{"id":"https://openalex.org/W4283380233","doi":"https://doi.org/10.1136/jitc-2021-004133","title":"BCG hydrogel promotes CTSS-mediated antigen processing and presentation, thereby suppressing metastasis and prolonging survival in melanoma","display_name":"BCG hydrogel promotes CTSS-mediated antigen processing and presentation, thereby suppressing metastasis and prolonging survival in melanoma","publication_year":2022,"publication_date":"2022-06-01","ids":{"openalex":"https://openalex.org/W4283380233","doi":"https://doi.org/10.1136/jitc-2021-004133","pmid":"https://pubmed.ncbi.nlm.nih.gov/35732347","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9226922"},"language":"en","primary_location":{"id":"doi:10.1136/jitc-2021-004133","doi":"https://doi.org/10.1136/jitc-2021-004133","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2021-004133","pdf_url":"https://jitc.bmj.com/content/jitc/10/6/e004133.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal for ImmunoTherapy of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jitc.bmj.com/content/jitc/10/6/e004133.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063262671","display_name":"Mirela Kremenovic","orcid":"https://orcid.org/0000-0002-7617-2621","observed_orcids":["https://orcid.org/0000-0002-7617-2621"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Mirela Kremenovic","raw_affiliation_strings":["Experimental Pathology, University of Bern Institute of Pathology, Bern, Switzerland","Graduate School Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Pathology, University of Bern Institute of Pathology, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Graduate School Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032417513","display_name":"Alfred A. Chan","orcid":"https://orcid.org/0009-0008-2866-6548","observed_orcids":["https://orcid.org/0009-0008-2866-6548"]},"institutions":[{"id":"https://openalex.org/I177607063","display_name":"The Lundquist Institute","ror":"https://ror.org/025j2nd68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I177607063"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alfred A Chan","raw_affiliation_strings":["Division of Dermatology, Department of Medicine, The Lundquist Institute, Torrance, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Dermatology, Department of Medicine, The Lundquist Institute, Torrance, California, USA","institution_ids":["https://openalex.org/I177607063"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058759390","display_name":"Bing Feng","orcid":"https://orcid.org/0000-0002-6108-2017","observed_orcids":["https://orcid.org/0000-0002-6108-2017"]},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Bing Feng","raw_affiliation_strings":["Institute of Bioengineering and Institute of Materials Science and Engineering, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne, VD, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Bioengineering and Institute of Materials Science and Engineering, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne, VD, Switzerland","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042772031","display_name":"Lukas B\u00e4riswyl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Lukas B\u00e4riswyl","raw_affiliation_strings":["Experimental Pathology, University of Bern Institute of Pathology, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Pathology, University of Bern Institute of Pathology, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025318817","display_name":"Steve Robatel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Steve Robatel","raw_affiliation_strings":["Experimental Pathology, University of Bern Institute of Pathology, Bern, Switzerland","Graduate School Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Pathology, University of Bern Institute of Pathology, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Graduate School Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070961411","display_name":"Thomas Gruber","orcid":"https://orcid.org/0000-0001-5210-1995","observed_orcids":["https://orcid.org/0000-0001-5210-1995"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Thomas Gruber","raw_affiliation_strings":["Experimental Pathology, University of Bern Institute of Pathology, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Pathology, University of Bern Institute of Pathology, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065125027","display_name":"Li Tang","orcid":"https://orcid.org/0000-0002-6393-982X","observed_orcids":["https://orcid.org/0000-0002-6393-982X","https://orcid.org/0000-0002-6776-1846"]},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Li Tang","raw_affiliation_strings":["Institute of Bioengineering and Institute of Materials Science and Engineering, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne, VD, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Bioengineering and Institute of Materials Science and Engineering, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne, VD, Switzerland","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075444437","display_name":"Delphine J. Lee","orcid":"https://orcid.org/0000-0003-0063-5295","observed_orcids":["https://orcid.org/0000-0003-0063-5295"]},"institutions":[{"id":"https://openalex.org/I177607063","display_name":"The