{"id":"https://openalex.org/W4283372824","doi":"https://doi.org/10.1371/journal.pntd.0010528","title":"Extracellular vesicles from Trichinella spiralis: Proteomic analysis and protective immunity","display_name":"Extracellular vesicles from Trichinella spiralis: Proteomic analysis and protective immunity","publication_year":2022,"publication_date":"2022-06-23","ids":{"openalex":"https://openalex.org/W4283372824","doi":"https://doi.org/10.1371/journal.pntd.0010528","pmid":"https://pubmed.ncbi.nlm.nih.gov/35737719","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9258885"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pntd.0010528","doi":"https://doi.org/10.1371/journal.pntd.0010528","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pntd.0010528","pdf_url":"https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0010528&type=printable","source":{"id":"https://openalex.org/S46544255","display_name":"PLoS neglected tropical diseases","issn_l":"1935-2727","issn":["1935-2727","1935-2735"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Neglected Tropical Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0010528&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100618900","display_name":"Xin Gao","orcid":"https://orcid.org/0000-0002-7108-3574","observed_orcids":["https://orcid.org/0000-0002-7108-3574","https://orcid.org/0000-0002-3367-3725"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Gao","raw_affiliation_strings":["Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101857407","display_name":"Yong Yang","orcid":"https://orcid.org/0000-0003-2752-2039","observed_orcids":["https://orcid.org/0000-0003-2752-2039"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210122896","display_name":"Yunnan Institute of Parasitic Diseases","ror":"https://ror.org/03sasjr79","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210122896"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong Yang","raw_affiliation_strings":["Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China","Yunnan Institute of Parasitic Diseases, Puer, Yunnan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716"]},{"raw_affiliation_string":"Yunnan Institute of Parasitic Diseases, Puer, Yunnan, China","institution_ids":["https://openalex.org/I4210122896"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100442737","display_name":"Xiaolei Liu","orcid":"https://orcid.org/0000-0001-8262-0876","observed_orcids":["https://orcid.org/0000-0001-8262-0876"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaolei Liu","raw_affiliation_strings":["Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China"],"raw_orcid":"https://orcid.org/0000-0001-8262-0876","affiliations":[{"raw_affiliation_string":"Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101422019","display_name":"Fengyan Xu","orcid":"https://orcid.org/0000-0003-1063-3592","observed_orcids":["https://orcid.org/0000-0003-1063-3592"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fengyan Xu","raw_affiliation_strings":["Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100619066","display_name":"Yang Wang","orcid":"https://orcid.org/0000-0001-8055-9522","observed_orcids":["https://orcid.org/0000-0001-8055-9522"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Wang","raw_affiliation_strings":["Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017785968","display_name":"Lei Liu","orcid":"https://orcid.org/0000-0001-8076-0269","observed_orcids":["https://orcid.org/0000-0001-8076-0269"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Liu","raw_affiliation_strings":["Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China"],"raw_orcid":"https://orcid.org/0000-0001-8076-0269","affiliations":[{"raw_affiliation_string":"Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065930365","display_name":"Yaming Yang","orcid":"https://orcid.org/0000-0003-4599-0397","observed_orcids":["https://orcid.org/0000-0003-4599-0397"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210122896","display_name":"Yunnan Institute of Parasitic Diseases","ror":"https://ror.org/03sasjr79","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210122896"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yaming Yang","raw_affiliation_strings":["Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China","Yunnan Institute of Parasitic Diseases, Puer, Yunnan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716"]},{"raw_affiliation_string":"Yunnan Institute of Parasitic Diseases, Puer, Yunnan, China","institution_ids":["https://openalex.org/I4210122896"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100635747","display_name":"Mingyuan Liu","orcid":"https://orcid.org/0000-0002-2948-4868","observed_orcids":["https://orcid.org/0000-0002-2948-4868"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I78978612","display_name":"Yangzhou