{"id":"https://openalex.org/W4283528596","doi":"https://doi.org/10.1080/19490976.2022.2089003","title":"Microbiota, not host origin drives ex vivo intestinal epithelial responses","display_name":"Microbiota, not host origin drives ex vivo intestinal epithelial responses","publication_year":2022,"publication_date":"2022-06-26","ids":{"openalex":"https://openalex.org/W4283528596","doi":"https://doi.org/10.1080/19490976.2022.2089003","pmid":"https://pubmed.ncbi.nlm.nih.gov/35758256","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9235885"},"language":"en","primary_location":{"id":"doi:10.1080/19490976.2022.2089003","doi":"https://doi.org/10.1080/19490976.2022.2089003","is_oa":true,"landing_page_url":"https://doi.org/10.1080/19490976.2022.2089003","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/19490976.2022.2089003?needAccess=true","source":{"id":"https://openalex.org/S2764770702","display_name":"Gut Microbes","issn_l":"1949-0976","issn":["1949-0976","1949-0984"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut Microbes","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.tandfonline.com/doi/pdf/10.1080/19490976.2022.2089003?needAccess=true","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029528010","display_name":"Kaline Arnauts","orcid":"https://orcid.org/0000-0003-0872-7776","observed_orcids":["https://orcid.org/0000-0003-0872-7776"]},"institutions":[{"id":"https://openalex.org/I4405264342","display_name":"Leuven Stem Cell Institute","ror":"https://ror.org/01mt46z25","country_code":"BE","type":"education","lineage":["https://openalex.org/I4405264342","https://openalex.org/I99464096"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Kaline Arnauts","raw_affiliation_strings":["Metabolism and Ageing (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven","Stem Cell Institute Leuven (SCIL), KU Leuven","Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium","Department of Development and Regeneration, Stem Cell Institute Leuven (SCIL), KU Leuven, Leuven, Belgium"],"raw_orcid":"https://orcid.org/0000-0003-0872-7776","affiliations":[{"raw_affiliation_string":"Metabolism and Ageing (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Stem Cell Institute Leuven (SCIL), KU Leuven","institution_ids":["https://openalex.org/I4405264342","https://openalex.org/I99464096"]},{"raw_affiliation_string":"Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Department of Development and Regeneration, Stem Cell Institute Leuven (SCIL), KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I4405264342","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073934272","display_name":"Padhmanand Sudhakar","orcid":"https://orcid.org/0000-0003-1907-4491","observed_orcids":["https://orcid.org/0000-0003-1907-4491"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Padhmanand Sudhakar","raw_affiliation_strings":["Metabolism and Ageing (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven","Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium"],"raw_orcid":"https://orcid.org/0000-0003-1907-4491","affiliations":[{"raw_affiliation_string":"Metabolism and Ageing (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083440554","display_name":"Sare Verstockt","orcid":"https://orcid.org/0000-0001-6222-8527","observed_orcids":["https://orcid.org/0000-0001-6222-8527"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Sare Verstockt","raw_affiliation_strings":["Metabolism and Ageing (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven","Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium"],"raw_orcid":"https://orcid.org/0000-0001-6222-8527","affiliations":[{"raw_affiliation_string":"Metabolism and Ageing (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018400570","display_name":"Cynthia Lapierre","orcid":"https://orcid.org/0000-0001-9270-1813","observed_orcids":["https://orcid.org/0000-0001-9270-1813"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Cynthia Lapierre","raw_affiliation_strings":["Metabolism and Ageing (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven","Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium"],"raw_orcid":"https://orcid.org/0000-0001-9270-1813","affiliations":[{"raw_affiliation_string":"Metabolism and Ageing (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042155856","display_name":"Selina Potche","orcid":"https://orcid.org/0000-0003-2161-6253","observed_orcids":["https://orcid.org/0000-0003-2161-6253"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Selina Potche","raw_affiliation_strings":["Metabolism and Ageing (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven","Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium"],"raw_orcid":"https://orcid.org/0000-0003-2161-6253","affiliations":[{"raw_affiliation_string":"Metabolism and Ageing (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009391192","display_name":"Clara