{"id":"https://openalex.org/W4283372039","doi":"https://doi.org/10.1002/bab.2371","title":"Immunomodulatory effect of Linalool (Lin) against CCl 4 \u2010induced hepatotoxicity and oxidative damage in rats","display_name":"Immunomodulatory effect of Linalool (Lin) against CCl 4 \u2010induced hepatotoxicity and oxidative damage in rats","publication_year":2022,"publication_date":"2022-06-24","ids":{"openalex":"https://openalex.org/W4283372039","doi":"https://doi.org/10.1002/bab.2371","pmid":"https://pubmed.ncbi.nlm.nih.gov/35748559"},"language":"en","primary_location":{"id":"doi:10.1002/bab.2371","doi":"https://doi.org/10.1002/bab.2371","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bab.2371","pdf_url":null,"source":{"id":"https://openalex.org/S34872747","display_name":"Biotechnology and Applied Biochemistry","issn_l":"0885-4513","issn":["0885-4513","1470-8744"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology and Applied Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089376618","display_name":"Anis Ben Hsouna","orcid":"https://orcid.org/0000-0002-3837-5532","observed_orcids":["https://orcid.org/0000-0002-3837-5532"]},"institutions":[{"id":"https://openalex.org/I35845393","display_name":"University of Gafsa","ror":"https://ror.org/01kzjzn40","country_code":"TN","type":"education","lineage":["https://openalex.org/I35845393"]},{"id":"https://openalex.org/I4210162466","display_name":"Centre of Biotechnology of Sfax","ror":"https://ror.org/05acynk65","country_code":"TN","type":"facility","lineage":["https://openalex.org/I4210162466"]}],"countries":["TN"],"is_corresponding":true,"raw_author_name":"Anis Ben Hsouna","raw_affiliation_strings":["Department of Life Sciences, Faculty of Sciences of Gafsa, Gafsa, Tunisia","Laboratory of Biotechnology and Plant Improvement, Centre of Biotechnology of Sfax, Sfax, Tunisia"],"raw_orcid":"https://orcid.org/0000-0002-3837-5532","affiliations":[{"raw_affiliation_string":"Department of Life Sciences, Faculty of Sciences of Gafsa, Gafsa, Tunisia","institution_ids":["https://openalex.org/I35845393"]},{"raw_affiliation_string":"Laboratory of Biotechnology and Plant Improvement, Centre of Biotechnology of Sfax, Sfax, Tunisia","institution_ids":["https://openalex.org/I4210162466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067245359","display_name":"Carmen Sadaka","orcid":"https://orcid.org/0000-0002-9243-1056","observed_orcids":["https://orcid.org/0000-0002-9243-1056"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carmen Sadaka","raw_affiliation_strings":["Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"],"raw_orcid":"https://orcid.org/0000-0002-9243-1056","affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038709760","display_name":"Marc El Beyrouthy","orcid":"https://orcid.org/0000-0002-4909-4154","observed_orcids":["https://orcid.org/0000-0002-4909-4154"]},"institutions":[{"id":"https://openalex.org/I189998669","display_name":"Holy Spirit University of Kaslik","ror":"https://ror.org/05g06bh89","country_code":"LB","type":"education","lineage":["https://openalex.org/I189998669"]}],"countries":["LB"],"is_corresponding":false,"raw_author_name":"Marc El Beyrouthy","raw_affiliation_strings":["Holy Spirit University of Kaslik, Jounieh Mount Lebanon, Lebanon"],"raw_orcid":"https://orcid.org/0000-0002-4909-4154","affiliations":[{"raw_affiliation_string":"Holy Spirit University of Kaslik, Jounieh Mount Lebanon, Lebanon","institution_ids":["https://openalex.org/I189998669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081391653","display_name":"Mbarka Hfaiedh","orcid":"https://orcid.org/0000-0002-2966-4551","observed_orcids":["https://orcid.org/0000-0002-2966-4551"]},"institutions":[{"id":"https://openalex.org/I68916915","display_name":"University of Gab\u00e8s","ror":"https://ror.org/022efad20","country_code":"TN","type":"education","lineage":["https://openalex.org/I68916915"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Mbarka Hfaiedh","raw_affiliation_strings":["Research Unit of Active Biomolecules Valorisation, Higher Institute of Applied Biology of Medicine, University of Gabes, Medenine, Tunisia"],"raw_orcid":"https://orcid.org/0000-0002-2966-4551","affiliations":[{"raw_affiliation_string":"Research Unit of Active Biomolecules Valorisation, Higher Institute of Applied Biology of Medicine, University of