University","ror":"https://ror.org/03tqb8s11","country_code":"CN","type":"education","lineage":["https://openalex.org/I78978612"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Mingyuan Liu","raw_affiliation_strings":["Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China","Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China","institution_ids":["https://openalex.org/I78978612"]},{"raw_affiliation_string":"Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009151203","display_name":"Xue Bai","orcid":"https://orcid.org/0000-0002-5973-0353","observed_orcids":["https://orcid.org/0000-0002-5973-0353"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xue Bai","raw_affiliation_strings":["Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China"],"raw_orcid":"https://orcid.org/0000-0002-5973-0353","affiliations":[{"raw_affiliation_string":"Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5009151203","https://openalex.org/A5100635747"],"corresponding_institution_ids":["https://openalex.org/I194450716","https://openalex.org/I78978612"],"apc_list":{"value":2495,"currency":"USD","value_usd":2495},"apc_paid":{"value":2495,"currency":"USD","value_usd":2495},"fwci":2.0315,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.88231932,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"16","issue":"6","first_page":"e0010528","last_page":"e0010528"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11702","display_name":"Parasitic Diseases Research and Treatment","score":0.9003999829292297,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11702","display_name":"Parasitic Diseases Research and Treatment","score":0.9003999829292297,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.05260000005364418,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.02710000053048134,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trichinella-spiralis","display_name":"Trichinella spiralis","score":1.0},{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":0.9639999866485596},{"id":"https://openalex.org/keywords/muscle-larvae","display_name":"muscle larvae","score":0.9900000095367432},{"id":"https://openalex.org/keywords/vesicle-proteome","display_name":"vesicle proteome","score":0.7940000295639038},{"id":"https://openalex.org/keywords/host-immune-response","display_name":"host immune response","score":0.6899999976158142},{"id":"https://openalex.org/keywords/th2-response","display_name":"Th2 immune response","score":0.7239999771118164},{"id":"https://openalex.org/keywords/th1-th2-balance","display_name":"Th1/Th2 balance","score":0.8029999732971191},{"id":"https://openalex.org/keywords/host-parasite-interactions","display_name":"host-parasite interactions","score":0.6029999852180481},{"id":"https://openalex.org/keywords/vaccine-candidate","display_name":"vaccine candidate","score":0.375},{"id":"https://openalex.org/keywords/glycan-degradation","display_name":"glycan degradation","score":0.675000011920929},{"id":"https://openalex.org/keywords/complement-and-coagulation-pathways","display_name":"complement and coagulation pathways","score":0.8339999914169312},{"id":"https://openalex.org/keywords/proteasome","display_name":"proteasome","score":0.5809999704360962},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.7099999785423279},{"id":"https://openalex.org/keywords/antibody-response","display_name":"antibody response","score":0.5379999876022339}],"concepts":[{"id":"https://openalex.org/C2781320125","wikidata":"https://www.wikidata.org/wiki/Q730937","display_name":"Trichinella spiralis","level":3,"score":0.8054229021072388},{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.6913778781890869},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6248762607574463},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6041133999824524},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.6016177535057068},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.4822981357574463},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.4458681046962738},{"id":"https://openalex.org/C2908689518","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicle","level":5,"score":0.42168718576431274},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.4166218638420105},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4120924770832062},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27828362584114075},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.25635826587677},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24141550064086914},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.1578596830368042},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1493702530860901},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09738922119140625},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.09460005164146423},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014235","descriptor_name":"Trichinellosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017160","descriptor_name":"Trichinella