Caenepeel","orcid":"https://orcid.org/0000-0002-6827-6287","observed_orcids":["https://orcid.org/0000-0002-6827-6287"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Clara Caenepeel","raw_affiliation_strings":["Metabolism and Ageing (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven","University Hospitals Leuven, KU Leuven","Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium","Department of Gastroenterology and Hepatology, University Hospitals Leuven, KU Leuven, Leuven, Belgium"],"raw_orcid":"https://orcid.org/0000-0002-6827-6287","affiliations":[{"raw_affiliation_string":"Metabolism and Ageing (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"University Hospitals Leuven, KU Leuven","institution_ids":["https://openalex.org/I2800231306","https://openalex.org/I99464096"]},{"raw_affiliation_string":"Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, University Hospitals Leuven, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I2800231306","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036654221","display_name":"Bram Verstockt","orcid":"https://orcid.org/0000-0003-3898-7093","observed_orcids":["https://orcid.org/0000-0003-3898-7093","https://orcid.org/0000-0002-7013-9548"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Bram Verstockt","raw_affiliation_strings":["Metabolism and Ageing (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven","University Hospitals Leuven, KU Leuven","Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium","Department of Gastroenterology and Hepatology, University Hospitals Leuven, KU Leuven, Leuven, Belgium"],"raw_orcid":"https://orcid.org/0000-0003-3898-7093","affiliations":[{"raw_affiliation_string":"Metabolism and Ageing (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"University Hospitals Leuven, KU Leuven","institution_ids":["https://openalex.org/I2800231306","https://openalex.org/I99464096"]},{"raw_affiliation_string":"Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, University Hospitals Leuven, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I2800231306","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023078719","display_name":"Jeroen Raes","orcid":"https://orcid.org/0000-0002-1337-041X","observed_orcids":["https://orcid.org/0000-0002-1337-041X"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jeroen Raes","raw_affiliation_strings":["Rega Institute, KU Leuven","Department of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium"],"raw_orcid":"https://orcid.org/0000-0002-1337-041X","affiliations":[{"raw_affiliation_string":"Rega Institute, KU Leuven","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019474609","display_name":"S\u00e9verine Vermeire","orcid":"https://orcid.org/0000-0001-9942-3019","observed_orcids":["https://orcid.org/0000-0001-9942-3019"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"S\u00e9verine Vermeire","raw_affiliation_strings":["Metabolism and Ageing (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven","University Hospitals Leuven, KU Leuven","Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium","Department of Gastroenterology and Hepatology, University Hospitals Leuven, KU Leuven, Leuven, Belgium"],"raw_orcid":"https://orcid.org/0000-0001-9942-3019","affiliations":[{"raw_affiliation_string":"Metabolism and Ageing (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"University Hospitals Leuven, KU Leuven","institution_ids":["https://openalex.org/I2800231306","https://openalex.org/I99464096"]},{"raw_affiliation_string":"Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, University Hospitals Leuven, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I2800231306","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077041880","display_name":"Jo\u00e3o Sabino","orcid":"https://orcid.org/0000-0002-8892-7075","observed_orcids":["https://orcid.org/0000-0002-8892-7075","https://orcid.org/0000-0001-5371-8428"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jo\u00e3o Sabino","raw_affiliation_strings":["Metabolism and Ageing (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven","University Hospitals Leuven, KU Leuven","Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium","Department of Gastroenterology and Hepatology, University Hospitals Leuven, KU Leuven, Leuven, Belgium"],"raw_orcid":"https://orcid.org/0000-0002-8892-7075","affiliations":[{"raw_affiliation_string":"Metabolism and Ageing (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"University Hospitals Leuven, KU Leuven","institution_ids":["https://openalex.org/I2800231306","https://openalex.org/I99464096"]},{"raw_affiliation_string":"Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, University Hospitals Leuven, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I2800231306","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030197044","display_name":"Catherine