{"id":"https://openalex.org/W4283445993","doi":"https://doi.org/10.3349/ymj.2022.63.7.648","title":"Ovarian Tissue-Based Hormone Replacement Therapy Recovers Menopause-Related Signs in Mice","display_name":"Ovarian Tissue-Based Hormone Replacement Therapy Recovers Menopause-Related Signs in Mice","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4283445993","doi":"https://doi.org/10.3349/ymj.2022.63.7.648","pmid":"https://pubmed.ncbi.nlm.nih.gov/35748076","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9226832"},"language":"en","primary_location":{"id":"doi:10.3349/ymj.2022.63.7.648","doi":"https://doi.org/10.3349/ymj.2022.63.7.648","is_oa":true,"landing_page_url":"https://doi.org/10.3349/ymj.2022.63.7.648","pdf_url":null,"source":{"id":"https://openalex.org/S107862393","display_name":"Yonsei Medical Journal","issn_l":"0513-5796","issn":["0513-5796","1976-2437"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","kci-registered","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319467","host_organization_name":"Yonsei University College of Medicine","host_organization_lineage":["https://openalex.org/P4310319467"],"host_organization_lineage_names":["Yonsei University College of Medicine"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Yonsei Medical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3349/ymj.2022.63.7.648","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045297239","display_name":"Dahyeon Yoo","orcid":"https://orcid.org/0000-0002-4021-4498","observed_orcids":["https://orcid.org/0000-0002-4021-4498"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I21028721","display_name":"Eulji University","ror":"https://ror.org/005bty106","country_code":"KR","type":"education","lineage":["https://openalex.org/I21028721"]},{"id":"https://openalex.org/I2803058125","display_name":"Seoul National University Bundang Hospital","ror":"https://ror.org/00cb3km46","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I2803058125"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dahyeon Yoo","raw_affiliation_strings":["Department of Biomedical Laboratory Science, Eulji University, Seongnam, Korea","Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea","Department of Senior Healthcare, BK21 Plus Program, Graduate School of Eulji University, Seongnam, Korea"],"raw_orcid":"https://orcid.org/0000-0002-4021-4498","affiliations":[{"raw_affiliation_string":"Department of Biomedical Laboratory Science, Eulji University, Seongnam, Korea","institution_ids":["https://openalex.org/I21028721"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2803058125"]},{"raw_affiliation_string":"Department of Senior Healthcare, BK21 Plus Program, Graduate School of Eulji University, Seongnam, Korea","institution_ids":["https://openalex.org/I21028721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009918144","display_name":"Nanum Chung","orcid":"https://orcid.org/0000-0001-9912-7615","observed_orcids":["https://orcid.org/0000-0001-9912-7615"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2803058125","display_name":"Seoul National University Bundang Hospital","ror":"https://ror.org/00cb3km46","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I2803058125"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Nanum Chung","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea","Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0001-9912-7615","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2803058125"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050240158","display_name":"Jungyoung Yoo","orcid":"https://orcid.org/0000-0001-6357-7569","observed_orcids":["https://orcid.org/0000-0001-6357-7569"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I21028721","display_name":"Eulji University","ror":"https://ror.org/005bty106","country_code":"KR","type":"education","lineage":["https://openalex.org/I21028721"]},{"id":"https://openalex.org/I2803058125","display_name":"Seoul National University Bundang Hospital","ror":"https://ror.org/00cb3km46","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I2803058125"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jungyoung Yoo","raw_affiliation_strings":["Department of Biomedical Laboratory Science, Eulji University, Seongnam, Korea","Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea"],"raw_orcid":"https://orcid.org/0000-0001-6357-7569","affiliations":[{"raw_affiliation_string":"Department of Biomedical Laboratory Science, Eulji University, Seongnam, Korea","institution_ids":["https://openalex.org/I21028721"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2803058125"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043822223","display_name":"Chae Young Song","orcid":"https://orcid.org/0000-0002-7566-7454","observed_orcids":["https://orcid.org/0000-0002-7566-7454"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2803058125","display_name":"Seoul National University Bundang Hospital","ror":"https://ror.org/00cb3km46","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I2803058125"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Chae Young Song","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea","Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0002-7566-7454","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2803058125"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054962626","display_name":"Chungmo Yang","orcid":"https://orcid.org/0000-0002-4690-1061","observed_orcids":["https://orcid.org/0000-0002-4690-1061"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2803058125","display_name":"Seoul