{"id":"https://openalex.org/W4283693285","doi":"https://doi.org/10.1016/j.crstbi.2022.06.003","title":"Metabolically-incorporated deuterium in myelin localized by neutron diffraction and identified by mass spectrometry","display_name":"Metabolically-incorporated deuterium in myelin localized by neutron diffraction and identified by mass spectrometry","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4283693285","doi":"https://doi.org/10.1016/j.crstbi.2022.06.003","pmid":"https://pubmed.ncbi.nlm.nih.gov/35941866","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9356250"},"language":"en","primary_location":{"id":"doi:10.1016/j.crstbi.2022.06.003","doi":"https://doi.org/10.1016/j.crstbi.2022.06.003","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.crstbi.2022.06.003","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2665928X22000204/pdf","source":{"id":"https://openalex.org/S4210227336","display_name":"Current Research in Structural Biology","issn_l":"2665-928X","issn":["2665-928X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","oarl","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Research in Structural Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S2665928X22000204/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025129057","display_name":"Anne Baumann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103531236","display_name":"Boston College","ror":"https://ror.org/02n2fzt79","country_code":"US","type":"education","lineage":["https://openalex.org/I103531236"]},{"id":"https://openalex.org/I2800740805","display_name":"Haukeland University Hospital","ror":"https://ror.org/03np4e098","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I2800740805"]},{"id":"https://openalex.org/I4432739","display_name":"University of Bergen","ror":"https://ror.org/03zga2b32","country_code":"NO","type":"education","lineage":["https://openalex.org/I4432739"]}],"countries":["NO","US"],"is_corresponding":false,"raw_author_name":"Anne Baumann","raw_affiliation_strings":["Department of Biology, Boston College, Chestnut Hill, MA, USA","Department of Biomedicine, University of Bergen, Bergen, Norway","Division of Psychiatry, Haukeland University Hospital, Bergen, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Boston College, Chestnut Hill, MA, USA","institution_ids":["https://openalex.org/I103531236"]},{"raw_affiliation_string":"Department of Biomedicine, University of Bergen, Bergen, Norway","institution_ids":["https://openalex.org/I4432739"]},{"raw_affiliation_string":"Division of Psychiatry, Haukeland University Hospital, Bergen, Norway","institution_ids":["https://openalex.org/I2800740805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009200297","display_name":"Andrew R. Denninger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103531236","display_name":"Boston College","ror":"https://ror.org/02n2fzt79","country_code":"US","type":"education","lineage":["https://openalex.org/I103531236"]},{"id":"https://openalex.org/I4210109703","display_name":"Epizyme (United States)","ror":"https://ror.org/01mmhvx47","country_code":"US","type":"company","lineage":["https://openalex.org/I4210109703"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew R. Denninger","raw_affiliation_strings":["Department of Biology, Boston College, Chestnut Hill, MA, USA","Epizyme Inc, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Boston College, Chestnut Hill, MA, USA","institution_ids":["https://openalex.org/I103531236"]},{"raw_affiliation_string":"Epizyme Inc, Cambridge, MA, USA","institution_ids":["https://openalex.org/I4210109703"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068422393","display_name":"Marek A. Domin","orcid":"https://orcid.org/0000-0003-4037-363X","observed_orcids":["https://orcid.org/0000-0003-4037-363X"]},"institutions":[{"id":"https://openalex.org/I103531236","display_name":"Boston College","ror":"https://ror.org/02n2fzt79","country_code":"US","type":"education","lineage":["https://openalex.org/I103531236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marek Domin","raw_affiliation_strings":["Department of Chemistry, Boston College, Chestnut Hill, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Boston College, Chestnut Hill, MA, USA","institution_ids":["https://openalex.org/I103531236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085225128","display_name":"Bruno Dem\u00e9","orcid":"https://orcid.org/0000-0002-9523-7662","observed_orcids":["https://orcid.org/0000-0002-9523-7662"]},"institutions":[{"id":"https://openalex.org/I4210113448","display_name":"Institut Laue-Langevin","ror":"https://ror.org/01xtjs520","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210113448"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bruno Dem\u00e9","raw_affiliation_strings":["Institut Laue-Langevin, Grenoble, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Laue-Langevin, Grenoble, France","institution_ids":["https://openalex.org/I4210113448"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039151870","display_name":"Daniel