{"id":"https://openalex.org/W4283661973","doi":"https://doi.org/10.3389/fonc.2022.853660","title":"Towards Photodynamic Image-Guided Surgery of Head and Neck Tumors: Photodynamic Priming Improves Delivery and Diagnostic Accuracy of Cetuximab-IRDye800CW","display_name":"Towards Photodynamic Image-Guided Surgery of Head and Neck Tumors: Photodynamic Priming Improves Delivery and Diagnostic Accuracy of Cetuximab-IRDye800CW","publication_year":2022,"publication_date":"2022-06-28","ids":{"openalex":"https://openalex.org/W4283661973","doi":"https://doi.org/10.3389/fonc.2022.853660","pmid":"https://pubmed.ncbi.nlm.nih.gov/35837101"},"language":"en","primary_location":{"id":"doi:10.3389/fonc.2022.853660","doi":"https://doi.org/10.3389/fonc.2022.853660","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2022.853660","pdf_url":null,"source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fonc.2022.853660","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080233695","display_name":"Chanda Bhandari","orcid":"https://orcid.org/0000-0002-4056-4754","observed_orcids":["https://orcid.org/0000-0002-4056-4754"]},"institutions":[{"id":"https://openalex.org/I162577319","display_name":"The University of Texas at Dallas","ror":"https://ror.org/049emcs32","country_code":"US","type":"education","lineage":["https://openalex.org/I162577319"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chanda Bhandari","raw_affiliation_strings":["Department of Bioengineering, University of Texas at Dallas, Richardson, TX, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Texas at Dallas, Richardson, TX, United States","institution_ids":["https://openalex.org/I162577319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063332417","display_name":"John Fakhry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162577319","display_name":"The University of Texas at Dallas","ror":"https://ror.org/049emcs32","country_code":"US","type":"education","lineage":["https://openalex.org/I162577319"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Fakhry","raw_affiliation_strings":["Department of Bioengineering, University of Texas at Dallas, Richardson, TX, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Texas at Dallas, Richardson, TX, United States","institution_ids":["https://openalex.org/I162577319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004905110","display_name":"Menitte Eroy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162577319","display_name":"The University of Texas at Dallas","ror":"https://ror.org/049emcs32","country_code":"US","type":"education","lineage":["https://openalex.org/I162577319"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Menitte Eroy","raw_affiliation_strings":["Department of Bioengineering, University of Texas at Dallas, Richardson, TX, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Texas at Dallas, Richardson, TX, United States","institution_ids":["https://openalex.org/I162577319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025583762","display_name":"Jane Junghwa Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162577319","display_name":"The University of Texas at Dallas","ror":"https://ror.org/049emcs32","country_code":"US","type":"education","lineage":["https://openalex.org/I162577319"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jane Junghwa Song","raw_affiliation_strings":["Department of Bioengineering, University of Texas at Dallas, Richardson, TX, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Texas at Dallas, Richardson, TX, United States","institution_ids":["https://openalex.org/I162577319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075937385","display_name":"Kimberley S. Samkoe","orcid":"https://orcid.org/0000-0002-8234-2308","observed_orcids":["https://orcid.org/0000-0002-8234-2308"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimberley Samkoe","raw_affiliation_strings":["Thayer School of Engineering, Dartmouth College, Hanover, NH, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thayer School of Engineering, Dartmouth College, Hanover, NH, United States","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058184923","display_name":"Tayyaba G. Hasan","orcid":"https://orcid.org/0000-0003-0871-6057","observed_orcids":["https://orcid.org/0000-0003-0871-6057"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tayyaba