{"id":"https://openalex.org/W4283513537","doi":"https://doi.org/10.1101/2022.06.24.497440","title":"Half-calcified Calmodulin Promotes Basal Activity and Inactivation of the Calcium Channel Ca V 1.2","display_name":"Half-calcified Calmodulin Promotes Basal Activity and Inactivation of the Calcium Channel Ca V 1.2","publication_year":2022,"publication_date":"2022-06-24","ids":{"openalex":"https://openalex.org/W4283513537","doi":"https://doi.org/10.1101/2022.06.24.497440"},"language":"en","primary_location":{"id":"doi:10.1101/2022.06.24.497440","doi":"https://doi.org/10.1101/2022.06.24.497440","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.06.24.497440","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/06/24/2022.06.24.497440.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2022/06/24/2022.06.24.497440.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Peter Bartels","orcid":"https://orcid.org/0000-0001-5852-1835","observed_orcids":["https://orcid.org/0000-0001-5852-1835"]},"institutions":[{"id":"https://openalex.org/I2803209242","display_name":"University of California System","ror":"https://ror.org/00pjdza24","country_code":"US","type":"education","lineage":["https://openalex.org/I2803209242"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Bartels","raw_affiliation_strings":["Department of Pharmacology, University of California, Davis, CA 95616, USA","Deprtment of Phrmcology, University of Cliforni, Dvis, CA 95616, USA"],"raw_orcid":"https://orcid.org/0000-0001-5852-1835","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of California, Davis, CA 95616, USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Deprtment of Phrmcology, University of Cliforni, Dvis, CA 95616, USA","institution_ids":["https://openalex.org/I2803209242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067692707","display_name":"Ian Salveson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ian Salveson","raw_affiliation_strings":["Department of Chemistry, University of California, Davis, CA 95616, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of California, Davis, CA 95616, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040668401","display_name":"Andrea M. Coleman","orcid":"https://orcid.org/0000-0001-7564-8723","observed_orcids":["https://orcid.org/0000-0001-7564-8723"]},"institutions":[{"id":"https://openalex.org/I2803209242","display_name":"University of California System","ror":"https://ror.org/00pjdza24","country_code":"US","type":"education","lineage":["https://openalex.org/I2803209242"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrea M. Coleman","raw_affiliation_strings":["Department of Chemistry, University of California, Davis, CA 95616, USA","Department of Pharmacology, University of California, Davis, CA 95616, USA","Deprtment of Phrmcology, University of Cliforni, Dvis, CA 95616, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of California, Davis, CA 95616, USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Department of Pharmacology, University of California, Davis, CA 95616, USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Deprtment of Phrmcology, University of Cliforni, Dvis, CA 95616, USA","institution_ids":["https://openalex.org/I2803209242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086008177","display_name":"David E. Anderson","orcid":"https://orcid.org/0000-0001-9334-6438","observed_orcids":["https://orcid.org/0000-0001-9334-6438"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David E. Anderson","raw_affiliation_strings":["Department of Chemistry, University of California, Davis, CA 95616, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of California, Davis, CA 95616, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113788233","display_name":"Grace Jeng","orcid":"https://orcid.org/0000-0003-0604-3952","observed_orcids":["https://orcid.org/0000-0003-0604-3952"]},"institutions":[{"id":"https://openalex.org/I2803209242","display_name":"University of California System","ror":"https://ror.org/00pjdza24","country_code":"US","type":"education","lineage":["https://openalex.org/I2803209242"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Grace Jeng","raw_affiliation_strings":["Department of Pharmacology, University of California, Davis, CA 95616, USA","Deprtment of Phrmcology, University of Cliforni, Dvis, CA 95616, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of California, Davis, CA 95616, USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Deprtment of Phrmcology, University of Cliforni, Dvis, CA 95616, USA","institution_ids":["https://openalex.org/I2803209242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086271134","display_name":"Zoila M. Estrada\u2010Tobar","orcid":"https://orcid.org/0000-0002-4212-5325","observed_orcids":["https://orcid.org/0000-0002-4212-5325"]},"institutions":[{"id":"https://openalex.org/I2803209242","display_name":"University of California System","ror":"https://ror.org/00pjdza24","country_code":"US","type":"education","lineage":["https://openalex.org/I2803209242"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zoila M. Estrada-Tobar","raw_affiliation_strings":["Department of Pharmacology, University of