National University Bundang Hospital","ror":"https://ror.org/00cb3km46","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I2803058125"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Chungmo Yang","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea","Program in Nanoscience and Technology, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0002-4690-1061","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2803058125"]},{"raw_affiliation_string":"Program in Nanoscience and Technology, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062578804","display_name":"Hye Won Youm","orcid":"https://orcid.org/0000-0002-1735-7191","observed_orcids":["https://orcid.org/0000-0002-1735-7191"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2803058125","display_name":"Seoul National University Bundang Hospital","ror":"https://ror.org/00cb3km46","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I2803058125"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hye Won Youm","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea"],"raw_orcid":"https://orcid.org/0000-0002-1735-7191","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2803058125"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039472466","display_name":"Kangwon Lee","orcid":"https://orcid.org/0000-0001-5745-313X","observed_orcids":["https://orcid.org/0000-0001-5745-313X"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kangwon Lee","raw_affiliation_strings":["Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0001-5745-313X","affiliations":[{"raw_affiliation_string":"Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014289143","display_name":"Jin Hyun Jun","orcid":"https://orcid.org/0000-0001-9898-4471","observed_orcids":["https://orcid.org/0000-0001-9898-4471"]},"institutions":[{"id":"https://openalex.org/I21028721","display_name":"Eulji University","ror":"https://ror.org/005bty106","country_code":"KR","type":"education","lineage":["https://openalex.org/I21028721"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jin Hyun Jun","raw_affiliation_strings":["Department of Biomedical Laboratory Science, Eulji University, Seongnam, Korea","Department of Senior Healthcare, BK21 Plus Program, Graduate School of Eulji University, Seongnam, Korea","Eulji Medi-Bio Research Institute (EMBRI), Eulji University, Daejeon, Korea"],"raw_orcid":"https://orcid.org/0000-0001-9898-4471","affiliations":[{"raw_affiliation_string":"Department of Biomedical Laboratory Science, Eulji University, Seongnam, Korea","institution_ids":["https://openalex.org/I21028721"]},{"raw_affiliation_string":"Department of Senior Healthcare, BK21 Plus Program, Graduate School of Eulji University, Seongnam, Korea","institution_ids":["https://openalex.org/I21028721"]},{"raw_affiliation_string":"Eulji Medi-Bio Research Institute (EMBRI), Eulji University, Daejeon, Korea","institution_ids":["https://openalex.org/I21028721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103019601","display_name":"Jaewang Lee","orcid":"https://orcid.org/0000-0001-6801-7149","observed_orcids":["https://orcid.org/0000-0001-6801-7149"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I21028721","display_name":"Eulji University","ror":"https://ror.org/005bty106","country_code":"KR","type":"education","lineage":["https://openalex.org/I21028721"]},{"id":"https://openalex.org/I2803058125","display_name":"Seoul National University Bundang Hospital","ror":"https://ror.org/00cb3km46","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I2803058125"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jaewang Lee","raw_affiliation_strings":["Department of Biomedical Laboratory Science, Eulji University, Seongnam, Korea","Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea","Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0001-6801-7149","affiliations":[{"raw_affiliation_string":"Department of Biomedical Laboratory Science, Eulji University, Seongnam, Korea","institution_ids":["https://openalex.org/I21028721"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2803058125"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075020481","display_name":"Jung Ryeol Lee","orcid":"https://orcid.org/0000-0003-3743-2934","observed_orcids":["https://orcid.org/0000-0003-3743-2934"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I21028721","display_name":"Eulji University","ror":"https://ror.org/005bty106","country_code":"KR","type":"education","lineage":["https://openalex.org/I21028721"]},{"id":"https://openalex.org/I2803058125","display_name":"Seoul National University Bundang Hospital","ror":"https://ror.org/00cb3km46","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I2803058125"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jung Ryeol Lee","raw_affiliation_strings":["Department of Biomedical Laboratory Science, Eulji University, Seongnam, Korea","Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea","Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0003-3743-2934","affiliations":[{"raw_affiliation_string":"Department of Biomedical Laboratory Science, Eulji