{"id":"https://openalex.org/W4283448682","doi":"https://doi.org/10.1158/0008-5472.can-21-3713","title":"Inhibition of Karyopherin \u03b21-Mediated Nuclear Import Disrupts Oncogenic Lineage-Defining Transcription Factor Activity in Small Cell Lung Cancer","display_name":"Inhibition of Karyopherin \u03b21-Mediated Nuclear Import Disrupts Oncogenic Lineage-Defining Transcription Factor Activity in Small Cell Lung Cancer","publication_year":2022,"publication_date":"2022-06-24","ids":{"openalex":"https://openalex.org/W4283448682","doi":"https://doi.org/10.1158/0008-5472.can-21-3713","pmid":"https://pubmed.ncbi.nlm.nih.gov/35748745","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9444950"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-21-3713","doi":"https://doi.org/10.1158/0008-5472.can-21-3713","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-21-3713","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/82/17/3058/3196484/3058.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://aacrjournals.org/cancerres/article-pdf/82/17/3058/3196484/3058.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003054607","display_name":"Demetra P. Kelenis","orcid":"https://orcid.org/0000-0003-1718-6633","observed_orcids":["https://orcid.org/0000-0003-1718-6633"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Demetra P. Kelenis","raw_affiliation_strings":["1Department of Neuroscience, UT Southwestern Medical Center, Dallas, Texas"],"raw_orcid":"https://orcid.org/0000-0003-1718-6633","affiliations":[{"raw_affiliation_string":"1Department of Neuroscience, UT Southwestern Medical Center, Dallas, Texas","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003073498","display_name":"Kathia E. Rodarte","orcid":"https://orcid.org/0000-0001-7608-7585","observed_orcids":["https://orcid.org/0000-0001-7608-7585"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathia E. Rodarte","raw_affiliation_strings":["1Department of Neuroscience, UT Southwestern Medical Center, Dallas, Texas"],"raw_orcid":"https://orcid.org/0000-0001-7608-7585","affiliations":[{"raw_affiliation_string":"1Department of Neuroscience, UT Southwestern Medical Center, Dallas, Texas","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018072357","display_name":"Rahul Krishna Kollipara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rahul K. Kollipara","raw_affiliation_strings":["2McDermott Center for Human Growth and Development, UT Southwestern Medical Center, Dallas, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2McDermott Center for Human Growth and Development, UT Southwestern Medical Center, Dallas, Texas","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074324053","display_name":"Karine Pozo","orcid":"https://orcid.org/0000-0002-2749-9353","observed_orcids":["https://orcid.org/0000-0002-2749-9353"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karine Pozo","raw_affiliation_strings":["1Department of Neuroscience, UT Southwestern Medical Center, Dallas, Texas","3Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Neuroscience, UT Southwestern Medical Center, Dallas, Texas","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"3Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082261686","display_name":"Shreoshi Pal Choudhuri","orcid":"https://orcid.org/0000-0003-1600-7664","observed_orcids":["https://orcid.org/0000-0003-1600-7664"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shreoshi Pal Choudhuri","raw_affiliation_strings":["3Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas"],"raw_orcid":"https://orcid.org/0000-0003-1600-7664","affiliations":[{"raw_affiliation_string":"3Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114050299","display_name":"Kyle B. Spainhower","orcid":"https://orcid.org/0000-0001-5136-0389","observed_orcids":["https://orcid.org/0000-0001-5136-0389"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyle B. Spainhower","raw_affiliation_strings":["4Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah","institution_ids":["https://openalex.org/I223532165","https://openalex.org/I2801159745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047369963","display_name":"Sarah J. Wait","orcid":"https://orcid.org/0000-0001-5660-2391","observed_orcids":["https://orcid.org/0000-0001-5660-2391"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah J. Wait","raw_affiliation_strings":["4Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah"],"raw_orcid":"https://orcid.org/0000-0001-5660-2391","affiliations":[{"raw_affiliation_string":"4Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah","institution_ids":["https://openalex.org/I223532165","https://openalex.org/I2801159745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051772933","display_name":"Victor Stastny","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victor Stastny","raw_affiliation_strings":["5Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center, Dallas, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center, Dallas, Texas","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053303798","display_name":"Trudy G. Oliver","orcid":"https://orcid.org/0000-0003-2082-2397","observed_orcids":["https://orcid.org/0000-0003-2082-2397"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Trudy G. Oliver","raw_affiliation_strings":["4Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah"],"raw_orcid":"https://orcid.org/0000-0003-2082-2397","affiliations":[{"raw_affiliation_string":"4Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah","institution_ids":["https://openalex.org/I223532165","https://openalex.org/I2801159745"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032159010","display_name":"Jane E. B. Johnson","orcid":"https://orcid.org/0000-0002-8605-2746","observed_orcids":["https://orcid.org/0000-0002-8605-2746"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jane E. Johnson","raw_affiliation_strings":["1Department of Neuroscience, UT Southwestern Medical Center, Dallas, Texas"],"raw_orcid":"https://orcid.org/0000-0002-8605-2746","affiliations":[{"raw_affiliation_string":"1Department of Neuroscience, UT Southwestern Medical Center, Dallas, Texas","institution_ids":["https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5032159010"],"corresponding_institution_ids":["https://openalex.org/I867280407"],"apc_list":null,"apc_paid":null,"fwci":1.3473,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.82383927,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"82","issue":"17","first_page":"3058","last_page":"3073"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/small-cell-lung-cancer","display_name":"small cell lung cancer","score":0.9909999966621399},{"id":"https://openalex.org/keywords/kpnb1","display_name":"KPNB1","score":0.968999981880188},{"id":"https://openalex.org/keywords/nuclear-import","display_name":"nuclear import","score":0.8460000157356262},{"id":"https://openalex.org/keywords/ascl1","display_name":"ASCL1","score":0.9010000228881836},{"id":"https://openalex.org/keywords/neurod1","display_name":"NeuroD1","score":1.0},{"id":"https://openalex.org/keywords/nuclear-localization","display_name":"nuclear localization","score":0.699999988079071},{"id":"https://openalex.org/keywords/transcriptional-activity","display_name":"transcriptional activity","score":0.6539999842643738},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.6520000100135803},{"id":"https://openalex.org/keywords/proteostasis","display_name":"proteostasis","score":0.9309999942779541},{"id":"https://openalex.org/keywords/targeted-cancer-therapy","display_name":"targeted cancer therapy","score":0.7509999871253967}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7358778119087219},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.689280092716217},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6872931122779846},{"id":"https://openalex.org/C2777336224","wikidata":"https://www.wikidata.org/wiki/Q3193641","display_name":"Karyopherin","level":5,"score":0.46640387177467346},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3219590485095978},{"id":"https://openalex.org/C59157529","wikidata":"https://www.wikidata.org/wiki/Q994741","display_name":"Nuclear transport","level":4,"score":0.2781892418861389},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2108170986175537},{"id":"https://openalex.org/C2780114586","wikidata":"https://www.wikidata.org/wiki/Q40260","display_name":"Cell nucleus","level":3,"score":0.14000621438026428},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07529273629188538},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021581","descriptor_name":"Active Transport, Cell Nucleus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D028884","descriptor_name":"Karyopherins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055752","descriptor_name":"Small Cell Lung Carcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D055752","descriptor_name":"Small Cell Lung Carcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D055752","descriptor_name":"Small Cell Lung Carcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1158/0008-5472.can-21-3713","doi":"https://doi.org/10.1158/0008-5472.can-21-3713","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-21-3713","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/82/17/3058/3196484/3058.