{"id":"https://openalex.org/W4283575232","doi":"https://doi.org/10.4274/tjod.galenos.2022.84883","title":"Correlation of serum leptin and ghrelin levels with endocrine and reproductive parameters in women with clomiphene citrate resistant polycystic ovary syndrome","display_name":"Correlation of serum leptin and ghrelin levels with endocrine and reproductive parameters in women with clomiphene citrate resistant polycystic ovary syndrome","publication_year":2022,"publication_date":"2022-06-27","ids":{"openalex":"https://openalex.org/W4283575232","doi":"https://doi.org/10.4274/tjod.galenos.2022.84883","pmid":"https://pubmed.ncbi.nlm.nih.gov/35770481","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9249363"},"language":"en","primary_location":{"id":"doi:10.4274/tjod.galenos.2022.84883","doi":"https://doi.org/10.4274/tjod.galenos.2022.84883","is_oa":true,"landing_page_url":"https://doi.org/10.4274/tjod.galenos.2022.84883","pdf_url":"https://doi.org/10.4274/tjod.galenos.2022.84883","source":{"id":"https://openalex.org/S4210205408","display_name":"Journal of Turkish Society of Obstetric and Gynecology","issn_l":"1307-699X","issn":["1307-699X","1307-7007","2149-9322","2149-9330"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-c","poland-20","russia-white-list-3","tr-dizin"],"host_organization":"https://openalex.org/P4310320331","host_organization_name":"Galenos Yayinevi","host_organization_lineage":["https://openalex.org/P4310320331"],"host_organization_lineage_names":["Galenos Yayinevi"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Turkish Society of Obstetric and Gynecology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.4274/tjod.galenos.2022.84883","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035941235","display_name":"Arzu Yurci","orcid":"https://orcid.org/0000-0003-4808-9019","observed_orcids":["https://orcid.org/0000-0003-4808-9019"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arzu Yurci","raw_affiliation_strings":["Bah\u00e7elievler Memorial Hospital In Vitro Fertilization, \u0130stanbul, Turkey"],"raw_orcid":"https://orcid.org/0000-0003-4808-9019","affiliations":[{"raw_affiliation_string":"Bah\u00e7elievler Memorial Hospital In Vitro Fertilization, \u0130stanbul, Turkey","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089413985","display_name":"Nur DOKUZEYL\u00dcL G\u00dcNG\u00d6R","orcid":"https://orcid.org/0000-0002-7234-3876","observed_orcids":["https://orcid.org/0000-0002-7234-3876"]},"institutions":[{"id":"https://openalex.org/I128277893","display_name":"Bah\u00e7e\u015fehir University","ror":"https://ror.org/00yze4d93","country_code":"TR","type":"education","lineage":["https://openalex.org/I128277893"]},{"id":"https://openalex.org/I57913696","display_name":"Istanbul Medeniyet University","ror":"https://ror.org/05j1qpr59","country_code":"TR","type":"education","lineage":["https://openalex.org/I57913696"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Nur Dokuzeyl\u00fcl G\u00fcng\u00f6r","raw_affiliation_strings":["Bah\u00e7e\u015fehir University, Medical Park G\u00f6ztepe Hospital, Clinic of Reproductive Endocrinology and In Vitro Fertilization, \u0130stanbul, Turkey","\u0130stanbul Medeniyet University Faculty of Medicine, Department of Endocrinology and Metabolism, \u0130stanbul, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-7234-3876","affiliations":[{"raw_affiliation_string":"Bah\u00e7e\u015fehir University, Medical Park G\u00f6ztepe Hospital, Clinic of Reproductive Endocrinology and In Vitro Fertilization, \u0130stanbul, Turkey","institution_ids":["https://openalex.org/I128277893"]},{"raw_affiliation_string":"\u0130stanbul Medeniyet University Faculty of Medicine, Department of Endocrinology and Metabolism, \u0130stanbul, Turkey","institution_ids":["https://openalex.org/I57913696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021836469","display_name":"Ka\u011fan