{"id":"https://openalex.org/W4283325779","doi":"https://doi.org/10.3389/fimmu.2022.916277","title":"Antibodies to Citrullinated Protein Antigens, Rheumatoid Factor Isotypes and the Shared Epitope and the Near-Term Development of Clinically-Apparent Rheumatoid Arthritis","display_name":"Antibodies to Citrullinated Protein Antigens, Rheumatoid Factor Isotypes and the Shared Epitope and the Near-Term Development of Clinically-Apparent Rheumatoid Arthritis","publication_year":2022,"publication_date":"2022-06-22","ids":{"openalex":"https://openalex.org/W4283325779","doi":"https://doi.org/10.3389/fimmu.2022.916277","pmid":"https://pubmed.ncbi.nlm.nih.gov/35812446","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9265214"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2022.916277","doi":"https://doi.org/10.3389/fimmu.2022.916277","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2022.916277","pdf_url":null,"source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fimmu.2022.916277","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075206406","display_name":"Dylan T. Bergstedt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210164538","display_name":"St. Vincent's HealthCare","ror":"https://ror.org/05kre7h31","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210164538"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dylan T. Bergstedt","raw_affiliation_strings":["Department of Medicine, St. Joseph's Hospital, SCL Health, Denver, CO, United States","Division of Rheumatology, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, St. Joseph's Hospital, SCL Health, Denver, CO, United States","institution_ids":["https://openalex.org/I4210164538"]},{"raw_affiliation_string":"Division of Rheumatology, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, United States","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039434068","display_name":"Wyatt J. Tarter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I151808059","display_name":"Colorado School of Public Health","ror":"https://ror.org/005x9g035","country_code":"US","type":"education","lineage":["https://openalex.org/I151808059"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wyatt J. Tarter","raw_affiliation_strings":["Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado-Denver Anschutz Medical Campus, Aurora, CO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado-Denver Anschutz Medical Campus, Aurora, CO, United States","institution_ids":["https://openalex.org/I151808059","https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087940810","display_name":"Ryan Peterson","orcid":"https://orcid.org/0000-0002-4650-5798","observed_orcids":["https://orcid.org/0000-0002-4650-5798"]},"institutions":[{"id":"https://openalex.org/I151808059","display_name":"Colorado School of Public Health","ror":"https://ror.org/005x9g035","country_code":"US","type":"education","lineage":["https://openalex.org/I151808059"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan A. Peterson","raw_affiliation_strings":["Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado-Denver Anschutz Medical Campus, Aurora, CO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado-Denver Anschutz Medical Campus, Aurora, CO, United States","institution_ids":["https://openalex.org/I151808059","https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082706285","display_name":"Marie L. Feser","orcid":"https://orcid.org/0009-0003-0598-853X","observed_orcids":["https://orcid.org/0009-0003-0598-853X"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marie L. Feser","raw_affiliation_strings":["Division of Rheumatology, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, United States","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033677285","display_name":"Mark C. Parish","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark C. Parish","raw_affiliation_strings":["Division of Rheumatology, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, United States","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050777704","display_name":"Christopher C. Striebich","orcid":"https://orcid.org/0000-0003-2582-7752","observed_orcids":["https://orcid.org/0000-0003-2582-7752"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher C. Striebich","raw_affiliation_strings":["Division of Rheumatology, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, United States","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045733957","display_name":"Mary Kristen Demoruelle","orcid":"https://orcid.org/0000-0002-2563-5155","observed_orcids":["https://orcid.org/0000-0002-2563-5155"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Kristen