{"id":"https://openalex.org/W4283574352","doi":"https://doi.org/10.1080/19336950.2022.2085379","title":"Piezo1-mediated fluid shear stress promotes OPG and inhibits RANKL via NOTCH3 in MLO-Y4 osteocytes","display_name":"Piezo1-mediated fluid shear stress promotes OPG and inhibits RANKL via NOTCH3 in MLO-Y4 osteocytes","publication_year":2022,"publication_date":"2022-06-27","ids":{"openalex":"https://openalex.org/W4283574352","doi":"https://doi.org/10.1080/19336950.2022.2085379","pmid":"https://pubmed.ncbi.nlm.nih.gov/35754337","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9721416"},"language":"en","primary_location":{"id":"doi:10.1080/19336950.2022.2085379","doi":"https://doi.org/10.1080/19336950.2022.2085379","is_oa":true,"landing_page_url":"https://doi.org/10.1080/19336950.2022.2085379","pdf_url":null,"source":{"id":"https://openalex.org/S202658786","display_name":"Channels","issn_l":"1933-6950","issn":["1933-6950","1933-6969"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Channels","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1080/19336950.2022.2085379","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091768873","display_name":"Zhongcheng Liu","orcid":"https://orcid.org/0000-0002-1632-5956","observed_orcids":["https://orcid.org/0000-0002-1632-5956"]},"institutions":[{"id":"https://openalex.org/I4210124531","display_name":"Lanzhou University Second Hospital","ror":"https://ror.org/02erhaz63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhongcheng Liu","raw_affiliation_strings":["Department of Orthopaedics, Gansu Key Laboratory of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, Gansu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Gansu Key Laboratory of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, Gansu, China","institution_ids":["https://openalex.org/I4210124531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078429626","display_name":"Yuchen Tang","orcid":"https://orcid.org/0000-0002-5635-6319","observed_orcids":["https://orcid.org/0000-0002-5635-6319"]},"institutions":[{"id":"https://openalex.org/I4210124531","display_name":"Lanzhou University Second Hospital","ror":"https://ror.org/02erhaz63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuchen Tang","raw_affiliation_strings":["Department of Orthopaedics, Gansu Key Laboratory of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, Gansu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Gansu Key Laboratory of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, Gansu, China","institution_ids":["https://openalex.org/I4210124531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010125914","display_name":"Liangzhi He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124531","display_name":"Lanzhou University Second Hospital","ror":"https://ror.org/02erhaz63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liangzhi He","raw_affiliation_strings":["Department of Orthopaedics, Gansu Key Laboratory of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, Gansu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Gansu Key Laboratory of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, Gansu, China","institution_ids":["https://openalex.org/I4210124531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031598662","display_name":"Bin Geng","orcid":"https://orcid.org/0000-0002-1505-3645","observed_orcids":["https://orcid.org/0000-0002-1505-3645"]},"institutions":[{"id":"https://openalex.org/I4210124531","display_name":"Lanzhou University Second Hospital","ror":"https://ror.org/02erhaz63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Geng","raw_affiliation_strings":["Department of Orthopaedics, Gansu Key Laboratory of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, Gansu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Gansu Key Laboratory of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, Gansu, China","institution_ids":["https://openalex.org/I4210124531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030886412","display_name":"Fan L\u00fc","orcid":"https://orcid.org/0000-0001-5455-4277","observed_orcids":["https://orcid.org/0000-0001-5455-4277","https://orcid.org/0009-0007-5242-8227"]},"institutions":[{"id":"https://openalex.org/I4210124531","display_name":"Lanzhou University Second Hospital","ror":"https://ror.org/02erhaz63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fan Lu","raw_affiliation_strings":["Department of Orthopaedics, Gansu Key Laboratory