G\u00fcng\u00f6r","orcid":"https://orcid.org/0000-0003-1019-3769","observed_orcids":["https://orcid.org/0000-0003-1019-3769"]},"institutions":[{"id":"https://openalex.org/I128277893","display_name":"Bah\u00e7e\u015fehir University","ror":"https://ror.org/00yze4d93","country_code":"TR","type":"education","lineage":["https://openalex.org/I128277893"]},{"id":"https://openalex.org/I57913696","display_name":"Istanbul Medeniyet University","ror":"https://ror.org/05j1qpr59","country_code":"TR","type":"education","lineage":["https://openalex.org/I57913696"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ka\u011fan G\u00fcng\u00f6r","raw_affiliation_strings":["\u0130stanbul Medeniyet University Faculty of Medicine, Department of Endocrinology and Metabolism, \u0130stanbul, Turkey","Bah\u00e7e\u015fehir University, Medical Park G\u00f6ztepe Hospital, Clinic of Reproductive Endocrinology and In Vitro Fertilization, \u0130stanbul, Turkey"],"raw_orcid":"https://orcid.org/0000-0003-1019-3769","affiliations":[{"raw_affiliation_string":"\u0130stanbul Medeniyet University Faculty of Medicine, Department of Endocrinology and Metabolism, \u0130stanbul, Turkey","institution_ids":["https://openalex.org/I57913696"]},{"raw_affiliation_string":"Bah\u00e7e\u015fehir University, Medical Park G\u00f6ztepe Hospital, Clinic of Reproductive Endocrinology and In Vitro Fertilization, \u0130stanbul, Turkey","institution_ids":["https://openalex.org/I128277893"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007165044","display_name":"\u015eafak Hat\u0131rnaz","orcid":"https://orcid.org/0000-0001-8859-0639","observed_orcids":["https://orcid.org/0000-0001-8859-0639","https://orcid.org/0000-0002-9406-3007"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u015eafak Hat\u0131rnaz","raw_affiliation_strings":["Mediliv Medical Center, \u0130lkad\u0131m, Samsun, Turkey"],"raw_orcid":"https://orcid.org/0000-0001-8859-0639","affiliations":[{"raw_affiliation_string":"Mediliv Medical Center, \u0130lkad\u0131m, Samsun, Turkey","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5089413985"],"corresponding_institution_ids":["https://openalex.org/I128277893","https://openalex.org/I57913696"],"apc_list":null,"apc_paid":null,"fwci":1.5668,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.78729871,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"19","issue":"2","first_page":"124","last_page":"129"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polycystic-ovary-syndrome","display_name":"polycystic ovary syndrome","score":0.9750000238418579},{"id":"https://openalex.org/keywords/clomiphene-resistance","display_name":"clomiphene citrate resistance","score":0.9800000190734863},{"id":"https://openalex.org/keywords/ghrelin","display_name":"ghrelin","score":0.8859999775886536},{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":1.0},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.5789999961853027},{"id":"https://openalex.org/keywords/luteinizing-hormone","display_name":"luteinizing hormone","score":0.9950000047683716},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.5659999847412109},{"id":"https://openalex.org/keywords/oocyte-maturity","display_name":"oocyte maturity","score":0.6840000152587891},{"id":"https://openalex.org/keywords/implantation-rate","display_name":"implantation rate","score":0.9589999914169312},{"id":"https://openalex.org/keywords/ivf-icsi-outcomes","display_name":"IVF/ICSI outcomes","score":0.7400000095367432},{"id":"https://openalex.org/keywords/female-infertility","display_name":"female infertility","score":0.7099999785423279},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.8999999761581421}],"concepts":[{"id":"https://openalex.org/C3018442814","wikidata":"https://www.wikidata.org/wiki/Q500816","display_name":"Polycystic