{"id":"https://openalex.org/W4283580964","doi":"https://doi.org/10.3389/fendo.2022.927834","title":"Thinning or Opening: A Randomized Sibling-Embryo Pilot Trial on the Efficacy of Two Laser-Assisted Hatching Modes During the Extended Culture of Highly Fragmented Cleavage Embryos","display_name":"Thinning or Opening: A Randomized Sibling-Embryo Pilot Trial on the Efficacy of Two Laser-Assisted Hatching Modes During the Extended Culture of Highly Fragmented Cleavage Embryos","publication_year":2022,"publication_date":"2022-06-27","ids":{"openalex":"https://openalex.org/W4283580964","doi":"https://doi.org/10.3389/fendo.2022.927834","pmid":"https://pubmed.ncbi.nlm.nih.gov/35832433","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9271933"},"language":"en","primary_location":{"id":"doi:10.3389/fendo.2022.927834","doi":"https://doi.org/10.3389/fendo.2022.927834","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2022.927834","pdf_url":"https://www.frontiersin.org/articles/10.3389/fendo.2022.927834/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fendo.2022.927834/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100450747","display_name":"Ling Zhang","orcid":"https://orcid.org/0000-0002-7917-7671","observed_orcids":["https://orcid.org/0000-0002-7917-7671"]},"institutions":[{"id":"https://openalex.org/I4210131061","display_name":"Zhejiang Provincial People's Hospital","ror":"https://ror.org/03k14e164","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131061"]},{"id":"https://openalex.org/I4210165441","display_name":"Hangzhou Medical College","ror":"https://ror.org/05gpas306","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165441"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling Zhang","raw_affiliation_strings":["Reproductive Medicine Center, Department of Reproductive Endocrinology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Medicine Center, Department of Reproductive Endocrinology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, China","institution_ids":["https://openalex.org/I4210131061","https://openalex.org/I4210165441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073781695","display_name":"Yier Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131061","display_name":"Zhejiang Provincial People's Hospital","ror":"https://ror.org/03k14e164","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131061"]},{"id":"https://openalex.org/I4210165441","display_name":"Hangzhou Medical College","ror":"https://ror.org/05gpas306","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165441"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi-er Zhou","raw_affiliation_strings":["Reproductive Medicine Center, Department of Reproductive Endocrinology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Medicine Center, Department of Reproductive Endocrinology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, China","institution_ids":["https://openalex.org/I4210131061","https://openalex.org/I4210165441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101618964","display_name":"Yuejin Wu","orcid":"https://orcid.org/0000-0003-0369-1591","observed_orcids":["https://orcid.org/0000-0003-0369-1591"]},"institutions":[{"id":"https://openalex.org/I4210165441","display_name":"Hangzhou Medical College","ror":"https://ror.org/05gpas306","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165441"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue-jin Wu","raw_affiliation_strings":["Institute of Food Science and Engineering, Hangzhou Medical College, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Food Science and Engineering, Hangzhou Medical College, Hangzhou, China","institution_ids":["https://openalex.org/I4210165441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101572418","display_name":"Limei Wu","orcid":"https://orcid.org/0000-0002-1378-740X","observed_orcids":["https://orcid.org/0000-0002-1378-740X"]},"institutions":[{"id":"https://openalex.org/I4210131061","display_name":"Zhejiang Provincial People's Hospital","ror":"https://ror.org/03k14e164","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131061"]},{"id":"https://openalex.org/I4210165441","display_name":"Hangzhou Medical College","ror":"https://ror.org/05gpas306","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165441"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li-mei Wu","raw_affiliation_strings":["Reproductive Medicine Center, Department of Reproductive Endocrinology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Medicine Center, Department of Reproductive Endocrinology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, China","institution_ids":["https://openalex.org/I4210131061","https://openalex.org/I4210165441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103065863","display_name":"Shishi Li","orcid":"https://orcid.org/0000-0002-4763-0419","observed_orcids":["https://orcid.org/0000-0002-4763-0419"]},"institutions":[{"id":"https://openalex.org/I4210131061","display_name":"Zhejiang Provincial People's Hospital","ror":"https://ror.org/03k14e164","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131061"]},{"id":"https://openalex.org/I4210165441","display_name":"Hangzhou