{"id":"https://openalex.org/W4283583333","doi":"https://doi.org/10.1152/physiolgenomics.00177.2021","title":"MicroRNA cargo of extracellular vesicles released by skeletal muscle fibro-adipogenic progenitor cells is significantly altered with disuse atrophy and IL-1\u03b2 deficiency","display_name":"MicroRNA cargo of extracellular vesicles released by skeletal muscle fibro-adipogenic progenitor cells is significantly altered with disuse atrophy and IL-1\u03b2 deficiency","publication_year":2022,"publication_date":"2022-06-27","ids":{"openalex":"https://openalex.org/W4283583333","doi":"https://doi.org/10.1152/physiolgenomics.00177.2021","pmid":"https://pubmed.ncbi.nlm.nih.gov/35759450"},"language":"en","primary_location":{"id":"doi:10.1152/physiolgenomics.00177.2021","doi":"https://doi.org/10.1152/physiolgenomics.00177.2021","is_oa":false,"landing_page_url":"https://doi.org/10.1152/physiolgenomics.00177.2021","pdf_url":null,"source":{"id":"https://openalex.org/S57123121","display_name":"Physiological Genomics","issn_l":"1094-8341","issn":["1094-8341","1531-2267"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiological Genomics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9342138","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101488111","display_name":"Emily J. Parker","orcid":"https://orcid.org/0000-0002-0707-4876","observed_orcids":["https://orcid.org/0000-0002-0707-4876"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily Parker","raw_affiliation_strings":["Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050881509","display_name":"Bharati Mendhe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bharati Mendhe","raw_affiliation_strings":["Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067804076","display_name":"Ling Ruan","orcid":"https://orcid.org/0000-0002-9241-3528","observed_orcids":["https://orcid.org/0000-0002-9241-3528"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ling Ruan","raw_affiliation_strings":["Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025716675","display_name":"Brendan Marshall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brendan Marshall","raw_affiliation_strings":["EM/Histology Core Laboratory, Medical College of Georgia at Augusta University, Augusta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EM/Histology Core Laboratory, Medical College of Georgia at Augusta University, Augusta, Georgia","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054056899","display_name":"Wenbo Zhi","orcid":"https://orcid.org/0000-0002-7720-7048","observed_orcids":["https://orcid.org/0000-0002-7720-7048"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenbo Zhi","raw_affiliation_strings":["Center for Biotechnology and Genomic Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biotechnology and Genomic Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100422850","display_name":"Yutao Liu","orcid":"https://orcid.org/0000-0003-2870-4504","observed_orcids":["https://orcid.org/0000-0003-2870-4504"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yutao Liu","raw_affiliation_strings":["Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015971774","display_name":"Sadanand Fulzele","orcid":"https://orcid.org/0000-0002-3510-6759","observed_orcids":["https://orcid.org/0000-0002-3510-6759"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sadanand Fulzele","raw_affiliation_strings":["Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051831883","display_name":"Yaoliang Tang","orcid":"https://orcid.org/0000-0002-8372-1545","observed_orcids":["https://orcid.org/0000-0002-8372-1545"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]},{"id":"https://openalex.org/I4210087454","display_name":"Augusta University Health","ror":"https://ror.org/007rawr89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yao Liang Tang","raw_affiliation_strings":["Vascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia"],"raw_orcid":"https://orcid.org/0000-0002-8372-1545","affiliations":[{"raw_affiliation_string":"Vascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia","institution_ids":["https://openalex.org/I25041050","https://openalex.org/I4210087454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028968559","display_name":"Meghan E. McGee\u2010Lawrence","orcid":"https://orcid.org/0000-0002-2728-5849","observed_orcids":["https://orcid.org/0000-0002-2728-5849"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meghan McGee-Lawrence","raw_affiliation_strings":["Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tae Jin Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tae Jin Lee","raw_affiliation_strings":["Center for Biotechnology and Genomic Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biotechnology and Genomic Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002893934","display_name":"Ashok Kumar Sharma","orcid":"https://orcid.org/0000-0001-9597-4374","observed_orcids":["https://orcid.org/0000-0001-9597-4374"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashok Sharma","raw_affiliation_strings":["Center for Biotechnology and Genomic Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biotechnology and Genomic Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077118754","display_name":"Maribeth H. Johnson","orcid":"https://orcid.org/0000-0001-5468-4522","observed_orcids":["https://orcid.org/0000-0001-5468-4522"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maribeth Johnson","raw_affiliation_strings":["Division of Biostatistics and Data Science, Medical College of Georgia at Augusta University, Augusta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biostatistics and Data Science, Medical College of Georgia at Augusta University, Augusta, Georgia","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jie Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jie Chen","raw_affiliation_strings":["Division of Biostatistics and Data