ovary","level":4,"score":0.8281188011169434},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.8135138750076294},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8070780038833618},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7794252634048462},{"id":"https://openalex.org/C2779357093","wikidata":"https://www.wikidata.org/wiki/Q422269","display_name":"Ghrelin","level":3,"score":0.7538775205612183},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6193397641181946},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.5683000087738037},{"id":"https://openalex.org/C2777688143","wikidata":"https://www.wikidata.org/wiki/Q179399","display_name":"Infertility","level":3,"score":0.5394185185432434},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.5105377435684204},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.47612887620925903},{"id":"https://openalex.org/C2777702977","wikidata":"https://www.wikidata.org/wiki/Q187082","display_name":"Ovulation","level":3,"score":0.474589079618454},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4490545094013214},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.3823540508747101},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.37574201822280884},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.23052722215652466},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22364553809165955},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.4274/tjod.galenos.2022.84883","doi":"https://doi.org/10.4274/tjod.galenos.2022.84883","is_oa":true,"landing_page_url":"https://doi.org/10.4274/tjod.galenos.2022.84883","pdf_url":"https://doi.org/10.4274/tjod.galenos.2022.84883","source":{"id":"https://openalex.org/S4210205408","display_name":"Journal of Turkish Society of Obstetric and Gynecology","issn_l":"1307-699X","issn":["1307-699X","1307-7007","2149-9322","2149-9330"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-c","poland-20","russia-white-list-3","tr-dizin"],"host_organization":"https://openalex.org/P4310320331","host_organization_name":"Galenos Yayinevi","host_organization_lineage":["https://openalex.org/P4310320331"],"host_organization_lineage_names":["Galenos Yayinevi"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Turkish Society of Obstetric and Gynecology","raw_type":"journal-article"},{"id":"pmid:35770481","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35770481","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turkish journal of obstetrics and gynecology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9249363","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9249363/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turk J Obstet Gynecol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.4274/tjod.galenos.2022.84883","doi":"https://doi.org/10.4274/tjod.galenos.2022.84883","is_oa":true,"landing_page_url":"https://doi.org/10.4274/tjod.galenos.2022.84883","pdf_url":"https://doi.org/10.4274/tjod.galenos.2022.84883","source":{"id":"https://openalex.org/S4210205408","display_name":"Journal of Turkish Society of Obstetric and Gynecology","issn_l":"1307-699X","issn":["1307-699X","1307-7007","2149-9322","2149-9330"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-c","poland-20","russia-white-list-3","tr-dizin"],"host_organization":"https://openalex.org/P4310320331","host_organization_name":"Galenos Yayinevi","host_organization_lineage":["https://openalex.org/P4310320331"],"host_organization_lineage_names":["Galenos Yayinevi"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Turkish Society of Obstetric and Gynecology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4283575232.pdf","grobid_xml":"https://content.openalex.org/works/W4283575232.