Demoruelle","raw_affiliation_strings":["Division of Rheumatology, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, United States","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110699033","display_name":"LauraKay Moss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LauraKay Moss","raw_affiliation_strings":["Division of Rheumatology, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, United States","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071389566","display_name":"Elizabeth A. Bemis","orcid":"https://orcid.org/0000-0002-3556-3175","observed_orcids":["https://orcid.org/0000-0002-3556-3175"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth A. Bemis","raw_affiliation_strings":["Division of Rheumatology, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, United States","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011886992","display_name":"Jill M. Norris","orcid":"https://orcid.org/0000-0001-8674-2598","observed_orcids":["https://orcid.org/0000-0001-8674-2598"]},"institutions":[{"id":"https://openalex.org/I151808059","display_name":"Colorado School of Public Health","ror":"https://ror.org/005x9g035","country_code":"US","type":"education","lineage":["https://openalex.org/I151808059"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jill M. Norris","raw_affiliation_strings":["Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, United States","institution_ids":["https://openalex.org/I151808059","https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040063597","display_name":"Vernon Michael Holers","orcid":"https://orcid.org/0000-0002-5634-7746","observed_orcids":["https://orcid.org/0000-0002-5634-7746"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V. Michael Holers","raw_affiliation_strings":["Division of Rheumatology, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, United States","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063041987","display_name":"Jess D. Edison","orcid":"https://orcid.org/0000-0002-5260-0273","observed_orcids":["https://orcid.org/0000-0002-5260-0273"]},"institutions":[{"id":"https://openalex.org/I2800363604","display_name":"Walter Reed National Military Medical Center","ror":"https://ror.org/025cem651","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330347796","https://openalex.org/I2800250139","https://openalex.org/I2800363604","https://openalex.org/I2800386880"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jess D. Edison","raw_affiliation_strings":["Department of Medicine, Walter Reed National Military Medical Center, Bethesda, MD, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Walter Reed National Military Medical Center, Bethesda, MD, United States","institution_ids":["https://openalex.org/I2800363604"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049420631","display_name":"Geoffrey M. Thiele","orcid":"https://orcid.org/0000-0001-5688-8596","observed_orcids":["https://orcid.org/0000-0001-5688-8596"]},"institutions":[{"id":"https://openalex.org/I4210155874","display_name":"VA Nebraska Western Iowa Health Care System","ror":"https://ror.org/0594ske86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210117924","https://openalex.org/I4210155874"]},{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Geoffrey M. Thiele","raw_affiliation_strings":["University of Nebraska Medical Center and VA Nebraska-Western Iowa Health Care System, Omaha, NE, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nebraska Medical Center and VA Nebraska-Western Iowa Health Care System, Omaha, NE, United States","institution_ids":["https://openalex.org/I4210155874","https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086105954","display_name":"Ted R. Mikuls","orcid":"https://orcid.org/0000-0002-0897-2272","observed_orcids":["https://orcid.org/0000-0002-0897-2272"]},"institutions":[{"id":"https://openalex.org/I4210155874","display_name":"VA Nebraska Western Iowa Health Care System","ror":"https://ror.org/0594ske86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210117924","https://openalex.org/I4210155874"]},{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ted R. Mikuls","raw_affiliation_strings":["University of Nebraska Medical Center and VA Nebraska-Western Iowa Health Care System, Omaha, NE, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nebraska Medical Center and VA Nebraska-Western Iowa Health Care System, Omaha, NE, United States","institution_ids":["https://openalex.org/I4210155874","https://openalex.org/I59130452"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011051142","display_name":"Kevin