University, Seongnam, Korea","institution_ids":["https://openalex.org/I21028721"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2803058125"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5103019601"],"corresponding_institution_ids":["https://openalex.org/I139264467","https://openalex.org/I21028721","https://openalex.org/I2803058125"],"apc_list":{"value":700,"currency":"USD","value_usd":700},"apc_paid":{"value":700,"currency":"USD","value_usd":700},"fwci":0.4948,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.58514667,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"63","issue":"7","first_page":"648","last_page":"648"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.492900013923645,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.492900013923645,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.43869999051094055,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.028999999165534973,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ovarian-tissue-transplantation","display_name":"ovarian tissue transplantation","score":0.6899999976158142},{"id":"https://openalex.org/keywords/ovarian-tissue-cryopreservation","display_name":"ovarian tissue cryopreservation","score":0.8059999942779541},{"id":"https://openalex.org/keywords/menopause","display_name":"menopause","score":0.8180000185966492},{"id":"https://openalex.org/keywords/postmenopausal-osteoporosis","display_name":"postmenopausal osteoporosis","score":0.9319999814033508},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.8939999938011169},{"id":"https://openalex.org/keywords/bone-microarchitecture","display_name":"bone microarchitecture","score":0.7889999747276306},{"id":"https://openalex.org/keywords/uterine-atrophy","display_name":"uterine atrophy","score":0.996999979019165},{"id":"https://openalex.org/keywords/sex-steroid-deficiency","display_name":"sex hormone deficiency","score":0.8569999933242798},{"id":"https://openalex.org/keywords/ovariectomy","display_name":"ovariectomy","score":0.7889999747276306},{"id":"https://openalex.org/keywords/fertility-preservation","display_name":"fertility preservation","score":0.5989999771118164}],"concepts":[{"id":"https://openalex.org/C2778562196","wikidata":"https://www.wikidata.org/wiki/Q177708","display_name":"Menopause","level":2,"score":0.8180875778198242},{"id":"https://openalex.org/C2780159708","wikidata":"https://www.wikidata.org/wiki/Q17003363","display_name":"Hormone replacement therapy (female-to-male)","level":3,"score":0.6814620494842529},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5532742738723755},{"id":"https://openalex.org/C2780275930","wikidata":"https://www.wikidata.org/wiki/Q1628266","display_name":"Hormone therapy","level":4,"score":0.5006358623504639},{"id":"https://openalex.org/C2910557164","wikidata":"https://www.wikidata.org/wiki/Q177708","display_name":"Surgical Menopause","level":3,"score":0.43326476216316223},{"id":"https://openalex.org/C3019229754","wikidata":"https://www.wikidata.org/wiki/Q3354346","display_name":"Hormone replacement","level":3,"score":0.4306159019470215},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4261450469493866},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35578691959381104},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.34194034337997437},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.32128551602363586},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.13943400979042053},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.08555781841278076},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0749158263206482}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001284","descriptor_name":"Atrophy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006728","descriptor_name":"Hormones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008593","descriptor_name":"Menopause","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015502","descriptor_name":"Absorptiometry, Photon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015519","descriptor_name":"Bone Density","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015914","descriptor_name":"Estrogen Replacement Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020249","descriptor_name":"Hormone Replacement Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055114","descriptor_name":"X-Ray Microtomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3349/ymj.2022.63.7.648","doi":"https://doi.org/10.3349/ymj.2022.63.7.648","is_oa":true,"landing_page_url":"https://doi.org/10.3349/ymj.2022.63.7.648","pdf_url":null,"source":{"id":"https://openalex.org/S107862393","display_name":"Yonsei Medical Journal","issn_l":"0513-5796","issn":["0513-5796","1976-2437"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","kci-registered","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319467","host_organization_name":"Yonsei University College of Medicine","host_organization_lineage":["https://openalex.org/P4310319467"],"host_organization_lineage_names":["Yonsei University College of Medicine"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Yonsei Medical Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9226832","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9226832/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9226832/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Yonsei Med J","raw_type":"Text"},{"id":"pmid:35748076","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35748076","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Yonsei medical journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3349/ymj.2022.63.7.648","doi":"https://doi.org/10.3349/ymj.2022.63.7.648","is_oa":true,"landing_page_url":"https://doi.org/10.3349/ymj.2022.63.7.648","pdf_url":null,"source":{"id":"https://openalex.org/S107862393","display_name":"Yonsei Medical