{"id":"https://openalex.org/W4283587730","doi":"https://doi.org/10.1038/s41467-022-30877-5","title":"Laboratory evolution of synthetic electron transport system variants reveals a larger metabolic respiratory system and its plasticity","display_name":"Laboratory evolution of synthetic electron transport system variants reveals a larger metabolic respiratory system and its plasticity","publication_year":2022,"publication_date":"2022-06-27","ids":{"openalex":"https://openalex.org/W4283587730","doi":"https://doi.org/10.1038/s41467-022-30877-5","pmid":"https://pubmed.ncbi.nlm.nih.gov/35760776","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9237125"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-022-30877-5","doi":"https://doi.org/10.1038/s41467-022-30877-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-022-30877-5","pdf_url":"https://www.nature.com/articles/s41467-022-30877-5.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-022-30877-5.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032841458","display_name":"Amitesh Anand","orcid":"https://orcid.org/0000-0002-3720-4301","observed_orcids":["https://orcid.org/0000-0002-3720-4301"]},"institutions":[{"id":"https://openalex.org/I11947397","display_name":"Tata Institute of Fundamental Research","ror":"https://ror.org/03ht1xw27","country_code":"IN","type":"education","lineage":["https://openalex.org/I11947397","https://openalex.org/I2799351866","https://openalex.org/I3149292468"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["IN","US"],"is_corresponding":true,"raw_author_name":"Amitesh Anand","raw_affiliation_strings":["Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA. amitesh.anand@tifr.res.in","Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, Maharashtra, India. amitesh.anand@tifr.res.in","Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA","Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA. amitesh.anand@tifr.res.in","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, Maharashtra, India. amitesh.anand@tifr.res.in","institution_ids":["https://openalex.org/I11947397"]},{"raw_affiliation_string":"Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, Maharashtra, India","institution_ids":["https://openalex.org/I11947397"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018168734","display_name":"Arjun Patel","orcid":"https://orcid.org/0000-0003-1959-0445","observed_orcids":["https://orcid.org/0000-0003-1959-0445"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arjun Patel","raw_affiliation_strings":["Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039563394","display_name":"Ke Chen","orcid":"https://orcid.org/0000-0003-2089-1288","observed_orcids":["https://orcid.org/0000-0003-2089-1288"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ke Chen","raw_affiliation_strings":["Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA"],"raw_orcid":"https://orcid.org/0000-0003-2089-1288","affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028654663","display_name":"Connor A. Olson","orcid":"https://orcid.org/0000-0003-3681-0446","observed_orcids":["https://orcid.org/0000-0003-3681-0446"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Connor A. Olson","raw_affiliation_strings":["Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073232270","display_name":"Patrick V. Phaneuf","orcid":"https://orcid.org/0000-0002-4122-6589","observed_orcids":["https://orcid.org/0000-0002-4122-6589"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick V. Phaneuf","raw_affiliation_strings":["Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA"],"raw_orcid":"https://orcid.org/0000-0002-4122-6589","affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012946533","display_name":"Cameron R. Lamoureux","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cameron Lamoureux","raw_affiliation_strings":["Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072991489","display_name":"Ying Hefner","orcid":"https://orcid.org/0000-0003-3092-2914","observed_orcids":["https://orcid.org/0000-0003-3092-2914"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying Hefner","raw_affiliation_strings":["Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071564078","display_name":"Richard Szubin","orcid":"https://orcid.org/0000-0002-1212-8728","observed_orcids":["https://orcid.org/0000-0002-1212-8728"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Szubin","raw_affiliation_strings":["Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062042072","display_name":"Adam M. Feist","orcid":"https://orcid.org/0000-0002-8630-4800","observed_orcids":["https://orcid.org/0000-0002-8630-4800"]},"institutions":[{"id":"https://openalex.org/I2801134892","display_name":"Novo Nordisk Foundation","ror":"https://ror.org/04txyc737","country_code":"DK","type":"facility","lineage":["https://openalex.org/I2801134892"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I96673099","display_name":"Technical University of Denmark","ror":"https://ror.org/04qtj9h94","country_code":"DK","type":"education","lineage":["https://openalex.org/I96673099"]}],"countries":["DK","US"],"is_corresponding":false,"raw_author_name":"Adam M. Feist","raw_affiliation_strings":["Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA","Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet, Kongens, Lyngby, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-8630-4800","affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet, Kongens, Lyngby, Denmark","institution_ids":["https://openalex.org/I2801134892","https://openalex.org/I96673099"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051097609","display_name":"Bernhard \u00d8rn Palsson","orcid":"https://orcid.org/0000-0003-2357-6785","observed_orcids":["https://orcid.org/0000-0003-2357-6785"]},"institutions":[{"id":"https://openalex.org/I2801134892","display_name":"Novo Nordisk