of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, Gansu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Gansu Key Laboratory of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, Gansu, China","institution_ids":["https://openalex.org/I4210124531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085018532","display_name":"Jinwen He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124531","display_name":"Lanzhou University Second Hospital","ror":"https://ror.org/02erhaz63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinwen He","raw_affiliation_strings":["Department of Orthopaedics, Gansu Key Laboratory of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, Gansu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Gansu Key Laboratory of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, Gansu, China","institution_ids":["https://openalex.org/I4210124531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002767945","display_name":"Qiong Yi","orcid":"https://orcid.org/0000-0002-8384-5089","observed_orcids":["https://orcid.org/0000-0002-8384-5089"]},"institutions":[{"id":"https://openalex.org/I4210124531","display_name":"Lanzhou University Second Hospital","ror":"https://ror.org/02erhaz63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiong Yi","raw_affiliation_strings":["Department of Orthopaedics, Gansu Key Laboratory of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, Gansu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Gansu Key Laboratory of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, Gansu, China","institution_ids":["https://openalex.org/I4210124531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080190160","display_name":"Xuening Liu","orcid":"https://orcid.org/0009-0007-3969-3093","observed_orcids":["https://orcid.org/0009-0007-3969-3093"]},"institutions":[{"id":"https://openalex.org/I4210124531","display_name":"Lanzhou University Second Hospital","ror":"https://ror.org/02erhaz63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuening Liu","raw_affiliation_strings":["Department of Orthopaedics, Gansu Key Laboratory of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, Gansu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Gansu Key Laboratory of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, Gansu, China","institution_ids":["https://openalex.org/I4210124531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100342365","display_name":"Kun Zhang","orcid":"https://orcid.org/0000-0002-8916-556X","observed_orcids":["https://orcid.org/0000-0002-8916-556X"]},"institutions":[{"id":"https://openalex.org/I4210124531","display_name":"Lanzhou University Second Hospital","ror":"https://ror.org/02erhaz63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kun Zhang","raw_affiliation_strings":["Department of Orthopaedics, Gansu Key Laboratory of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, Gansu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Gansu Key Laboratory of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, Gansu, China","institution_ids":["https://openalex.org/I4210124531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101922066","display_name":"Lifu Wang","orcid":"https://orcid.org/0000-0001-5172-9932","observed_orcids":["https://orcid.org/0000-0001-5172-9932"]},"institutions":[{"id":"https://openalex.org/I4210124531","display_name":"Lanzhou University Second Hospital","ror":"https://ror.org/02erhaz63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lifu Wang","raw_affiliation_strings":["Department of Orthopaedics, Gansu Key Laboratory of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, Gansu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Gansu Key Laboratory of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, Gansu, China","institution_ids":["https://openalex.org/I4210124531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021269195","display_name":"Yayi Xia","orcid":"https://orcid.org/0000-0002-3574-6297","observed_orcids":["https://orcid.org/0000-0002-3574-6297"]},"institutions":[{"id":"https://openalex.org/I4210124531","display_name":"Lanzhou University Second Hospital","ror":"https://ror.org/02erhaz63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124531"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yayi Xia","raw_affiliation_strings":["Department of Orthopaedics, Gansu Key Laboratory of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, Gansu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Gansu Key Laboratory