{"id":"https://openalex.org/W4283464614","doi":"https://doi.org/10.1158/1078-0432.ccr-21-1129","title":"Facts and Hopes for Gut Microbiota Interventions in Cancer Immunotherapy","display_name":"Facts and Hopes for Gut Microbiota Interventions in Cancer Immunotherapy","publication_year":2022,"publication_date":"2022-06-24","ids":{"openalex":"https://openalex.org/W4283464614","doi":"https://doi.org/10.1158/1078-0432.ccr-21-1129","pmid":"https://pubmed.ncbi.nlm.nih.gov/35748749","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9561605"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.ccr-21-1129","doi":"https://doi.org/10.1158/1078-0432.ccr-21-1129","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-21-1129","pdf_url":"https://aacrjournals.org/clincancerres/article-pdf/28/20/4370/3212764/4370.pdf","source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://aacrjournals.org/clincancerres/article-pdf/28/20/4370/3212764/4370.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030169825","display_name":"Diwakar Davar","orcid":"https://orcid.org/0000-0002-7846-8055","observed_orcids":["https://orcid.org/0000-0002-7846-8055"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210098814","display_name":"UPMC Health System","ror":"https://ror.org/011htkb76","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Diwakar Davar","raw_affiliation_strings":["1Department of Medicine and UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania"],"raw_orcid":"https://orcid.org/0000-0002-7846-8055","affiliations":[{"raw_affiliation_string":"1Department of Medicine and UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210098814","https://openalex.org/I4210128526","https://openalex.org/I4210134769"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025286759","display_name":"Hassane M. Zarour","orcid":"https://orcid.org/0000-0003-2525-2688","observed_orcids":["https://orcid.org/0000-0003-2525-2688"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210098814","display_name":"UPMC Health System","ror":"https://ror.org/011htkb76","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hassane M. Zarour","raw_affiliation_strings":["1Department of Medicine and UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania","2Department of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania"],"raw_orcid":"https://orcid.org/0000-0003-2525-2688","affiliations":[{"raw_affiliation_string":"1Department of Medicine and UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210098814","https://openalex.org/I4210128526","https://openalex.org/I4210134769"]},{"raw_affiliation_string":"2Department of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5030169825"],"corresponding_institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210098814","https://openalex.org/I4210128526","https://openalex.org/I4210134769"],"apc_list":null,"apc_paid":null,"fwci":1.0592,"has_fulltext":true,"cited_by_count":41,"citation_normalized_percentile":{"value":0.77615262,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"28","issue":"20","first_page":"4370","last_page":"4384"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.7226999998092651,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.7226999998092651,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.2727000117301941,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.8880000114440918},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.9459999799728394},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":1.0},{"id":"https://openalex.org/keywords/ctla-4","display_name":"CTLA-4","score":0.9959999918937683},{"id":"https://openalex.org/keywords/pd-1","display_name":"PD-1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/microbiome-based-therapy","display_name":"microbiota-based therapy","score":0.8320000171661377},{"id":"https://openalex.org/keywords/immunotherapy-response","display_name":"immunotherapy response","score":0.6940000057220459},{"id":"https://openalex.org/keywords/clinical-trials","display_name":"clinical trials","score":0.546999990940094},{"id":"https://openalex.org/keywords/host-immunity","display_name":"host immunity","score":0.4359999895095825}],"concepts":[{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.6888538599014282},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6456087827682495},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6309298872947693},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6146578788757324},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.575605034828186},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.5732587575912476},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5659472942352295},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.47204267978668213},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4626195728778839},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41767317056655884},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.26884037256240845},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0857459306716919}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060908","descriptor_name":"CTLA-4 