California, Davis, CA 95616, USA","Deprtment of Phrmcology, University of Cliforni, Dvis, CA 95616, USA"],"raw_orcid":"https://orcid.org/0000-0002-4212-5325","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of California, Davis, CA 95616, USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Deprtment of Phrmcology, University of Cliforni, Dvis, CA 95616, USA","institution_ids":["https://openalex.org/I2803209242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068243350","display_name":"Kwun Nok Mimi Man","orcid":"https://orcid.org/0000-0002-0132-9129","observed_orcids":["https://orcid.org/0000-0002-0132-9129"]},"institutions":[{"id":"https://openalex.org/I2803209242","display_name":"University of California System","ror":"https://ror.org/00pjdza24","country_code":"US","type":"education","lineage":["https://openalex.org/I2803209242"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kwun Nok Mimi Man","raw_affiliation_strings":["Department of Pharmacology, University of California, Davis, CA 95616, USA","Deprtment of Phrmcology, University of Cliforni, Dvis, CA 95616, USA"],"raw_orcid":"https://orcid.org/0000-0002-0132-9129","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of California, Davis, CA 95616, USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Deprtment of Phrmcology, University of Cliforni, Dvis, CA 95616, USA","institution_ids":["https://openalex.org/I2803209242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027522209","display_name":"Qinhong Yu","orcid":"https://orcid.org/0000-0003-3855-5469","observed_orcids":["https://orcid.org/0000-0003-3855-5469"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qinhong Yu","raw_affiliation_strings":["Department of Chemistry, University of California, Davis, CA 95616, USA"],"raw_orcid":"https://orcid.org/0000-0003-3855-5469","affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of California, Davis, CA 95616, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082723092","display_name":"Elza V. Kuzmenkina","orcid":"https://orcid.org/0000-0002-0385-3581","observed_orcids":["https://orcid.org/0000-0002-0385-3581"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Elza Kuzmenkina","raw_affiliation_strings":["Center for Pharmacology, University of Cologne, Cologne, Germany","Center for Pharmaology, University of Cologne, Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Pharmacology, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]},{"raw_affiliation_string":"Center for Pharmaology, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051894335","display_name":"Madeline Nieves\u2010Cintr\u00f3n","orcid":"https://orcid.org/0000-0003-1935-8400","observed_orcids":["https://orcid.org/0000-0003-1935-8400"]},"institutions":[{"id":"https://openalex.org/I2803209242","display_name":"University of California System","ror":"https://ror.org/00pjdza24","country_code":"US","type":"education","lineage":["https://openalex.org/I2803209242"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Madeline Nieves-Cintron","raw_affiliation_strings":["Department of Pharmacology, University of California, Davis, CA 95616, USA","Deprtment of Phrmcology, University of Cliforni, Dvis, CA 95616, USA"],"raw_orcid":"https://orcid.org/0000-0003-1935-8400","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of California, Davis, CA 95616, USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Deprtment of Phrmcology, University of Cliforni, Dvis, CA 95616, USA","institution_ids":["https://openalex.org/I2803209242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045266509","display_name":"Manuel F. Navedo","orcid":"https://orcid.org/0000-0001-6864-6594","observed_orcids":["https://orcid.org/0000-0001-6864-6594"]},"institutions":[{"id":"https://openalex.org/I2803209242","display_name":"University of California System","ror":"https://ror.org/00pjdza24","country_code":"US","type":"education","lineage":["https://openalex.org/I2803209242"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manuel F. Navedo","raw_affiliation_strings":["Department of Pharmacology, University of California, Davis, CA 95616, USA","Deprtment of Phrmcology, University of Cliforni, Dvis, CA 95616, USA"],"raw_orcid":"https://orcid.org/0000-0001-6864-6594","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of California, Davis, CA 95616, USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Deprtment of Phrmcology, University of Cliforni, Dvis, CA 95616, USA","institution_ids":["https://openalex.org/I2803209242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071886776","display_name":"Mary C. Horne","orcid":"https://orcid.org/0000-0002-2799-3212","observed_orcids":["https://orcid.org/0000-0002-2799-3212"]},"institutions":[{"id":"https://openalex.org/I2803209242","display_name":"University of California System","ror":"https://ror.org/00pjdza24","country_code":"US","type":"education","lineage":["https://openalex.org/I2803209242"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mary C. Horne","raw_affiliation_strings":["Department of Pharmacology, University of California, Davis, CA 95616, USA","Deprtment of Phrmcology, University of Cliforni, Dvis, CA 