Lundquist Institute","ror":"https://ror.org/025j2nd68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I177607063"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Delphine J Lee","raw_affiliation_strings":["Division of Dermatology, Department of Medicine, The Lundquist Institute, Torrance, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Dermatology, Department of Medicine, The Lundquist Institute, Torrance, California, USA","institution_ids":["https://openalex.org/I177607063"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001238403","display_name":"Mirjam Schenk","orcid":"https://orcid.org/0000-0002-1637-0730","observed_orcids":["https://orcid.org/0000-0002-1637-0730"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Mirjam Schenk","raw_affiliation_strings":["Experimental Pathology, University of Bern Institute of Pathology, Bern, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-1637-0730","affiliations":[{"raw_affiliation_string":"Experimental Pathology, University of Bern Institute of Pathology, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5001238403"],"corresponding_institution_ids":["https://openalex.org/I118564535"],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":1234,"currency":"EUR","value_usd":1330},"fwci":3.4734,"has_fulltext":true,"cited_by_count":48,"citation_normalized_percentile":{"value":0.94545014,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"10","issue":"6","first_page":"e004133","last_page":"e004133"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.02459999918937683,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.009499999694526196,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metastatic-melanoma","display_name":"metastatic melanoma","score":0.9089999794960022},{"id":"https://openalex.org/keywords/cathepsin-s","display_name":"cathepsin S","score":0.9399999976158142},{"id":"https://openalex.org/keywords/antigen-processing-and-presentation","display_name":"antigen processing and presentation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.6990000009536743},{"id":"https://openalex.org/keywords/m1-macrophage-polarization","display_name":"M1 macrophage polarization","score":0.972000002861023},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.8339999914169312},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.5350000262260437},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.7269999980926514},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.6970000267028809},{"id":"https://openalex.org/keywords/tumor-infiltrating-immune-cells","display_name":"tumor-infiltrating immune cells","score":0.628000020980835},{"id":"https://openalex.org/keywords/t-cell-receptor-diversity","display_name":"T cell receptor diversity","score":0.5899999737739563}],"concepts":[{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.6809654235839844},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6027770042419434},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.525571882724762},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5232530832290649},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5098218321800232},{"id":"https://openalex.org/C2994587330","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Metastatic melanoma","level":3,"score":0.4672068953514099},{"id":"https://openalex.org/C2777601897","wikidata":"https://www.wikidata.org/wiki/Q3409113","display_name":"Presentation (obstetrics)","level":2,"score":0.43935853242874146},{"id":"https://openalex.org/C83464605","wikidata":"https://www.wikidata.org/wiki/Q575296","display_name":"Antigen presentation","level":4,"score":0.43851256370544434},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4255565106868744},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.23647764325141907},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.18702027201652527},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.17647594213485718},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17377910017967224},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.08810609579086304}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001500","descriptor_name":"BCG Vaccine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002403","descriptor_name":"Cathepsins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017951","descriptor_name":"Antigen Presentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020100","descriptor_name":"Hydrogels","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1136/jitc-2021-004133","doi":"https://doi.org/10.1136/jitc-2021-004133","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2021-004133","pdf_url":"https://jitc.bmj.com/content/jitc/10/6/e004133.