{"id":"https://openalex.org/W4283333340","doi":"https://doi.org/10.3390/ijms23136954","title":"Role of Impaired Mitochondrial Dynamics Processes in the Pathogenesis of Alzheimer\u2019s Disease","display_name":"Role of Impaired Mitochondrial Dynamics Processes in the Pathogenesis of Alzheimer\u2019s Disease","publication_year":2022,"publication_date":"2022-06-23","ids":{"openalex":"https://openalex.org/W4283333340","doi":"https://doi.org/10.3390/ijms23136954","pmid":"https://pubmed.ncbi.nlm.nih.gov/35805958","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9266759"},"language":"en","primary_location":{"id":"doi:10.3390/ijms23136954","doi":"https://doi.org/10.3390/ijms23136954","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms23136954","pdf_url":"https://www.mdpi.com/1422-0067/23/13/6954/pdf?version=1655958116","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/23/13/6954/pdf?version=1655958116","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087726347","display_name":"Alexander V. Blagov","orcid":"https://orcid.org/0000-0003-1372-9477","observed_orcids":["https://orcid.org/0000-0003-1372-9477"]},"institutions":[{"id":"https://openalex.org/I4210131054","display_name":"Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences","ror":"https://ror.org/03jmc9t23","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210131054"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Alexander V. Blagov","raw_affiliation_strings":["Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, 8 Baltiiskaya Street, 125315 Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, 8 Baltiiskaya Street, 125315 Moscow, Russia","institution_ids":["https://openalex.org/I4210131054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039991073","display_name":"Andrey V. Grechko","orcid":"https://orcid.org/0000-0003-3318-796X","observed_orcids":["https://orcid.org/0000-0003-3318-796X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrey V. Grechko","raw_affiliation_strings":["Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, 14-3 Solyanka Street, 109240 Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, 14-3 Solyanka Street, 109240 Moscow, Russia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060595668","display_name":"Nikita Gennadievich Nikiforov","orcid":"https://orcid.org/0000-0002-2082-2429","observed_orcids":["https://orcid.org/0000-0002-2082-2429"]},"institutions":[{"id":"https://openalex.org/I4210131054","display_name":"Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences","ror":"https://ror.org/03jmc9t23","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210131054"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Nikita G. Nikiforov","raw_affiliation_strings":["Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, 8 Baltiiskaya Street, 125315 Moscow, Russia"],"raw_orcid":"https://orcid.org/0000-0002-2082-2429","affiliations":[{"raw_affiliation_string":"Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, 8 Baltiiskaya Street, 125315 Moscow, Russia","institution_ids":["https://openalex.org/I4210131054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045664804","display_name":"Evgeny E. Borisov","orcid":"https://orcid.org/0000-0002-2581-3601","observed_orcids":["https://orcid.org/0000-0002-2581-3601"]},"institutions":[{"id":"https://openalex.org/I4210145101","display_name":"Research Institute of Human Morphology","ror":"https://ror.org/042k8ng80","country_code":"RU","type":"nonprofit","lineage":["https://openalex.org/I4210145101"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Evgeny E. Borisov","raw_affiliation_strings":["Petrovsky National Research Centre of Surgery, AP Avtsyn Institute of Human Morphology, 117418 Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Petrovsky National Research Centre of Surgery, AP Avtsyn Institute of Human Morphology, 117418 Moscow, Russia","institution_ids":["https://openalex.org/I4210145101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019319211","display_name":"Nikolay K. Sadykhov","orcid":"https://orcid.org/0000-0002-3800-1506","observed_orcids":["https://orcid.org/0000-0002-3800-1506"]},"institutions":[{"id":"https://openalex.org/I4210131054","display_name":"Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences","ror":"https://ror.org/03jmc9t23","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210131054"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Nikolay K. Sadykhov","raw_affiliation_strings":["Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, 8 Baltiiskaya Street, 125315 Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, 8 Baltiiskaya Street, 125315 Moscow, Russia","institution_ids":["https://openalex.org/I4210131054"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105411377","display_name":"Alexander Nikolaevich Orekhov","orcid":"https://orcid.org/0000-0002-3318-4681","observed_orcids":["https://orcid.org/0000-0002-3318-4681"]},"institutions":[{"id":"https://openalex.org/I4210131054","display_name":"Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences","ror":"https://ror.org/03jmc9t23","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210131054"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Alexander