Hasan","raw_affiliation_strings":["Division of Health Sciences and Technology, Harvard University and Massachusetts Institute of Technology, Cambridge, MA, United States","Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Health Sciences and Technology, Harvard University and Massachusetts Institute of Technology, Cambridge, MA, United States","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I63966007"]},{"raw_affiliation_string":"Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048052461","display_name":"Kenneth Hoyt","orcid":"https://orcid.org/0000-0003-2379-8273","observed_orcids":["https://orcid.org/0000-0003-2379-8273","https://orcid.org/0000-0001-9187-1263"]},"institutions":[{"id":"https://openalex.org/I162577319","display_name":"The University of Texas at Dallas","ror":"https://ror.org/049emcs32","country_code":"US","type":"education","lineage":["https://openalex.org/I162577319"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth Hoyt","raw_affiliation_strings":["Department of Bioengineering, University of Texas at Dallas, Richardson, TX, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Texas at Dallas, Richardson, TX, United States","institution_ids":["https://openalex.org/I162577319"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021133351","display_name":"Girgis Obaid","orcid":"https://orcid.org/0000-0002-9452-4467","observed_orcids":["https://orcid.org/0000-0002-9452-4467"]},"institutions":[{"id":"https://openalex.org/I162577319","display_name":"The University of Texas at Dallas","ror":"https://ror.org/049emcs32","country_code":"US","type":"education","lineage":["https://openalex.org/I162577319"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Girgis Obaid","raw_affiliation_strings":["Department of Bioengineering, University of Texas at Dallas, Richardson, TX, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Texas at Dallas, Richardson, TX, United States","institution_ids":["https://openalex.org/I162577319"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5021133351"],"corresponding_institution_ids":["https://openalex.org/I162577319"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":1.5453,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.83793446,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"12","issue":null,"first_page":"853660","last_page":"853660"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9193999767303467,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9193999767303467,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.07020000368356705,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cetuximab","display_name":"cetuximab","score":0.8199999928474426},{"id":"https://openalex.org/keywords/irdye800cw","display_name":"IRDye800CW","score":0.9829999804496765},{"id":"https://openalex.org/keywords/head-and-neck-cancer","display_name":"head and neck cancer","score":0.8299999833106995},{"id":"https://openalex.org/keywords/photoimmunotherapy","display_name":"photoimmunotherapy","score":0.8830000162124634},{"id":"https://openalex.org/keywords/antibody-delivery","display_name":"antibody delivery","score":0.5019999742507935},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7889999747276306},{"id":"https://openalex.org/keywords/fluorescence-imaging","display_name":"fluorescence imaging","score":0.5809999704360962},{"id":"https://openalex.org/keywords/cytoreductive-surgery","display_name":"cytoreductive surgery","score":0.7689999938011169},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.4880000054836273},{"id":"https://openalex.org/keywords/time-to-surgery","display_name":"time to surgery","score":0.5400000214576721},{"id":"https://openalex.org/keywords/photodynamic-therapy","display_name":"photodynamic therapy","score":0.46799999475479126},{"id":"https://openalex.org/keywords/salivary-glands","display_name":"salivary glands","score":0.4690000116825104}],"concepts":[{"id":"https://openalex.org/C2779998722","wikidata":"https://www.wikidata.org/wiki/Q420296","display_name":"Cetuximab","level":4,"score":0.8505831956863403},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.783785343170166},{"id":"https://openalex.org/C2781323092","wikidata":"https://www.wikidata.org/wiki/Q1428072","display_name":"Photodynamic