887434","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9320417"},"language":"en","primary_location":{"id":"doi:10.3390/jof8070677","doi":"https://doi.org/10.3390/jof8070677","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jof8070677","pdf_url":"https://www.mdpi.com/2309-608X/8/7/677/pdf?version=1656412017","source":{"id":"https://openalex.org/S2737643958","display_name":"Journal of Fungi","issn_l":"2309-608X","issn":["2309-608X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Fungi","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2309-608X/8/7/677/pdf?version=1656412017","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027928256","display_name":"Nat\u00e1lia Kronbauer Oliveira","orcid":"https://orcid.org/0000-0001-5381-0988","observed_orcids":["https://orcid.org/0000-0001-5381-0988"]},"institutions":[{"id":"https://openalex.org/I4210087560","display_name":"Stony Brook School","ror":"https://ror.org/003wx9n05","country_code":"US","type":"education","lineage":["https://openalex.org/I4210087560"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natalia Kronbauer Oliveira","raw_affiliation_strings":["Department of Microbiology and Immunology , Renaissance School of Medicine , Stony Brook University , Stony Brook , New York , USA","Department of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology , Renaissance School of Medicine , Stony Brook University , Stony Brook , New York , USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA","institution_ids":["https://openalex.org/I4210087560","https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025065541","display_name":"Somanon Bhattacharya","orcid":"https://orcid.org/0000-0002-8562-3877","observed_orcids":["https://orcid.org/0000-0002-8562-3877"]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Somanon Bhattacharya","raw_affiliation_strings":["Division of Infectious Diseases , Department of Medicine , Stony Brook University , Stony Brook , New York , USA","Division of Infectious Diseases, Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA"],"raw_orcid":"https://orcid.org/0000-0002-8562-3877","affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases , Department of Medicine , Stony Brook University , Stony Brook , New York , USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Division of Infectious Diseases, Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010546522","display_name":"Rina Gambhir","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rina Gambhir","raw_affiliation_strings":["Stony Brook University , Stony Brook , New York , USA","Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stony Brook University , Stony Brook , New York , USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011458367","display_name":"Manav Joshi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manav Joshi","raw_affiliation_strings":["Stony Brook University , Stony Brook , New York , USA","Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stony Brook University , Stony Brook , New York , USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012849145","display_name":"Bettina C. Fries","orcid":"https://orcid.org/0000-0002-6847-5518","observed_orcids":["https://orcid.org/0000-0002-6847-5518"]},"institutions":[{"id":"https://openalex.org/I4210087560","display_name":"Stony Brook School","ror":"https://ror.org/003wx9n05","country_code":"US","type":"education","lineage":["https://openalex.org/I4210087560"]},{"id":"https://openalex.org/I4210109353","display_name":"Northport VA Medical Center","ror":"https://ror.org/01xtpc441","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094901","https://openalex.org/I4210109353"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bettina C Fries","raw_affiliation_strings":["Department of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA","Division of Infectious Diseases, Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA","Veterans Administration Medical Center, Northport, NY 11768, USA"],"raw_orcid":"https://orcid.org/0000-0002-6847-5518","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA","institution_ids":["https://openalex.org/I4210087560","https://openalex.org/I59553526"]},{"raw_affiliation_string":"Division of Infectious Diseases, Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Veterans Administration Medical Center, Northport, NY 11768, USA","institution_ids":["https://openalex.org/I4210109353"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5012849145"],"corresponding_institution_ids":["https://openalex.org/I4210087560","https://openalex.org/I4210109353","https://openalex.org/I59553526"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2094},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2094},"fwci":2.5394,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.91256102,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"8","issue":"7","first_page":"677","last_page":"677"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.9312000274658203,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.9312000274658203,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.043299999088048935,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.013899999670684338,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cryptococcus-neoformans","display_name":"Cryptococcus