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:35748745","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35748745","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9444950","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9444950","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.can-21-3713","doi":"https://doi.org/10.1158/0008-5472.can-21-3713","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-21-3713","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/82/17/3058/3196484/3058.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3710054059","display_name":"Genomic and Functional Identification of Chemotherapy Resistance Mechanisms in Small Cell Lung Cancer","funder_award_id":"U01CA231844","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5746294","display_name":"Targeting Lung Cancer Vulnerabilities","funder_award_id":"P50CA070907","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6065737213","display_name":"Phosphorylation of ASCL1 to disrupt oncogenic activity in SCLC","funder_award_id":"F30CA228314","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G85496787","display_name":"Cancer Intervention and Prevention Discoveries Program","funder_award_id":"RP160157","funder_id":"https://openalex.org/F4320308129","funder_display_name":"Cancer Prevention and Research Institute of Texas"},{"id":"https://openalex.org/G9000895596","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA042014","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000899377","display_name":"Coordinating center for the NCI small cell lung cancer research consortium","funder_award_id":"U24CA213274","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G979718324","display_name":"Developing ASCL1 and NeuroD1 lineage oncogene targeted therapy for small cell lung cancer","funder_award_id":"U01CA213338","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320308129","display_name":"Cancer Prevention and Research Institute of Texas","ror":"https://ror.org/0003xa228"},{"id":"https://openalex.org/F4320310169","display_name":"University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4283448682.pdf","grobid_xml":"https://content.openalex.org/works/W4283448682.grobid-xml"},"referenced_works_count":77,"referenced_works":["https://openalex.org/W38520883","https://openalex.org/W281513593","https://openalex.org/W1841811394","https://openalex.org/W1867526322","https://openalex.org/W1903523058","https://openalex.org/W1972570571","https://openalex.org/W1972676659","https://openalex.org/W1974374273","https://openalex.org/W1978028702","https://openalex.org/W1978286483","https://openalex.org/W1996257262","https://openalex.org/W2003876192","https://openalex.org/W2012935774","https://openalex.org/W2016722600","https://openalex.org/W2018495846","https://openalex.org/W2025555096","https://openalex.org/W2030612525","https://openalex.org/W2038011290","https://openalex.org/W2043655216","https://openalex.org/W2046107611","https://openalex.org/W2052189122","https://openalex.org/W2062951422","https://openalex.org/W2076887412","https://openalex.org/W2080259626","https://openalex.org/W2087126781","https://openalex.org/W2090074847","https://openalex.org/W2093640897","https://openalex.org/W2095475448","https://openalex.org/W2101749257","https://openalex.org/W2108927999","https://openalex.org/W2119483052","https://openalex.org/W2128132456","https://openalex.org/W2130411917","https://openalex.org/W2136541538","https://openalex.org/W2143310531","https://openalex.org/W2150561279","https://openalex.org/W2154147842","https://openalex.org/W2155978263","https://openalex.org/W2157241157","https://openalex.org/W2160051211","https://openalex.org/W2161563128","https://openalex.org/W2239511084","https://openalex.org/W2259087545","https