{"id":"https://openalex.org/W4283465307","doi":"https://doi.org/10.31083/j.rcm2307236","title":"Stroke, Thrombosis, Bleeding and Addiction to Anticoagulants in the Context of Course Therapy: A Pharmacologic Perspective","display_name":"Stroke, Thrombosis, Bleeding and Addiction to Anticoagulants in the Context of Course Therapy: A Pharmacologic Perspective","publication_year":2022,"publication_date":"2022-06-24","ids":{"openalex":"https://openalex.org/W4283465307","doi":"https://doi.org/10.31083/j.rcm2307236","pmid":"https://pubmed.ncbi.nlm.nih.gov/39076898","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11266771"},"language":"en","primary_location":{"id":"doi:10.31083/j.rcm2307236","doi":"https://doi.org/10.31083/j.rcm2307236","is_oa":true,"landing_page_url":"https://doi.org/10.31083/j.rcm2307236","pdf_url":"https://www.imrpress.com/journal/RCM/23/7/10.31083/j.rcm2307236/pdf","source":{"id":"https://openalex.org/S140574793","display_name":"Reviews in Cardiovascular Medicine","issn_l":"1530-6550","issn":["1530-6550","2153-8174"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310322753","host_organization_name":"IMR Press","host_organization_lineage":["https://openalex.org/P4310322753"],"host_organization_lineage_names":["IMR Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reviews in Cardiovascular Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.imrpress.com/journal/RCM/23/7/10.31083/j.rcm2307236/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060896477","display_name":"\u0410\u043b\u0435\u043a\u0441\u0430\u043d\u0434\u0440 \u041b\u0438\u0432\u0438\u0435\u0432\u0438\u0447 \u0423\u0440\u0430\u043a\u043e\u0432","orcid":"https://orcid.org/0000-0002-9829-9463","observed_orcids":["https://orcid.org/0000-0002-9829-9463","https://orcid.org/0000-0002-4233-9550"]},"institutions":[{"id":"https://openalex.org/I4210127015","display_name":"Izhevsk State Medical Academy","ror":"https://ror.org/03sna8255","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210127015"]},{"id":"https://openalex.org/I4210132697","display_name":"Udmurt Federal Research Center, Ural Branch of the Russian Academy of Sciences","ror":"https://ror.org/03aesme15","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210119369","https://openalex.org/I4210132697"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Aleksandr Urakov","raw_affiliation_strings":["Department of General and Clinical Pharmacology, Izhevsk State Medical Academy, 426034 Izhevsk, Udmurt Republic, Russia","Department of Modeling and Synthesis of Technological Structures, Institute of Mechanics, Udmurt Federal Research Center, 426067 Izhevsk, Udmurt Republic, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General and Clinical Pharmacology, Izhevsk State Medical Academy, 426034 Izhevsk, Udmurt Republic, Russia","institution_ids":["https://openalex.org/I4210127015"]},{"raw_affiliation_string":"Department of Modeling and Synthesis of Technological Structures, Institute of Mechanics, Udmurt Federal Research Center, 426067 Izhevsk, Udmurt Republic, Russia","institution_ids":["https://openalex.org/I4210132697"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002019772","display_name":"Anastasia P Stolyarenko","orcid":"https://orcid.org/0000-0002-0439-6546","observed_orcids":["https://orcid.org/0000-0002-0439-6546"]},"institutions":[{"id":"https://openalex.org/I4210127015","display_name":"Izhevsk State Medical Academy","ror":"https://ror.org/03sna8255","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210127015"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Anastasia Stolyarenko","raw_affiliation_strings":["Department of General and Clinical Pharmacology, Izhevsk State Medical Academy, 426034 Izhevsk, Udmurt Republic, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General and Clinical Pharmacology, Izhevsk State Medical Academy, 426034 Izhevsk, Udmurt Republic, Russia","institution_ids":["https://openalex.org/I4210127015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053675218","display_name":"Ilnur I. Yagudin","orcid":"https://orcid.org/0000-0002-6032-8839","observed_orcids":["https://orcid.org/0000-0002-6032-8839"]},"institutions":[{"id":"https://openalex.org/I4210127015","display_name":"Izhevsk State Medical Academy","ror":"https://ror.org/03sna8255","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210127015"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Ilnur Yagudin","raw_affiliation_strings":["Department of General and Clinical Pharmacology, Izhevsk State Medical Academy, 426034 Izhevsk, Udmurt Republic, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General and Clinical Pharmacology, Izhevsk State Medical Academy, 426034 Izhevsk, Udmurt Republic, Russia","institution_ids":["https://openalex.org/I4210127015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007304653","display_name":"Nikita