neoformans","score":0.9819999933242798},{"id":"https://openalex.org/keywords/fluconazole-resistance","display_name":"fluconazole resistance","score":0.8659999966621399},{"id":"https://openalex.org/keywords/abc-transporters","display_name":"ABC transporters","score":0.8240000009536743},{"id":"https://openalex.org/keywords/efflux-pumps","display_name":"efflux pumps","score":0.8700000047683716},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.47200000286102295},{"id":"https://openalex.org/keywords/replicative-lifespan","display_name":"replicative lifespan","score":0.9319999814033508},{"id":"https://openalex.org/keywords/azole-resistance","display_name":"azole resistance","score":0.8040000200271606},{"id":"https://openalex.org/keywords/chronic-infection","display_name":"chronic infection","score":0.6790000200271606},{"id":"https://openalex.org/keywords/macrophage-killing","display_name":"macrophage killing","score":0.8339999914169312},{"id":"https://openalex.org/keywords/virulence","display_name":"virulence","score":0.9129999876022339},{"id":"https://openalex.org/keywords/galleria-mellonella","display_name":"Galleria mellonella","score":0.9359999895095825}],"concepts":[{"id":"https://openalex.org/C200082930","wikidata":"https://www.wikidata.org/wiki/Q22327148","display_name":"Efflux","level":2,"score":0.9420849084854126},{"id":"https://openalex.org/C2777893358","wikidata":"https://www.wikidata.org/wiki/Q131924","display_name":"Cryptococcus neoformans","level":2,"score":0.868376612663269},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6898382306098938},{"id":"https://openalex.org/C44312359","wikidata":"https://www.wikidata.org/wiki/Q286958","display_name":"ATP-binding cassette transporter","level":4,"score":0.6374941468238831},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6241310834884644},{"id":"https://openalex.org/C2778589691","wikidata":"https://www.wikidata.org/wiki/Q3429577","display_name":"Rhodamine 123","level":4,"score":0.5689648389816284},{"id":"https://openalex.org/C2780651595","wikidata":"https://www.wikidata.org/wiki/Q411478","display_name":"Fluconazole","level":3,"score":0.5091678500175476},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.4362505078315735},{"id":"https://openalex.org/C2779413141","wikidata":"https://www.wikidata.org/wiki/Q1470140","display_name":"Cryptococcosis","level":2,"score":0.4360063672065735},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.35422295331954956},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.28971385955810547},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12175315618515015},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08452636003494263},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/jof8070677","doi":"https://doi.org/10.3390/jof8070677","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jof8070677","pdf_url":"https://www.mdpi.com/2309-608X/8/7/677/pdf?version=1656412017","source":{"id":"https://openalex.org/S2737643958","display_name":"Journal of Fungi","issn_l":"2309-608X","issn":["2309-608X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Fungi","raw_type":"journal-article"},{"id":"doi:10.20944/preprints202201.0263.v1","doi":"https://doi.org/10.20944/preprints202201.0263.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202201.0263.v1","pdf_url":"https://www.preprints.org/manuscript/202201.0263/v1/download","source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:9320417","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9320417","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Fungi (Basel)","raw_type":"Text"},{"id":"pmid:35887434","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35887434","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of fungi (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:0104b70716b84962a97dd42bf3159e3b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0104b70716b84962a97dd42bf3159e3b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Fungi, Vol 8, Iss 7, p 677 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/jof8070677","doi":"https://doi.org/10.3390/jof8070677","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jof8070677","pdf_url":"https://www.mdpi.com/2309-608X/8/7/677/pdf?version=1656412017","source":{"id":"https://openalex.org/S2737643958","display_name":"Journal of Fungi","issn_l":"2309-608X","issn":["2309-608X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Fungi","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5756738779","display_name":null,"funder_award_id":"I01 BX003741","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G6363265938","display_name":"Investigation on Replicative aging in Cryptococcus neoformans populations","funder_award_id":"R01AI127704","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320309568","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4283699427.pdf","grobid_xml":"https://content.openalex.org/works/W4283699427.