95616, USA"],"raw_orcid":"https://orcid.org/0000-0002-2799-3212","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of California, Davis, CA 95616, USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Deprtment of Phrmcology, University of Cliforni, Dvis, CA 95616, USA","institution_ids":["https://openalex.org/I2803209242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029091929","display_name":"Johannes Wilhelm Hell","orcid":"https://orcid.org/0000-0001-7960-7531","observed_orcids":["https://orcid.org/0000-0001-7960-7531"]},"institutions":[{"id":"https://openalex.org/I2803209242","display_name":"University of California System","ror":"https://ror.org/00pjdza24","country_code":"US","type":"education","lineage":["https://openalex.org/I2803209242"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Johannes W. Hell","raw_affiliation_strings":["Department of Pharmacology, University of California, Davis, CA 95616, USA","Deprtment of Phrmcology, University of Cliforni, Dvis, CA 95616, USA"],"raw_orcid":"https://orcid.org/0000-0001-7960-7531","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of California, Davis, CA 95616, USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Deprtment of Phrmcology, University of Cliforni, Dvis, CA 95616, USA","institution_ids":["https://openalex.org/I2803209242"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057047177","display_name":"James B. Ames","orcid":"https://orcid.org/0000-0003-0934-2595","observed_orcids":["https://orcid.org/0000-0003-0934-2595"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James B. Ames","raw_affiliation_strings":["Department of Chemistry, University of California, Davis, CA 95616, USA"],"raw_orcid":"https://orcid.org/0000-0003-0934-2595","affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of California, Davis, CA 95616, USA","institution_ids":["https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5029091929","https://openalex.org/A5057047177","https://openalex.org/A5071886776"],"corresponding_institution_ids":["https://openalex.org/I2803209242","https://openalex.org/I84218800"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calmodulin","display_name":"calmodulin","score":0.925000011920929},{"id":"https://openalex.org/keywords/cav1-2","display_name":"Cav1.2","score":0.7799999713897705},{"id":"https://openalex.org/keywords/l-type-calcium-channels","display_name":"L-type calcium channels","score":0.9940000176429749},{"id":"https://openalex.org/keywords/calcium-dependent-inactivation","display_name":"calcium-dependent inactivation","score":0.6489999890327454},{"id":"https://openalex.org/keywords/open-probability","display_name":"open probability","score":0.7480000257492065},{"id":"https://openalex.org/keywords/ef-hand-calcium-binding","display_name":"EF-hand calcium binding","score":0.8029999732971191},{"id":"https://openalex.org/keywords/iq-motif","display_name":"IQ motif","score":0.9240000247955322},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.5889999866485596},{"id":"https://openalex.org/keywords/channel-gating","display_name":"channel gating","score":0.3700000047683716}],"concepts":[{"id":"https://openalex.org/C29688787","wikidata":"https://www.wikidata.org/wiki/Q409145","display_name":"Calmodulin","level":3,"score":0.9040272235870361},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6546185612678528},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6393091082572937},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.6084643602371216},{"id":"https://openalex.org/C42086223","wikidata":"https://www.wikidata.org/wiki/Q24723907","display_name":"EF hand","level":4,"score":0.5521749258041382},{"id":"https://openalex.org/C122229402","wikidata":"https://www.wikidata.org/wiki/Q5018802","display_name":"Calcium-binding protein","level":3,"score":0.4849379360675812},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4767616391181946},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.40534090995788574},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3966854214668274},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3289947509765625},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3094366490840912},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24591457843780518},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22392964363098145},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2022.06.24.497440","doi":"https://doi.org/10.1101/2022.06.24.497440","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.06.24.497440","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/06/24/2022.06.24.497440.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2022.06.24.497440","doi":"https://doi.org/10.1101/2022.06.24.497440","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.06.24.497440","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/06/24/2022.06.24.497440.