A. Kirschner","orcid":"https://orcid.org/0000-0003-3498-1452","observed_orcids":["https://orcid.org/0000-0003-3498-1452"]},"institutions":[{"id":"https://openalex.org/I103531236","display_name":"Boston College","ror":"https://ror.org/02n2fzt79","country_code":"US","type":"education","lineage":["https://openalex.org/I103531236"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Daniel A. Kirschner","raw_affiliation_strings":["Department of Biology, Boston College, Chestnut Hill, MA, USA"],"raw_orcid":"https://orcid.org/0000-0003-3498-1452","affiliations":[{"raw_affiliation_string":"Department of Biology, Boston College, Chestnut Hill, MA, USA","institution_ids":["https://openalex.org/I103531236"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5039151870"],"corresponding_institution_ids":["https://openalex.org/I103531236"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":{"value":2500,"currency":"USD","value_usd":2500},"fwci":0.1471,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.31731644,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"4","issue":null,"first_page":"231","last_page":"245"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.5151000022888184,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.5151000022888184,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.18039999902248383,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11949","display_name":"Nuclear Physics and Applications","score":0.051600001752376556,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myelin","display_name":"myelin","score":0.9559999704360962},{"id":"https://openalex.org/keywords/deuterium-labeling","display_name":"deuterium labeling","score":0.796999990940094},{"id":"https://openalex.org/keywords/neutron-diffraction","display_name":"neutron diffraction","score":0.746999979019165},{"id":"https://openalex.org/keywords/trigeminal-nerve","display_name":"trigeminal nerve","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cerebrosides","display_name":"cerebrosides","score":0.6389999985694885},{"id":"https://openalex.org/keywords/sulfatide","display_name":"sulfatide","score":0.8019999861717224},{"id":"https://openalex.org/keywords/sphingomyelin","display_name":"sphingomyelin","score":0.8970000147819519}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6620029211044312},{"id":"https://openalex.org/C58364064","wikidata":"https://www.wikidata.org/wiki/Q102296","display_name":"Deuterium","level":2,"score":0.6569110751152039},{"id":"https://openalex.org/C2778609137","wikidata":"https://www.wikidata.org/wiki/Q105790271","display_name":"Myelin","level":3,"score":0.5876912474632263},{"id":"https://openalex.org/C73585123","wikidata":"https://www.wikidata.org/wiki/Q910499","display_name":"Neutron diffraction","level":3,"score":0.5431306958198547},{"id":"https://openalex.org/C152568617","wikidata":"https://www.wikidata.org/wiki/Q2348","display_name":"Neutron","level":2,"score":0.44896838068962097},{"id":"https://openalex.org/C2780876595","wikidata":"https://www.wikidata.org/wiki/Q410974","display_name":"Myelin basic protein","level":4,"score":0.44520726799964905},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.4197457432746887},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.41533878445625305},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.38149428367614746},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.35234975814819336},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.24959316849708557},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21071696281433105},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.20906949043273926},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.108377605676651},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C115624301","wikidata":"https://www.wikidata.org/wiki/Q895901","display_name":"Crystal structure","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1016/j.crstbi.2022.06.003","doi":"https://doi.org/10.1016/j.crstbi.2022.06.003","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.crstbi.2022.06.003","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2665928X22000204/pdf","source":{"id":"https://openalex.org/S4210227336","display_name":"Current Research in Structural Biology","issn_l":"2665-928X","issn":["2665-928X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","oarl","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Research in Structural Biology","raw_type":"journal-article"},{"id":"doi:10.1101/2021.12.17.473245","doi":"https://doi.org/10.1101/2021.12.17.473245","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.12.17.473245","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/04/30/2021.12.17.473245.