of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, Gansu, China","institution_ids":["https://openalex.org/I4210124531"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113648319","display_name":"Jin Fang Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124531","display_name":"Lanzhou University Second Hospital","ror":"https://ror.org/02erhaz63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124531"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jin Jiang","raw_affiliation_strings":["Department of Orthopaedics, Gansu Key Laboratory of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, Gansu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Gansu Key Laboratory of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, Gansu, China","institution_ids":["https://openalex.org/I4210124531"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5021269195","https://openalex.org/A5113648319"],"corresponding_institution_ids":["https://openalex.org/I4210124531"],"apc_list":{"value":1880,"currency":"GBP","value_usd":2306},"apc_paid":{"value":1880,"currency":"GBP","value_usd":2306},"fwci":1.6912,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.85045029,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"16","issue":"1","first_page":"127","last_page":"136"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/piezo1","display_name":"Piezo1","score":1.0},{"id":"https://openalex.org/keywords/mechanosensitive-channels","display_name":"mechanosensitive ion channels","score":0.8560000061988831},{"id":"https://openalex.org/keywords/fluid-shear-stress","display_name":"fluid shear stress","score":0.9990000128746033},{"id":"https://openalex.org/keywords/osteocytes","display_name":"osteocytes","score":0.9800000190734863},{"id":"https://openalex.org/keywords/mlo-y4-cells","display_name":"MLO-Y4 cells","score":0.8640000224113464},{"id":"https://openalex.org/keywords/osteoprotegerin","display_name":"osteoprotegerin","score":0.8600000143051147},{"id":"https://openalex.org/keywords/rankl","display_name":"RANKL","score":0.9929999709129333},{"id":"https://openalex.org/keywords/notch3","display_name":"Notch3","score":0.9710000157356262},{"id":"https://openalex.org/keywords/gsmtx4","display_name":"GsMTx4","score":0.875},{"id":"https://openalex.org/keywords/bone-homeostasis","display_name":"bone homeostasis","score":0.8830000162124634},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.5680000185966492},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.8479999899864197},{"id":"https://openalex.org/keywords/mechanotransduction","display_name":"mechanotransduction","score":0.8949999809265137}],"concepts":[{"id":"https://openalex.org/C2779428903","wikidata":"https://www.wikidata.org/wiki/Q418934","display_name":"RANKL","level":4,"score":0.9427930116653442},{"id":"https://openalex.org/C2780785647","wikidata":"https://www.wikidata.org/wiki/Q18034667","display_name":"PIEZO1","level":5,"score":0.8406944870948792},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7684798240661621},{"id":"https://openalex.org/C2780426850","wikidata":"https://www.wikidata.org/wiki/Q3357478","display_name":"Osteoprotegerin","level":4,"score":0.7381877899169922},{"id":"https://openalex.org/C4001165","wikidata":"https://www.wikidata.org/wiki/Q6804689","display_name":"Mechanosensitive channels","level":4,"score":0.6038991808891296},{"id":"https://openalex.org/C2780973866","wikidata":"https://www.wikidata.org/wiki/Q913236","display_name":"Osteocyte","level":4,"score":0.5974392890930176},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5910102128982544},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.5360517501831055},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5218173861503601},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.503715455532074},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49742820858955383},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4885154962539673},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.477366179227829},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.4446066915988922},{"id":"https://openalex.org/C181104049","wikidata":"https://www.wikidata.org/wiki/Q11936292","display_name":"Mechanotransduction","level":2,"score":0.4438643157482147},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.442410409450531},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.3421470522880554},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.24913904070854187},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.22832262516021729},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