spiralis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pntd.0010528","doi":"https://doi.org/10.1371/journal.pntd.0010528","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pntd.0010528","pdf_url":"https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0010528&type=printable","source":{"id":"https://openalex.org/S46544255","display_name":"PLoS neglected tropical diseases","issn_l":"1935-2727","issn":["1935-2727","1935-2735"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Neglected Tropical Diseases","raw_type":"journal-article"},{"id":"pmid:35737719","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35737719","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS neglected tropical diseases","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9258885","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9258885/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Negl Trop Dis","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:aa533122559e4ce5a93ba66c795f88db","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/aa533122559e4ce5a93ba66c795f88db","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Neglected Tropical Diseases, Vol 16, Iss 6, p e0010528 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pntd.0010528","doi":"https://doi.org/10.1371/journal.pntd.0010528","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pntd.0010528","pdf_url":"https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0010528&type=printable","source":{"id":"https://openalex.org/S46544255","display_name":"PLoS neglected tropical diseases","issn_l":"1935-2727","issn":["1935-2727","1935-2735"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Neglected Tropical Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7246000170707703}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1976874309","display_name":null,"funder_award_id":"2017YFC1601206","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G2488406380","display_name":null,"funder_award_id":"2017YFD0501300","funder_id":"https://openalex.org/F4320336022","funder_display_name":"Program for Jilin University Science and Technology Innovative Research Team"},{"id":"https://openalex.org/G285392418","display_name":null,"funder_award_id":"31520103916","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2977707857","display_name":null,"funder_award_id":"NSFC 31520103916, 31872467","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3610380684","display_name":null,"funder_award_id":"2017TD-32","funder_id":"https://openalex.org/F4320336022","funder_display_name":"Program for Jilin University Science and Technology Innovative Research Team"},{"id":"https://openalex.org/G363843752","display_name":null,"funder_award_id":"31872467","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G5152678105","display_name":null,"funder_award_id":"2017YFD0501300","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G5288536762","display_name":null,"funder_award_id":"31872467","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5603411710","display_name":null,"funder_award_id":"31520103916","funder_id":"https://openalex.org/F4320336022","funder_display_name":"Program for Jilin University Science and Technology Innovative Research Team"},{"id":"https://openalex.org/G5644679344","display_name":null,"funder_award_id":"2017YFD0501300","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7004752745","display_name":null,"funder_award_id":"31872467","funder_id":"https://openalex.org/F4320336022","funder_display_name":"Program for Jilin University Science and Technology Innovative Research Team"},{"id":"https://openalex.org/G7517509000","display_name":null,"funder_award_id":"NSFC 31520103916","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8833261770","display_name":null,"funder_award_id":"31520103916","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null},{"id":"https://openalex.org/F4320336022","display_name":"Program for Jilin University Science and Technology Innovative Research Team","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4283372824.pdf","grobid_xml":"https://content.openalex.org/works/W4283372824.