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:9356250","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9356250","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Curr Res Struct Biol","raw_type":"Text"},{"id":"pmid:35941866","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35941866","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current research in structural biology","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-05566689v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-05566689","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Current Research in Structural Biology, 2022, 4, pp.231--245. ⟨10.1016/j.crstbi.2022.06.003⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:e26932fff54d4084b010438bb6c32038","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e26932fff54d4084b010438bb6c32038","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Current Research in Structural Biology, Vol 4, Iss , Pp 231-245 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.crstbi.2022.06.003","doi":"https://doi.org/10.1016/j.crstbi.2022.06.003","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.crstbi.2022.06.003","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2665928X22000204/pdf","source":{"id":"https://openalex.org/S4210227336","display_name":"Current Research in Structural Biology","issn_l":"2665-928X","issn":["2665-928X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","oarl","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Research in Structural Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.428600013256073,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320308357","display_name":"Boston College","ror":"https://ror.org/02n2fzt79"},{"id":"https://openalex.org/F4320320119","display_name":"Company of Biologists","ror":"https://ror.org/0033z1132"},{"id":"https://openalex.org/F4320322496","display_name":"Helse Vest","ror":"https://ror.org/001212e83"},{"id":"https://openalex.org/F4320323078","display_name":"Universitetet i Bergen","ror":"https://ror.org/03zga2b32"},{"id":"https://openalex.org/F4320323692","display_name":"Oulun Yliopisto","ror":"https://ror.org/03yj89h83"},{"id":"https://openalex.org/F4320336904","display_name":"Biocenter, University of Oulu","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4283693285.pdf","grobid_xml":"https://content.openalex.org/works/W4283693285.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W37344274","https://openalex.org/W187332323","https://openalex.org/W565854973","https://openalex.org/W642251971","https://openalex.org/W652829974","https://openalex.org/W1483086770","https://openalex.org/W1497989081","https://openalex.org/W1509326295","https://openalex.org/W1652241690","https://openalex.org/W1963970055","https://openalex.org/W1965719377","https://openalex.org/W1970331265","https://openalex.org/W1982216518","https://openalex.org/W2009453329","https://openalex.org/W2019423178","https://openalex.org/W2024601115","https://openalex.org/W2026770865","https://openalex.org/W2028617079","https://openalex.org/W2030113244","https://openalex.org/W2030418928","https://openalex.org/W2033268373","https://openalex.org/W2039866201","https://openalex.org/W2041356794","https://openalex.org/W2041827716","https://openalex.org/W2068319847","https://openalex.org/W2070146968","https://openalex.org/W2091108957","https://openalex.org/W2091784787","https://openalex.org/W2093589942","https://openalex.org/W2101379454","https://openalex.org/W2114683502","https://openalex.org/W2116687544","https://openalex.org/W2117306286","https://openalex.org/W2118382345","https://openalex.org/W2121319617","https://openalex.org/W2123521520","https://openalex.org/W2140884992","https://openalex.org/W2144071088","https://openalex.org/W2162242212","https://openalex.org/W2167702038","https://openalex.org/W2170974587","https://openalex.org/W2231806200","https://openalex.org/W2338479637","https://openalex.org/W2403567882","https://openalex.org/W2409175377","https://openalex.org/W2416404022","https://openalex.org/W2489640251","https://openalex.org/W2516430929","https://openalex.org/W2557013328","https://openalex.org/W2732487156","https://openalex.org/W2734391667","https://openalex.org/W2754309346","https://openalex.org/W2768134564","https://openalex.org/W2802521428","https://openalex.org/W2902201351","https://openalex.org/W2922816857","https://openalex.org/W2949362202","https://openalex.org/W2977444843","https://openalex.org/W2985897872","https://openalex.org/W3004220601","https://openalex.org/W3005645571","https://openalex.org/W3013269049","https://openalex.org/W3091953196","https://openalex.org/W3094602846","https://openalex.org/W3155234867","https://openalex.org/W3160898671","https://openalex.org/W3201253200","https://openalex.org/W4316500278"],"related_works":["https://openalex.org/W4417415256","https://openalex.org/W2619594105","https://openalex.org/W2121319617","https://openalex.org/W1544874960","https://openalex.org/W2403567882","https://openalex.org/W1940074063","https://openalex.org/W7096222011","https://openalex.org/W90084471","https://openalex.org/W2094857684","https://openalex.org/W2434857025"],"abstract_inverted_index":{"Abstract":[0],"Myelin":[1],"is":[2],"a":[3,72,290,298,319,328,342,414,429,449],"natural":[4],"and":[5,17,26,33,76,102,178,249,281,335,348,368,408,420,457,464],"dynamic":[6],"multilamellar":[7],"membrane":[8,167],"structure":[9],"that":[10,109,206,214,315,401,422],"continues":[11],"to":[12,23,297,341,361,427,436,445,447,472,496