{"id":"https://openalex.org/W4283370104","doi":"https://doi.org/10.1080/01676830.2022.2090014","title":"Bilateral enlargement of all extraocular muscles: a presenting ophthalmic sign of hematologic malignancy","display_name":"Bilateral enlargement of all extraocular muscles: a presenting ophthalmic sign of hematologic malignancy","publication_year":2022,"publication_date":"2022-06-22","ids":{"openalex":"https://openalex.org/W4283370104","doi":"https://doi.org/10.1080/01676830.2022.2090014","pmid":"https://pubmed.ncbi.nlm.nih.gov/35734822"},"language":"en","primary_location":{"id":"doi:10.1080/01676830.2022.2090014","doi":"https://doi.org/10.1080/01676830.2022.2090014","is_oa":false,"landing_page_url":"https://doi.org/10.1080/01676830.2022.2090014","pdf_url":null,"source":{"id":"https://openalex.org/S112377731","display_name":"Orbit","issn_l":"0167-6830","issn":["0167-6830","1744-5108"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Orbit","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002231683","display_name":"Makayla M. McCoskey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Makayla McCoskey","raw_affiliation_strings":["Ophthalmic Plastic Surgery Service, Department of Ophthalmology, Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmic Plastic Surgery Service, Department of Ophthalmology, Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028426879","display_name":"Edith R. Reshef","orcid":"https://orcid.org/0000-0001-8282-5409","observed_orcids":["https://orcid.org/0000-0001-8282-5409"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edith R. Reshef","raw_affiliation_strings":["Ophthalmic Plastic Surgery Service, Department of Ophthalmology, Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":"https://orcid.org/0000-0001-8282-5409","affiliations":[{"raw_affiliation_string":"Ophthalmic Plastic Surgery Service, Department of Ophthalmology, Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039279616","display_name":"Natalie Wolkow","orcid":"https://orcid.org/0000-0003-1524-115X","observed_orcids":["https://orcid.org/0000-0003-1524-115X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natalie Wolkow","raw_affiliation_strings":["Cogan Laboratory of Ophthalmic Pathology, Department of Ophthalmology, Eye and Ear, Harvard Medical SchoolDavid G. , Boston, Massachusetts, USA","Ophthalmic Plastic Surgery Service, Department of Ophthalmology, Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cogan Laboratory of Ophthalmic Pathology, Department of Ophthalmology, Eye and Ear, Harvard Medical SchoolDavid G. , Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Ophthalmic Plastic Surgery Service, Department of Ophthalmology, Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090407540","display_name":"Michael K. Yoon","orcid":"https://orcid.org/0000-0002-8793-7685","observed_orcids":["https://orcid.org/0000-0002-8793-7685"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael K. Yoon","raw_affiliation_strings":["Ophthalmic Plastic Surgery Service, Department of Ophthalmology, Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmic Plastic Surgery Service, Department of Ophthalmology, Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5090407540"],"corresponding_institution_ids":["https://openalex.org/I136199984"],"apc_list":null,"apc_paid":null,"fwci":0.4494,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.55550838,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":95},"biblio":{"volume":"43","issue":"1","first_page":"160","last_page":"163"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11328","display_name":"Ocular Oncology and Treatments","score":0.9531000256538391,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11328","display_name":"Ocular Oncology and Treatments","score":0.9531000256538391,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11538","display_name":"Ophthalmology and Eye Disorders","score":0.030300000682473183,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extraocular-muscle-enlargement","display_name":"extraocular muscle enlargement","score":0.9589999914169312},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.921999990940094},{"id":"https://openalex.org/keywords/leukemia","display_name":"leukemia","score":0.9210000038146973},{"id":"https://openalex.org/keywords/lymphoma","display_name":"lymphoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/compressive-optic-neuropathy","display_name":"compressive optic neuropathy","score":0.9390000104904175},{"id":"https://openalex.org/keywords/orbital-involvement","display_name":"orbital involvement","score":0.7699999809265137},{"id":"https://openalex.org/keywords/differential-diagnosis","display_name":"differential diagnosis","score":0.7480000257492065},{"id":"https://openalex.org/keywords/targeted-chemotherapy","display_name":"targeted chemotherapy","score":0.6690000295639038}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9550851583480835},{"id":"https://openalex.org/C2776807875","wikidata":"https://www.wikidata.org/wiki/Q533979","display_name":"Extraocular muscles","level":2,"score":0.9197515845298767},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.7543513178825378},{"id":"https://openalex.org/C2909984355","wikidata":"https://www.wikidata.org/wiki/Q2509220","display_name":"Hematologic