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal for ImmunoTherapy of Cancer","raw_type":"journal-article"},{"id":"pmid:35732347","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35732347","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal for immunotherapy of cancer","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9226922","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9226922/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Immunother Cancer","raw_type":"Text"},{"id":"pmh:doi:10.48350/170849","doi":null,"is_oa":false,"landing_page_url":"https://boris-portal.unibe.ch/handle/20.500.12422/85776","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"pmh:oai:boris.unibe.ch:170849","doi":null,"is_oa":true,"landing_page_url":"https://boris.unibe.ch/170849/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401086","display_name":"Bern Open Repository and Information System (University of Bern)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I118564535","host_organization_name":"University of Bern","host_organization_lineage":["https://openalex.org/I118564535"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Kremenovic, Mirela; Chan, Alfred A; Feng, Bing; B\u00e4riswyl, Lukas; Robatel, Steve; Gruber, Thomas; Tang, Li; Lee, Delphine J; Schenk, Mirjam (2022). BCG hydrogel promotes CTSS-mediated antigen processing and presentation, thereby suppressing metastasis and prolonging survival in melanoma. Journal for immunotherapy of cancer, 10(6), e004133. BioMed Central 10.1136/jitc-2021-004133 &lt;http://dx.doi.org/10.1136/jitc-2021-004133&gt;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:f8260457f1284e40aa841743562bb8fb","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/f8260457f1284e40aa841743562bb8fb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal for ImmunoTherapy of Cancer, Vol 10, Iss 6 (2022)","raw_type":"article"},{"id":"pmh:oai:infoscience.epfl.ch:294919","doi":null,"is_oa":true,"landing_page_url":"https://infoscience.epfl.ch/handle/20.500.14299/188900","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"WoS","raw_type":"research article"},{"id":"doi:10.48350/170849","doi":"https://doi.org/10.48350/170849","is_oa":true,"landing_page_url":"https://doi.org/10.48350/170849","pdf_url":null,"source":{"id":"https://openalex.org/S7407053152","display_name":"Open Access CRIS of the University of Bern","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.1136/jitc-2021-004133","doi":"https://doi.org/10.1136/jitc-2021-004133","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2021-004133","pdf_url":"https://jitc.bmj.com/content/jitc/10/6/e004133.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal for ImmunoTherapy of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1710954185","display_name":"Deciphering the role of DC subsets in regulating the immune response to cancer therapies","funder_award_id":"176083","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G4374074183","display_name":"Immunoengineering through responsive nanoparticle drug delivery","funder_award_id":"173243","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G4402400530","display_name":null,"funder_award_id":"2018.114.1","funder_id":"https://openalex.org/F4320310707","funder_display_name":"Wilhelm Sander-Stiftung"},{"id":"https://openalex.org/G4966013024","display_name":null,"funder_award_id":"315230","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G5483670483","display_name":null,"funder_award_id":"320030_176083","funder_id":"https://openalex.org/F4320310707","funder_display_name":"Wilhelm Sander-Stiftung"},{"id":"https://openalex.org/G7330746317","display_name":"Mechanical Immunoengineering for Enhanced T-cell Immunotherapy","funder_award_id":"805337","funder_id":"https://openalex.org/F4320338335","funder_display_name":"H2020 European Research Council"},{"id":"https://openalex.org/G880118091","display_name":null,"funder_award_id":"320030","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306454","display_name":"Kenneth T. and Eileen L. Norris Foundation","ror":"https://ror.org/00azwrb54"},{"id":"https://openalex.org/F4320310707","display_name":"Wilhelm Sander-Stiftung","ror":"https://ror.org/02q83sc19"},{"id":"https://openalex.org/F4320310992","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320328148","display_name":"Helmut Horten Stiftung","ror":"https://ror.org/00dc6k529"},{"id":"https://openalex.org/F4320338335","display_name":"H2020 European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4283380233.pdf","grobid_xml":"https://content.openalex.org/works/W4283380233.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W1711559113","https://openalex.org/W1883768105","https://openalex.org/W1959677146","https://openalex.org/W1963918439","https://openalex.org/W1966673927","https://openalex.org/W1966729619","https://openalex.org/W1992847016","https://openalex.org/W1999498760","https://openalex.org/W2001717792","https://openalex.org/W2026676002","https://openalex.org/W2027147390","https://openalex.org/W2043071551","https://openalex.org/W2046505430","https://openalex.org/W2047117683","https://openalex.org/W2053433376","https://openalex.org/W2057577614","https://openalex.org/W2061383517","https://openalex.org/W2065020204","https://openalex.org/W2068051174","https://openalex.org/W2083071223","https://openalex.org/W2093403578","https://openalex.org/W2096331814","https://openalex.org/W2101653483","https://openalex.org/W2122533036","https://openalex.org/W2130832456","https://openalex.org/W2143163879","https://openalex.org/W2144081123","https://openalex.org/W2150633526","https://openalex.org/W2151