M. Verfaillie","orcid":"https://orcid.org/0000-0001-7564-4079","observed_orcids":["https://orcid.org/0000-0001-7564-4079"]},"institutions":[{"id":"https://openalex.org/I4405264342","display_name":"Leuven Stem Cell Institute","ror":"https://ror.org/01mt46z25","country_code":"BE","type":"education","lineage":["https://openalex.org/I4405264342","https://openalex.org/I99464096"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Catherine Verfaillie","raw_affiliation_strings":["Stem Cell Institute Leuven (SCIL), KU Leuven","Department of Development and Regeneration, Stem Cell Institute Leuven (SCIL), KU Leuven, Leuven, Belgium"],"raw_orcid":"https://orcid.org/0000-0001-7564-4079","affiliations":[{"raw_affiliation_string":"Stem Cell Institute Leuven (SCIL), KU Leuven","institution_ids":["https://openalex.org/I4405264342","https://openalex.org/I99464096"]},{"raw_affiliation_string":"Department of Development and Regeneration, Stem Cell Institute Leuven (SCIL), KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I4405264342","https://openalex.org/I99464096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029428855","display_name":"Marc Ferrante","orcid":"https://orcid.org/0000-0003-1492-0716","observed_orcids":["https://orcid.org/0000-0003-1492-0716"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Marc Ferrante","raw_affiliation_strings":["Metabolism and Ageing (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven","University Hospitals Leuven, KU Leuven","Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium","Department of Gastroenterology and Hepatology, University Hospitals Leuven, KU Leuven, Leuven, Belgium"],"raw_orcid":"https://orcid.org/0000-0003-1492-0716","affiliations":[{"raw_affiliation_string":"Metabolism and Ageing (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"University Hospitals Leuven, KU Leuven","institution_ids":["https://openalex.org/I2800231306","https://openalex.org/I99464096"]},{"raw_affiliation_string":"Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, University Hospitals Leuven, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I2800231306","https://openalex.org/I99464096"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5029428855"],"corresponding_institution_ids":["https://openalex.org/I2800231306","https://openalex.org/I99464096"],"apc_list":{"value":2495,"currency":"GBP","value_usd":3060},"apc_paid":{"value":2495,"currency":"GBP","value_usd":3060},"fwci":3.7702,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.94187914,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"14","issue":"1","first_page":"2089003","last_page":"2089003"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.7095000147819519,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.7095000147819519,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.2865999937057495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13569","display_name":"Microscopic Colitis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.8109999895095825},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.7559999823570251},{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/intestinal-epithelial-cells","display_name":"intestinal epithelial cells","score":0.9290000200271606},{"id":"https://openalex.org/keywords/microbiota-host-interactions","display_name":"microbiota-host interactions","score":0.5740000009536743},{"id":"https://openalex.org/keywords/epithelial-barrier-integrity","display_name":"epithelial barrier integrity","score":0.8289999961853027},{"id":"https://openalex.org/keywords/dysbiosis","display_name":"dysbiosis","score":0.7799999713897705},{"id":"https://openalex.org/keywords/stress-signaling","display_name":"stress signaling","score":0.5559999942779541},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.6439999938011169},{"id":"https://openalex.org/keywords/jak-stat-signaling","display_name":"JAK/STAT signaling","score":0.9829999804496765},{"id":"https://openalex.org/keywords/egr1","display_name":"EGR1","score":0.7480000257492065},{"id":"https://openalex.org/keywords/donor-microbiota","display_name":"donor microbiota","score":0.39899998903274536},{"id":"https://openalex.org/keywords/co-culture","display_name":"co-culture","score":0.6309999823570251}],"concepts":[{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.7907929420471191},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7409986257553101},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6993127465248108},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.6019450426101685},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.5701869130134583},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.5502713322639465},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.508962869644165},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.4966300129890442},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.47029349207878113},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.43267685174942017},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38568463921546936},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.25732797384262085},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1848103404045105},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10784262418746948},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09010007977485657},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08784177899360657},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08457756042480469},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.08181333541870117}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012336","descriptor_name":"RNA, Ribosomal, 