therapy","level":2,"score":0.6504642367362976},{"id":"https://openalex.org/C2781100745","wikidata":"https://www.wikidata.org/wiki/Q1977435","display_name":"Debulking","level":4,"score":0.5681252479553223},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.4958110749721527},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4018828868865967},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.38481438159942627},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33934831619262695},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.32605451345443726},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2749517560005188},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.24539288878440857},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21571403741836548},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.10107278823852539},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fonc.2022.853660","doi":"https://doi.org/10.3389/fonc.2022.853660","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2022.853660","pdf_url":null,"source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},{"id":"pmid:35837101","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35837101","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in oncology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9273965","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9273965","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Oncol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:3f8234b1c7cf4b5b93f65c7332661e5e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3f8234b1c7cf4b5b93f65c7332661e5e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Oncology, Vol 12 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fonc.2022.853660","doi":"https://doi.org/10.3389/fonc.2022.853660","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2022.853660","pdf_url":null,"source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7400000095367432}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1509001784","display_name":"Molecular imaging-directed bioengineering of nanoconjugates as adaptable tumor targeting platforms","funder_award_id":"R00CA215301","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2457774837","display_name":null,"funder_award_id":"RP180670","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2760027446","display_name":null,"funder_award_id":"R00CA215301, R01EB025841","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3689200193","display_name":null,"funder_award_id":"R01EB025841","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6438562313","display_name":"Small Animal Imaging Core Facility for Cancer Research at UT Dallas","funder_award_id":"RP180670","funder_id":"https://openalex.org/F4320308129","funder_display_name":"Cancer Prevention and Research Institute of Texas"},{"id":"https://openalex.org/G6604753749","display_name":null,"funder_award_id":"R01 EB025841","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G9000186202","display_name":null,"funder_award_id":"R01EB025841","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320308129","display_name":"Cancer Prevention and Research Institute of Texas","ror":"https://ror.org/0003xa228"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1607545743","https://openalex.org/W1609648169","https://openalex.org/W1966050112","https://openalex.org/W1970845490","https://openalex.org/W1998966049","https://openalex.org/W2006664904","https://openalex.org/W2013316743","https://openalex.org/W2021149350","https://openalex.org/W2028946041","https://openalex.org/W2033045524","https://openalex.org/W2035551471","https://openalex.org/W2036205949","https://openalex.org/W2038541292","https://openalex.org/W2039230982","https://openalex.org/W2055203322","https://openalex.org/W2065495407","https://openalex.org/W2106235642","https://openalex.org/W2112579958","https://openalex.org/W2141499145","https://openalex.org/W2172083191","https://openalex.org/W2315592053","https://openalex.org/W2429541564","https://openalex.org/W2752262427","https://openalex.org/W2771025011","https://openalex.org/W2795715780","https://openalex.org/W2802536159","https://openalex.org/W2810142842","https://openalex.org/W2888027660","https://openalex.org/W2900577110","https://openalex.org/W2914506266","https://openalex.org/W2947530111","https://openalex.org/W2969961817","https://openalex.org/W2972671795","https://openalex.org/W2990393958","https://openalex.org/W2991707064","https://openalex.org/W3001797