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1952765928","https://openalex.org/W1956207872","https://openalex.org/W1970761114","https://openalex.org/W1971661217","https://openalex.org/W1971727163","https://openalex.org/W1979246036","https://openalex.org/W2005207632","https://openalex.org/W2021004292","https://openalex.org/W2041959790","https://openalex.org/W2044198861","https://openalex.org/W2074297938","https://openalex.org/W2097761110","https://openalex.org/W2098084008","https://openalex.org/W2098259366","https://openalex.org/W2103463718","https://openalex.org/W2107008239","https://openalex.org/W2112271609","https://openalex.org/W2124769302","https://openalex.org/W2125198788","https://openalex.org/W2131984189","https://openalex.org/W2139712080","https://openalex.org/W2176750505","https://openalex.org/W2283708996","https://openalex.org/W2487169691","https://openalex.org/W2568481431","https://openalex.org/W2618954565","https://openalex.org/W2692074759","https://openalex.org/W2805950261","https://openalex.org/W2889240364","https://openalex.org/W2922290179","https://openalex.org/W2940314632","https://openalex.org/W2940967386","https://openalex.org/W2944023254","https://openalex.org/W2947792460","https://openalex.org/W2967855330","https://openalex.org/W2984342889","https://openalex.org/W2996369328","https://openalex.org/W2996752197","https://openalex.org/W3009861811","https://openalex.org/W3011154462","https://openalex.org/W3019500828","https://openalex.org/W3020276435","https://openalex.org/W3022662229","https://openalex.org/W3034999515","https://openalex.org/W3036953355","https://openalex.org/W3084303837","https://openalex.org/W3100166393","https://openalex.org/W3106123940","https://openalex.org/W3122777614","https://openalex.org/W3159579274","https://openalex.org/W3162966153","https://openalex.org/W4211223413"],"related_works":["https://openalex.org/W4306907921","https://openalex.org/W2965473572","https://openalex.org/W3034999515","https://openalex.org/W4387955585","https://openalex.org/W4296736446","https://openalex.org/W4385597323","https://openalex.org/W3106123940","https://openalex.org/W2088493891","https://openalex.org/W4406606471","https://openalex.org/W2883890462"],"abstract_inverted_index":{"Trichinella":[0],"spiralis":[1,36,41,232,249],"(T.":[2],"spiralis)":[3],"derived":[4],"extracellular":[5],"vesicles":[6],"(EVs)":[7],"have":[8],"been":[9],"proposed":[10],"to":[11,246],"play":[12],"a":[13,159,166,214,225,243],"key":[14],"role":[15,227],"in":[16,69,83,131,162,169,205,230,235],"regulating":[17],"the":[18,27,70,185,236],"host":[19],"immune":[20,177,217],"responses.":[21],"In":[22,144],"this":[23],"study,":[24],"we":[25,65],"provided":[26,242],"first":[28],"investigation":[29],"of":[30,90,103,128,153,187,228],"EVs":[31,43],"proteomics":[32],"released":[33],"by":[34,50,75,86,150,180],"T.":[35,40,231,248],"muscle":[37],"larvae":[38],"(ML).":[39],"ML":[42,170],"(Ts-ML-EVs)":[44],"were":[45,81,148,182],"successfully":[46],"isolated":[47],"and":[48,55,73,92,95,108,136,140,165,175,194,203],"characterized":[49],"transmission":[51],"electron":[52],"microscopy":[53],"(TEM)":[54],"western":[56],"blotting.":[57],"Using":[58],"liquid":[59],"chromatograph":[60],"mass":[61],"spectrometer":[62],"(LC-MS/MS)":[63],"analysis,":[64],"identified":[66],"753":[67],"proteins":[68,80,114,130],"Ts-ML-EVs":[71,129,156,181,211,229],"proteome":[72],"annotated":[74],"gene":[76],"ontology":[77],"(GO).":[78],"These":[79],"enriched":[82],"different":[84],"categories":[85],"GO,":[87],"kyoto":[88],"encyclopedia":[89],"genes":[91],"genomes":[93],"(KEGG)":[94],"domain":[96],"analysis.":[97],"GO":[98],"enrichment":[99,124],"analysis":[100,125],"indicated":[101],"association":[102],"protein":[104],"deglutathionylation,":[105],"lysosomal":[106],"lumen":[107],"serine-type":[109],"endopeptidase":[110],"inhibitor":[111],"activity":[112],"with":[113,219,238],"which":[115],"may":[116],"be":[117],"helpful":[118],"during":[119],"parasite-host":[120],"interaction.":[121],"Moreover,":[122],"KEGG":[123],"revealed":[126,224],"involvement":[127],"other":[132],"glycan":[133],"degradation,":[134],"complement":[135],"coagulation":[137],"cascades,":[138],"proteasome":[139],"various":[141],"metabolism":[142],"pathways.":[143],"addition,":[145],"BALB/c":[146],"mice":[147],"immunized":[149],"subcutaneous":[151],"injection":[152],"purified":[154],"Ts-ML-EVs.":[155,253],"group":[157],"demonstrated":[158],"23.4%":[160],"reduction":[161,168],"adult":[163],"worms":[164],"43.7%":[167],"after":[171],"parasite":[172],"challenge.":[173],"Cellular":[174],"humoral":[176],"responses":[178],"induced":[179],"detected,":[183],"including":[184],"levels":[186],"specific":[188],"antibodies":[189],"(IgG,":[190],"IgM,":[191],"IgE,":[192],"IgG1":[193],"IgG2a)":[195],"as":[196,198],"well":[197],"cytokines":[199],"(IL-12,":[200],"IFN-\u03b3,":[201],"IL-4":[202],"IL-10)":[204],"serum.":[206],"The":[207],"results":[208],"showed":[209],"that":[210],"could":[212],"induce":[213],"Th1/Th2":[215],"mixed":[216],"response":[218],"Th2":[220],"predominant.":[221],"This":[222,240],"study":[223],"potential":[226],"biology,":[233],"particularly":[234],"interaction":[237],"host.":[239],"work":[241],"critical":[244],"step":[245],"against":[247],"infection":[250],"based":[251],"on":[252]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":7}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-06-25T00:00:00"}