Antigen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061026","descriptor_name":"Programmed Cell Death 1 Receptor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1158/1078-0432.ccr-21-1129","doi":"https://doi.org/10.1158/1078-0432.ccr-21-1129","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-21-1129","pdf_url":"https://aacrjournals.org/clincancerres/article-pdf/28/20/4370/3212764/4370.pdf","source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9561605","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9561605","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Cancer Res","raw_type":"Text"},{"id":"pmid:35748749","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35748749","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.ccr-21-1129","doi":"https://doi.org/10.1158/1078-0432.ccr-21-1129","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-21-1129","pdf_url":"https://aacrjournals.org/clincancerres/article-pdf/28/20/4370/3212764/4370.pdf","source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G344363415","display_name":"Fecal Microbiota Transplant and PD-1 blockade in Melanoma","funder_award_id":"R01CA222203","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5686869940","display_name":"SPORE in Skin Cancer","funder_award_id":"P50CA121973","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8622307029","display_name":"Targeting TIGIT and PD-1 in Melanoma","funder_award_id":"R01CA228181","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8900834227","display_name":null,"funder_award_id":"P50CA257265","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000896014","display_name":"Melanoma and Skin Cancer Program SPORE","funder_award_id":"P50CA254865","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000915585","display_name":"Neoadjuvant Immunotherapy with Intratumoral CPG and PD-1 Blockade in Melanoma","funder_award_id":"R01CA257265","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4283464614.pdf","grobid_xml":"https://content.openalex.org/works/W4283464614.grobid-xml"},"referenced_works_count":151,"referenced_works":["https://openalex.org/W1520492432","https://openalex.org/W1592407962","https://openalex.org/W1974092500","https://openalex.org/W1978838773","https://openalex.org/W1988821718","https://openalex.org/W1990515033","https://openalex.org/W1999906527","https://openalex.org/W2003342633","https://openalex.org/W2032230795","https://openalex.org/W2036851895","https://openalex.org/W2039123767","https://openalex.org/W2039907390","https://openalex.org/W2047703946","https://openalex.org/W2048469790","https://openalex.org/W2059128083","https://openalex.org/W2060185417","https://openalex.org/W2070404820","https://openalex.org/W2072865199","https://openalex.org/W2098016933","https://openalex.org/W2103018035","https://openalex.org/W2104096962","https://openalex.org/W2109485845","https://openalex.org/W2111117990","https://openalex.org/W2118531873","https://openalex.org/W2124427232","https://openalex.org/W2124632458","https://openalex.org/W2130542755","https://openalex.org/W2131766513","https://openalex.org/W2139284253","https://openalex.org/W2147605136","https://openalex.org/W2153512326","https://openalex.org/W2165456770","https://openalex.org/W2166562121","https://openalex.org/W2185075416","https://openalex.org/W2195422852","https://openalex.org/W2275606382","https://openalex.org/W2278335898","https://openalex.org/W2291072263","https://openalex.org/W2292051166","https://openalex.org/W2333091667","https://openalex.org/W2370050032","https://openalex.org/W2407774696","https://openalex.org/W2419941872","https://openalex.org/W2509638174","https://openalex.org/W2528306813","https://openalex.org/W2560367415","https://openalex.org/W2567261527","https://openalex.org/W2586223583","https://openalex.org/W2586360538","https://openalex.org/W2601055810","https://openalex.org/W2609972574","https://openalex.org/W2655262992","https://openalex.org/W2739380776","https://openalex.org/W2746788320","https://openalex.org/W2755951643","https://openalex.org/W2756403351","https://openalex.org/W2765314233","https://openalex.org/W2766903152","https://openalex.org/W2767699537","https://openalex.org/W2768799378","https://openalex.org/W2782333299","https://openalex.org/W2783897381","https://openalex.org/W2786985471","https://openalex.org/W2790589159","https://openalex.org/W2795186863","https://openalex.org/W2795242892","https://openalex.org/W2803360616","https://openalex.org/W2804448077","https://openalex.org/W2890014497","https://openalex.org/W2893527230","https://openalex.org/W2897815318