168","https://openalex.org/W3081669051","https://openalex.org/W3112701101","https://openalex.org/W3112975251","https://openalex.org/W3171582080","https://openalex.org/W3172022498","https://openalex.org/W3177925006","https://openalex.org/W3180934265","https://openalex.org/W3196254557","https://openalex.org/W3207500668","https://openalex.org/W4406965925"],"related_works":["https://openalex.org/W2560759455","https://openalex.org/W2465099763","https://openalex.org/W2047962734","https://openalex.org/W2885989590","https://openalex.org/W2170971614","https://openalex.org/W2002270485","https://openalex.org/W2019717485","https://openalex.org/W2411474233","https://openalex.org/W2418097565","https://openalex.org/W4239209003"],"abstract_inverted_index":{"Fluorescence":[0],"image-guided":[1,122],"surgery":[2,123],"(IGS)":[3],"using":[4],"antibody":[5,36],"conjugates":[6],"of":[7,16,76,88,100,129,139,148,178,212,262,266,289,302,308,318],"the":[8,13,32,62,94,111,127,134,140,145,176,209,237,260,273,287,294,300,305,322],"fluorophore":[9],"IRDye800CW":[10,29],"have":[11],"revolutionized":[12],"surgical":[14,52,264,295],"debulking":[15,265],"tumors.":[17],"Cetuximab,":[18],"an":[19],"anti-epidermal":[20],"growth":[21],"factor":[22],"receptor":[23],"(EGFR)":[24],"monoclonal":[25],"antibody,":[26],"conjugated":[27],"to":[28,38,51,182,217,221,239,245,321],"(Cet-IRDye800)":[30],"is":[31,59,133,317],"first":[33,135],"molecular":[34],"targeted":[35],"probe":[37],"be":[39],"used":[40],"for":[41,68,85,118,172,286],"IGS":[42,117],"in":[43,61,82,170,293,304,314],"head":[44,69,89,166,267],"and":[45,70,90,96,116,167,191,258,268,271,311],"neck":[46,71,91,168,269],"cancer":[47],"patients.":[48],"In":[49,153],"addition":[50],"debulking,":[53],"Cetuximab-targeted":[54],"photodynamic":[55,102,105,121],"therapy":[56],"(photoimmunotherapy;":[57],"PIT)":[58],"emerging":[60],"clinic":[63],"as":[64],"a":[65,119,158,232,252,282],"powerful":[66],"modality":[67],"tumor":[72,141,146,196,213],"photodestruction.":[73],"A":[74],"plethora":[75],"other":[77],"photoactivable":[78],"agents":[79],"are":[80],"also":[81,280],"clinical":[83],"trials":[84],"photodynamic-based":[86],"therapies":[87],"cancer.":[92],"Considering":[93],"vascular":[95],"stromal":[97],"modulating":[98],"effects":[99],"sub-therapeutic":[101],"therapy,":[103],"namely":[104,151],"priming":[106],"(PDP),":[107],"this":[108,132,154,276,298],"study":[109],"explores":[110],"potential":[112],"synergy":[113],"between":[114],"PDP":[115,138,161,207,230,254,303],"novel":[120],"(P-IGS)":[124],"strategy.":[125],"To":[126],"best":[128],"our":[130],"knowledge,":[131],"demonstration":[136],"that":[137,160,251],"microenvironment":[142],"can":[143,256,279],"augment":[144,259],"delivery":[147,177,307],"full-length":[149],"antibodies,":[150],"Cet-IRDye800.":[152],"study,":[155],"we":[156],"demonstrate":[157],"proof-of-concept":[159],"primes":[162],"orthotopic":[163],"FaDu":[164],"human":[165],"tumors":[169,270,316],"mice":[171],"P-IGS":[173,277],"by":[174,180,184,189,192,198,215,235],"increasing":[175,193],"Cet-IRDye800":[179,204],"up":[181,216],"138.6%,":[183],"expediting":[185],"its":[186,194],"interstitial":[187],"accumulation":[188],"10.5-fold,":[190],"fractional":[195],"coverage":[197],"49.5%":[199],"at":[200,225],"1":[201,226],"h":[202,244],"following":[203],"administration.":[205],"Importantly,":[206],"improves":[208],"diagnostic":[210],"accuracy":[211,261],"detection":[214],"264.2%":[218],"with":[219],"respect":[220],"vicinal":[222],"salivary":[223],"glands":[224],"h.":[227,247],"As":[228],"such,":[229],"provides":[231],"time-to-surgery":[233],"benefit":[234],"reducing":[236],"time":[238],"plateau":[240],"10-fold":[241],"from":[242],"25.7":[243],"2.5":[246],"We":[248],"therefore":[249],"propose":[250],"pre-operative":[253],"regimen":[255],"expedite":[257],"IGS-mediated":[263],"reduce":[272],"time-to-IGS.":[274],"Furthermore,":[275],"regimen,":[278],"enable":[281],"forward-looking":[283],"post-operative":[284],"protocol":[285],"photodestruction":[288],"unresectable":[290],"microscopic":[291],"disease":[292],"bed.":[296],"Beyond":[297],"scope,":[299],"role":[301],"homogenous":[306],"diagnostic,":[309],"theranostic":[310],"therapeutic":[312],"antibodies":[313],"solid":[315],"considerable":[319],"significance":[320],"wider":[323],"community.":[324]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
