{"id":"https://openalex.org/W4283368576","doi":"https://doi.org/10.1021/acs.accounts.2c00216","title":"Native Mass Spectrometry at the Convergence of Structural Biology and Compositional Proteomics","display_name":"Native Mass Spectrometry at the Convergence of Structural Biology and Compositional Proteomics","publication_year":2022,"publication_date":"2022-06-24","ids":{"openalex":"https://openalex.org/W4283368576","doi":"https://doi.org/10.1021/acs.accounts.2c00216","pmid":"https://pubmed.ncbi.nlm.nih.gov/35749283","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9296611"},"language":"en","primary_location":{"id":"doi:10.1021/acs.accounts.2c00216","doi":"https://doi.org/10.1021/acs.accounts.2c00216","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.accounts.2c00216","pdf_url":null,"source":{"id":"https://openalex.org/S145378405","display_name":"Accounts of Chemical Research","issn_l":"0001-4842","issn":["0001-4842","1520-4898"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Accounts of Chemical Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9296611","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053251511","display_name":"Kevin Joo\u00df","orcid":"https://orcid.org/0000-0003-1669-7837","observed_orcids":["https://orcid.org/0000-0003-1669-7837"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4405271717","display_name":"Chemistry of Life Processes Institute","ror":"https://ror.org/02x58fh78","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405271717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin Joo\u00df","raw_affiliation_strings":["Departments of Chemistry and Molecular Biosciences, the Chemistry of Life Processes Institute, and the Proteomics Center of Excellence, Northwestern University, Evanston, Illinois 60208, United States"],"raw_orcid":"https://orcid.org/0000-0003-1669-7837","affiliations":[{"raw_affiliation_string":"Departments of Chemistry and Molecular Biosciences, the Chemistry of Life Processes Institute, and the Proteomics Center of Excellence, Northwestern University, Evanston, Illinois 60208, United States","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4405271717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022622245","display_name":"John P. McGee","orcid":"https://orcid.org/0000-0002-0527-8904","observed_orcids":["https://orcid.org/0000-0002-0527-8904"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4405271717","display_name":"Chemistry of Life Processes Institute","ror":"https://ror.org/02x58fh78","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405271717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John P. McGee","raw_affiliation_strings":["Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois 60208, United States","Departments of Chemistry and Molecular Biosciences, the Chemistry of Life Processes Institute, and the Proteomics Center of Excellence, Northwestern University, Evanston, Illinois 60208, United States"],"raw_orcid":"https://orcid.org/0000-0002-0527-8904","affiliations":[{"raw_affiliation_string":"Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois 60208, United States","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Departments of Chemistry and Molecular Biosciences, the Chemistry of Life Processes Institute, and the Proteomics Center of Excellence, Northwestern University, Evanston, Illinois 60208, United States","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4405271717"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076257201","display_name":"Neil L. Kelleher","orcid":"https://orcid.org/0000-0002-8815-3372","observed_orcids":["https://orcid.org/0000-0002-8815-3372"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4405271717","display_name":"Chemistry of Life Processes Institute","ror":"https://ror.org/02x58fh78","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405271717"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Neil L. Kelleher","raw_affiliation_strings":["Departments of Chemistry and Molecular Biosciences, the Chemistry of Life Processes Institute, and the Proteomics Center of Excellence, Northwestern University, Evanston, Illinois 60208, United States"],"raw_orcid":"https://orcid.org/0000-0002-8815-3372","affiliations":[{"raw_affiliation_string":"Departments of Chemistry and Molecular Biosciences, the Chemistry of Life Processes Institute, and the Proteomics Center of Excellence, Northwestern University, Evanston, Illinois 60208, United States","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4405271717"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5076257201"],"corresponding_institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4405271717"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":1.6247,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.82767826,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"55","issue":"14","first_page":"1928","last_page":"1937"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.8784000277519226,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.8784000277519226,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.12060000002384186,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/native-mass-spectrometry","display_name":"native mass