16S","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064806","descriptor_name":"Dysbiosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1080/19490976.2022.2089003","doi":"https://doi.org/10.1080/19490976.2022.2089003","is_oa":true,"landing_page_url":"https://doi.org/10.1080/19490976.2022.2089003","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/19490976.2022.2089003?needAccess=true","source":{"id":"https://openalex.org/S2764770702","display_name":"Gut Microbes","issn_l":"1949-0976","issn":["1949-0976","1949-0984"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut Microbes","raw_type":"journal-article"},{"id":"pmid:35758256","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35758256","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut microbes","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9235885","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9235885/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut Microbes","raw_type":"Text"},{"id":"pmh:oai:lirias2repo.kuleuven.be:20.500.12942/698201","doi":null,"is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/handle/20.500.12942/698201","pdf_url":"https://lirias.kuleuven.be/retrieve/c9613a04-a34a-4e27-a75d-459534e48407","source":{"id":"https://openalex.org/S7407055369","display_name":"Lirias","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Gut Microbes, vol. 14 (1), Art.No. ARTN 2089003","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:9f2e0aa4b7f14da68d410886ab58b74b","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/9f2e0aa4b7f14da68d410886ab58b74b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Gut Microbes, Vol 14, Iss 1 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1080/19490976.2022.2089003","doi":"https://doi.org/10.1080/19490976.2022.2089003","is_oa":true,"landing_page_url":"https://doi.org/10.1080/19490976.2022.2089003","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/19490976.2022.2089003?needAccess=true","source":{"id":"https://openalex.org/S2764770702","display_name":"Gut Microbes","issn_l":"1949-0976","issn":["1949-0976","1949-0984"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut Microbes","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G137960103","display_name":null,"funder_award_id":"CREA/12/031","funder_id":"https://openalex.org/F4320322308","funder_display_name":"KU Leuven"},{"id":"https://openalex.org/G1807618672","display_name":null,"funder_award_id":"ZKC4621/10143459","funder_id":"https://openalex.org/F4320318113","funder_display_name":"European Crohn's and Colitis Organisation"},{"id":"https://openalex.org/G5547025565","display_name":null,"funder_award_id":"ERC-2015-AdG","funder_id":"https://openalex.org/F4320322308","funder_display_name":"KU Leuven"},{"id":"https://openalex.org/G5594029882","display_name":null,"funder_award_id":"694679","funder_id":"https://openalex.org/F4320321730","funder_display_name":"Fonds Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G5887563653","display_name":"Establishing an organoid derived 2D transwell model containing intestinal epithelial cells and dendritic cells to predict individual responses to microbiota in ulcerative colitis","funder_award_id":"1S49419N","funder_id":"https://openalex.org/F4320321730","funder_display_name":"Fonds Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G8240134949","display_name":null,"funder_award_id":"694679","funder_id":"https://openalex.org/F4320322308","funder_display_name":"KU Leuven"},{"id":"https://openalex.org/G8253217416","display_name":null,"funder_award_id":"ERC-2015-AdG","funder_id":"https://openalex.org/F4320321730","funder_display_name":"Fonds Wetenschappelijk Onderzoek"}],"funders":[{"id":"https://openalex.org/F4320318113","display_name":"European Crohn's and Colitis Organisation","ror":"https://ror.org/05beaae04"},{"id":"https://openalex.org/F4320321730","display_name":"Fonds Wetenschappelijk Onderzoek","ror":"https://ror.org/03qtxy027"},{"id":"https://openalex.org/F4320322308","display_name":"KU Leuven","ror":"https://ror.org/05f950310"},{"id":"https://openalex.org/F4320327336","display_name":"Vlaamse regering","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4283528596.pdf","grobid_xml":"https://content.openalex.org/works/W4283528596.