{"id":"https://openalex.org/W4283392371","doi":"https://doi.org/10.3389/fvets.2022.905488","title":"Dimethylglycine Sodium Salt Alleviates Intrauterine Growth Restriction-Induced Low Growth Performance, Redox Status Imbalance, and Hepatic Mitochondrial Dysfunction in Suckling Piglets","display_name":"Dimethylglycine Sodium Salt Alleviates Intrauterine Growth Restriction-Induced Low Growth Performance, Redox Status Imbalance, and Hepatic Mitochondrial Dysfunction in Suckling Piglets","publication_year":2022,"publication_date":"2022-06-24","ids":{"openalex":"https://openalex.org/W4283392371","doi":"https://doi.org/10.3389/fvets.2022.905488","pmid":"https://pubmed.ncbi.nlm.nih.gov/35812869","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9263627"},"language":"en","primary_location":{"id":"doi:10.3389/fvets.2022.905488","doi":"https://doi.org/10.3389/fvets.2022.905488","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fvets.2022.905488","pdf_url":null,"source":{"id":"https://openalex.org/S2594976040","display_name":"Frontiers in Veterinary Science","issn_l":"2297-1769","issn":["2297-1769"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Veterinary Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fvets.2022.905488","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114027918","display_name":"Kaiwen Bai","orcid":"https://orcid.org/0000-0002-4927-3099","observed_orcids":["https://orcid.org/0000-0002-4927-3099"]},"institutions":[{"id":"https://openalex.org/I119454577","display_name":"Nanjing Agricultural University","ror":"https://ror.org/05td3s095","country_code":"CN","type":"education","lineage":["https://openalex.org/I119454577"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kaiwen Bai","raw_affiliation_strings":["College of Animal Sciences and Technology, Nanjing Agricultural University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Animal Sciences and Technology, Nanjing Agricultural University, Nanjing, China","institution_ids":["https://openalex.org/I119454577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102389959","display_name":"Luyi Jiang","orcid":"https://orcid.org/0009-0008-1459-6913","observed_orcids":["https://orcid.org/0009-0008-1459-6913"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Luyi Jiang","raw_affiliation_strings":["Institute of Dairy Science, College of Animal Sciences, Zhejiang University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Dairy Science, College of Animal Sciences, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100732609","display_name":"Tian Wang","orcid":"https://orcid.org/0000-0002-9038-5009","observed_orcids":["https://orcid.org/0000-0002-9038-5009"]},"institutions":[{"id":"https://openalex.org/I119454577","display_name":"Nanjing Agricultural University","ror":"https://ror.org/05td3s095","country_code":"CN","type":"education","lineage":["https://openalex.org/I119454577"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Tian Wang","raw_affiliation_strings":["College of Animal Sciences and Technology, Nanjing Agricultural University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Animal Sciences and Technology, Nanjing Agricultural University, Nanjing, China","institution_ids":["https://openalex.org/I119454577"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100732609"],"corresponding_institution_ids":["https://openalex.org/I119454577"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":1.0479,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.70868526,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"9","issue":null,"first_page":"905488","last_page":"905488"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10152","display_name":"Animal Nutrition and Physiology","score":0.5648999810218811,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10152","display_name":"Animal Nutrition and Physiology","score":0.5648999810218811,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.399399995803833,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.007300000172108412,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intrauterine-growth-restriction","display_name":"fetal growth restriction","score":0.9990000128746033},{"id":"https://openalex.org/keywords/suckling-piglets","display_name":"suckling piglets","score":0.968999981880188},{"id":"https://openalex.org/keywords/hepatic-mitochondrial-dysfunction","display_name":"hepatic mitochondrial dysfunction","score":0.8830000162124634},{"id":"https://openalex.org/keywords/growth-performance","display_name":"growth performance","score":0.8519999980926514},{"id":"https://openalex.org/keywords/dietary-supplementation","display_name":"dietary supplementation","score":0.6940000057220459},{"id":"https://openalex.org/keywords/neonatal-piglets","display_name":"newborn piglets","score":0.41600000858306885}],"concepts":[{"id":"https://openalex.org/C2779429622","wikidata":"https://www.wikidata.org/wiki/Q1780867","display_name":"Litter","level":2,"score":0.7252942323684692},{"id":"https://openalex.org/C2778780700","wikidata":"https://www.wikidata.org/wiki/Q1671598","display_name":"Intrauterine growth restriction","level":4,"score":0.6648306846618652},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5449988842010498},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5007114410400391},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4631044268608093},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38877347111701965},{"id":"https://openalex.org/C140793950","wikidata":"https://www.wikidata.org/wiki/Q168091","display_name":"Animal