spectrometry","score":0.996999979019165},{"id":"https://openalex.org/keywords/native-top-down-mass-spectrometry","display_name":"native top-down mass spectrometry","score":0.9190000295639038},{"id":"https://openalex.org/keywords/protein-complexes","display_name":"protein complexes","score":0.8510000109672546},{"id":"https://openalex.org/keywords/noncovalent-interactions","display_name":"non-covalent interactions","score":0.7549999952316284},{"id":"https://openalex.org/keywords/protein-modification","display_name":"protein modification","score":0.4230000078678131},{"id":"https://openalex.org/keywords/nucleosome","display_name":"nucleosome","score":0.6769999861717224},{"id":"https://openalex.org/keywords/virus-particles","display_name":"virus particles","score":0.9509999752044678},{"id":"https://openalex.org/keywords/exosomes","display_name":"exosomes","score":0.996999979019165},{"id":"https://openalex.org/keywords/high-density-lipoprotein","display_name":"high-density lipoprotein","score":0.9079999923706055},{"id":"https://openalex.org/keywords/structural-biology","display_name":"structural biology","score":0.5680000185966492},{"id":"https://openalex.org/keywords/proteoforms","display_name":"proteoforms","score":0.7459999918937683},{"id":"https://openalex.org/keywords/protein-misfolding","display_name":"protein misfolding","score":0.628000020980835}],"concepts":[{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.725139319896698},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.701232373714447},{"id":"https://openalex.org/C2777303404","wikidata":"https://www.wikidata.org/wiki/Q759757","display_name":"Convergence (economics)","level":2,"score":0.5362192392349243},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5066131353378296},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4515487551689148},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.2814563512802124},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19362875819206238},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14413365721702576},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C50522688","wikidata":"https://www.wikidata.org/wiki/Q189833","display_name":"Economic growth","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007477","descriptor_name":"Ions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1021/acs.accounts.2c00216","doi":"https://doi.org/10.1021/acs.accounts.2c00216","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.accounts.2c00216","pdf_url":null,"source":{"id":"https://openalex.org/S145378405","display_name":"Accounts of Chemical Research","issn_l":"0001-4842","issn":["0001-4842","1520-4898"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Accounts of Chemical Research","raw_type":"journal-article"},{"id":"pmid:35749283","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35749283","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Accounts of chemical research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9296611","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9296611","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Acc Chem Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9296611","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9296611","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Acc Chem Res","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1331468899","display_name":"Alzheimer's Disease Characterization via a Novel Native Mass Spectrometry Platform","funder_award_id":"F31AG069456","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G27085544","display_name":"National Resource for Translational and Developmental Proteomics","funder_award_id":"P41GM108569","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W1568341953","https://openalex.org/W1979187818","https://openalex.org/W1982076968","https://openalex.org/W1993726835","https://openalex.org/W2002508442","https://openalex.org/W2008876483","https://openalex.org/W2017926405","https://openalex.org/W2031929695","https://openalex.org/W2048382073","https://openalex.org/W2070948666","https://openalex.org/W2077247149","https://openalex.org/W2081433287","https://openalex.org/W2088091102","https://openalex.org/W2127071500","https://openalex.org/W2143658931","https://openalex.org/W2144792857","https://openalex.org/W2146345525","https://openalex.org/W2280412535","https://openalex.org/W2289676395","https://openalex.org/W2302819319","https://openalex.org/W2338850909","https://openalex.org/W2408391104","https://openalex.org/W2439361170","https://openalex.org/W2471121098","https://openalex.org/W2497675190","https://openalex.org/W2625241052","https://openalex.org/W2727482182","https://openalex.org/W2739174192","https://openalex.org/W2745586739","https://openalex.org/W2752396658","https://openalex.org/W2768727863","https://openalex.org/W2781755425","https://openalex.org/W2790214985","https://openalex.org/W2796068395","https://openalex.org/W2809702123","https://openalex.org/W2885135849","https://openalex.org/W2896816499","https://openalex.org/W2901712030","https://openalex.org/W2902511468","https://openalex.org/W2908399125","https://openalex.org/W2911350956","https://openalex.org/W2951999277","https://openalex.org/W2955168413","https://openalex.org/W2966585592","https://openalex.org/W3009899209","https://openalex.org/W3009934971","https://openalex