Foundation","ror":"https://ror.org/04txyc737","country_code":"DK","type":"facility","lineage":["https://openalex.org/I2801134892"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I96673099","display_name":"Technical University of Denmark","ror":"https://ror.org/04qtj9h94","country_code":"DK","type":"education","lineage":["https://openalex.org/I96673099"]}],"countries":["DK","US"],"is_corresponding":true,"raw_author_name":"Bernhard O. Palsson","raw_affiliation_strings":["Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA. palsson@ucsd.edu","Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet, Kongens, Lyngby, Denmark. palsson@ucsd.edu","Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA","Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet, Kongens, Lyngby, Denmark"],"raw_orcid":"https://orcid.org/0000-0003-2357-6785","affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA. palsson@ucsd.edu","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet, Kongens, Lyngby, Denmark. palsson@ucsd.edu","institution_ids":["https://openalex.org/I2801134892","https://openalex.org/I96673099"]},{"raw_affiliation_string":"Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet, Kongens, Lyngby, Denmark","institution_ids":["https://openalex.org/I2801134892","https://openalex.org/I96673099"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5032841458","https://openalex.org/A5051097609"],"corresponding_institution_ids":["https://openalex.org/I11947397","https://openalex.org/I2801134892","https://openalex.org/I36258959","https://openalex.org/I96673099"],"apc_list":{"value":5890,"currency":"USD","value_usd":5890},"apc_paid":{"value":5890,"currency":"USD","value_usd":5890},"fwci":1.3236,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.79467472,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"13","issue":"1","first_page":"3682","last_page":"3682"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9496999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9496999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.03359999880194664,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/respiratory-electron-transport-system","display_name":"respiratory electron transport system","score":0.871999979019165},{"id":"https://openalex.org/keywords/proton-pumping","display_name":"proton translocation","score":0.48100000619888306},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.8920000195503235},{"id":"https://openalex.org/keywords/adaptive-laboratory-evolution","display_name":"adaptive laboratory evolution","score":0.9020000100135803},{"id":"https://openalex.org/keywords/metabolic-plasticity","display_name":"metabolic plasticity","score":0.7519999742507935},{"id":"https://openalex.org/keywords/energy-metabolism","display_name":"energy metabolism","score":0.5070000290870667},{"id":"https://openalex.org/keywords/atp-production","display_name":"ATP production","score":0.8199999928474426},{"id":"https://openalex.org/keywords/proteome-allocation","display_name":"proteome allocation","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C79186407","wikidata":"https://www.wikidata.org/wiki/Q472074","display_name":"Plasticity","level":2,"score":0.5085252523422241},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4315153956413269},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43054595589637756},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.43038463592529297},{"id":"https://openalex.org/C24840226","wikidata":"https://www.wikidata.org/wiki/Q211016","display_name":"Electron transport chain","level":2,"score":0.417754590511322},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.19548624753952026},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09971433877944946},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004579","descriptor_name":"Electron Transport","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012137","descriptor_name":"Respiratory System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.1038/s41467-022-30877-5","doi":"https://doi.org/10.1038/s41467-022-30877-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-022-30877-5","pdf_url":"https://www.nature.com/articles/s41467-022-30877-5.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"doi:10.1101/2022.04.04.487013","doi":"https://doi.org/10.1101/2022.04.04.487013","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.04.04.487013","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/04/05/2022.04.04.487013.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:35760776","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35760776","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9237125","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9237125/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmh:oai:RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30877-5","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-022-30877-5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:2a048520a218438793dbdfbe86ca7d20","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2a048520a218438793dbdfbe86ca7d20","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt4ks7f23c","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/4ks7f23c","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, vol 13, iss 1","raw_type":"article"},{"id":"pmh:oai:pure.atira.dk:publications/5b5c0c4c-f73a-4fd9-8842-ad5ef859c69d","doi":null,"is_oa":true,"landing_page_url":"https://orbit.dtu.dk/en/publications/5b5c0c4c-f73a-4fd9-8842-ad5ef859c69d","pdf_url":null,"source":{"id":"https://openalex.org/S4306400705","display_name":"Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I96673099","host_organization_name":"Technical University of Denmark","host_organization_lineage":["https://openalex.org/I96673099"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Anand , A , Patel , A , Chen , K , Olson , C A , Phaneuf , P V , Lamoureux , C , Hefner , Y , Szubin , R , Feist , A M & Palsson , B O 2022 , ' Laboratory evolution of synthetic electron transport system variants reveals a larger metabolic respiratory system and its plasticity ' , Nature Communications , vol. 13 , 3682 . https://doi.org/10.1038/s41467-022-30877-5","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41467-022-30877-5","doi":"https://doi.org/10.1038/s41467-022-30877-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-022-30877-5","pdf_url":"https://www.nature.com/articles/s41467-022-30877-5.