science","level":1,"score":0.3636307716369629},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32805711030960083},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.2510727643966675},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.20075729489326477},{"id":"https://openalex.org/C6557445","wikidata":"https://www.wikidata.org/wiki/Q173113","display_name":"Agronomy","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fvets.2022.905488","doi":"https://doi.org/10.3389/fvets.2022.905488","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fvets.2022.905488","pdf_url":null,"source":{"id":"https://openalex.org/S2594976040","display_name":"Frontiers in Veterinary Science","issn_l":"2297-1769","issn":["2297-1769"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Veterinary Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9263627","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9263627","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Vet Sci","raw_type":"Text"},{"id":"pmid:35812869","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35812869","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in veterinary science","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:9b094fb0534e43e1a848b30c2314b320","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/9b094fb0534e43e1a848b30c2314b320","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Veterinary Science, Vol 9 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fvets.2022.905488","doi":"https://doi.org/10.3389/fvets.2022.905488","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fvets.2022.905488","pdf_url":null,"source":{"id":"https://openalex.org/S2594976040","display_name":"Frontiers in Veterinary Science","issn_l":"2297-1769","issn":["2297-1769"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Veterinary Science","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8409000039100647,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"},{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2645672634","display_name":null,"funder_award_id":"31572418","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7348342113","display_name":null,"funder_award_id":"2018YFD0501101","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1986118866","https://openalex.org/W2066147003","https://openalex.org/W2077823671","https://openalex.org/W2107277218","https://openalex.org/W2114360920","https://openalex.org/W2152101492","https://openalex.org/W2763698944","https://openalex.org/W2795692601","https://openalex.org/W2809237069","https://openalex.org/W2890860154","https://openalex.org/W2901283457","https://openalex.org/W2913879799","https://openalex.org/W2914673158","https://openalex.org/W2965996124","https://openalex.org/W2967028785","https://openalex.org/W2971341695","https://openalex.org/W2980622391","https://openalex.org/W2994935207","https://openalex.org/W2998422085","https://openalex.org/W3006608178","https://openalex.org/W3006907677","https://openalex.org/W3008000594","https://openalex.org/W3011651865","https://openalex.org/W3013508607","https://openalex.org/W3020336784","https://openalex.org/W3031361580","https://openalex.org/W3032570712","https://openalex.org/W3047433286","https://openalex.org/W3088651085","https://openalex.org/W3117313833","https://openalex.org/W3119526168","https://openalex.org/W3162558234","https://openalex.org/W3172831063","https://openalex.org/W3196032083","https://openalex.org/W4223568258"],"related_works":["https://openalex.org/W4210444160","https://openalex.org/W3184217145","https://openalex.org/W3172831063","https://openalex.org/W3159911239","https://openalex.org/W4292246557","https://openalex.org/W4399258130","https://openalex.org/W7155016028","https://openalex.org/W2809237069","https://openalex.org/W2903835877","https://openalex.org/W2005216163"],"abstract_inverted_index":{"This":[0],"study":[1],"aimed":[2],"to":[3,95,113,151,170,192],"investigate":[4],"the":[5,32,96,114,126,147,152,171,180],"mechanism":[6],"of":[7,61,85,182],"redox":[8,132],"status":[9],"imbalance":[10],"and":[11,21,40,52,64,67,76,89,102,117,130,134,137,160,175,189],"hepatic":[12,131,135,194],"mitochondrial":[13],"dysfunction":[14],"induced":[15],"by":[16],"intrauterine":[17],"growth":[18,127],"restriction":[19],"(IUGR)":[20],"relieve":[22],"this":[23,190],"condition":[24],"through":[25],"dimethylglycine":[26],"sodium":[27],"salt":[28],"(DMG-Na)":[29],"supplementation":[30,156],"during":[31],"suckling":[33],"period.":[34],"Thirty":[35],"normal":[36],"birth":[37],"weight":[38],"(NBW)":[39],"30":[41],"IUGR":[42,54,69,78,109,187,202],"newborns":[43,70,79,92,110],"were":[44,56,71,80,93,111,141],"selected":[45],"from":[46,58,82],"20":[47,90,108],"sows.":[48],"Briefly,":[49],"1":[50,53],"NBW":[51,66,75,91],"newborn":[55],"obtained":[57,81],"each":[59,83],"litter":[60,84],"10":[62,65,68,87],"sows,":[63,88],"obtained.":[72],"Additionally,":[73,155],"2":[74,77],"another":[86],"allocated":[94],"N":[97,153],"[basic":[98],"milk":[99],"diets":[100],"(BMDs)]":[101],"ND":[103],"(BMDs+0.1%":[104,119],"DMG-Na)":[105,120],"groups.":[106,121],"Furthermore,":[107],"assigned":[112],"I":[115,148,176],"(BMDs)":[116],"ID":[118,161],"The":[122],"results":[123],"revealed":[124],"that":[125],"performance,":[128],"serum":[129],"status,":[133],"gene":[136],"protein":[138],"expression":[139],"levels":[140],"lower":[142],"(P":[143,164],"<":[144,165],"0.05)":[145,166],"in":[146,186,201],"group":[149],"compared":[150,169],"group.":[154],"with":[157,197],"DMG-Na":[158,198],"(ND":[159],"groups)":[162],"improved":[163],"these":[167],"parameters":[168],"non-supplemented":[172],"groups":[173],"(N":[174],"groups).":[177],"In":[178],"conclusion,":[179],"activity":[181],"Nrf2/SIRT1/PGC1\u03b1":[183,200],"was":[184],"inhibited":[185],"newborns,":[188,203],"led":[191],"their":[193,206],"dysfunctions.":[195],"Supplementation":[196],"activated":[199],"thereby":[204],"improving":[205],"performance.":[207]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2022-06-25T00:00:00"}