{"id":"https://openalex.org/W4283323692","doi":"https://doi.org/10.3389/frph.2022.915948","title":"The Impact of Over-The-Counter Lactic Acid Containing Vaginal Gels on the Integrity and Inflammatory State of the Vaginal Epithelium in vitro","display_name":"The Impact of Over-The-Counter Lactic Acid Containing Vaginal Gels on the Integrity and Inflammatory State of the Vaginal Epithelium in vitro","publication_year":2022,"publication_date":"2022-06-23","ids":{"openalex":"https://openalex.org/W4283323692","doi":"https://doi.org/10.3389/frph.2022.915948","pmid":"https://pubmed.ncbi.nlm.nih.gov/36303665","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9580709"},"language":"en","primary_location":{"id":"doi:10.3389/frph.2022.915948","doi":"https://doi.org/10.3389/frph.2022.915948","is_oa":true,"landing_page_url":"https://doi.org/10.3389/frph.2022.915948","pdf_url":"https://www.frontiersin.org/articles/10.3389/frph.2022.915948/pdf","source":{"id":"https://openalex.org/S4210207188","display_name":"Frontiers in Reproductive Health","issn_l":"2673-3153","issn":["2673-3153"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Reproductive Health","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/frph.2022.915948/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055118021","display_name":"David P. Tyssen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145902186","display_name":"Burnet Institute","ror":"https://ror.org/05ktbsm52","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I145902186"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"David Tyssen","raw_affiliation_strings":["Life Sciences Discipline, Burnet Institute, Melbourne, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Life Sciences Discipline, Burnet Institute, Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I145902186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021248144","display_name":"Anna C. Hearps","orcid":"https://orcid.org/0000-0002-8492-9815","observed_orcids":["https://orcid.org/0000-0002-8492-9815"]},"institutions":[{"id":"https://openalex.org/I145902186","display_name":"Burnet Institute","ror":"https://ror.org/05ktbsm52","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I145902186"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Anna C. Hearps","raw_affiliation_strings":["Central Clinical School, Monash University, Melbourne, VIC, Australia","Life Sciences Discipline, Burnet Institute, Melbourne, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Clinical School, Monash University, Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Life Sciences Discipline, Burnet Institute, Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I145902186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003282331","display_name":"Kalyani Guntur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121331","display_name":"MatTek Corporation (United States)","ror":"https://ror.org/0305ndp35","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121331"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kalyani Guntur","raw_affiliation_strings":["MatTek Corporation, Ashland, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MatTek Corporation, Ashland, MA, United States","institution_ids":["https://openalex.org/I4210121331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018542045","display_name":"Lindi Masson","orcid":"https://orcid.org/0000-0002-2539-817X","observed_orcids":["https://orcid.org/0000-0002-2539-817X"]},"institutions":[{"id":"https://openalex.org/I145902186","display_name":"Burnet Institute","ror":"https://ror.org/05ktbsm52","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I145902186"]},{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]},{"id":"https://openalex.org/I2800715850","display_name":"Centre for the AIDS Programme of Research in South Africa","ror":"https://ror.org/04qkg4668","country_code":"ZA","type":"other","lineage":["https://openalex.org/I2800715850"]},{"id":"https://openalex.org/I4405266898","display_name":"Institute of Infectious Disease and Molecular Medicine","ror":"https://ror.org/00900dw59","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274","https://openalex.org/I4405266898"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU","ZA"],"is_corresponding":false,"raw_author_name":"Lindi Masson","raw_affiliation_strings":["Central Clinical School, Monash University, Melbourne, VIC, Australia","Centre for the AIDS Programme of Research in South Africa, Durban, South Africa","Department of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa","Life Sciences Discipline, Burnet Institute, Melbourne, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Clinical School, Monash University, Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Centre for the AIDS Programme of Research in South Africa, Durban, South Africa","institution_ids":["https://openalex.org/I2800715850"]},{"raw_affiliation_string":"Department of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa","institution_ids":["https://openalex.org/I157614274","https://openalex.org/I4405266898"]},{"raw_affiliation_string":"Life Sciences Discipline, Burnet Institute, Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I145902186"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Simon Cook","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115521","display_name":"ARC