.16718095541000366},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14073041081428528},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12374988198280334},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09691640734672546},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010011","descriptor_name":"Osteocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053244","descriptor_name":"Osteoprotegerin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053244","descriptor_name":"Osteoprotegerin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1080/19336950.2022.2085379","doi":"https://doi.org/10.1080/19336950.2022.2085379","is_oa":true,"landing_page_url":"https://doi.org/10.1080/19336950.2022.2085379","pdf_url":null,"source":{"id":"https://openalex.org/S202658786","display_name":"Channels","issn_l":"1933-6950","issn":["1933-6950","1933-6969"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Channels","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9721416","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9721416/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9721416/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Channels (Austin)","raw_type":"Text"},{"id":"pmid:35754337","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35754337","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Channels (Austin, Tex.)","raw_type":"Journal Article"},{"id":"pmh:oai:/ir.lzu.edu.cn/:262010/483226","doi":null,"is_oa":false,"landing_page_url":"https://ir.lzu.edu.cn/handle/262010/483226","pdf_url":null,"source":{"id":"https://openalex.org/S4406923049","display_name":"Lanzhou University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:fed70fda235c4e98913eb81017d85c53","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/fed70fda235c4e98913eb81017d85c53","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Channels, Vol 16, Iss 1, Pp 127-136 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1080/19336950.2022.2085379","doi":"https://doi.org/10.1080/19336950.2022.2085379","is_oa":true,"landing_page_url":"https://doi.org/10.1080/19336950.2022.2085379","pdf_url":null,"source":{"id":"https://openalex.org/S202658786","display_name":"Channels","issn_l":"1933-6950","issn":["1933-6950","1933-6969"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Channels","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1304725172","display_name":null,"funder_award_id":"CY2021-MS-A07","funder_id":"https://openalex.org/F4320322880","funder_display_name":"Natural Science Foundation of Gansu Province"},{"id":"https://openalex.org/G1489446898","display_name":"\u6d41\u4f53\u526a\u5207\u5e94\u529b\u901a\u8fc7TGFBR2/ERK5\u4fe1\u53f7\u901a\u8def\u8c03\u63a7\u6210\u9aa8\u7ec6\u80de\u548c\u7834\u9aa8\u7ec6\u80de\u7684\u751f\u7406\u529f\u80fd\uff1a\u57fa\u4e8e\u7ade\u4e89\u6027\u5185\u6e90RNA/ceRNA\u7684\u5206\u5b50\u673a\u5236\u7814\u7a76","funder_award_id":"82060405","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G150031274","display_name":null,"funder_award_id":"81874017","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3269236488","display_name":null,"funder_award_id":"CY2017-ZD02","funder_id":"https://openalex.org/F4320322880","funder_display_name":"Natural Science Foundation of Gansu Province"},{"id":"https://openalex.org/G3330866679","display_name":null,"funder_award_id":"81874017","funder_id":"https://openalex.org/F4320313889","funder_display_name":"Lanzhou University"},{"id":"https://openalex.org/G4343993035","display_name":null,"funder_award_id":"21JR7RA393","funder_id":"https://openalex.org/F4320322880","funder_display_name":"Natural Science Foundation of Gansu Province"},{"id":"https://openalex.org/G4457589723","display_name":null,"funder_award_id":"81960403","funder_id":"https://openalex.org/F4320313889","funder_display_name":"Lanzhou University"},{"id":"https://openalex.org/G5681423454","display_name":null,"funder_award_id":"82160422","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5964159994","display_name":"BMK1\u4fe1\u53f7\u901a\u8def\u5728\u7ef4\u6301\u9aa8\u9ad3\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6210\u8102\u5206\u5316\u548c\u6210\u9aa8\u5206\u5316\u5e73\u8861\u4e2d\u7684\u8868\u89c2\u9057\u4f20\u5b66\u7814\u7a76","funder_award_id":"81960403","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6180531912","display_name":null,"funder_award_id":"CY2017-ZD02","funder_id":"https://openalex.org/F4320313889","funder_display_name":"Lanzhou