://openalex.org/W2427872948","https://openalex.org/W2466317387","https://openalex.org/W2479269395","https://openalex.org/W2529120786","https://openalex.org/W2560855631","https://openalex.org/W2576845640","https://openalex.org/W2586885021","https://openalex.org/W2592448908","https://openalex.org/W2613590416","https://openalex.org/W2765782352","https://openalex.org/W2787615428","https://openalex.org/W2790556761","https://openalex.org/W2791897005","https://openalex.org/W2794191776","https://openalex.org/W2898452867","https://openalex.org/W2900893865","https://openalex.org/W2914878923","https://openalex.org/W2928432651","https://openalex.org/W2946990319","https://openalex.org/W2969185256","https://openalex.org/W2972546786","https://openalex.org/W3028669282","https://openalex.org/W3090613431","https://openalex.org/W3094447601","https://openalex.org/W3095506465","https://openalex.org/W3096170160","https://openalex.org/W3126312907","https://openalex.org/W3148185623","https://openalex.org/W3156184669","https://openalex.org/W3177408844","https://openalex.org/W3192786952","https://openalex.org/W3202041537","https://openalex.org/W4239268086","https://openalex.org/W6638864366"],"related_works":["https://openalex.org/W4309099314","https://openalex.org/W4221037483","https://openalex.org/W2479269395","https://openalex.org/W2890835242","https://openalex.org/W4393093523","https://openalex.org/W4241875517","https://openalex.org/W2008125588","https://openalex.org/W4408408433","https://openalex.org/W1540676355","https://openalex.org/W2154147842"],"abstract_inverted_index":{"Genomic":[0],"studies":[1],"support":[2,220],"the":[3,15,45,72,86,95,134,139,183,219],"classification":[4],"of":[5,17,30,52,74,99,141,164,179,185,206,244],"small":[6],"cell":[7],"lung":[8],"cancer":[9,263],"(SCLC)":[10],"into":[11],"subtypes":[12,89],"based":[13],"on":[14],"expression":[16],"lineage-defining":[18,252],"transcription":[19,143,253],"factors":[20,236,254],"ASCL1":[21,32,53,57,111,126,157,169,208],"and":[22,33,43,49,90,127,158,162,170,174,187,193,214,230],"NEUROD1,":[23],"which":[24],"together":[25],"are":[26,105],"expressed":[27],"in":[28,46,64,130,160,191,198,237,255],"\u223c86%":[29],"SCLC.":[31,56,240],"NEUROD1":[34,113,128,159,171],"activate":[35],"SCLC":[36,65,88,101,131,189,256],"oncogene":[37],"expression,":[38,211],"drive":[39],"distinct":[40],"transcriptional":[41,175],"programs,":[42],"maintain":[44],"vitro":[47,192],"growth":[48,184,197],"oncogenic":[50,76],"properties":[51],"or":[54,112],"NEUROD1-expressing":[55],"is":[58],"also":[59],"required":[60,137],"for":[61,85,138,155,221,233,251,262],"tumor":[62,196],"formation":[63],"mouse":[66],"models.":[67],"A":[68],"strategy":[69,122,229,261],"to":[70,93,123,167],"inhibit":[71,110],"activity":[73,129],"these":[75,142],"drivers":[77],"may":[78],"therefore":[79],"provide":[80],"both":[81,156],"a":[82,91,120,151,204,247,258],"targeted":[83],"therapy":[84],"predominant":[87],"tool":[92],"investigate":[94],"underlying":[96],"lineage":[97],"plasticity":[98],"established":[100],"tumors.":[102],"However,":[103],"there":[104],"no":[106],"known":[107],"agents":[108],"that":[109],"function.":[114],"In":[115],"this":[116],"study,":[117],"we":[118],"identify":[119],"novel":[121],"pharmacologically":[124],"target":[125,210],"by":[132,203],"exploiting":[133],"nuclear":[135,152,172,223,248],"localization":[136],"function":[140],"factors.":[144],"Karyopherin":[145],"\u03b21":[146],"(KPNB1)":[147],"was":[148],"identified":[149],"as":[150,225,246],"import":[153,249],"receptor":[154,250],"SCLC,":[161],"inhibition":[163],"KPNB1":[165,180,245],"led":[166],"impaired":[168,207],"accumulation":[173],"activity.":[176],"Pharmacologic":[177],"targeting":[178,222,234],"preferentially":[181],"disrupted":[182],"ASCL1+":[186,195],"NEUROD1+":[188],"cells":[190],"suppressed":[194],"vivo,":[199],"an":[200,226],"effect":[201],"mediated":[202],"combination":[205],"downstream":[209],"cell-cycle":[212],"activity,":[213],"proteostasis.":[215],"These":[216],"findings":[217],"broaden":[218],"transport":[224],"anticancer":[227],"therapeutic":[228,260],"have":[231],"implications":[232],"lineage-transcription":[235],"tumors":[238],"beyond":[239],"SIGNIFICANCE:":[241],"The":[242],"identification":[243],"reveals":[257],"viable":[259],"treatment.":[264]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-06-26T00:00:00"}