Muhutdinov","orcid":"https://orcid.org/0000-0002-1968-0566","observed_orcids":["https://orcid.org/0000-0002-1968-0566"]},"institutions":[{"id":"https://openalex.org/I4210127015","display_name":"Izhevsk State Medical Academy","ror":"https://ror.org/03sna8255","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210127015"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Nikita Mukhutdinov","raw_affiliation_strings":["Department of General and Clinical Pharmacology, Izhevsk State Medical Academy, 426034 Izhevsk, Udmurt Republic, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General and Clinical Pharmacology, Izhevsk State Medical Academy, 426034 Izhevsk, Udmurt Republic, Russia","institution_ids":["https://openalex.org/I4210127015"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013928294","display_name":"\u0418\u043b\u044c\u043d\u0443\u0440 \u0418\u0440\u0435\u043a\u043e\u0432\u0438\u0447 \u0411\u0430\u0448\u0438\u0440\u043e\u0432","orcid":"https://orcid.org/0000-0002-6632-4409","observed_orcids":["https://orcid.org/0000-0002-6632-4409"]},"institutions":[{"id":"https://openalex.org/I4210127015","display_name":"Izhevsk State Medical Academy","ror":"https://ror.org/03sna8255","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210127015"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Ilnur Bashirov","raw_affiliation_strings":["Department of General and Clinical Pharmacology, Izhevsk State Medical Academy, 426034 Izhevsk, Udmurt Republic, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General and Clinical Pharmacology, Izhevsk State Medical Academy, 426034 Izhevsk, Udmurt Republic, Russia","institution_ids":["https://openalex.org/I4210127015"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5060896477"],"corresponding_institution_ids":["https://openalex.org/I4210127015","https://openalex.org/I4210132697"],"apc_list":{"value":2200,"currency":"USD","value_usd":2200},"apc_paid":{"value":2200,"currency":"USD","value_usd":2200},"fwci":0.3497,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.54814187,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"23","issue":"7","first_page":"236","last_page":"236"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/direct-oral-anticoagulants","display_name":"direct oral anticoagulants","score":0.9629999995231628},{"id":"https://openalex.org/keywords/non-valvular-atrial-fibrillation","display_name":"non-valvular atrial fibrillation","score":0.984000027179718},{"id":"https://openalex.org/keywords/stroke-prevention","display_name":"stroke prevention","score":0.5509999990463257},{"id":"https://openalex.org/keywords/thrombosis","display_name":"thrombosis","score":0.9729999899864197},{"id":"https://openalex.org/keywords/bleeding-risk","display_name":"bleeding risk","score":0.7480000257492065},{"id":"https://openalex.org/keywords/blood-coagulation-system","display_name":"coagulation system","score":0.7960000038146973},{"id":"https://openalex.org/keywords/chronic-poisoning","display_name":"chronic poisoning","score":0.5180000066757202},{"id":"https://openalex.org/keywords/liver-failure","display_name":"liver failure","score":0.7419999837875366},{"id":"https://openalex.org/keywords/anticoagulant-dose","display_name":"anticoagulant dose","score":0.6740000247955322}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9315807223320007},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6706821918487549},{"id":"https://openalex.org/C12713177","wikidata":"https://www.wikidata.org/wiki/Q1900281","display_name":"Perspective (graphical)","level":2,"score":0.6090534925460815},{"id":"https://openalex.org/C48856860","wikidata":"https://www.wikidata.org/wiki/Q12029","display_name":"Addiction","level":2,"score":0.5429295301437378},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.530086100101471},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.47573065757751465},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.40642571449279785},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2514318823814392},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.20620885491371155},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.31083/j.rcm2307236","doi":"https://doi.org/10.31083/j.rcm2307236","is_oa":true,"landing_page_url":"https://doi.org/10.31083/j.rcm2307236","pdf_url":"https://www.imrpress.com/journal/RCM/23/7/10.31083/j.rcm2307236/pdf","source":{"id":"https://openalex.org/S140574793","display_name":"Reviews in Cardiovascular Medicine","issn_l":"1530-6550","issn":["1530-6550","2153-8174"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310322753","host_organization_name":"IMR Press","host_organization_lineage":["https://openalex.org/P4310322753"],"host_organization_lineage_names":["IMR Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reviews