Science, Medical College of Georgia at Augusta University, Augusta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biostatistics and Data Science, Medical College of Georgia at Augusta University, Augusta, Georgia","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016224286","display_name":"Mark W. Hamrick","orcid":"https://orcid.org/0000-0003-2246-3121","observed_orcids":["https://orcid.org/0000-0003-2246-3121"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mark W. Hamrick","raw_affiliation_strings":["Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia"],"raw_orcid":"https://orcid.org/0000-0003-2246-3121","affiliations":[{"raw_affiliation_string":"Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia","institution_ids":["https://openalex.org/I25041050"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5016224286"],"corresponding_institution_ids":["https://openalex.org/I25041050"],"apc_list":null,"apc_paid":null,"fwci":0.6916,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.62738325,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"54","issue":"8","first_page":"296","last_page":"304"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.6015999913215637,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.6015999913215637,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.3878999948501587,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fibro-adipogenic-progenitor-cells","display_name":"fibro-adipogenic progenitor cells","score":0.9089999794960022},{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":0.9300000071525574},{"id":"https://openalex.org/keywords/microrna-cargo","display_name":"microRNA cargo","score":0.9350000023841858},{"id":"https://openalex.org/keywords/disuse-muscle-atrophy","display_name":"disuse atrophy","score":0.9279999732971191},{"id":"https://openalex.org/keywords/immobilization","display_name":"immobilization","score":0.8870000243186951},{"id":"https://openalex.org/keywords/skeletal-muscle-stem-cells","display_name":"skeletal muscle stem cells","score":0.6380000114440918},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.8489999771118164},{"id":"https://openalex.org/keywords/mir-181a","display_name":"miR-181a","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mir-124","display_name":"miR-124","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hindlimb-unloading","display_name":"hindlimb unloading","score":0.7440000176429749},{"id":"https://openalex.org/keywords/muscle-regeneration","display_name":"muscle regeneration","score":0.42500001192092896}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7404779195785522},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.6529261469841003},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.6063388586044312},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5878857970237732},{"id":"https://openalex.org/C2776263037","wikidata":"https://www.wikidata.org/wiki/Q1557686","display_name":"Muscle atrophy","level":3,"score":0.5837165117263794},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.49535858631134033},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.43686673045158386},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.37607988715171814},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3306387662887573},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10957008600234985},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07591083645820618},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020796","descriptor_name":"Receptor, Platelet-Derived Growth Factor alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020796","descriptor_name":"Receptor, Platelet-Derived Growth Factor alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020796","descriptor_name":"Receptor, Platelet-Derived Growth Factor alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020796","descriptor_name":"Receptor, Platelet-Derived Growth Factor alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020796","descriptor_name":"Receptor, Platelet-Derived Growth Factor alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020796","descriptor_name":"Receptor, Platelet-Derived Growth Factor alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020966","descriptor_name":"Muscular Disorders, Atrophic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020966","descriptor_name":"Muscular Disorders, Atrophic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020966","descriptor_name":"Muscular Disorders, Atrophic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020966","descriptor_name":"Muscular Disorders, Atrophic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020966","descriptor_name":"Muscular Disorders, Atrophic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020966","descriptor_name":"Muscular Disorders, Atrophic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053583","descriptor_name":"Interleukin-1beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053583","descriptor_name":"Interleukin-1beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053583","descriptor_name":"Interleukin-1beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053583","descriptor_name":"Interleukin-1beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053583","descriptor_name":"Interleukin-1beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053583","descriptor_name":"Interleukin-1beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1152/physiolgenomics.00177.2021","doi":"https://doi.org/10.1152/physiolgenomics.00177.2021","is_oa":false,"landing_page_url":"https://doi.org/10.1152/physiolgenomics.00177.2021","pdf_url":null,"source":{"id":"https://openalex.org/S57123121","display_name":"Physiological Genomics","issn_l":"1094-8341","issn":["1094-8341","1531-2267"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiological Genomics","raw_type":"journal-article"},{"id":"pmid:35759450","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35759450","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiological genomics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9342138","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9342138","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Physiol Genomics","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9342138","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9342138","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Physiol Genomics","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5228379334","display_name":null,"funder_award_id":"AG036675","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G599522285","display_name":null,"funder_award_id":"P01-AG 036675","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W370485077","https://openalex.org/W1926685779","https://openalex.org/W1995873637","https://openalex.org/W1999353686","https://openalex.org/W1999902156","https://openalex.org/W2000674381","https://openalex.org/W2003816656","https://openalex.org/W2017213538","https://openalex.org/W2021188633","https://openalex.org/W2031918149","https://openalex.org/W2054517754","https://openalex.org/W2112508321","https://openalex.org/W2124844208","https://openalex.org/W2130610927","https://openalex.org/W2134193049","https://openalex.org/W2137459257","https://openalex.org/W2147381804","https://openalex.org/W2207956082","https://openalex.org/W2342565208","https://openalex.org/W2413780710","https://openalex.org/W2767654638","https://openalex.org/W2782804476","https://openalex.org/W2803929840","https://openalex.org/W2883058468","https://openalex.org/W2883365705","https://openalex.org/W2884826410","https://openalex.org/W2899178822","https://openalex.org/W2899356454","https://openalex.org/W2900801136","https://openalex.org/W2903751680","https://openalex.org/W2917748066","https://openalex.org/W2929898918","https://openalex.org/W2935952674","https://openalex.org/W2945170397","https://openalex.org/W2951890867","https://openalex.org/W2953649139","https://openalex.org/W2965455118","https://openalex.org/W2969805437","https://openalex.org/W2992063658","https://openalex.org/W2996620265","https://openalex.org/W2999482784","https://openalex.org/W3000623168","https://openalex.org/W3011739739","https://openalex.org/W3039429923","https://openalex.org/W3041545048","https://openalex.org/W3047115945","https://openalex.org/W3119647749","https://openalex.org/W3128724145","https://openalex.org/W3138190732","https://openalex.org/W3150297242","https://openalex.org/W3153146681","https://openalex.org/W3161017372","https://openalex.org/W3161120507","https://openalex.org/W3199689438","https://openalex.org/W4206801019"],"related_works":["https://openalex.org/W2381633759","https://openalex.org/W2152362174","https://openalex.org/W3130842181","https://openalex.org/W2057881865","https://openalex.org/W3084283449","https://openalex.org/W2463258730","https://openalex.org/W3192476914","https://openalex.org/W2300366807","https://openalex.org/W2078182947","https://openalex.org/W2090702815"],"abstract_inverted_index":{"Fibro-adipogenic":[0],"progenitor":[1],"cells":[2,9],"(FAPs)":[3],"are":[4,63],"a":[5,152],"population":[6],"of":[7,70,81,95,104,183,206,213,221],"stem":[8],"in":[10,17,52,135,155,174,191,229],"skeletal":[11],"muscle":[12,18,39,178,233,243,247],"that":[13,45,144,203],"play":[14,171],"multiple":[15],"roles":[16,173],"repair":[19],"and":[20,56,60,97,117,127,139,162,177,223,245],"regeneration":[21],"through":[22],"their":[23],"complex":[24],"secretome;":[25],"however,":[26],"it":[27],"is":[28,36,50],"not":[29,188],"well":[30],"understood":[31],"how":[32],"the":[33,46,68,77,114,145,181,196,210,219,239],"FAP":[34],"secretome":[35],"altered":[37,190],"with":[38,54,137,232],"disuse":[40,55,234],"atrophy.":[41,179],"Previous":[42],"work":[43],"suggests":[44],"inflammatory":[47],"cytokine":[48],"IL-1\u03b2":[49,61,98,140,198,207],"increased":[51],"FAPs":[53,228],"denervation.":[57],"Inflammasome":[58],"activation":[59,205],"secretion":[62],"also":[64],"known":[65],"to":[66,132,170,218,241],"stimulate":[67],"release":[69,220],"extracellular":[71,120],"vesicles":[72,121],"(EVs).":[73],"Here,":[74],"we":[75],"examined":[76],"microRNA":[78],"(miRNA)":[79],"cargo":[80,212],"FAP-derived,":[82],"platelet-derived":[83],"growth":[84],"factor":[85],"receptor":[86],"A":[87],"(PDGFR\u03b1":[88],"+":[89,119,147],")":[90],"EVs":[91,150,193],"from":[92,111,195],"hindlimb":[93],"muscles":[94,108],"wild-type":[96],"KO":[99],"mice":[100,112],"after":[101],"14":[102],"days":[103],"single-hindlimb":[105],"immobilization.":[106],"Hindlimb":[107],"were":[109,122,130],"isolated":[110,123,194],"following":[113],"immobilization":[115],"period,":[116],"PDGFR\u03b1":[118,146],"using":[124],"size-exclusion":[125],"chromatography":[126],"immunoprecipitation.":[128],"Microarrays":[129],"performed":[131],"detect":[133],"changes":[134],"miRNAs":[136,165,186],"unloading":[138],"deficiency.":[141],"Results":[142],"indicate":[143],",":[148],"FAP-derived":[149,192,214],"show":[151],"significant":[153],"increase":[154],"miRNAs,":[156],"such":[157],"as":[158],"miR-let-7c,":[159],"miR-let-7b,":[160],"miR-181a,":[161],"miR-124.":[163],"These":[164,200],"have":[166,238],"previously":[167],"been":[168],"demonstrated":[169],"important":[172],"cellular":[175],"senescence":[176],"Furthermore,":[180],"expression":[182],"these":[184],"same":[185],"was":[187],"significantly":[189],"immobilized":[197],"KO.":[199],"data":[201],"suggest":[202],"disuse-related":[204],"can":[208],"mediate":[209],"miRNA":[211],"EVs,":[215],"contributing":[216],"directly":[217],"senescence-":[222],"atrophy-related":[224],"miRNAs.":[225],"Therapies":[226],"targeting":[227],"settings":[230],"associated":[231],"atrophy":[235],"may":[236],"therefore":[237],"potential":[240],"preserve":[242],"function":[244],"enhance":[246],"recovery.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}