Journal","issn_l":"0513-5796","issn":["0513-5796","1976-2437"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","kci-registered","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319467","host_organization_name":"Yonsei University College of Medicine","host_organization_lineage":["https://openalex.org/P4310319467"],"host_organization_lineage_names":["Yonsei University College of Medicine"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Yonsei Medical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2050743994","display_name":null,"funder_award_id":"HI21C1353","funder_id":"https://openalex.org/F4320322107","funder_display_name":"Korea Health Industry Development Institute"},{"id":"https://openalex.org/G5143527424","display_name":null,"funder_award_id":"NRF-2018R1D-1A1B07046419","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G696657169","display_name":null,"funder_award_id":"2018R1D-1A1B07046419","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320322107","display_name":"Korea Health Industry Development Institute","ror":"https://ror.org/00fdzyk40"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4283445993.pdf","grobid_xml":"https://content.openalex.org/works/W4283445993.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W338576824","https://openalex.org/W1897525269","https://openalex.org/W1903373243","https://openalex.org/W1966347658","https://openalex.org/W1983721719","https://openalex.org/W1985268496","https://openalex.org/W1991649178","https://openalex.org/W1994500053","https://openalex.org/W2019081179","https://openalex.org/W2024368609","https://openalex.org/W2027932600","https://openalex.org/W2035180720","https://openalex.org/W2085326091","https://openalex.org/W2110908464","https://openalex.org/W2150923376","https://openalex.org/W2157483575","https://openalex.org/W2160715802","https://openalex.org/W2162137928","https://openalex.org/W2163004416","https://openalex.org/W2172880627","https://openalex.org/W2313746835","https://openalex.org/W2423080305","https://openalex.org/W2526184544","https://openalex.org/W2606393834","https://openalex.org/W2769370289","https://openalex.org/W2782664527","https://openalex.org/W2795453669","https://openalex.org/W2808218105","https://openalex.org/W2883693957","https://openalex.org/W2891742934","https://openalex.org/W2897289416","https://openalex.org/W2978741566","https://openalex.org/W3007128881","https://openalex.org/W3011197168"],"related_works":["https://openalex.org/W4312225742","https://openalex.org/W7120588713","https://openalex.org/W2782664527","https://openalex.org/W2416260062","https://openalex.org/W2060111981","https://openalex.org/W7120791017","https://openalex.org/W2024634360","https://openalex.org/W3044385281","https://openalex.org/W2021713865","https://openalex.org/W1990865555"],"abstract_inverted_index":{"PURPOSE:":[0],"In":[1],"women,":[2],"menopause":[3],"manifests":[4],"with":[5,17,30],"a":[6],"variety":[7],"of":[8,55,82,140,143,152,187],"symptoms":[9],"related":[10,92],"to":[11,38,42,51,93,211],"sex-hormone":[12],"deficiency.":[13],"Supplementing":[14],"steroid":[15],"hormones":[16],"pharmacological":[18,43],"drugs":[19],"has":[20],"been":[21,36],"widely":[22],"practiced.":[23],"However,":[24],"considering":[25],"the":[26,53,75,141,146,179],"possible":[27],"complications":[28],"associated":[29],"artificial":[31,80],"hormone":[32,44,57],"therapy,":[33],"studies":[34],"have":[35],"conducted":[37],"find":[39],"an":[40],"alternative":[41],"replacement":[45,58],"therapy.":[46],"Accordingly,":[47],"this":[48],"study":[49],"aimed":[50],"evaluate":[52],"efficacy":[54],"tissue-based":[56],"therapy":[59],"(tHRT)":[60],"for":[61,98],"treating":[62],"post-menopausal":[63,83,219],"signs":[64],"and":[65,74,90,113,129,149,174,191,201],"symptoms.":[66],"MATERIALS":[67],"AND":[68],"METHODS:":[69],"CD-1":[70],"mice":[71,153,171],"were":[72,77,87,96,117,132,158,172],"ovariectomized,":[73],"ovaries":[76,86],"cryopreserved.":[78],"Following":[79],"induction":[81],"osteoporosis,":[84],"cryopreserved":[85],"subcutaneously":[88],"autografted,":[89],"indexes":[91],"bone":[94,105,110,130,180,189],"health":[95],"monitored":[97],"12":[99],"weeks.":[100],"Bone":[101],"mineral":[102,106],"density":[103],"(BMD),":[104],"contents":[107],"(BMC),":[108],"total":[109],"volume":[111],"(BV),":[112],"body":[114],"fat":[115],"mass":[116],"measured":[118],"by":[119,134],"dual":[120],"energy":[121],"X-ray":[122],"absorptiometry.":[123],"Uterine":[124],"atrophy":[125,193],"was":[126,194],"assessed":[127],"histologically,":[128],"microstructures":[131],"imaged":[133],"micro-computed":[135],"tomography":[136],"analysis.":[137],"RESULTS:":[138],"Regardless":[139],"number":[142],"grafted":[144],"ovaries,":[145],"BMC,":[147],"BMD,":[148],"BV":[150],"values":[151],"that":[154,162],"underwent":[155],"ovary":[156],"transplantation":[157,202],"better":[159],"than":[160],"those":[161],"did":[163],"not":[164,206],"undergo":[165],"transplantation.":[166],"The":[167],"uteruses":[168],"in":[169,208,216],"these":[170],"thicker":[173],"heavier":[175],"after":[176,183],"auto-transplantation.":[177],"Furthermore,":[178],"microstructure":[181],"recovered":[182],"tHRT.":[184,197],"CONCLUSION:":[185],"Recovery":[186],"menopause-related":[188],"loss":[190],"uterine":[192],"achieved":[195],"through":[196],"Ovarian":[198],"tissue":[199],"cryopreservation":[200],"may":[203],"be":[204],"applicable":[205],"only":[207],"patients":[209],"wanting":[210],"preserve":[212],"fertility":[213],"but":[214],"also":[215],"sex":[217],"hormone-deficient":[218],"women.":[220]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2022-06-26T00:00:00"}