in Cardiovascular Medicine","raw_type":"journal-article"},{"id":"pmid:39076898","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39076898","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reviews in cardiovascular medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11266771","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11266771/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rev Cardiovasc Med","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:52dbc8f5156642dd8baa49bf9a665dd5","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/52dbc8f5156642dd8baa49bf9a665dd5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Reviews in Cardiovascular Medicine, Vol 23, Iss 7, p 236 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.31083/j.rcm2307236","doi":"https://doi.org/10.31083/j.rcm2307236","is_oa":true,"landing_page_url":"https://doi.org/10.31083/j.rcm2307236","pdf_url":"https://www.imrpress.com/journal/RCM/23/7/10.31083/j.rcm2307236/pdf","source":{"id":"https://openalex.org/S140574793","display_name":"Reviews in Cardiovascular Medicine","issn_l":"1530-6550","issn":["1530-6550","2153-8174"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310322753","host_organization_name":"IMR Press","host_organization_lineage":["https://openalex.org/P4310322753"],"host_organization_lineage_names":["IMR Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reviews in Cardiovascular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4283465307.pdf","grobid_xml":"https://content.openalex.org/works/W4283465307.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W1552830208","https://openalex.org/W2074708727","https://openalex.org/W2916586190","https://openalex.org/W2977328755","https://openalex.org/W2991573074","https://openalex.org/W2994664186","https://openalex.org/W3044680096","https://openalex.org/W3159673032","https://openalex.org/W3173312086","https://openalex.org/W4210446484","https://openalex.org/W4220875753"],"related_works":["https://openalex.org/W2467386864","https://openalex.org/W2085501100","https://openalex.org/W2116226269","https://openalex.org/W2331171947","https://openalex.org/W2049043083","https://openalex.org/W2805537297","https://openalex.org/W2802816738","https://openalex.org/W2990111757","https://openalex.org/W2143058201","https://openalex.org/W2765747489"],"abstract_inverted_index":{"After":[0],"reading":[1],"with":[2,24,61,113,218],"great":[3],"interest":[4],"the":[5,17,51,88,104,109,124,131,135,140,145,148,198,201,206,211],"article":[6],"entitled:":[7],"\u201cNon-vitamin":[8],"K":[9],"antagonist":[10],"oral":[11,118,177,204],"anticoagulants":[12,55,71,119,180],"(NOACs)":[13],"do":[14],"not":[15],"increase":[16],"risk":[18,106],"of":[19,90,111,117,123,137,147,160,179,203,208,213],"hepatic":[20],"impairment":[21],"in":[22,43,59,78,216],"patients":[23,60,112,217],"non-valvular":[25,62,219],"atrial":[26,63,220],"fibrillation:":[27],"insights":[28],"from":[29],"multi-source":[30],"medical":[31],"data\u201d":[32],"authored":[33],"by":[34,41],"Zhi-Chun":[35],"Gu":[36],"et":[37],"al.":[38],"and":[39,68,87,156,165,175,185,210],"published":[40],"Reviews":[42],"Cardiovascular":[44],"Medicine,":[45],"we":[46,81],"would":[47],"like":[48],"to":[49,65,162,183,187,195],"add":[50],"following":[52],"thoughts.":[53],"Oral":[54],"are":[56,72],"generally":[57],"accepted":[58],"fibrillation":[64],"prevent":[66],"thrombosis":[67,214],"stroke.":[69],"Since":[70],"taken":[73],"daily":[74],"for":[75,108],"many":[76],"months":[77],"these":[79],"patients,":[80],"cannot":[82],"rule":[83],"out":[84],"chronic":[85],"poisoning":[86],"development":[89,212],"liver":[91],"failure.":[92],"But":[93],"another":[94],"complication":[95],"is":[96,120,144,153,172,181,190,193],"just":[97],"as":[98],"likely,":[99],"that":[100,152,173],"being":[101],"bleeding.":[102],"Thus,":[103],"determining":[105],"factor":[107],"health":[110],"a":[114],"prolonged":[115,176],"course":[116,136],"hypofunctional":[121],"activity":[122,146],"blood":[125,149],"coagulation":[126,150],"system,":[127],"which":[128],"remains":[129],"at":[130],"same":[132,141],"level":[133],"throughout":[134],"treatment.":[138],"At":[139],"time,":[142],"it":[143,192],"system":[151],"an":[154],"important":[155],"very":[157],"sensitive":[158],"link":[159],"adaptation":[161],"various":[163],"external":[164],"internal":[166],"factors,":[167],"including":[168],"anticoagulants.":[169],"The":[170],"fact":[171],"regular":[174],"use":[178],"likely":[182],"develop":[184],"tolerance":[186],"them.":[188],"That":[189],"why":[191],"necessary":[194],"carefully":[196],"study":[197],"relationship":[199],"between":[200],"dose":[202],"anticoagulants,":[205],"duration":[207],"pharmacotherapy":[209],"(bleeding)":[215],"fibrillation.":[221]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-06-26T00:00:00"}