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W634611655","https://openalex.org/W1970941152","https://openalex.org/W1971433476","https://openalex.org/W1974118452","https://openalex.org/W1978154261","https://openalex.org/W1985843421","https://openalex.org/W1988198723","https://openalex.org/W2043093540","https://openalex.org/W2087744465","https://openalex.org/W2101680331","https://openalex.org/W2102131488","https://openalex.org/W2102710461","https://openalex.org/W2109676898","https://openalex.org/W2114225029","https://openalex.org/W2167945741","https://openalex.org/W2181564370","https://openalex.org/W2216233534","https://openalex.org/W2397036223","https://openalex.org/W2542236253","https://openalex.org/W2907414992","https://openalex.org/W2909184064","https://openalex.org/W2928337350","https://openalex.org/W2999840138","https://openalex.org/W3009581762","https://openalex.org/W3084191047","https://openalex.org/W3124550116"],"related_works":["https://openalex.org/W2749137797","https://openalex.org/W2181564370","https://openalex.org/W2043093540","https://openalex.org/W2001251506","https://openalex.org/W2888119829","https://openalex.org/W2378965053","https://openalex.org/W3154634997","https://openalex.org/W2019543222","https://openalex.org/W2383109918","https://openalex.org/W4402348272"],"abstract_inverted_index":{"Objective:":[0],"To":[1],"investigate":[2],"the":[3,41,49,72,76,80,85,148,155,165,172],"changes":[4],"in":[5,11,40,52,82,97,119,127,236],"serum":[6,209,221],"ghrelin":[7,89,145,210,231],"and":[8,20,56,66,90,111,138,181,196,211,215,226],"leptin":[9,91,162,179],"levels":[10,92,146,163,180],"patients":[12,23,44,174],"with":[13,48,233,238],"clomiphene-resistant":[14],"polycystic":[15],"ovary":[16],"syndrome":[17],"(PCOS).":[18],"Materials":[19],"Methods:":[21],"Thirty-five":[22,43],"who":[24,45],"could":[25],"not":[26,63],"achieve":[27],"ovulation":[28],"or":[29],"pregnancy":[30,113],"despite":[31],"using":[32],"150":[33],"mg/day":[34],"of":[35,54,69,79,129,147,164],"clomiphene":[36],"citrate":[37],"(CC)":[38],"participated":[39],"study.":[42],"were":[46,93,115,122,151,168],"compatible":[47],"study":[50],"group":[51,150,157,167],"terms":[53,128],"age":[55,130],"body":[57],"mass":[58],"index":[59],"(BMI)":[60],"but":[61],"did":[62],"have":[64],"clinical":[65,112],"laboratory":[67],"findings":[68],"PCOS":[70,149,166,240],"constituted":[71],"control":[73,156,173],"group.":[74],"On":[75],"third":[77],"day":[78],"cycle,":[81],"addition":[83],"to":[84,101,124],"basal":[86],"hormone":[87,104,192],"profile,":[88],"also":[94],"measured.":[95],"Patients":[96,118],"both":[98,120],"groups":[99,121],"went":[100],"IVF/ICSI.":[102,242],"Basal":[103],"values,":[105],"leptin,":[106],"ghrelin,":[107,222],"metabolic,":[108],"demographic":[109],"parameters,":[110],"rates":[114],"correlated.":[116],"Results:":[117],"recorded":[123],"be":[125],"similar":[126],"(29.4\u00b10.11":[131],"vs":[132,136,142,159,176],"28.5\u00b17.30),":[133],"BMI":[134,182],"(24.3\u00b13.07":[135],"23.8\u00b11.55),":[137],"infertility":[139],"time":[140],"(6.14\u00b14.30":[141],"6.03\u00b11.28).":[143],"Serum":[144,161,178,230],"significantly":[152,169],"lower":[153],"than":[154,171],"(0.48\u00b12.21":[158],"1.19\u00b14.02)":[160],"higher":[170],"(45.6\u00b1304":[175],"16.5\u00b10.32).":[177],"(r=0.65,":[183],"p<0.01)":[184],"A":[185,213],"positive":[186,214],"correlation":[187,207,217],"was":[188,202,218],"found":[189,219],"between":[190,208,220],"luteinizing":[191],"(LH)":[193],"(r=0.53,":[194],"p<0.02),":[195],"insulin":[197],"resistance":[198],"(r=0.74,":[199],"p<0.03).":[200],"There":[201],"a":[203],"negative":[204],"(r=-0.76,":[205],"p<0.03)":[206],"LH.":[212],"significant":[216],"testosterone,":[223],"mature":[224],"oocyte,":[225],"implantation":[227],"rates.":[228],"Conclusion:":[229],"correlates":[232],"fertility":[234],"outcomes":[235],"women":[237],"CC-resistant":[239],"undergoing":[241]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-06-28T00:00:00"}