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1601466212","https://openalex.org/W1967217097","https://openalex.org/W1967338335","https://openalex.org/W1987264412","https://openalex.org/W1988307013","https://openalex.org/W1988964423","https://openalex.org/W1992938326","https://openalex.org/W1997702183","https://openalex.org/W2034831207","https://openalex.org/W2035618305","https://openalex.org/W2066548490","https://openalex.org/W2078754045","https://openalex.org/W2080747432","https://openalex.org/W2089204801","https://openalex.org/W2090236453","https://openalex.org/W2091258745","https://openalex.org/W2096666146","https://openalex.org/W2108639003","https://openalex.org/W2117765445","https://openalex.org/W2126131092","https://openalex.org/W2135437310","https://openalex.org/W2147832388","https://openalex.org/W2162143298","https://openalex.org/W2172557341","https://openalex.org/W2179438025","https://openalex.org/W2218434982","https://openalex.org/W2235910927","https://openalex.org/W2288187473","https://openalex.org/W2548791670","https://openalex.org/W2588070196","https://openalex.org/W2588997555","https://openalex.org/W2592452407","https://openalex.org/W2594389980","https://openalex.org/W2620068414","https://openalex.org/W2762883136","https://openalex.org/W2770269406","https://openalex.org/W2770282900","https://openalex.org/W2799862405","https://openalex.org/W2809469011","https://openalex.org/W2888061430","https://openalex.org/W2910898181","https://openalex.org/W2912651600","https://openalex.org/W2933861736","https://openalex.org/W2944263569","https://openalex.org/W2953200221","https://openalex.org/W2982473772","https://openalex.org/W2996612201","https://openalex.org/W2998047889","https://openalex.org/W3012377065","https://openalex.org/W3029680339","https://openalex.org/W3114009994","https://openalex.org/W3136819357","https://openalex.org/W7098463221"],"related_works":["https://openalex.org/W4206920859","https://openalex.org/W3169287775","https://openalex.org/W7011315273","https://openalex.org/W2922048969","https://openalex.org/W7133018139","https://openalex.org/W7128308554","https://openalex.org/W2050378238","https://openalex.org/W1964923650","https://openalex.org/W4384700543","https://openalex.org/W2322784754"],"abstract_inverted_index":{"Microbial":[0],"dysbiosis":[1],"is":[2,230],"an":[3,67],"established":[4],"finding":[5],"in":[6,61,127,133,210],"patients":[7,39,55,112],"with":[8,49],"inflammatory":[9,68],"bowel":[10],"disease":[11],"(IBD),":[12],"but":[13,120,192],"host-microbial":[14],"interactions":[15],"are":[16],"poorly":[17],"understood.":[18],"We":[19,181],"aimed":[20],"to":[21,150,201,206,218,223],"unravel":[22],"the":[23,62,185,193,220,225],"effect":[24],"of":[25,36,53,66,147,159,228],"microbiota":[26,50,93,102,118,152,177,203],"exposure":[27,103,200],"on":[28,85,92,216],"intestinal":[29],"epithelial":[30,86,108,128,138,186,212],"cells.":[31,213],"Confluent":[32],"Transwell\u00ae":[33],"organoid":[34],"monolayers":[35],"eight":[37,41],"UC":[38,54,111,117,135,151,202],"and":[40,80,88,96,136,142,162,170],"non-IBD":[42,114],"controls":[43],"were":[44,83,179],"co-cultured":[45],"for":[46],"six":[47],"hours":[48],"(3x108":[51],"cells)":[52],"or":[56,64,113],"a":[57,124],"healthy":[58],"volunteer":[59],"(HV),":[60],"presence":[63],"absence":[65],"cytokine":[69],"mix.":[70],"Transepithelial":[71],"electrical":[72],"resistance":[73],"(TEER),":[74],"fluorescein":[75],"isothiocyanate":[76],"(FITC)":[77],"dextran":[78,144],"measurements,":[79],"RNA":[81],"sequencing":[82,91],"performed":[84],"cells,":[87],"16S":[89],"rRNA":[90],"samples":[94],"before":[95],"after":[97,175],"co-culture.":[98],"Transcriptomic":[99],"response":[100],"following":[101],"was":[104,131,204],"not":[105,121,184],"different":[106],"between":[107],"cells":[109,139],"from":[110],"controls.":[115],"Following":[116],"exposure,":[119],"HV":[122,137,176],"microbiota,":[123],"strong":[125],"decrease":[126],"barrier":[129],"integrity":[130],"observed":[132],"both":[134],"by":[140],"TEER":[141],"FITC":[143],"measurements.":[145],"Exposure":[146],"inflamed":[148],"epithelium":[149],"induced":[153],"transcriptomic":[154,197],"stress":[155,208],"pathways":[156],"including":[157],"activation":[158],"EGR1,":[160],"MAPK":[161],"JAK/STAT":[163],"signaling,":[164],"as":[165,167,199],"well":[166],"AP-1":[168],"family":[169],"FOSL":[171],"transcripts.":[172],"Stress":[173],"responses":[174,209],"stimulation":[178],"milder.":[180],"conclude":[182],"that":[183],"cell":[187],"origin":[188],"(UC":[189],"versus":[190],"non-IBD)":[191],"microbial":[194,221],"donor":[195],"drives":[196],"responses,":[198],"sufficient":[205],"induce":[207],"all":[211],"Further":[214],"research":[215],"therapies":[217],"restore":[219],"balance,":[222],"remove":[224],"constant":[226],"trigger":[227],"dysbiosis,":[229],"required.":[231]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-06-27T00:00:00"}