826099","https://openalex.org/W2153746213","https://openalex.org/W2159482845","https://openalex.org/W2160834915","https://openalex.org/W2169589032","https://openalex.org/W2256291785","https://openalex.org/W2273849298","https://openalex.org/W2345356016","https://openalex.org/W2401718791","https://openalex.org/W2461271870","https://openalex.org/W2468076816","https://openalex.org/W2560367415","https://openalex.org/W2572174216","https://openalex.org/W2587048937","https://openalex.org/W2588457489","https://openalex.org/W2601468666","https://openalex.org/W2603218564","https://openalex.org/W2604183104","https://openalex.org/W2612299843","https://openalex.org/W2738771093","https://openalex.org/W2743882727","https://openalex.org/W2783035773","https://openalex.org/W2794480084","https://openalex.org/W2795686629","https://openalex.org/W2810866068","https://openalex.org/W2939676267","https://openalex.org/W2967251939","https://openalex.org/W3009809948","https://openalex.org/W4211166201","https://openalex.org/W4239133705","https://openalex.org/W4294216483"],"related_works":["https://openalex.org/W4405531885","https://openalex.org/W2606849095","https://openalex.org/W2743882727","https://openalex.org/W2090332169","https://openalex.org/W2037032239","https://openalex.org/W1998686998","https://openalex.org/W4398175199","https://openalex.org/W4324278900","https://openalex.org/W2604183104","https://openalex.org/W4385691647"],"abstract_inverted_index":{"Background":[0],"The":[1,80,188],"use":[2],"of":[3,14,20,25,82,103,108,142,149,191,215,240,252,303,314,319],"intralesional":[4],"Mycobacterium":[5],"bovis":[6],"BCG":[7,50,83,113,165,192,204,222,244,304],"(intralesional":[8],"live":[9,173],"BCG)":[10],"for":[11,299,316],"the":[12,67,137,300,311,317],"treatment":[13,85,206,246,263,318],"metastatic":[15],"melanoma":[16,152],"resulted":[17],"in":[18,33,74,186,210,229,234],"regression":[19],"directly":[21],"injected,":[22],"and":[23,38,52,91,107,123,175,181,200,218,231,238,274],"occasionally":[24],"distal":[26],"lesions.":[27],"However,":[28],"intralesional-BCG":[29,156,262],"is":[30],"less":[31],"effective":[32],"patients":[34,150,259,320],"with":[35,151,213,249,260,266,279,286,321],"visceral":[36],"metastases":[37,148,217],"did":[39],"not":[40],"significantly":[41],"improve":[42],"overall":[43],"survival.":[44,220,288],"Methods":[45],"We":[46],"generated":[47],"a":[48,56,177],"novel":[49],"lysate":[51,166],"developed":[53],"it":[54],"into":[55],"thermosensitive":[57],"PLGA-PEG-PLGA":[58],"hydrogel":[59,84,205,223,245,305],"(BCG":[60],"hydrogel),":[61],"which":[62,283],"was":[63,93,131,247,264],"injected":[64],"adjacent":[65],"to":[66,69,95,172,309],"tumor":[68,76,179,194],"assess":[70],"its":[71],"antitumor":[72,169],"effect":[73,81],"syngeneic":[75],"models":[77],"(B16F10,":[78],"MC38).":[79],"on":[86,198],"contralateral":[87],"tumors,":[88],"lung":[89,216],"metastases,":[90],"survival":[92],"assessed":[94,132],"evaluate":[96],"systemic":[97,208],"long-term":[98],"efficacy.":[99],"Gene":[100],"expression":[101,282],"profiles":[102],"tumor-infiltrating":[104],"immune":[105],"cells":[106,202],"tumor-draining":[109],"lymph":[110],"nodes":[111],"from":[112,145],"hydrogel-treated":[114],"mice":[115,212],"were":[116,158],"analyzed":[117],"by":[118,133],"single-cell":[119],"RNA":[120],"sequencing":[121],"(scRNA-seq)":[122],"CD8+":[124,254],"T":[125,255],"cell":[126],"receptor":[127],"(TCR)":[128],"repertoire":[129],"diversity":[130],"TCR-sequencing.":[134],"To":[135],"confirm":[136],"mechanistic":[138,293],"findings,":[139],"RNA-seq":[140],"data":[141],"biopsies":[143],"obtained":[144],"in-transit":[146],"cutaneous":[147],"who":[153],"had":[154],"received":[155],"therapy":[157],"analyzed.":[159],"Results":[160],"Here,":[161],"we":[162],"show":[163],"that":[164],"exhibits":[167],"enhanced":[168,235,267],"efficacy":[170],"compared":[171],"mycobacteria":[174],"promotes":[176],"proinflammatory":[178],"microenvironment":[180],"M1":[182,268],"macrophage":[183],"(M\u03a6)":[184],"polarization":[185],"vivo.":[187],"underlying":[189],"mechanisms":[190],"lysate-mediated":[193],"immunity":[195,209],"are":[196],"dependent":[197],"M\u03a6":[199,230],"dendritic":[201],"(DCs).":[203],"induced":[207],"melanoma-bearing":[211],"suppression":[214],"improved":[219],"Furthermore,":[221],"promoted":[224],"cathepsin":[225],"S":[226],"(CTSS)":[227],"activity":[228],"DCs,":[232],"resulting":[233],"antigen":[236,272],"processing":[237,273],"presentation":[239],"tumor-associated":[241],"antigens.":[242],"Finally,":[243],"associated":[248,265],"increased":[250,280],"frequencies":[251],"melanoma-reactive":[253],"cells.":[256],"In":[257],"human":[258],"melanoma,":[261],"M\u03a6,":[269],"mature":[270],"DC,":[271],"presentation,":[275],"as":[276,278,295,297,306],"well":[277,296],"CTSS":[281],"positively":[284],"correlated":[285],"patient":[287],"Conclusions":[289],"These":[290],"findings":[291],"provide":[292],"insights":[294],"rationale":[298],"clinical":[301],"translation":[302],"cancer":[307],"immunotherapy":[308],"overcome":[310],"current":[312],"limitations":[313],"immunotherapies":[315],"melanoma.":[322]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2022-06-25T00:00:00"}