Centre of Excellence for Electromaterials Science","ror":"https://ror.org/020g3wn65","country_code":"AU","type":"facility","lineage":["https://openalex.org/I1337719021","https://openalex.org/I204824540","https://openalex.org/I2801453606","https://openalex.org/I4210115521","https://openalex.org/I4210132349"]},{"id":"https://openalex.org/I57093077","display_name":"Swinburne University of Technology","ror":"https://ror.org/031rekg67","country_code":"AU","type":"education","lineage":["https://openalex.org/I57093077"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Simon Cook","raw_affiliation_strings":["Australian Research Council (ARC) Centre of Excellence for Electromaterials Science, School of Science, Computing and Engineering Technologies, Swinburne University of Technology, Melbourne, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Australian Research Council (ARC) Centre of Excellence for Electromaterials Science, School of Science, Computing and Engineering Technologies, Swinburne University of Technology, Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I4210115521","https://openalex.org/I57093077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088607207","display_name":"Simon Edward Moulton","orcid":"https://orcid.org/0000-0002-8320-3852","observed_orcids":["https://orcid.org/0000-0002-8320-3852"]},"institutions":[{"id":"https://openalex.org/I4210087110","display_name":"St Vincent's Hospital Melbourne","ror":"https://ror.org/001kjn539","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087110","https://openalex.org/I4210098850"]},{"id":"https://openalex.org/I4210115521","display_name":"ARC Centre of Excellence for Electromaterials Science","ror":"https://ror.org/020g3wn65","country_code":"AU","type":"facility","lineage":["https://openalex.org/I1337719021","https://openalex.org/I204824540","https://openalex.org/I2801453606","https://openalex.org/I4210115521","https://openalex.org/I4210132349"]},{"id":"https://openalex.org/I57093077","display_name":"Swinburne University of Technology","ror":"https://ror.org/031rekg67","country_code":"AU","type":"education","lineage":["https://openalex.org/I57093077"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Simon E. Moulton","raw_affiliation_strings":["Aikenhead Centre for Medical Discovery, St. Vincent's Hospital Melbourne, Melbourne, VIC, Australia","Australian Research Council (ARC) Centre of Excellence for Electromaterials Science, School of Science, Computing and Engineering Technologies, Swinburne University of Technology, Melbourne, VIC, Australia","Iverson Health Innovation Research Institute, Swinburne University of Technology, Melbourne, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aikenhead Centre for Medical Discovery, St. Vincent's Hospital Melbourne, Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I4210087110"]},{"raw_affiliation_string":"Australian Research Council (ARC) Centre of Excellence for Electromaterials Science, School of Science, Computing and Engineering Technologies, Swinburne University of Technology, Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I4210115521","https://openalex.org/I57093077"]},{"raw_affiliation_string":"Iverson Health Innovation Research Institute, Swinburne University of Technology, Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I57093077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053827358","display_name":"Jacques Ravel","orcid":"https://orcid.org/0000-0002-0851-2233","observed_orcids":["https://orcid.org/0000-0002-0851-2233"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacques Ravel","raw_affiliation_strings":["Department of Microbiology and Immunology, University of Maryland, Baltimore, MD, United States","Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Maryland, Baltimore, MD, United States","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, United States","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067622825","display_name":"Catriona S. Bradshaw","orcid":"https://orcid.org/0000-0002-6643-5678","observed_orcids":["https://orcid.org/0000-0002-6643-5678"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I2801993434","display_name":"The Alfred Hospital","ror":"https://ror.org/01wddqe20","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2801993434","https://openalex.org/I4210163178"]},{"id":"https://openalex.org/I4210099671","display_name":"Melbourne Sexual Health Centre","ror":"https://ror.org/013fdz725","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210099671","https://openalex.org/I4210163178"]},{"id":"https://openalex.org/I4210163178","display_name":"Alfred Health","ror":"https://ror.org/04scfb908","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210163178"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Catriona S. Bradshaw","raw_affiliation_strings":["Central Clinical School, Monash University, Melbourne, VIC, Australia","Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia","Melbourne Sexual Health Centre, Alfred Health, Melbourne, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Clinical School, Monash University, Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Melbourne Sexual Health Centre, Alfred Health, Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I2801993434","https://openalex.org/I4210099671","https://openalex.org/I4210163178"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082282921","display_name":"Seyoum