D. Deane","orcid":"https://orcid.org/0000-0003-2211-4861","observed_orcids":["https://orcid.org/0000-0003-2211-4861"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kevin D. Deane","raw_affiliation_strings":["Division of Rheumatology, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, United States","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5011051142"],"corresponding_institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":2.0423,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.86978565,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"13","issue":null,"first_page":"916277","last_page":"916277"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/anti-citrullinated-protein-antibodies","display_name":"anti-citrullinated protein antibodies","score":0.8479999899864197},{"id":"https://openalex.org/keywords/rheumatoid-factor-isotypes","display_name":"rheumatoid factor isotypes","score":0.9269999861717224},{"id":"https://openalex.org/keywords/shared-epitope","display_name":"shared epitope","score":0.7889999747276306},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.7889999747276306},{"id":"https://openalex.org/keywords/time-to-diagnosis","display_name":"time to diagnosis","score":0.796999990940094},{"id":"https://openalex.org/keywords/igm-rheumatoid-factor","display_name":"IgM rheumatoid factor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.5659999847412109},{"id":"https://openalex.org/keywords/rheumatoid-arthritis-prevention","display_name":"rheumatoid arthritis prevention","score":0.8999999761581421},{"id":"https://openalex.org/keywords/surrogate-endpoints","display_name":"surrogate endpoints","score":0.42899999022483826}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9010969996452332},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.7584789991378784},{"id":"https://openalex.org/C2776232647","wikidata":"https://www.wikidata.org/wiki/Q702883","display_name":"Rheumatoid factor","level":3,"score":0.738144040107727},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.7111712098121643},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.6043165922164917},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5930017232894897},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5409653186798096},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5306816101074219},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.475988507270813},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.46332094073295593},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.4316890239715576},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.4284655451774597}],"mesh":[{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007070","descriptor_name":"Immunoglobulin A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007075","descriptor_name":"Immunoglobulin M","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007132","descriptor_name":"Immunoglobulin Isotypes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012217","descriptor_name":"Rheumatoid Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3389/fimmu.2022.916277","doi":"https://doi.org/10.3389/fimmu.2022.916277","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2022.916277","pdf_url":null,"source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9265214","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9265214","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:35812446","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35812446","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:c55d5c1e5a054515822d35369da9f6ce","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c55d5c1e5a054515822d35369da9f6ce","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 13 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2022.916277","doi":"https://doi.org/10.3389/fimmu.2022.916277","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2022.916277","pdf_url":null,"source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G3422739702","display_name":null,"funder_award_id":"PR191079","funder_id":"https://openalex.org/F4320338273","funder_display_name":"Congressionally Directed Medical Research Programs"},{"id":"https://openalex.org/G6287115172","display_name":null,"funder_award_id":"PR191079","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G9000904705","display_name":"Center for Mucosal Immunobiology and Rheumatic Disease Pathogenesis","funder_award_id":"P30AR079369","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"},{"id":"https://openalex.org/F4320338273","display_name":"Congressionally Directed Medical Research