Medical College","ror":"https://ror.org/05gpas306","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165441"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shi-shi Li","raw_affiliation_strings":["Reproductive Medicine Center, Department of Reproductive Endocrinology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Medicine Center, Department of Reproductive Endocrinology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, China","institution_ids":["https://openalex.org/I4210131061","https://openalex.org/I4210165441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111909917","display_name":"Lin Zhang","orcid":"https://orcid.org/0000-0002-2064-8440","observed_orcids":["https://orcid.org/0000-0002-2064-8440"]},"institutions":[{"id":"https://openalex.org/I4210131061","display_name":"Zhejiang Provincial People's Hospital","ror":"https://ror.org/03k14e164","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131061"]},{"id":"https://openalex.org/I4210165441","display_name":"Hangzhou Medical College","ror":"https://ror.org/05gpas306","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165441"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Zhang","raw_affiliation_strings":["Reproductive Medicine Center, Department of Reproductive Endocrinology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Medicine Center, Department of Reproductive Endocrinology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, China","institution_ids":["https://openalex.org/I4210131061","https://openalex.org/I4210165441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100406015","display_name":"Zhen Jin","orcid":"https://orcid.org/0000-0003-3647-9845","observed_orcids":["https://orcid.org/0000-0003-3647-9845"]},"institutions":[{"id":"https://openalex.org/I4210131061","display_name":"Zhejiang Provincial People's Hospital","ror":"https://ror.org/03k14e164","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131061"]},{"id":"https://openalex.org/I4210165441","display_name":"Hangzhou Medical College","ror":"https://ror.org/05gpas306","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165441"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhen Jin","raw_affiliation_strings":["Reproductive Medicine Center, Department of Reproductive Endocrinology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Medicine Center, Department of Reproductive Endocrinology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, China","institution_ids":["https://openalex.org/I4210131061","https://openalex.org/I4210165441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084289905","display_name":"Chongyi Shu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131061","display_name":"Zhejiang Provincial People's Hospital","ror":"https://ror.org/03k14e164","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131061"]},{"id":"https://openalex.org/I4210165441","display_name":"Hangzhou Medical College","ror":"https://ror.org/05gpas306","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165441"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chong-yi Shu","raw_affiliation_strings":["Reproductive Medicine Center, Department of Reproductive Endocrinology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Medicine Center, Department of Reproductive Endocrinology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, China","institution_ids":["https://openalex.org/I4210131061","https://openalex.org/I4210165441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040196353","display_name":"Weihai Xu","orcid":"https://orcid.org/0000-0001-9764-8820","observed_orcids":["https://orcid.org/0000-0001-9764-8820"]},"institutions":[{"id":"https://openalex.org/I4210131061","display_name":"Zhejiang Provincial People's Hospital","ror":"https://ror.org/03k14e164","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131061"]},{"id":"https://openalex.org/I4210165441","display_name":"Hangzhou Medical College","ror":"https://ror.org/05gpas306","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165441"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wei-hai Xu","raw_affiliation_strings":["Reproductive Medicine Center, Department of Reproductive Endocrinology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Medicine Center, Department of Reproductive Endocrinology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, China","institution_ids":["https://openalex.org/I4210131061","https://openalex.org/I4210165441"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053165285","display_name":"Jing Shu","orcid":"https://orcid.org/0000-0003-0398-2188","observed_orcids":["https://orcid.org/0000-0003-0398-2188"]},"institutions":[{"id":"https://openalex.org/I4210131061","display_name":"Zhejiang Provincial People's Hospital","ror":"https://ror.org/03k14e164","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131061"]},{"id":"https://openalex.org/I4210165441","display_name":"Hangzhou Medical College","ror":"https://ror.org/05gpas306","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165441"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jing Shu","raw_affiliation_strings":["Reproductive Medicine Center, Department