Ayehunie","orcid":"https://orcid.org/0000-0002-4365-5504","observed_orcids":["https://orcid.org/0000-0002-4365-5504"]},"institutions":[{"id":"https://openalex.org/I4210121331","display_name":"MatTek Corporation (United States)","ror":"https://ror.org/0305ndp35","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121331"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seyoum Ayehunie","raw_affiliation_strings":["MatTek Corporation, Ashland, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MatTek Corporation, Ashland, MA, United States","institution_ids":["https://openalex.org/I4210121331"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091161981","display_name":"Gilda Tachedjian","orcid":"https://orcid.org/0000-0002-7733-7037","observed_orcids":["https://orcid.org/0000-0002-7733-7037"]},"institutions":[{"id":"https://openalex.org/I145902186","display_name":"Burnet Institute","ror":"https://ror.org/05ktbsm52","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I145902186"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210105123","display_name":"Peter Doherty Institute","ror":"https://ror.org/016899r71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I1320473756","https://openalex.org/I165779595","https://openalex.org/I4210105123","https://openalex.org/I4210158168"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Gilda Tachedjian","raw_affiliation_strings":["Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, Australia","Department of Microbiology, Monash University, Clayton, VIC, Australia","Life Sciences Discipline, Burnet Institute, Melbourne, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210105123"]},{"raw_affiliation_string":"Department of Microbiology, Monash University, Clayton, VIC, Australia","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Life Sciences Discipline, Burnet Institute, Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I145902186"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":15,"corresponding_author_ids":["https://openalex.org/A5091161981"],"corresponding_institution_ids":["https://openalex.org/I145902186","https://openalex.org/I165779595","https://openalex.org/I4210105123","https://openalex.org/I56590836"],"apc_list":{"value":1900,"currency":"USD","value_usd":1900},"apc_paid":{"value":1900,"currency":"USD","value_usd":1900},"fwci":1.7194,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.8157085,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"4","issue":null,"first_page":"915948","last_page":"915948"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10428","display_name":"Reproductive tract infections research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10428","display_name":"Reproductive tract infections research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lactic-acid","display_name":"lactic acid","score":0.8059999942779541},{"id":"https://openalex.org/keywords/vaginal-gel","display_name":"vaginal gel","score":0.9760000109672546},{"id":"https://openalex.org/keywords/vaginal-microbiota","display_name":"vaginal microbiota","score":0.718999981880188},{"id":"https://openalex.org/keywords/lactobacillus","display_name":"Lactobacillus","score":0.9700000286102295},{"id":"https://openalex.org/keywords/bacterial-vaginosis","display_name":"bacterial vaginosis","score":0.8949999809265137},{"id":"https://openalex.org/keywords/vaginal-epithelium","display_name":"vaginal epithelium","score":0.7749999761581421},{"id":"https://openalex.org/keywords/epithelial-barrier-integrity","display_name":"epithelial barrier integrity","score":0.9919999837875366},{"id":"https://openalex.org/keywords/osmolality","display_name":"osmolality","score":0.8090000152587891},{"id":"https://openalex.org/keywords/hyperosmolarity","display_name":"hyperosmolarity","score":0.8009999990463257},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7910000085830688},{"id":"https://openalex.org/keywords/il-1alpha","display_name":"IL-1\u03b1","score":0.859000027179718},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":1.0},{"id":"https://openalex.org/keywords/hiv-acquisition","display_name":"HIV acquisition","score":0.6330000162124634},{"id":"https://openalex.org/keywords/vaginal-inflammation","display_name":"vaginal inflammation","score":0.3050000071525574}],"concepts":[{"id":"https://openalex.org/C2779952448","wikidata":"https://www.wikidata.org/wiki/Q804521","display_name":"Bacterial vaginosis","level":2,"score":0.8692582845687866},{"id":"https://openalex.org/C2777744392","wikidata":"https://www.wikidata.org/wiki/Q5880","display_name":"Vagina","level":2,"score":0.7687355279922485},{"id":"https://openalex.org/C2780206646","wikidata":"https://www.wikidata.org/wiki/Q1061596","display_name":"Lactobacillus","level":3,"score":0.7332980036735535},{"id":"https://openalex.org/C197746943","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Microbicide","level":3,"score":0.5557910203933716},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5129730105400085},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.4903707504272461},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.48537981510162354},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4453495442867279},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.41389745473861694},{"id":