","https://openalex.org/W2898631010","https://openalex.org/W2904822700","https://openalex.org/W2909679049","https://openalex.org/W2910615673","https://openalex.org/W2910849865","https://openalex.org/W2912967789","https://openalex.org/W2913013571","https://openalex.org/W2915010259","https://openalex.org/W2927453907","https://openalex.org/W2930205604","https://openalex.org/W2932049125","https://openalex.org/W2942123458","https://openalex.org/W2949947154","https://openalex.org/W2952093130","https://openalex.org/W2955245896","https://openalex.org/W2956016709","https://openalex.org/W2958220850","https://openalex.org/W2961510294","https://openalex.org/W2972507666","https://openalex.org/W2972674410","https://openalex.org/W2976586374","https://openalex.org/W2979141921","https://openalex.org/W2979785336","https://openalex.org/W2988734364","https://openalex.org/W2993330612","https://openalex.org/W2995026154","https://openalex.org/W2999416853","https://openalex.org/W3005566802","https://openalex.org/W3005776909","https://openalex.org/W3008213618","https://openalex.org/W3009785090","https://openalex.org/W3011301336","https://openalex.org/W3016607029","https://openalex.org/W3017739100","https://openalex.org/W3021579311","https://openalex.org/W3022450273","https://openalex.org/W3027339018","https://openalex.org/W3028293850","https://openalex.org/W3029644367","https://openalex.org/W3033331291","https://openalex.org/W3033825041","https://openalex.org/W3034524707","https://openalex.org/W3037088183","https://openalex.org/W3038366207","https://openalex.org/W3044111226","https://openalex.org/W3049052172","https://openalex.org/W3068948923","https://openalex.org/W3081393016","https://openalex.org/W3081548621","https://openalex.org/W3086420584","https://openalex.org/W3111076305","https://openalex.org/W3111836013","https://openalex.org/W3112934313","https://openalex.org/W3119089710","https://openalex.org/W3126095956","https://openalex.org/W3126208996","https://openalex.org/W3129637558","https://openalex.org/W3136288655","https://openalex.org/W3137283383","https://openalex.org/W3137683977","https://openalex.org/W3138068311","https://openalex.org/W3158907042","https://openalex.org/W3175164605","https://openalex.org/W3175895832","https://openalex.org/W3178490306","https://openalex.org/W3179327521","https://openalex.org/W3179557623","https://openalex.org/W3181952999","https://openalex.org/W3194929095","https://openalex.org/W4200001874","https://openalex.org/W4200119638","https://openalex.org/W4206012887","https://openalex.org/W4210773546","https://openalex.org/W4214673864","https://openalex.org/W4214706689","https://openalex.org/W4214737502","https://openalex.org/W4230931443","https://openalex.org/W6774485077","https://openalex.org/W6787554194","https://openalex.org/W6809192640"],"related_works":["https://openalex.org/W2982486449","https://openalex.org/W4400844682","https://openalex.org/W2897273439","https://openalex.org/W2801088707","https://openalex.org/W7126296511","https://openalex.org/W4387574001","https://openalex.org/W7214295043","https://openalex.org/W7160389481","https://openalex.org/W3124733054","https://openalex.org/W3212490445"],"abstract_inverted_index":{"Immune":[0],"checkpoint":[1],"inhibitors":[2],"(ICI)":[3],"targeting":[4],"cytotoxic":[5],"T-lymphocyte-associated":[6],"antigen":[7],"4":[8],"(CTLA-4)":[9],"and":[10,27,51,77,100,122],"programmed":[11],"death":[12],"1":[13],"(PD-1)":[14],"proteins":[15],"transformed":[16],"the":[17,38,47,56,109,116],"management":[18],"of":[19,64],"advanced":[20],"cancers.":[21],"Many":[22],"tumor-intrinsic":[23],"factors":[24],"modulate":[25],"immunological":[26],"clinical":[28,120],"responses":[29],"to":[30,72,88,92],"such":[31],"therapies,":[32,115],"but":[33,67],"ample":[34],"evidence":[35],"also":[36],"implicates":[37],"gut":[39,44,112],"microbiome":[40],"in":[41,55,75,98],"responses.":[42],"The":[43],"microbiome,":[45],"comprising":[46],"bacteria,":[48],"archaea,":[49],"fungi,":[50],"viruses":[52],"that":[53],"live":[54],"human":[57],"digestive":[58],"tract,":[59],"is":[60],"an":[61],"established":[62],"determinant":[63],"host":[65],"immunity,":[66],"its":[68],"impact":[69],"on":[70],"response":[71],"ICI":[73],"therapy":[74],"mice":[76,99],"humans":[78,101],"with":[79,102],"cancer":[80,114],"has":[81],"only":[82],"recently":[83],"been":[84],"appreciated.":[85],"Therapeutic":[86],"interventions":[87],"optimize":[89],"microbiota":[90],"composition":[91],"improve":[93],"immunotherapy":[94],"outcomes":[95],"show":[96],"promise":[97],"cancer.":[103],"In":[104],"this":[105],"review,":[106],"we":[107],"discuss":[108],"rationale":[110],"for":[111],"microbiome-based":[113],"results":[117],"from":[118],"early-phase":[119],"trials,":[121],"possible":[123],"future":[124],"developments.":[125]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-06-26T00:00:00"}