Gabes, Medenine, Tunisia","institution_ids":["https://openalex.org/I68916915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026850570","display_name":"Wissal Dhifi","orcid":"https://orcid.org/0000-0002-1457-254X","observed_orcids":["https://orcid.org/0000-0002-1457-254X"]},"institutions":[{"id":"https://openalex.org/I83259278","display_name":"Manouba University","ror":"https://ror.org/0503ejf32","country_code":"TN","type":"education","lineage":["https://openalex.org/I83259278"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Wissal Dhifi","raw_affiliation_strings":["Laboratory of Biotechnology and Valorisation of Bio-GeoRessources, Higher Institute of Biotechnology of Sidi Thabet, University of Manouba, BiotechPole of Sidi Thabet, Ariana, Tunisia"],"raw_orcid":"https://orcid.org/0000-0002-1457-254X","affiliations":[{"raw_affiliation_string":"Laboratory of Biotechnology and Valorisation of Bio-GeoRessources, Higher Institute of Biotechnology of Sidi Thabet, University of Manouba, BiotechPole of Sidi Thabet, Ariana, Tunisia","institution_ids":["https://openalex.org/I83259278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008455240","display_name":"Fa\u00ef\u00e7al Brini","orcid":"https://orcid.org/0000-0002-8435-381X","observed_orcids":["https://orcid.org/0000-0002-8435-381X"]},"institutions":[{"id":"https://openalex.org/I4210162466","display_name":"Centre of Biotechnology of Sfax","ror":"https://ror.org/05acynk65","country_code":"TN","type":"facility","lineage":["https://openalex.org/I4210162466"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Faical Brini","raw_affiliation_strings":["Laboratory of Biotechnology and Plant Improvement, Centre of Biotechnology of Sfax, Sfax, Tunisia"],"raw_orcid":"https://orcid.org/0000-0002-8435-381X","affiliations":[{"raw_affiliation_string":"Laboratory of Biotechnology and Plant Improvement, Centre of Biotechnology of Sfax, Sfax, Tunisia","institution_ids":["https://openalex.org/I4210162466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065513896","display_name":"Rania Ben Saad","orcid":"https://orcid.org/0000-0003-0559-0911","observed_orcids":["https://orcid.org/0000-0003-0559-0911"]},"institutions":[{"id":"https://openalex.org/I4210162466","display_name":"Centre of Biotechnology of Sfax","ror":"https://ror.org/05acynk65","country_code":"TN","type":"facility","lineage":["https://openalex.org/I4210162466"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Rania Ben Saad","raw_affiliation_strings":["Laboratory of Biotechnology and Plant Improvement, Centre of Biotechnology of Sfax, Sfax, Tunisia"],"raw_orcid":"https://orcid.org/0000-0003-0559-0911","affiliations":[{"raw_affiliation_string":"Laboratory of Biotechnology and Plant Improvement, Centre of Biotechnology of Sfax, Sfax, Tunisia","institution_ids":["https://openalex.org/I4210162466"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066476211","display_name":"Wissem Mnif","orcid":"https://orcid.org/0000-0002-8123-4743","observed_orcids":["https://orcid.org/0000-0002-8123-4743"]},"institutions":[{"id":"https://openalex.org/I4210136004","display_name":"University of Bisha","ror":"https://ror.org/040548g92","country_code":"SA","type":"education","lineage":["https://openalex.org/I4210136004"]},{"id":"https://openalex.org/I83259278","display_name":"Manouba University","ror":"https://ror.org/0503ejf32","country_code":"TN","type":"education","lineage":["https://openalex.org/I83259278"]}],"countries":["SA","TN"],"is_corresponding":true,"raw_author_name":"Wissem Mnif","raw_affiliation_strings":["Department of Chemistry, Faculty of Sciences and Arts in Balgarn, University of Bisha, Bisha, Saudi Arabia","ISBST, BVBGR-LR11ES31, University of Manouba, Biotechpole Sidi Thabet, Ariana, Tunisia"],"raw_orcid":"https://orcid.org/0000-0002-8123-4743","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Sciences and Arts in Balgarn, University of Bisha, Bisha, Saudi Arabia","institution_ids":["https://openalex.org/I4210136004"]},{"raw_affiliation_string":"ISBST, BVBGR-LR11ES31, University of Manouba, Biotechpole Sidi