{"id":"https://openalex.org/W4283376904","doi":"https://doi.org/10.4314/tjpr.v21i5.3","title":"TWIST1 silencing attenuates intracranial aneurysms by inhibiting NF-\u03baB signaling","display_name":"TWIST1 silencing attenuates intracranial aneurysms by inhibiting NF-\u03baB signaling","publication_year":2022,"publication_date":"2022-06-16","ids":{"openalex":"https://openalex.org/W4283376904","doi":"https://doi.org/10.4314/tjpr.v21i5.3"},"language":"en","primary_location":{"id":"doi:10.4314/tjpr.v21i5.3","doi":"https://doi.org/10.4314/tjpr.v21i5.3","is_oa":true,"landing_page_url":"https://doi.org/10.4314/tjpr.v21i5.3","pdf_url":"https://www.ajol.info/index.php/tjpr/article/download/226981/214246","source":{"id":"https://openalex.org/S174262287","display_name":"Tropical Journal of Pharmaceutical Research","issn_l":"1596-5996","issn":["1596-5996","1596-9827"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jpps-1","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4310311017","host_organization_name":"Pharmacotherapy Group, University of Benin, Benin City","host_organization_lineage":["https://openalex.org/P4310311017"],"host_organization_lineage_names":["Pharmacotherapy Group, University of Benin, Benin City"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tropical Journal of Pharmaceutical Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.ajol.info/index.php/tjpr/article/download/226981/214246","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100755027","display_name":"Deng Wang","orcid":"https://orcid.org/0000-0002-0379-9204","observed_orcids":["https://orcid.org/0000-0002-0379-9204"]},"institutions":[{"id":"https://openalex.org/I4210121805","display_name":"Jiangxi Pingxiang People's Hospital","ror":"https://ror.org/02qkhx131","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121805"]},{"id":"https://openalex.org/I6406202","display_name":"University of Benin","ror":"https://ror.org/04mznrw11","country_code":"NG","type":"education","lineage":["https://openalex.org/I6406202"]}],"countries":["CN","NG"],"is_corresponding":false,"raw_author_name":"Deng Wang","raw_affiliation_strings":["Department of Neurosurgery, Jiangxi Pingxiang People's Hospital, Pingxiang, Jiangxi Province 337055, China","Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Jiangxi Pingxiang People's Hospital, Pingxiang, Jiangxi Province 337055, China","institution_ids":["https://openalex.org/I4210121805"]},{"raw_affiliation_string":"Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria","institution_ids":["https://openalex.org/I6406202"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Dan Lai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121805","display_name":"Jiangxi Pingxiang People's Hospital","ror":"https://ror.org/02qkhx131","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121805"]},{"id":"https://openalex.org/I6406202","display_name":"University of Benin","ror":"https://ror.org/04mznrw11","country_code":"NG","type":"education","lineage":["https://openalex.org/I6406202"]}],"countries":["CN","NG"],"is_corresponding":false,"raw_author_name":"Dan Lai","raw_affiliation_strings":["Department of Neurosurgery, Jiangxi Pingxiang People's Hospital, Pingxiang, Jiangxi Province 337055, China","Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Jiangxi Pingxiang People's Hospital, Pingxiang, Jiangxi Province 337055, China","institution_ids":["https://openalex.org/I4210121805"]},{"raw_affiliation_string":"Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria","institution_ids":["https://openalex.org/I6406202"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009908599","display_name":"Chengfu Peng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121805","display_name":"Jiangxi Pingxiang People's Hospital","ror":"https://ror.org/02qkhx131","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121805"]},{"id":"https://openalex.org/I6406202","display_name":"University of Benin","ror":"https://ror.org/04mznrw11","country_code":"NG","type":"education","lineage":["https://openalex.org/I6406202"]}],"countries":["CN","NG"],"is_corresponding":false,"raw_author_name":"Chengfu Peng","raw_affiliation_strings":["Department of Neurosurgery, Jiangxi Pingxiang People's Hospital, Pingxiang, Jiangxi Province 337055, China","\u00a9 Pharmacotherapy Group , Faculty of Pharmacy , University of Benin , Benin City , 300001 Nigeria","Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Jiangxi Pingxiang People's Hospital, Pingxiang, Jiangxi Province 337055, China","institution_ids":["https://openalex.org/I4210121805"]},{"raw_affiliation_string":"\u00a9 Pharmacotherapy Group , Faculty of Pharmacy , University of Benin , Benin City , 300001 Nigeria","institution_ids":["https://openalex.org/I6406202"]},{"raw_affiliation_string":"Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria","institution_ids":["https://openalex.org/I6406202"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":500,"currency":"USD","value_usd":500},"apc_paid":{"value":500,"currency":"USD","value_usd":500},"fwci":0.414,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.54591053,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"21","issue":"5","first_page":"927","last_page":"932"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10420","display_name":"Intracranial Aneurysms: Treatment and Complications","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10420","display_name":"Intracranial Aneurysms: Treatment and Complications","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10983","display_name":"Aortic aneurysm repair treatments","score":0.010200000368058681,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10816","display_name":"Cerebrovascular and Carotid Artery Diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/twist1","display_name":"TWIST1","score":0.949999988079071},{"id":"https://openalex.org/keywords/intracranial-aneurysm","display_name":"intracranial aneurysm","score":0.9909999966621399},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":1.0},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cell-apoptosis","display_name":"vascular smooth muscle cell apoptosis","score":0.9269999861717224},{"id":"https://openalex.org/keywords/vascular-remodeling","display_name":"vascular remodeling","score":0.8669999837875366},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7099999785423279},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.949999988079071},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9850000143051147},{"id":"https://openalex.org/keywords/arterial-wall-degeneration","display_name":"arterial wall degeneration","score":0.765999972820282},{"id":"https://openalex.org/keywords/carotid-artery-ligation","display_name":"carotid artery ligation","score":0.6830000281333923},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"gene silencing","score":0.5870000123977661}],"concepts":[{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.6890102028846741},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.5736427307128906},{"id":"https://openalex.org/C2776098176","wikidata":"https://www.wikidata.org/wiki/Q189389","display_name":"Aneurysm","level":2,"score":0.4875945448875427},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.48727238178253174},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.46922051906585693},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4667865037918091},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4607388377189636},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.4580290913581848},{"id":"https://openalex.org/C154113507","wikidata":"https://www.wikidata.org/wiki/Q411149","display_name":"Terminal deoxynucleotidyl transferase","level":4,"score":0.4351201057434082},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.42756757140159607},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3790135979652405},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3307802081108093},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22130417823791504},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.21339046955108643},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.12155735492706299},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0609191358089447},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4314/tjpr.v21i5.3","doi":"https://doi.org/10.4314/tjpr.v21i5.3","is_oa":true,"landing_page_url":"https://doi.org/10.4314/tjpr.v21i5.3","pdf_url":"https://www.ajol.info/index.php/tjpr/article/download/226981/214246","source":{"id":"https://openalex.org/S174262287","display_name":"Tropical Journal of Pharmaceutical