of Reproductive Endocrinology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Medicine Center, Department of Reproductive Endocrinology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, China","institution_ids":["https://openalex.org/I4210131061","https://openalex.org/I4210165441"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5040196353","https://openalex.org/A5053165285"],"corresponding_institution_ids":["https://openalex.org/I4210131061","https://openalex.org/I4210165441"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.6275,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.58955127,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":97},"biblio":{"volume":"13","issue":null,"first_page":"927834","last_page":"927834"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.7631999850273132,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.7631999850273132,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11732","display_name":"Assisted Reproductive Technology and Twin Pregnancy","score":0.1462000012397766,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11156","display_name":"Reproductive Health and Technologies","score":0.06700000166893005,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/laser-assisted-hatching","display_name":"laser-assisted hatching","score":0.9829999804496765},{"id":"https://openalex.org/keywords/zona-pellucida-thinning","display_name":"zona pellucida thinning","score":0.925000011920929},{"id":"https://openalex.org/keywords/embryo-fragmentation","display_name":"embryo fragmentation","score":0.7480000257492065},{"id":"https://openalex.org/keywords/extended-embryo-culture","display_name":"extended embryo culture","score":0.777999997138977},{"id":"https://openalex.org/keywords/blastocyst-development","display_name":"blastocyst development","score":0.8859999775886536},{"id":"https://openalex.org/keywords/blastocyst-quality","display_name":"blastocyst quality","score":0.9010000228881836},{"id":"https://openalex.org/keywords/clinical-pregnancy-rate","display_name":"clinical pregnancy rate","score":0.7429999709129333},{"id":"https://openalex.org/keywords/in-vitro-fertilization","display_name":"in vitro fertilization","score":0.7400000095367432},{"id":"https://openalex.org/keywords/embryo-transfer","display_name":"embryo transfer","score":0.824999988079071}],"concepts":[{"id":"https://openalex.org/C2777744765","wikidata":"https://www.wikidata.org/wiki/Q2734755","display_name":"Hatching","level":2,"score":0.7607266902923584},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.7541080713272095},{"id":"https://openalex.org/C2776194465","wikidata":"https://www.wikidata.org/wiki/Q31184","display_name":"Sibling","level":2,"score":0.5896033048629761},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.506060779094696},{"id":"https://openalex.org/C175156509","wikidata":"https://www.wikidata.org/wiki/Q1990218","display_name":"Cleavage (geology)","level":3,"score":0.47462737560272217},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41244417428970337},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.37012869119644165},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3569200038909912},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2636260688304901},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22298073768615723},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.16070187091827393},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.09662139415740967},{"id":"https://openalex.org/C140793950","wikidata":"https://www.wikidata.org/wiki/Q168091","display_name":"Animal science","level":1,"score":0.09236761927604675},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C43369102","wikidata":"https://www.wikidata.org/wiki/Q2307625","display_name":"Fracture (geology)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D004624","descriptor_name":"Embryo Transfer","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007834","descriptor_name":"Lasers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035781","descriptor_name":"Siblings","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D046149","descriptor_name":"Embryo Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3389/fendo.2022.927834","doi":"https://doi.org/10.3389/fendo.2022.927834","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2022.927834","pdf_url":"https://www.frontiersin.org/articles/10.3389/fendo.2022.927834/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},{"id":"pmid:35832433","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35832433","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in endocrinology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9271933","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9271933/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Endocrinol (Lausanne)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:99859808cf4f44eabc3e40337e9d02c2","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/99859808cf4f44eabc3e40337e9d02c2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Endocrinology, Vol 13 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fendo.2022.927834","doi":"https://doi.org/10.3389/fendo.2022.927834","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2022.927834","pdf_url":"https://www.frontiersin.org/articles/10.3389/fendo.2022.927834/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.766700029373169}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4283580964.pdf","grobid_xml":"https://content.openalex.org/works/W4283580964.