],"be":[13,359,406,425],"of":[14,40,47,53,62,81,123,140,164,185,197,212,255,263,285,292,300,323,330,339,344,354,376,389,432,440,452,459,484,500],"significant":[15],"biological":[16,502],"neurological":[18],"interest,":[19],"especially":[20],"with":[21,183,243],"respect":[22],"its":[24,29,179],"biosynthesis":[25],"assembly":[27],"during":[28,366,394],"normal":[30,463],"formation,":[31],"maintenance,":[32],"pathological":[34],"breakdown.":[35],"To":[36],"explore":[37],"the":[38,44,51,82,87,124,131,138,141,162,165,198,202,208,210,232,234,259,274,276,282,385,390,453,485,497],"usefulness":[39],"neutron":[41,105,411],"diffraction":[42,121,412],"in":[43,54,100,137,148,159,173,176,193,207,231,273,294,302,306,332,336,346,356,378,413,462],"structural":[45],"analysis":[46,196],"myelin,":[48,466,486],"we":[49],"investigated":[50],"use":[52],"vivo":[55],"labeling":[56],"by":[57,104,380,481],"metabolically":[58],"incorporating":[59],"non-toxic":[60],"levels":[61,244,375],"deuterium":[63,219],"(":[64],"2":[65],"H;":[66],"D)":[67],"via":[68],"drinking":[69],"water":[70],"into":[71],"pregnant":[73],"dam":[74],"(D-dam)":[75],"her":[77],"developing":[78],"embryos.":[79],"All":[80],"mice":[83,128],"were":[84,90,97,110,114,236,316],"sacrificed":[85],"when":[86],"pups":[88,209],"(D-pups)":[89],"55":[91],"days":[92],"old.":[93],"Myelinated":[94],"sciatic":[95],"nerves":[96,125,204],"dissected,":[98],"fixed":[99],"glutaraldehyde":[101],"examined":[103],"diffraction.":[106],"Parallel":[107],"samples":[108],"unfixed":[111],"(trigeminal":[112],"nerves)":[113],"frozen":[115],"for":[116,489],"mass":[117,252,483],"spectrometry":[118],"(MS).":[119],"The":[120,251,350,372],"patterns":[122],"from":[126,201,289,327],"deuterium-fed":[127],"(D-mice)":[129],"vs.":[130,487],"controls":[132],"(H-mice)":[133],"had":[134,215,310],"major":[135],"differences":[136,147],"intensities":[139],"Bragg":[142],"peaks":[143],"but":[144],"no":[145],"appreciable":[146,157],"myelin":[149,395,475],"periodicity.":[150],"Neutron":[151],"scattering":[152],"density":[153,160],"profiles":[154],"showed":[155],"an":[156],"increase":[158,170],"at":[161],"center":[163],"lipid-rich":[166],"bilayer.":[168],"This":[169],"was":[171,181,221,278],"greater":[172],"D-pups":[174,357],"than":[175],"D-dam,":[177,379],"localization":[180],"consistent":[182],"deuteration":[184,355,377],"lipid":[186,225,247,265,392,434,441],"hydrocarbon,":[187],"which":[188,325],"predominates":[189],"over":[190],"transmembrane":[191],"protein":[192],"myelin.":[194],"MS":[195,423],"lipids":[199,213,235,309,461],"isolated":[200],"trigeminal":[203],"demonstrated":[205],"percentage":[211],"one":[216,268,337],"or":[217,269],"more":[218,270,311,494],"atoms":[220,287],"uniformly":[222],"high":[223,299,343,352],"across":[224],"species":[226,248,338,393,435],"(97.6%":[227],"\u00b1":[228,241],"2.0%),":[229],"whereas":[230],"mother":[233],"substantially":[237],"less":[238],"deuterated":[239,433],"(60.6%":[240],"26.4%)":[242],"varying":[245,374],"among":[246],"subspecies.":[250],"distribution":[253],"pattern":[254,277],"deuterium-containing":[256],"isotopologues":[257],"indicated":[258],"fraction":[260],"(in":[261],"%)":[262],"each":[264],"(sub-)species":[266],"having":[267],"deuteriums":[271],"incorporated:":[272],"D-pups,":[275],"always":[279],"bell-shaped,":[280],"average":[283,321],"number":[284,322],"D":[286,403],"ranged":[288,326],"low":[291,329],"\u223c4":[293],"fatty":[295,333],"acid":[296,334],"\u223c9":[301],"cerebroside.":[303],"By":[304],"contrast,":[305,381],"D-dam":[307],"most":[308],"complex,":[312],"overlapping":[313],"distributions":[314],"weighted":[317],"toward":[318],"lower":[320],"deuteriums,":[324],"\u223c3\u20134":[331],"sulfatide":[340],"6\u20137":[345],"cerebroside":[347],"sphingomyelin.":[349],"consistently":[351],"level":[353],"can":[358,405,424],"attributed":[360],"their":[362],"de":[363,454],"novo":[364,455],"lipogenesis":[365],"gestation":[367],"rapid,":[369],"postnatal":[370],"myelination.":[371],"widely":[373],"likely":[382],"depends":[383],"on":[384,474],"relative":[386],"metabolic":[387],"stability":[388],"particular":[391],"maintenance.":[396],"Our":[397],"current":[398],"findings":[399],"demonstrate":[400],"stably-incorporated":[402],"label":[404],"detected":[407],"localized":[409],"using":[410],"complex":[415],"tissue":[416],"such":[417],"as":[418,491,493],"myelin;":[419],"moreover,":[421],"used":[426],"screen":[428],"broad":[430],"range":[431],"monitor":[437],"differential":[438],"rates":[439],"turnover.":[442],"In":[443],"addition":[444],"helping":[446],"develop":[448],"comprehensive":[450],"understanding":[451],"synthesis":[456],"turnover":[458],"specific":[460],"abnormal":[465],"our":[467],"results":[468],"also":[469],"suggest":[470],"application":[471],"studies":[473],"proteins":[476],"(which":[477],"constitute":[478],"only":[479],"20\u201330%":[480],"dry":[482],"70\u201380%":[488],"lipid),":[490],"well":[492],"broadly":[495],"molecular":[498],"constituents":[499],"other":[501],"tissues.":[503]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2022-06-30T00:00:00"}