Research","issn_l":"1596-5996","issn":["1596-5996","1596-9827"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jpps-1","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4310311017","host_organization_name":"Pharmacotherapy Group, University of Benin, Benin City","host_organization_lineage":["https://openalex.org/P4310311017"],"host_organization_lineage_names":["Pharmacotherapy Group, University of Benin, Benin City"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tropical Journal of Pharmaceutical Research","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.4314/tjpr.v21i5.3","doi":"https://doi.org/10.4314/tjpr.v21i5.3","is_oa":true,"landing_page_url":"https://doi.org/10.4314/tjpr.v21i5.3","pdf_url":"https://www.ajol.info/index.php/tjpr/article/download/226981/214246","source":{"id":"https://openalex.org/S174262287","display_name":"Tropical Journal of Pharmaceutical Research","issn_l":"1596-5996","issn":["1596-5996","1596-9827"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jpps-1","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4310311017","host_organization_name":"Pharmacotherapy Group, University of Benin, Benin City","host_organization_lineage":["https://openalex.org/P4310311017"],"host_organization_lineage_names":["Pharmacotherapy Group, University of Benin, Benin City"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tropical Journal of Pharmaceutical Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4283376904.pdf","grobid_xml":"https://content.openalex.org/works/W4283376904.grobid-xml"},"referenced_works_count":2,"referenced_works":["https://openalex.org/W2418487111","https://openalex.org/W4321258692"],"related_works":["https://openalex.org/W4389183499","https://openalex.org/W7172283460","https://openalex.org/W2134813582","https://openalex.org/W2324530951","https://openalex.org/W4401310243","https://openalex.org/W2591883468","https://openalex.org/W2885365510","https://openalex.org/W3125621943","https://openalex.org/W1897494558","https://openalex.org/W1986881368"],"abstract_inverted_index":{"Purpose:":[0],"To":[1],"investigate":[2],"the":[3,27,32,42,116,120],"effect":[4],"of":[5,20,30,153],"Twist":[6],"family":[7],"basic":[8],"helix-loop-helix":[9],"transcription":[10,58],"factor":[11,129],"1":[12],"(TWIST1)":[13],"on":[14],"intracranial":[15,21,43,93,146,163,170],"aneurysms.Methods:":[16],"A":[17],"rat":[18,165],"model":[19],"aneurysm":[22,103,164],"was":[23,53,72,84,106],"established":[24],"by":[25,74],"ligating":[26],"posterior":[28],"branches":[29],"both":[31],"renal":[33],"and":[34,63,112,132,136,157,160,177,184],"left":[35],"common":[36],"carotid":[37],"arteries.":[38],"Pathological":[39],"changes":[40,97,118],"in":[41,98,108,143,162],"arterial":[44,109,121,166],"wall":[45,100,110,167],"were":[46],"investigated":[47,73],"using":[48,55,86],"hematoxylin-eosin":[49],"staining.":[50,82],"TWIST1":[51,105,113,123,148,173,190],"expression":[52],"assessed":[54],"quantitative":[56],"reverse":[57],"polymerase":[59],"chain":[60],"reaction":[61],"(qRT-PCR)":[62],"western":[64],"blot,":[65],"while":[66],"vascular":[67,138,175,179],"smooth":[68,139,180],"muscle":[69,140,181],"cell":[70,141,182],"apoptosis":[71,142,183],"terminal":[75],"deoxynucleotidyl":[76],"transferase":[77],"dUTP":[78],"nick-end":[79],"labeling":[80],"(TUNEL)":[81],"Inflammation":[83],"evaluated":[85],"enzyme-linked":[87],"immunosorbent":[88],"assay":[89],"(ELISA).Results:":[90],"Rats":[91],"with":[92,145],"aneurysms":[94],"had":[95],"degenerative":[96],"vessel":[99],"structure.":[101],"Inintracranial":[102],"rats,":[104],"upregulated":[107],"sections,":[111],"knockdown":[114,149],"ameliorated":[115],"pathological":[117],"to":[119],"wall.":[122],"silencing":[124,172,191],"reduced":[125],"serum":[126],"tumor":[127],"necrosis":[128],"alpha":[130],"(TNF-\u03b1)":[131],"interleukin-6":[133],"(IL-6)":[134],"levels":[135],"suppressed":[137],"rats":[144],"aneurysms.":[147],"increased":[150],"phospho":[151],"(p)-inhibitor":[152],"nuclear":[154],"factor-\u03baB":[155],"(I\u03baB)":[156],"decreased":[158],"I\u03baB":[159],"p-p65":[161],"sections.Conclusion:":[168],"In":[169],"aneurysms,":[171],"promoted":[174],"remodeling":[176],"suppresses":[178],"inflammation":[185],"through":[186],"inactivating":[187],"NF-\u03baBsignaling,":[188],"revealing":[189],"as":[192],"a":[193],"potential":[194],"treatment":[195],"strategy.":[196]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-06-25T00:00:00"}