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W132180206","https://openalex.org/W1844946935","https://openalex.org/W1966811171","https://openalex.org/W1968805416","https://openalex.org/W1969173142","https://openalex.org/W1980363421","https://openalex.org/W1986223362","https://openalex.org/W1989540525","https://openalex.org/W1989928096","https://openalex.org/W1992086556","https://openalex.org/W2012224706","https://openalex.org/W2012291935","https://openalex.org/W2013655674","https://openalex.org/W2030968268","https://openalex.org/W2057297889","https://openalex.org/W2070243348","https://openalex.org/W2089698022","https://openalex.org/W2102607537","https://openalex.org/W2113591374","https://openalex.org/W2115899855","https://openalex.org/W2116159074","https://openalex.org/W2117260868","https://openalex.org/W2117485283","https://openalex.org/W2121309812","https://openalex.org/W2124656409","https://openalex.org/W2131474184","https://openalex.org/W2134251654","https://openalex.org/W2137189387","https://openalex.org/W2148002734","https://openalex.org/W2153114583","https://openalex.org/W2161719269","https://openalex.org/W2168139864","https://openalex.org/W2211303625","https://openalex.org/W2288381475","https://openalex.org/W2463775139","https://openalex.org/W2518360857","https://openalex.org/W2754160328","https://openalex.org/W2892044787","https://openalex.org/W2892363122","https://openalex.org/W2903979315","https://openalex.org/W2903999475","https://openalex.org/W2942698062","https://openalex.org/W3177919593"],"related_works":["https://openalex.org/W3177919593","https://openalex.org/W7167733243","https://openalex.org/W4387220963","https://openalex.org/W2138029547","https://openalex.org/W2063127493","https://openalex.org/W4408207448","https://openalex.org/W2018029883","https://openalex.org/W2062734024","https://openalex.org/W2079545883","https://openalex.org/W2161719269"],"abstract_inverted_index":{"A":[0,112],"randomized":[1,48],"sibling-embryo":[2],"pilot":[3],"trial":[4],"investigated":[5],"whether":[6],"two":[7,199],"ways":[8],"of":[9,25,36,92,114,123,148,213],"laser-assisted":[10,50],"hatching":[11],"result":[12],"in":[13,21,66,93,145,189],"different":[14],"blastulation":[15],"and":[16,47,55,60,75,96,99,130,171,219,227],"clinical":[17,81,190,225],"outcomes":[18,191],"after":[19,83,192],"extended":[20,211],"vitro":[22,94],"culture":[23,65,212],"process":[24],"highly":[26,38,214],"fragmented":[27,39,215],"day-3":[28,40,116],"cleavage":[29],"embryos.":[30],"From":[31],"92":[32],"couples,":[33],"a":[34,63,183,223],"total":[35,113],"315":[37],"embryos":[41,117],"(the":[42],"fragmentation":[43],">25%)":[44],"were":[45,86,126],"recruited":[46],"into":[49,119],"zona":[51],"thinning":[52],"(LAT,":[53],"n=157)":[54],"opening":[56],"(LAO,":[57],"n=158)":[58],"groups,":[59],"then":[61,100],"underwent":[62],"blastocyst":[64,73,84,109,120,155,193],"vitro.":[67],"The":[68,201],"main":[69],"endpoint":[70],"measurements":[71],"including":[72],"formation":[74],"grading":[76],"as":[77,79,164],"well":[78],"the":[80,89,146,158,179,198,207,210,228,234],"pregnancy":[82],"transfer":[85,194],"obtained":[87],"during":[88,209],"treatment":[90],"procedure":[91],"fertilization":[95],"embryo":[97],"transfer,":[98],"analyzed":[101],"with":[102,157],"generalized":[103],"estimating":[104],"equation":[105],"(GEE)":[106],"and/or":[107],"time-to":[108],"analysis":[110,181],"models.":[111],"166":[115],"developed":[118],"stage":[121],"(52.70%),":[122],"which":[124],"97":[125],"viable":[127],"blastocysts":[128],"(30.79%),":[129],"42":[131],"top-quality":[132,152],"ones":[133],"(13.33%).":[134],"LAT":[135,176,218,229],"did":[136],"not":[137],"have":[138],"any":[139],"inferior":[140],"or":[141,153],"superior":[142],"to":[143,233,243],"LAO":[144,220],"endpoints":[147],"either":[149],"total,":[150],"viable,":[151],"hatched":[154],"formation,":[156],"ORs":[159],"(95%CI)":[160],"from":[161],"GEE":[162],"model":[163],"0.89":[165],"(0.55-1.45),":[166],"0.71":[167],"(0.42-1.21),":[168],"1.12":[169],"(0.56-2.25)":[170],"0.68":[172],"(0.42-1.12)":[173],"respectively":[174],"for":[175],"treatment.":[177],"And":[178],"time-to-blastocyst":[180],"showed":[182],"similar":[184],"result.":[185],"Additionally,":[186],"no":[187],"difference":[188],"was":[195],"found":[196],"between":[197],"groups.":[200],"author":[202],"concluded":[203],"that":[204],"when":[205],"applying":[206],"LAHs":[208],"embryos,":[216],"both":[217],"can":[221],"generate":[222],"promising":[224],"outcome,":[226],"operation":[230],"be":[231],"equivalent":[232],"LAO.":[235],"Future":[236],"well-designed,":[237],"multiple-center,":[238],"larger-sample":[239],"investigations":[240],"are":[241],"required":[242],"ascertain":[244],"above":[245],"conclusion.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-06-28T00:00:00"}