N. Orekhov","raw_affiliation_strings":["Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, 8 Baltiiskaya Street, 125315 Moscow, Russia"],"raw_orcid":"https://orcid.org/0000-0002-3318-4681","affiliations":[{"raw_affiliation_string":"Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, 8 Baltiiskaya Street, 125315 Moscow, Russia","institution_ids":["https://openalex.org/I4210131054"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5087726347","https://openalex.org/A5105411377"],"corresponding_institution_ids":["https://openalex.org/I4210131054"],"apc_list":{"value":2300,"currency":"CHF","value_usd":2408},"apc_paid":{"value":2300,"currency":"CHF","value_usd":2408},"fwci":1.4367,"has_fulltext":true,"cited_by_count":71,"citation_normalized_percentile":{"value":0.83910373,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"23","issue":"13","first_page":"6954","last_page":"6954"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.017799999564886093,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9419999718666077},{"id":"https://openalex.org/keywords/mitochondrial-dynamics","display_name":"mitochondrial dynamics","score":0.9959999918937683},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.9819999933242798},{"id":"https://openalex.org/keywords/mitochondrial-fission","display_name":"mitochondrial fission","score":0.7049999833106995},{"id":"https://openalex.org/keywords/mitochondrial-fusion","display_name":"mitochondrial fusion","score":0.9459999799728394},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.8730000257492065},{"id":"https://openalex.org/keywords/energy-homeostasis","display_name":"energy homeostasis","score":0.6570000052452087},{"id":"https://openalex.org/keywords/neurons","display_name":"neurons","score":0.460999995470047},{"id":"https://openalex.org/keywords/treatment-strategy","display_name":"treatment options","score":0.7829999923706055}],"concepts":[{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.7544035911560059},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5741865634918213},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5680868625640869},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5590751767158508},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5564913749694824},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5425710082054138},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.49648457765579224},{"id":"https://openalex.org/C168240541","wikidata":"https://www.wikidata.org/wiki/Q45948","display_name":"Organelle","level":2,"score":0.4787989556789398},{"id":"https://openalex.org/C163950672","wikidata":"https://www.wikidata.org/wiki/Q14905375","display_name":"mitochondrial fusion","level":4,"score":0.42338305711746216},{"id":"https://openalex.org/C2991704936","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Cell metabolism","level":3,"score":0.41490161418914795},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40785613656044006},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3317776322364807},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3196713924407959},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24319633841514587},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.20496860146522522},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13405835628509521},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.13074874877929688},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.12246590852737427},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08990108966827393}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D063154","descriptor_name":"Mitochondrial Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3390/ijms23136954","doi":"https://doi.org/10.3390/ijms23136954","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms23136954","pdf_url":"https://www.mdpi.com/1422-0067/23/13/6954/pdf?version=1655958116","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmid:35805958","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35805958","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9266759","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9266759/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:bb843a2b4a8246bdb14cf516a42271dc","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/bb843a2b4a8246bdb14cf516a42271dc","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 23, Iss 6954, p 6954 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ijms23136954","doi":"https://doi.org/10.3390/ijms23136954","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms23136954","pdf_url":"https://www.mdpi.com/1422-0067/23/13/6954/pdf?version=1655958116","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G335483612","display_name":null,"funder_award_id":"22-15-00273-\u041f","funder_id":"https://openalex.org/F4320324099","funder_display_name":"Russian Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320324099","display_name":"Russian Science Foundation","ror":"https://ror.org/03y2gwe85"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4283333340.pdf","grobid_xml":"https://content.openalex.org/works/W4283333340.