.org/W3036168133","https://openalex.org/W3093646295","https://openalex.org/W3094051077","https://openalex.org/W3095622276","https://openalex.org/W3096559291","https://openalex.org/W3110774789","https://openalex.org/W3124741226","https://openalex.org/W3131730330","https://openalex.org/W3134020177","https://openalex.org/W3137239993","https://openalex.org/W3157357317","https://openalex.org/W3163911339","https://openalex.org/W3185739792","https://openalex.org/W3197580402","https://openalex.org/W3197934364","https://openalex.org/W4200078867","https://openalex.org/W4224943430"],"related_works":["https://openalex.org/W3021745504","https://openalex.org/W2121501020","https://openalex.org/W2768727863","https://openalex.org/W4322617283","https://openalex.org/W4386433854","https://openalex.org/W2111527039","https://openalex.org/W2767547055","https://openalex.org/W1571818877","https://openalex.org/W4283657210","https://openalex.org/W3151293110"],"abstract_inverted_index":{"Biology":[0],"is":[1,49],"driven":[2],"by":[3],"a":[4,26,104,315],"vast":[5],"set":[6],"of":[7,14,43,46,62,93,101,114,147,161,177,201,218,222,276,295,309,318,340,362,370],"molecular":[8,159,374],"interactions":[9,33,69,176,339],"that":[10,66],"evolved":[11,82],"over":[12],"billions":[13],"years.":[15,265],"Just":[16],"as":[17,55,241],"covalent":[18],"modifications":[19],"like":[20],"acetylations":[21],"and":[22,38,70,87,126,143,184,198,233,254,274,289,322,332,342,354],"phosphorylations":[23],"can":[24,31,106,151,244],"change":[25],"protein's":[27],"function,":[28],"so":[29],"too":[30],"noncovalent":[32,68],"with":[34,120,236],"metals,":[35],"small":[36],"molecules,":[37],"other":[39],"proteins.":[40],"However,":[41],"much":[42],"the":[44,60,74,83,90,139,144,148,157,162,175,196,202,207,209,219,262,272,307,337,360,373],"language":[45],"protein-level":[47],"biology":[48],"left":[50],"either":[51],"undiscovered":[52],"or":[53,112,123,134],"inferred,":[54],"traditional":[56],"methods":[57],"used":[58,153],"in":[59,73,169,188,261,297,311,351],"field":[61,210],"proteomics":[63,224],"use":[64,294],"conditions":[65],"dissociate":[67],"denature":[71],"proteins.Just":[72],"past":[75],"few":[76,264],"years,":[77],"mass":[78,102,231,287],"spectrometry":[79],"(MS)":[80],"has":[81],"capacity":[84],"to":[85,109,154,186,212,269,278,305,328],"preserve":[86],"subsequently":[88],"characterize":[89,213],"complete":[91],"composition":[92,160],"endogenous":[94,242],"protein":[95,179],"complexes.":[96],"Using":[97],"this":[98,192],"\"native\"":[99],"type":[100],"spectrometry,":[103,232,288],"complex":[105],"be":[107,152,182,245,259],"activated":[108,149],"liberate":[110],"some":[111],"all":[113],"its":[115],"subunits,":[116],"typically":[117],"via":[118],"collisions":[119],"neutral":[121],"gas":[122],"solid":[124],"surfaces":[125],"isolated":[127],"before":[128],"further":[129],"characterization":[130],"(\"Native":[131],"Top-Down":[132],"MS,\"":[133],"nTDMS).":[135],"The":[136,266,293],"subunit":[137],"mass,":[138,142],"parent":[140,163],"ion":[141,286],"fragment":[145],"ions":[146],"subunits":[150],"piece":[155],"together":[156],"precise":[158],"complex.":[164],"When":[165],"performed":[166],"en":[167],"masse":[168],"discovery":[170,298,323],"mode":[171,299,324],"(i.e.,":[172],"\"native":[173],"proteomics\"),":[174],"life\u2500including":[178],"modifications\u2500will":[180],"eventually":[181],"clarified":[183],"linked":[185],"dysfunction":[187],"human":[189],"disease":[190],"states.In":[191],"Account,":[193],"we":[194],"describe":[195],"current":[197],"future":[199,267],"components":[200],"native":[203,223,283],"MS":[204],"toolkit,":[205],"covering":[206],"challenges":[208],"faces":[211],"ever":[214],"larger":[215],"bioassemblies.":[216,335],"Each":[217],"three":[220],"pillars":[221],"are":[225],"addressed:":[226],"(i)":[227],"separations,":[228,284],"(ii)":[229],"top-down":[230],"(iii)":[234],"integration":[235],"structural":[237],"biology.":[238],"Complexes":[239],"such":[240],"nucleosomes":[243],"targeted":[246,321],"now":[247],"using":[248],"nTDMS,":[249],"whereas":[250],"virus":[251],"particles,":[252],"exosomes,":[253],"high-density":[255],"lipoprotein":[256],"particles":[257],"will":[258,281,300,326,356],"tackled":[260],"coming":[263],"work":[268],"adequately":[270],"address":[271],"size":[273],"complexity":[275],"mega-":[277],"gigadalton":[279],"complexes":[280,312,350],"include":[282,329],"single":[285],"new":[290,316],"data":[291],"types.":[292],"nTDMS":[296,325],"incorporate":[301],"native-compatible":[302],"separation":[303],"techniques":[304],"maximize":[306],"number":[308],"proteoforms":[310],"identified.":[313],"With":[314],"wave":[317],"innovations,":[319],"both":[320],"expand":[327],"extremely":[330],"scarce":[331],"exceedingly":[333],"heterogeneous":[334],"Understanding":[336],"proteinaceous":[338],"life":[341,371],"how":[343],"they":[344],"go":[345],"wrong":[346],"(e.g.,":[347],"misfolding,":[348],"forming":[349],"dysfunctional":[352],"stoichiometries":[353],"configurations)":[355],"not":[357],"only":[358],"inform":[359],"development":[361],"life-restoring":[363],"therapeutics":[364],"but":[365],"also":[366],"deepen":[367],"our":[368],"understanding":[369],"at":[372],"level.":[375]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-06-25T00:00:00"}