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1051665745","display_name":"L-type Ca2+ Channel Regulation by Calmodulin and CaBP1","funder_award_id":"R01GM130925","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1217123760","display_name":"Coupling of vascular CaV1.2 channels in health and disease","funder_award_id":"R01HL121059","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1872666725","display_name":"Training Program in Molecular and Cellular Biology","funder_award_id":"T32GM007377","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4396779611","display_name":"UC Davis Training Program in Chemical Biology","funder_award_id":"T32GM113770","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5400999779","display_name":"Membrane targeting calcium sensors in vision","funder_award_id":"R01EY012347","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G6209256292","display_name":null,"funder_award_id":"T32 GM","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8951721822","display_name":"Initiative for Maximizing Student Development","funder_award_id":"R25GM056765","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000893467","display_name":"Postsynaptic Signaling by Norepinephrine and cAMP","funder_award_id":"R01NS123050","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000921104","display_name":"Dysregulation of Cav1.2 by beta amyloid peptide","funder_award_id":"R01AG055357","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332564","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4283513537.pdf","grobid_xml":"https://content.openalex.org/works/W4283513537.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1628979938","https://openalex.org/W1975459052","https://openalex.org/W1984987102","https://openalex.org/W1993188952","https://openalex.org/W1997413420","https://openalex.org/W2019886106","https://openalex.org/W2022582268","https://openalex.org/W2029870632","https://openalex.org/W2035460326","https://openalex.org/W2035949896","https://openalex.org/W2038327233","https://openalex.org/W2040052193","https://openalex.org/W2040165826","https://openalex.org/W2042210724","https://openalex.org/W2053330127","https://openalex.org/W2053547709","https://openalex.org/W2056857490","https://openalex.org/W2057269307","https://openalex.org/W2070398050","https://openalex.org/W2072081603","https://openalex.org/W2073486807","https://openalex.org/W2087062865","https://openalex.org/W2126551164","https://openalex.org/W2128103118","https://openalex.org/W2131435989","https://openalex.org/W2138773108","https://openalex.org/W2139183106","https://openalex.org/W2141233921","https://openalex.org/W2146084836","https://openalex.org/W2154714625","https://openalex.org/W2579990257","https://openalex.org/W2625659438","https://openalex.org/W2767346509","https://openalex.org/W2808832906","https://openalex.org/W2896062856","https://openalex.org/W2898082354","https://openalex.org/W2916622771","https://openalex.org/W2973074739","https://openalex.org/W3001045327","https://openalex.org/W4200294965"],"related_works":["https://openalex.org/W4309108683","https://openalex.org/W6987452218","https://openalex.org/W4200294965","https://openalex.org/W4232239182","https://openalex.org/W4307770902","https://openalex.org/W2098917495","https://openalex.org/W2111108423","https://openalex.org/W2916622771","https://openalex.org/W2084923534","https://openalex.org/W2473000855"],"abstract_inverted_index":{"ABSTRACT":[0],"The":[1,120,131],"L-type":[2],"Ca":[3,6,20,27,41,50,65,74,92,100,110,137,163,184,189,196,204],"2+":[4,28,42,51,66,111,138,164],"channel":[5],"V":[7,21,75,93,190],"1.2":[8,22,76,94,191],"controls":[9],"gene":[10],"expression,":[11],"cardiac":[12],"contraction,":[13],"and":[14,26,57,61,80,99,115,140,148,151,158,168,193],"neuronal":[15],"activity.":[16],"Calmodulin":[17],"(CaM)":[18],"governs":[19],"open":[23],"probability":[24],"(Po)":[25],"-dependent":[29],"inactivation":[30],"(CDI)":[31],"but":[32],"the":[33,55,91,128,171],"mechanisms":[34],"remain":[35],"unclear.":[36],"We":[37,82],"identified":[38],"a":[39,88,105,181],"half":[40],"-saturated":[43],"CaM":[44,121,132,155,172],"species":[45,187],"(Ca":[46],"2":[47,101,185,197],"/CaM)":[48],"with":[49,73,127,144],"bound":[52,135],"solely":[53],"at":[54],"third":[56],"fourth":[58],"EF-hands":[59],"(EF3":[60],"EF4)":[62],"under":[63],"resting":[64],"concentrations":[67],"(50-100":[68],"nM)":[69],"that":[70],"constitutively":[71],"pre-associates":[72],"to":[77,113,166,177],"promote":[78],"Po":[79,192],"CDI.":[81],"present":[83],"an":[84,200],"NMR":[85],"structure":[86],"of":[87,203],"complex":[89],"between":[90],"IQ":[95,129,145],"motif":[96],"(residues":[97],"1644-1665)":[98],"/CaM":[102,186,198],"12\u2019":[103,122,133],",":[104],"calmodulin":[106],"mutant":[107,174],"in":[108,170],"which":[109],"binding":[112,165],"EF1":[114],"EF2":[116],"is":[117],"completely":[118],"disabled.":[119],"N-lobe":[123],"does":[124],"not":[125],"interact":[126],"motif.":[130],"C-lobe":[134],"two":[136],"ions":[139],"formed":[141],"close":[142],"contacts":[143],"residues":[146],"I1654":[147],"Y1657.":[149],"I1654A":[150],"Y1657D":[152],"mutations":[153],"impaired":[154],"binding,":[156],"CDI,":[157],"Po,":[159],"as":[160,199],"did":[161],"disabling":[162],"EF3":[167],"EF4":[169],"34":[173],"when":[175],"compared":[176],"wildtype":[178],"CaM.":[179],"Accordingly,":[180],"previously":[182],"unappreciated":[183],"promotes":[188],"CDI":[194],"identifying":[195],"important":[201],"mediator":[202],"signaling.":[205]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-06-27T00:00:00"}