Programs","ror":"https://ror.org/03g2zjp07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1554023045","https://openalex.org/W1863128385","https://openalex.org/W2023976647","https://openalex.org/W2024988150","https://openalex.org/W2031073334","https://openalex.org/W2032221360","https://openalex.org/W2042454450","https://openalex.org/W2082473356","https://openalex.org/W2098900658","https://openalex.org/W2103991421","https://openalex.org/W2107005433","https://openalex.org/W2110065044","https://openalex.org/W2117388542","https://openalex.org/W2122176733","https://openalex.org/W2128619333","https://openalex.org/W2128952811","https://openalex.org/W2151283377","https://openalex.org/W2152348310","https://openalex.org/W2157494519","https://openalex.org/W2529712876","https://openalex.org/W2610107585","https://openalex.org/W2754576320","https://openalex.org/W2793290320","https://openalex.org/W2804088990","https://openalex.org/W2886363262","https://openalex.org/W2889654109","https://openalex.org/W2899116898","https://openalex.org/W2903122430","https://openalex.org/W2905731063","https://openalex.org/W2921430480","https://openalex.org/W2958436323","https://openalex.org/W2970697665","https://openalex.org/W3007202353","https://openalex.org/W3009593236","https://openalex.org/W3036872165","https://openalex.org/W3038232344","https://openalex.org/W3039396378","https://openalex.org/W3085698963","https://openalex.org/W3133867686","https://openalex.org/W3186576597","https://openalex.org/W3202929180","https://openalex.org/W4206196919"],"related_works":["https://openalex.org/W2024988150","https://openalex.org/W2151521102","https://openalex.org/W2804088990","https://openalex.org/W2254127261","https://openalex.org/W2124313950","https://openalex.org/W7098319355","https://openalex.org/W3118518356","https://openalex.org/W2127818570","https://openalex.org/W2053622847","https://openalex.org/W1965604823"],"abstract_inverted_index":{"Background/Purpose:":[0],"In":[1,167],"rheumatoid":[2,14],"arthritis":[3,73],"(RA)":[4],"autoantibodies":[5],"including":[6],"antibodies":[7],"to":[8,141,186,199,207,239],"citrullinated":[9],"protein":[10],"antigens":[11],"(ACPA)":[12],"and":[13,40,47,60,84,87,125,176,206],"factor":[15],"(RF)":[16],"can":[17,196],"be":[18,197,221],"predictive":[19],"of":[20,29,37,42,67,89,95,103,110,113,149,160,182,228,243,246],"incident":[21,61,118,122,134,152],"clinical":[22,44,209],"RA.":[23,45,119,153],"However,":[24],"there":[25],"is":[26],"limited":[27],"understanding":[28],"how":[30],"antibody":[31],"changes":[32],"over":[33],"time":[34],"impact":[35],"prediction":[36],"the":[38,54,101,168,241],"likelihood":[39],"timing":[41],"future":[43,204],"Materials":[46],"Methods:":[48],"We":[49,80],"evaluated":[50,82],"relationships":[51],"between":[52],"ACPA,":[53,174],"shared":[55],"epitope":[56],"(SE),":[57],"RF":[58,85,219],"isotypes":[59,86],"RA":[62,90,99,135,161,187,205,212,233,250],"in":[63,91,147,232,249],"a":[64,92,180,222,226],"prospective":[65],"cohort":[66,94],"90":[68,111],"ACPA(+)":[69,114],"individuals":[70,97,150,201],"without":[71],"baseline":[72],"identified":[74],"through":[75],"health-fair":[76],"testing":[77],"(i.e.":[78],"Healthfair).":[79],"also":[81,216],"ACPA":[83],"time-to-diagnosis":[88],"retrospective":[93],"215":[96],"with":[98,130,151,157,189],"from":[100],"Department":[102],"Defense":[104],"Serum":[105],"Repository":[106],"(DoDSR).":[107],"Results:":[108],"Twenty-six":[109],"(29%)":[112],"Healthfair":[115],"participants":[116],"developed":[117],"Baseline":[120],"or":[121],"dual":[123],"RF-IgA":[124,175],"RF-IgM":[126,177],"positivity":[127,172],"was":[128,155,178],"associated":[129,156],"increased":[131,158],"risk":[132,159],"for":[133,173,203,211],"(HR":[136,162],"3.09;":[137],"95%":[138,164],"CI":[139,165],"1.15":[140],"8.29)":[142],"although":[143],"RFs":[144],"were":[145],"negative":[146],"~50%":[148],"SE":[154],"2.87,":[163],"1.22-6.76).":[166],"DoDSR":[169],"cohort,":[170],"triple":[171],"present":[179],"median":[181],"1-2":[183],"years":[184],"prior":[185],"diagnosis,":[188],"some":[190],"sex-specific":[191],"differences.":[192],"Conclusion:":[193],"These":[194],"findings":[195,215],"used":[198],"counsel":[200],"at-risk":[202],"design":[208],"trials":[210],"prevention.":[213,234],"The":[214],"suggest":[217],"that":[218],"could":[220],"surrogate":[223],"outcome":[224],"as":[225],"success":[227],"an":[229],"immunologic":[230],"intervention":[231],"Additional":[235],"studies":[236],"are":[237],"needed":[238],"understand":[240],"biologic":[242],"different":[244],"patterns":[245],"autoantibody":[247],"elevations":[248],"evolution.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2022-06-24T00:00:00"}