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1483456869","https://openalex.org/W1540935980","https://openalex.org/W1595790960","https://openalex.org/W1608204567","https://openalex.org/W1743763938","https://openalex.org/W1981239770","https://openalex.org/W2000307429","https://openalex.org/W2000804360","https://openalex.org/W2021132161","https://openalex.org/W2026474096","https://openalex.org/W2028793515","https://openalex.org/W2050248589","https://openalex.org/W2052931063","https://openalex.org/W2055230647","https://openalex.org/W2072969034","https://openalex.org/W2089051496","https://openalex.org/W2107013040","https://openalex.org/W2107277218","https://openalex.org/W2107297946","https://openalex.org/W2114360920","https://openalex.org/W2114409750","https://openalex.org/W2120923784","https://openalex.org/W2121539149","https://openalex.org/W2138705841","https://openalex.org/W2143481612","https://openalex.org/W2144543496","https://openalex.org/W2145329735","https://openalex.org/W2150702714","https://openalex.org/W2157882630","https://openalex.org/W2163758697","https://openalex.org/W2164001266","https://openalex.org/W2164432008","https://openalex.org/W2165923078","https://openalex.org/W2166266450","https://openalex.org/W2171992806","https://openalex.org/W2219376059","https://openalex.org/W2346365539","https://openalex.org/W2491627885","https://openalex.org/W2581958671","https://openalex.org/W2611697423","https://openalex.org/W2761770213","https://openalex.org/W2768483119","https://openalex.org/W2791761451","https://openalex.org/W2883719988","https://openalex.org/W2910992897","https://openalex.org/W2962391048","https://openalex.org/W2981972499","https://openalex.org/W2994239937","https://openalex.org/W3006511740","https://openalex.org/W3031116948","https://openalex.org/W3114181470","https://openalex.org/W3126821255","https://openalex.org/W3175699163"],"related_works":["https://openalex.org/W2164432008","https://openalex.org/W2791761451","https://openalex.org/W1595790960","https://openalex.org/W2073784848","https://openalex.org/W4401546933","https://openalex.org/W4283204431","https://openalex.org/W4393230500","https://openalex.org/W2052931063","https://openalex.org/W2883348911","https://openalex.org/W2007197843"],"abstract_inverted_index":{"Cryptococcus":[0],"neoformans":[1,50,66,212,243],"causes":[2],"meningoencephalitis":[3],"in":[4,46,64,122,190,210,231],"immunocompromised":[5],"individuals,":[6],"which":[7,24,61,128,207],"is":[8,43,62,208],"treated":[9],"with":[10,146],"Fluconazole":[11],"(FLC)":[12],"monotherapy":[13],"when":[14],"resources":[15],"are":[16],"limited.":[17],"This":[18],"can":[19,25],"lead":[20],"to":[21,113,184,219,237],"azole":[22],"resistance,":[23],"be":[26],"mediated":[27],"by":[28,85,92,224],"overexpression":[29],"of":[30,35,41,68,162,173,214,240],"ABC":[31,38,57,204],"transporters,":[32,132],"a":[33,55,93,143,170,202],"class":[34],"efflux":[36,40,111,145],"pumps.":[37],"pump-mediated":[39],"FLC":[42,83,86,102,156,222],"also":[44,91,235],"augmented":[45],"10-generation":[47],"old":[48],"C.":[49,65,211,242],"cells.":[51,118],"Here,":[52],"we":[53],"describe":[54],"new":[56],"transporter":[58],"Afr3":[59,119,140],"(CNAG_06909),":[60],"overexpressed":[63],"cells":[67,106,213,244],"advanced":[69,215],"generational":[70],"age,":[71],"that":[72,96,201],"accumulate":[73],"during":[74,245],"chronic":[75,246],"infection.":[76,247],"The":[77,137],"delta-afr3":[78,105,164,180],"mutant":[79,165],"strain":[80,141],"showed":[81],"higher":[82,144],"susceptibility":[84],"E-Test":[87],"strip":[88],"testing":[89],"and":[90,150,187],"killing":[94,186],"test":[95],"measured":[97],"survival":[98],"after":[99],"3":[100],"h":[101],"exposure.":[103],"Furthermore,":[104],"exhibited":[107,181],"lower":[108],"Rhodamine":[109,148],"6G":[110,149],"compared":[112],"the":[114,123,155,163,174,191,238],"H99":[115],"wild":[116],"type":[117],"was":[120],"expressed":[121],"Saccharomyces":[124],"cerevisiae":[125],"AD-delta":[126,138],"strain,":[127],"lacks":[129],"several":[130],"drug":[131,226],"thus":[133],"reducing":[134],"background":[135],"transport.":[136],"+":[139],"demonstrated":[142],"both":[147],"Nile":[151],"Red,":[152],"even":[153],"though":[154],"MICs":[157],"were":[158],"not":[159],"changed.":[160],"Characterization":[161],"revealed":[166],"unattenuated":[167],"growth":[168],"but":[169],"prolongation":[171],"(22%)":[172],"replicative":[175],"life":[176],"span.":[177],"In":[178,196],"addition,":[179],"decreased":[182],"resistance":[183,233],"macrophage":[185,232],"attenuated":[188],"virulence":[189],"Galleria":[192],"mellonella":[193],"infection":[194],"model.":[195],"summary,":[197],"our":[198],"data":[199],"indicate":[200],"novel":[203],"pump":[205],"Afr3p,":[206],"upregulated":[209],"age":[216],"may":[217,234],"contribute":[218,236],"their":[220],"enhanced":[221],"tolerance,":[223],"promoting":[225],"efflux.":[227],"Lastly,":[228],"its":[229],"role":[230],"selection":[239],"older":[241]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2022-06-30T00:00:00"}