University"},{"id":"https://openalex.org/G6459979750","display_name":null,"funder_award_id":"81960403","funder_id":"https://openalex.org/F4320322880","funder_display_name":"Natural Science Foundation of Gansu Province"},{"id":"https://openalex.org/G6520772848","display_name":null,"funder_award_id":"82060405","funder_id":"https://openalex.org/F4320313889","funder_display_name":"Lanzhou University"},{"id":"https://openalex.org/G7306913391","display_name":null,"funder_award_id":"82060405","funder_id":"https://openalex.org/F4320322880","funder_display_name":"Natural Science Foundation of Gansu Province"},{"id":"https://openalex.org/G929242327","display_name":null,"funder_award_id":"81874017","funder_id":"https://openalex.org/F4320322880","funder_display_name":"Natural Science Foundation of Gansu Province"}],"funders":[{"id":"https://openalex.org/F4320313889","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322880","display_name":"Natural Science Foundation of Gansu Province","ror":null},{"id":"https://openalex.org/F7910658730","display_name":"Lanzhou University Second Hospital","ror":"https://ror.org/02erhaz63"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4283574352.pdf","grobid_xml":"https://content.openalex.org/works/W4283574352.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W265902225","https://openalex.org/W1928745964","https://openalex.org/W1972071814","https://openalex.org/W1976402969","https://openalex.org/W1982395713","https://openalex.org/W1999720993","https://openalex.org/W2000647744","https://openalex.org/W2046675807","https://openalex.org/W2079597091","https://openalex.org/W2093252878","https://openalex.org/W2142302926","https://openalex.org/W2322722948","https://openalex.org/W2619460931","https://openalex.org/W2898266525","https://openalex.org/W2956354975","https://openalex.org/W2978956742","https://openalex.org/W2985300627","https://openalex.org/W2999910893","https://openalex.org/W3006279369","https://openalex.org/W3009206285","https://openalex.org/W3011339338","https://openalex.org/W3015701917","https://openalex.org/W3035534921","https://openalex.org/W3088328861","https://openalex.org/W3093365748","https://openalex.org/W3099127405","https://openalex.org/W3119057232","https://openalex.org/W3119693934","https://openalex.org/W3138226048","https://openalex.org/W3200332431","https://openalex.org/W3202368740"],"related_works":["https://openalex.org/W4394853643","https://openalex.org/W2978956742","https://openalex.org/W3011339338","https://openalex.org/W4313422890","https://openalex.org/W4385271603","https://openalex.org/W3012397626","https://openalex.org/W4220946038","https://openalex.org/W7160515051","https://openalex.org/W2366056853","https://openalex.org/W4394616495"],"abstract_inverted_index":{"Piezo1,":[0,123],"a":[1,7],"mechanosensitive":[2],"ion":[3],"channel,":[4],"participates":[5],"in":[6,12,21,31,142,165],"variety":[8],"of":[9,23,55,61,68,75,112,118,122,128,133,155,161],"biological":[10],"processes":[11],"maintaining":[13],"bone":[14,32,36,69],"homeostasis.":[15],"As":[16],"the":[17,24,45,53,59,62,66,110,116,126,131,146,153,159],"most":[18],"abundant":[19],"cells":[20],"bones":[22],"mammals,":[25],"osteocytes":[26,43,101],"play":[27],"an":[28,94,105],"essential":[29],"role":[30],"formation,":[33],"remodeling,":[34],"and":[35,71,80,114,157],"mass":[37],"maintenance.":[38],"Here,":[39],"by":[40],"exposing":[41],"MLO-Y4":[42,100,166],"to":[44,65,104],"fluid":[46],"shear":[47],"stress":[48],"(FSS)":[49],"microenvironment,":[50],"we":[51],"explored":[52],"effect":[54,127],"Piezo1-mediated":[56,150],"FSS":[57,106,108,129,151],"on":[58,97,130],"expression":[60,111,117,132,154,160],"molecules":[63],"critical":[64],"process":[67],"formation":[70],"resorption,":[72],"Receptor":[73],"Activator":[74],"Nuclear":[76],"Factor-Kappa-B":[77],"Ligand":[78],"(RANKL)":[79],"Osteoprotegerin":[81],"(OPG).":[82],"It":[83],"was":[84,140],"found":[85],"that":[86,149],"9":[87],"dyne/cm2":[88],"loading":[89],"for":[90],"30":[91],"minutes":[92],"showed":[93],"upregulation":[95],"trend":[96],"Piezo1":[98],"when":[99],"were":[102],"exposed":[103],"microenvironment.":[107],"promotes":[109,152],"OPG":[113,156],"inhibits":[115,158],"RANKL.":[119],"The":[120],"blocker":[121],"GsMTx4,":[124],"downregulates":[125],"these":[134],"two":[135],"molecules.":[136],"In":[137],"addition,":[138],"NOTCH3":[139,164],"involved":[141],"this":[143],"process.":[144],"Thus,":[145],"results":[147],"demonstrated":[148],"RANKL":[162],"via":[163],"osteocytes.":[167]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2022-06-28T00:00:00"}