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W316875680","https://openalex.org/W1502452094","https://openalex.org/W1897859562","https://openalex.org/W1946564394","https://openalex.org/W1972390896","https://openalex.org/W1974450506","https://openalex.org/W1982908434","https://openalex.org/W1984510450","https://openalex.org/W1984652813","https://openalex.org/W1984866299","https://openalex.org/W1987459699","https://openalex.org/W1992264711","https://openalex.org/W1995588572","https://openalex.org/W2009053617","https://openalex.org/W2010720463","https://openalex.org/W2017021169","https://openalex.org/W2018659142","https://openalex.org/W2035461748","https://openalex.org/W2055572268","https://openalex.org/W2075421841","https://openalex.org/W2077439322","https://openalex.org/W2077875978","https://openalex.org/W2087243986","https://openalex.org/W2089180401","https://openalex.org/W2093381644","https://openalex.org/W2138889414","https://openalex.org/W2146017165","https://openalex.org/W2157684072","https://openalex.org/W2164222787","https://openalex.org/W2168681379","https://openalex.org/W2268456576","https://openalex.org/W2272118410","https://openalex.org/W2277318350","https://openalex.org/W2344187877","https://openalex.org/W2396998791","https://openalex.org/W2419163642","https://openalex.org/W2471606802","https://openalex.org/W2496437652","https://openalex.org/W2536701740","https://openalex.org/W2550934658","https://openalex.org/W2553902009","https://openalex.org/W2564095879","https://openalex.org/W2573555074","https://openalex.org/W2577326796","https://openalex.org/W2743010525","https://openalex.org/W2747200758","https://openalex.org/W2782358406","https://openalex.org/W2790161245","https://openalex.org/W2791985271","https://openalex.org/W2800287140","https://openalex.org/W2804740558","https://openalex.org/W2806036204","https://openalex.org/W2884073029","https://openalex.org/W2885072940","https://openalex.org/W2885706121","https://openalex.org/W2899241243","https://openalex.org/W2924317848","https://openalex.org/W2937074474","https://openalex.org/W2941551392","https://openalex.org/W2952128048","https://openalex.org/W2955791765","https://openalex.org/W2958665365","https://openalex.org/W2963991899","https://openalex.org/W2965717703","https://openalex.org/W2973485359","https://openalex.org/W2995600606","https://openalex.org/W3012179806","https://openalex.org/W3015776834","https://openalex.org/W3028353037","https://openalex.org/W3097268735","https://openalex.org/W3143454653","https://openalex.org/W3158316719","https://openalex.org/W4280546587"],"related_works":["https://openalex.org/W2952128048","https://openalex.org/W2089940631","https://openalex.org/W2072329091","https://openalex.org/W2311380696","https://openalex.org/W1940759671","https://openalex.org/W2539401120","https://openalex.org/W4280542581","https://openalex.org/W2899568703","https://openalex.org/W2061527930","https://openalex.org/W2072595318"],"abstract_inverted_index":{"Mitochondrial":[0],"dysfunction":[1],"is":[2,48,72],"now":[3],"recognized":[4],"as":[5,86],"a":[6,21,103],"contributing":[7],"factor":[8],"to":[9,29,39,63,74,93,124,136],"neurodegenerative":[10],"diseases,":[11],"including":[12],"Alzheimer's":[13],"disease":[14],"(AD).":[15],"Mitochondria":[16],"are":[17],"signaling":[18],"organelles":[19],"with":[20],"variety":[22],"of":[23,32,44,54,61,98,109,115,127],"functions":[24],"ranging":[25],"from":[26],"energy":[27,35],"production":[28],"the":[30,52,59,69,96,107,125],"regulation":[31],"cellular":[33],"metabolism,":[34],"homeostasis,":[36],"and":[37,66,78,140],"response":[38],"stress.":[40],"The":[41],"successful":[42],"functioning":[43],"these":[45],"complex":[46],"processes":[47],"critically":[49],"dependent":[50],"on":[51],"accuracy":[53],"mitochondrial":[55,99,117,138],"dynamics,":[56],"which":[57,71],"includes":[58],"ability":[60],"mitochondria":[62],"change":[64],"shape":[65],"position":[67],"in":[68,82,106,119],"cell,":[70],"necessary":[73],"maintain":[75],"proper":[76],"function":[77,141],"quality":[79],"control,":[80],"especially":[81],"polarized":[83],"cells":[84],"such":[85],"neurons.":[87],"There":[88],"has":[89],"been":[90],"much":[91],"evidence":[92],"suggest":[94],"that":[95,121,142],"disruption":[97],"dynamics":[100,118,139],"may":[101,122,143],"play":[102],"critical":[104],"role":[105],"pathogenesis":[108],"AD.":[110],"This":[111],"review":[112],"highlights":[113],"aspects":[114],"altered":[116],"AD":[120],"contribute":[123],"etiology":[126],"this":[128],"debilitating":[129],"condition.":[130],"We":[131],"also":[132],"discuss":[133],"therapeutic":[134],"strategies":[135],"improve":[137],"provide":[144],"an":[145],"alternative":[146],"treatment":[147],"approach.":[148]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":6}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2022-06-24T00:00:00"}