Thabet, Ariana, Tunisia","institution_ids":["https://openalex.org/I83259278"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5066476211","https://openalex.org/A5089376618"],"corresponding_institution_ids":["https://openalex.org/I35845393","https://openalex.org/I4210136004","https://openalex.org/I4210162466","https://openalex.org/I83259278"],"apc_list":{"value":3050,"currency":"USD","value_usd":3050},"apc_paid":null,"fwci":2.0371,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.85523087,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"70","issue":"1","first_page":"469","last_page":"477"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13919","display_name":"Medicinal plant effects and applications","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/linalool","display_name":"linalool","score":0.996999979019165},{"id":"https://openalex.org/keywords/hepatoprotective-effect","display_name":"hepatoprotection","score":0.7900000214576721},{"id":"https://openalex.org/keywords/carbon-tetrachloride-induced-liver-injury","display_name":"carbon tetrachloride-induced liver injury","score":0.8930000066757202},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.8460000157356262},{"id":"https://openalex.org/keywords/oxidative-liver-injury","display_name":"oxidative liver damage","score":0.828000009059906},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.8109999895095825},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8349999785423279},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.902999997138977},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8700000047683716},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.8769999742507935},{"id":"https://openalex.org/keywords/liver-histopathology","display_name":"liver histopathology","score":0.9160000085830688},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.7319999933242798}],"concepts":[{"id":"https://openalex.org/C2777359374","wikidata":"https://www.wikidata.org/wiki/Q225045","display_name":"Carbon tetrachloride","level":2,"score":0.827795684337616},{"id":"https://openalex.org/C102124568","wikidata":"https://www.wikidata.org/wiki/Q5009626","display_name":"CCL4","level":3,"score":0.8198686838150024},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.6922500133514404},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5939911007881165},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5833714008331299},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5546694993972778},{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.49800896644592285},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4959734380245209},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.48339954018592834},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.46828123927116394},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.42636847496032715},{"id":"https://openalex.org/C2779729912","wikidata":"https://www.wikidata.org/wiki/Q410932","display_name":"Linalool","level":3,"score":0.42484188079833984},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33382341265678406},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23597213625907898},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22530660033226013},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18695807456970215},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.15671128034591675},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1306295096874237},{"id":"https://openalex.org/C2777278459","wikidata":"https://www.wikidata.org/wiki/Q170885","display_name":"Essential oil","level":2,"score":0.10229966044425964},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.09191921353340149},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069463","descriptor_name":"Olive Oil","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000069463","descriptor_name":"Olive Oil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000080462","descriptor_name":"Acyclic Monoterpenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/bab.2371","doi":"https://doi.org/10.1002/bab.2371","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bab.2371","pdf_url":null,"source":{"id":"https://openalex.org/S34872747","display_name":"Biotechnology and Applied Biochemistry","issn_l":"0885-4513","issn":["0885-4513","1470-8744"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology and Applied Biochemistry","raw_type":"journal-article"},{"id":"pmid:35748559","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35748559","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology and applied biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W223397789","https://openalex.org/W1534854079","https://openalex.org/W1775749144","https://openalex.org/W1791138468","https://openalex.org/W1918507985","https://openalex.org/W1966086522","https://openalex.org/W1976152197","https://openalex.org/W1978168480","https://openalex.org/W1982525676","https://openalex.org/W1983310681","https://openalex.org/W1997405268","https://openalex.org/W2000369852","https://openalex.org/W2002821702","https://openalex.org/W2021461388","https://openalex.org/W2026847938","https://openalex.org/W2029321905","https://openalex.org/W2031861429","https://openalex.org/W2072776570","https://openalex.org/W2076576023","https://openalex.org/W2076708571","https://openalex.org/W2085254524","https://openalex.org/W2132739516","https://openalex.org/W2164713906","https://openalex.org/W2165311122","https://openalex.org/W2394692111","https://openalex.org/W2397417098","https://openalex.org/W2414622870","https://openalex.org/W2479056383","https://openalex.org/W2493072109","https://openalex.org/W2513675909","https://openalex.org/W2538201653","https://openalex.org/W2562282801","https://openalex.org/W2745006122","https://openalex.org/W2783270031","https://openalex.org/W2884729409","https://openalex.org/W2893835498","https://openalex.org/W2902868331","https://openalex.org/W2905743309","https://openalex.org/W2938253416","https://openalex.org/W2966059605","https://openalex.org/W2968470226","https://openalex.org/W2972189281","https://openalex.org/W2986572076","https://openalex.org/W3022976730","https://openalex.org/W3152431780"],"related_works":["https://openalex.org/W3043318347","https://openalex.org/W2926292086","https://openalex.org/W2020109826","https://openalex.org/W4322741971","https://openalex.org/W7001883936","https://openalex.org/W2514434055","https://openalex.org/W2756422023","https://openalex.org/W3020254050","https://openalex.org/W2592745007","https://openalex.org/W3153326380"],"abstract_inverted_index":{"Abstract":[0],"The":[1,115,185],"current":[2,186],"study":[3,23],"explored":[4],"the":[5,118,124,132,135,162,177],"hepatoprotective":[6],"and":[7,37,64,97,129,131,210],"immunomodulatory":[8],"effects":[9],"of":[10,45,55,104,117,134,172,204],"Linalool":[11],"(Lin)":[12],"against":[13,213],"carbon":[14],"tetrachloride":[15],"(CCl":[16,166],"4":[17,47,57,101,106,167,194],")\u2010induced":[18],"toxicity":[19,40,163],"in":[20,58,107,148,161,198],"mice.":[21],"Four":[22],"groups":[24,67,179],"(":[25],"n":[26],"=":[27],"8":[28],"each)":[29],"were":[30,70,137,145,155],"used:":[31],"(1)":[32],"a":[33,39,158,207],"negative":[34],"control":[35,41],"group":[36,42,165],"(2)":[38],"(single":[43],"dose":[44],"CCl":[46,100,193],"administered":[48],"on":[49,112],"day":[50,113],"14":[51,95],"as":[52,206],"1":[53],"mL/kg":[54,103],"CCL":[56,105],"1%":[59,108],"olive":[60,109],"oil).":[61],"Intraperitoneally":[62],"(i.p.)),":[63],"two":[65],"experimental":[66],"where":[68],"mice":[69],"treated":[71],"with":[72,87,99],"either":[73],"(3)":[74],"Lin":[75,88,190,205],"(25":[76,89],"mg/kg":[77,90],"b.w.,":[78,91],"orally,":[79,92],"daily":[80,93],"for":[81,94],"15":[82],"days)":[83,96],"or":[84],"(4)":[85],"pretreated":[86],"intoxicated":[98],"(1":[102],"oil.":[110],"i.p.)":[111],"14.":[114],"levels":[116,154],"anti\u2010inflammatory":[119],"cytokine":[120,153],"interleukin":[121],"10":[122],"(IL\u201010),":[123],"proinflammatory":[125],"cytokines":[126],"TNF\u2010\u03b1,":[127],"IL\u20106,":[128],"TGF\u20101\u03b2,":[130],"histopathology":[133],"liver":[136,173,196],"assessed.":[138],"According":[139],"to":[140],"our":[141],"findings,":[142],"IL\u201010":[143],"concentrations":[144],"significantly":[146],"increased":[147],"Lin\u2010treated":[149,178],"groups,":[150],"while":[151],"other":[152],"marked":[156],"by":[157],"considerable":[159],"decrease":[160],"model":[164],"\u2010treated":[168],"group).":[169],"Histopathological":[170],"examinations":[171],"tissues":[174],"showed":[175,188],"that":[176,189],"had":[180],"an":[181],"almost":[182],"normal":[183],"structure.":[184],"findings":[187],"could":[191],"inhibit":[192],"\u2010induced":[195],"injury":[197],"mice,":[199],"which":[200],"warrants":[201],"further":[202],"investigation":[203],"potential":[208],"protective":[209],"therapeutic":[211],"agent":[212],"hepatotoxicity.":[214]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-06-25T00:00:00"}