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1710642666","display_name":null,"funder_award_id":"NNF10CC1016517 and NNF20CC0035580","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"},{"id":"https://openalex.org/G3803805154","display_name":"Genome-Scale Models of Stress Response for E. coli","funder_award_id":"R01GM057089","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5417901379","display_name":null,"funder_award_id":"NNF10CC1016517","funder_id":"https://openalex.org/F4320322436","funder_display_name":"Novo Nordisk"},{"id":"https://openalex.org/G6553254277","display_name":null,"funder_award_id":"NNF10CC1016517","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7013002931","display_name":null,"funder_award_id":"R01GM057089","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G7042228497","display_name":null,"funder_award_id":"NNF20CC0035580","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"},{"id":"https://openalex.org/G7361212524","display_name":null,"funder_award_id":"NNF20CC0035580","funder_id":"https://openalex.org/F4320322436","funder_display_name":"Novo Nordisk"},{"id":"https://openalex.org/G7701966108","display_name":null,"funder_award_id":"NNF10CC1016517","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"},{"id":"https://openalex.org/F4320325957","display_name":"Novo Nordisk Fonden","ror":"https://ror.org/04txyc737"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332603","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4283587730.pdf","grobid_xml":"https://content.openalex.org/works/W4283587730.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W154894623","https://openalex.org/W1693303585","https://openalex.org/W1752593232","https://openalex.org/W1939032890","https://openalex.org/W1957752345","https://openalex.org/W1965379872","https://openalex.org/W1972403536","https://openalex.org/W1978211365","https://openalex.org/W1984467885","https://openalex.org/W2021759624","https://openalex.org/W2035612098","https://openalex.org/W2036838585","https://openalex.org/W2041828183","https://openalex.org/W2065015207","https://openalex.org/W2072862994","https://openalex.org/W2074436710","https://openalex.org/W2080572036","https://openalex.org/W2083616106","https://openalex.org/W2084121452","https://openalex.org/W2110155277","https://openalex.org/W2111967267","https://openalex.org/W2124044155","https://openalex.org/W2125776233","https://openalex.org/W2129634655","https://openalex.org/W2144068357","https://openalex.org/W2157404832","https://openalex.org/W2195303995","https://openalex.org/W2342682081","https://openalex.org/W2609024085","https://openalex.org/W2760895823","https://openalex.org/W2806399642","https://openalex.org/W2898448106","https://openalex.org/W2900569176","https://openalex.org/W2904869350","https://openalex.org/W2914763463","https://openalex.org/W2919557129","https://openalex.org/W2944000333","https://openalex.org/W2947215881","https://openalex.org/W2951937015","https://openalex.org/W2953238103","https://openalex.org/W2967876620","https://openalex.org/W2993166334","https://openalex.org/W3029090796","https://openalex.org/W3119136244","https://openalex.org/W3125165012","https://openalex.org/W3136918052","https://openalex.org/W3147358936","https://openalex.org/W4318938985","https://openalex.org/W4386764170"],"related_works":["https://openalex.org/W7124253472","https://openalex.org/W2808192775","https://openalex.org/W7211024626","https://openalex.org/W7099062899","https://openalex.org/W6989205286","https://openalex.org/W2153445925","https://openalex.org/W7140269786","https://openalex.org/W2037913739","https://openalex.org/W4292473817","https://openalex.org/W2133634745"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"bacterial":[2],"respiratory":[3,29],"electron":[4,63],"transport":[5],"system":[6,37],"(ETS)":[7],"is":[8,18,41,127,135],"branched":[9],"to":[10,92,111,114],"allow":[11],"condition-specific":[12],"modulation":[13],"of":[14,22,28,35,48,70,80,106,130,141],"energy":[15],"metabolism.":[16],"There":[17],"a":[19,32,68,93,128,136],"detailed":[20],"understanding":[21],"the":[23,36,100,112,131],"structural":[24],"and":[25,38,64,78,98,134,143],"biochemical":[26],"features":[27],"enzymes;":[30],"however,":[31],"holistic":[33],"examination":[34],"its":[39,144],"plasticity":[40],"lacking.":[42],"Here":[43],"we":[44],"generate":[45,103],"four":[46,88],"strains":[47],"Escherichia":[49],"coli":[50],"harboring":[51],"unbranched":[52],"ETS":[53,89],"that":[54],"pump":[55],"1,":[56],"2,":[57],"3,":[58],"or":[59],"4":[60],"proton(s)":[61],"per":[62],"characterized":[65],"them":[66],"using":[67],"combination":[69],"synergistic":[71],"methods":[72],"(adaptive":[73],"laboratory":[74,101],"evolution,":[75],"multi-omic":[76],"analyses,":[77],"computation":[79],"proteome":[81],"allocation).":[82],"We":[83,119],"report":[84],"that:":[85],"(a)":[86],"all":[87],"variants":[90],"evolve":[91],"similar":[94],"optimized":[95],"growth":[96],"rate,":[97],"(b)":[99],"evolutions":[102],"specific":[104],"rewiring":[105],"major":[107],"energy-generating":[108],"pathways,":[109],"coupled":[110],"ETS,":[113],"optimize":[115],"ATP":[116],"production":[117],"capability.":[118],"thus":[120],"define":[121],"an":[122],"Aero-Type":[123],"System":[124],"(ATS),":[125],"which":[126],"generalization":[129],"aerobic":[132],"bioenergetics":[133],"metabolic":[137],"systems":[138],"biology":[139],"description":[140],"respiration":[142],"inherent":[145],"plasticity.":[146]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-06-28T00:00:00"}