malignancy","level":2,"score":0.7077117562294006},{"id":"https://openalex.org/C196644772","wikidata":"https://www.wikidata.org/wiki/Q3884964","display_name":"Orbit (dynamics)","level":2,"score":0.5586813688278198},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.5190070867538452},{"id":"https://openalex.org/C2780571819","wikidata":"https://www.wikidata.org/wiki/Q1963588","display_name":"Hematologic disease","level":3,"score":0.4934495985507965},{"id":"https://openalex.org/C2780801072","wikidata":"https://www.wikidata.org/wiki/Q837512","display_name":"Differential diagnosis","level":2,"score":0.4639522433280945},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3438050150871277},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3133161664009094},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.22474560141563416},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.198381245136261},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12922608852386475},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C146978453","wikidata":"https://www.wikidata.org/wiki/Q3798668","display_name":"Aerospace engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005123","descriptor_name":"Eye","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005123","descriptor_name":"Eye","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005123","descriptor_name":"Eye","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009801","descriptor_name":"Oculomotor Muscles","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D009801","descriptor_name":"Oculomotor Muscles","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D009801","descriptor_name":"Oculomotor Muscles","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D009801","descriptor_name":"Oculomotor Muscles","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009801","descriptor_name":"Oculomotor Muscles","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009801","descriptor_name":"Oculomotor Muscles","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009901","descriptor_name":"Optic Nerve Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D009901","descriptor_name":"Optic Nerve Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D009901","descriptor_name":"Optic Nerve Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D009915","descriptor_name":"Orbit","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009915","descriptor_name":"Orbit","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009915","descriptor_name":"Orbit","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1080/01676830.2022.2090014","doi":"https://doi.org/10.1080/01676830.2022.2090014","is_oa":false,"landing_page_url":"https://doi.org/10.1080/01676830.2022.2090014","pdf_url":null,"source":{"id":"https://openalex.org/S112377731","display_name":"Orbit","issn_l":"0167-6830","issn":["0167-6830","1744-5108"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Orbit","raw_type":"journal-article"},{"id":"pmid:35734822","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35734822","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Orbit (Amsterdam, Netherlands)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8199999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W2004817580","https://openalex.org/W2007481688","https://openalex.org/W2012748273","https://openalex.org/W2042579103","https://openalex.org/W2103388828","https://openalex.org/W2107868192","https://openalex.org/W2111079263","https://openalex.org/W2153452426","https://openalex.org/W2300064049","https://openalex.org/W2333296737","https://openalex.org/W2604605333","https://openalex.org/W2943345423","https://openalex.org/W2978843623","https://openalex.org/W2988883136","https://openalex.org/W2992525541","https://openalex.org/W3088082843","https://openalex.org/W3118826568","https://openalex.org/W4211242613"],"related_works":["https://openalex.org/W2153452426","https://openalex.org/W2967245078","https://openalex.org/W2604605333","https://openalex.org/W4200112388","https://openalex.org/W1970762682","https://openalex.org/W1522767479","https://openalex.org/W2992525541","https://openalex.org/W2092906104","https://openalex.org/W2515103110","https://openalex.org/W2559739741"],"abstract_inverted_index":{"Hematologic":[0],"malignancies":[1],"such":[2],"as":[3],"leukemia":[4],"and":[5,36,46,51],"lymphoma":[6],"can":[7],"frequently":[8],"present":[9],"in":[10,71],"the":[11,16,65,72],"orbit;":[12],"however,":[13],"involvement":[14],"of":[15,26,49,54,59,67,75],"extraocular":[17,33,78],"muscles":[18],"is":[19],"rare.":[20],"The":[21],"authors":[22],"report":[23],"two":[24],"cases":[25,63],"systemic":[27,52],"hematologic":[28,69],"malignancy":[29,70],"presenting":[30],"with":[31,56],"bilateral":[32,77],"muscle":[34,79],"enlargement":[35],"associated":[37],"compressive":[38],"optic":[39],"neuropathy":[40],"(CON).":[41],"Both":[42],"patients":[43],"experienced":[44],"clinical":[45],"radiographic":[47],"improvement":[48],"ocular":[50],"manifestations":[53],"disease":[55],"prompt":[57],"initiation":[58],"targeted":[60],"chemotherapy.":[61],"These":[62],"highlight":[64],"importance":[66],"including":[68],"differential":[73],"diagnosis":[74],"atypical":[76],"enlargement.":[80]},"counts_by_year":[{"year":2023,"cited_by_count":2}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2022-06-25T00:00:00"}