"https://openalex.org/C2780255968","wikidata":"https://www.wikidata.org/wiki/Q1816730","display_name":"Probiotic","level":3,"score":0.41117990016937256},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.406322181224823},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36143696308135986},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.35626596212387085},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2870311141014099},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.27883249521255493},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.1561797857284546},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.13320091366767883},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.07075786590576172},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/frph.2022.915948","doi":"https://doi.org/10.3389/frph.2022.915948","is_oa":true,"landing_page_url":"https://doi.org/10.3389/frph.2022.915948","pdf_url":"https://www.frontiersin.org/articles/10.3389/frph.2022.915948/pdf","source":{"id":"https://openalex.org/S4210207188","display_name":"Frontiers in Reproductive Health","issn_l":"2673-3153","issn":["2673-3153"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Reproductive Health","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9580709","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9580709","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Reprod Health","raw_type":"Text"},{"id":"pmid:36303665","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36303665","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in reproductive health","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:f729ddbc875949eda849d2ea7651b75b","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/f729ddbc875949eda849d2ea7651b75b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Reproductive Health, Vol 4 (2022)","raw_type":"article"},{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/322224","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11343/322224","pdf_url":null,"source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3389/frph.2022.915948","doi":"https://doi.org/10.3389/frph.2022.915948","is_oa":true,"landing_page_url":"https://doi.org/10.3389/frph.2022.915948","pdf_url":"https://www.frontiersin.org/articles/10.3389/frph.2022.915948/pdf","source":{"id":"https://openalex.org/S4210207188","display_name":"Frontiers in Reproductive Health","issn_l":"2673-3153","issn":["2673-3153"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Reproductive Health","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8600000143051147,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1320202863","display_name":"Antivirals for HIV Treatment and Prevention","funder_award_id":"1117748","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320310619","display_name":"Burnet Institute","ror":"https://ror.org/05ktbsm52"},{"id":"https://openalex.org/F4320311531","display_name":"Australian Centre for HIV and Hepatitis Virology Research","ror":"https://ror.org/02he67h29"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4283323692.pdf","grobid_xml":"https://content.openalex.org/works/W4283323692.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1474461326","https://openalex.org/W1699700768","https://openalex.org/W1919603305","https://openalex.org/W1964533994","https://openalex.org/W1979742728","https://openalex.org/W1980015247","https://openalex.org/W1998013812","https://openalex.org/W2009282049","https://openalex.org/W2013553461","https://openalex.org/W2014605450","https://openalex.org/W2017133346","https://openalex.org/W2024213191","https://openalex.org/W2027373982","https://openalex.org/W2042515647","https://openalex.org/W2044369525","https://openalex.org/W2046487574","https://openalex.org/W2055736665","https://openalex.org/W2066118072","https://openalex.org/W2087038569","https://openalex.org/W2099545010","https://openalex.org/W2105053076","https://openalex.org/W2110671752","https://openalex.org/W2111415362","https://openalex.org/W2112059343","https://openalex.org/W2114918609","https://openalex.org/W2117342940","https://openalex.org/W2139642740","https://openalex.org/W2146634980","https://openalex.org/W2154744654","https://openalex.org/W2172682788","https://openalex.org/W2435715880","https://openalex.org/W2522005194","https://openalex.org/W2571049130","https://openalex.org/W2605651569","https://openalex.org/W2773409958","https://openalex.org/W2810121668","https://openalex.org/W2888028793","https://openalex.org/W2898138831","https://openalex.org/W2903834952","https://openalex.org/W2909229435","https://openalex.org/W2924015319","https://openalex.org/W2940415202","https://openalex.org/W2964487836","https://openalex.org/W2971442704","https://openalex.org/W2989241750","https://openalex.org/W2990057398","https://openalex.org/W3000678207","https://openalex.org/W3024851520","https://openalex.org/W3081951413","https://openalex.org/W3090293983","https://openalex.org/W3111779579","https://openalex.org/W3126395207","https://openalex.org/W3126488488","https://openalex.org/W3199348874","https://openalex.org/W4205306341"],"related_works":["https://openalex.org/W4293741040","https://openalex.org/W3000678207","https://openalex.org/W4409760246","https://openalex.org/W2414021519","https://openalex.org/W2596980557","https://openalex.org/W2742210411","https://openalex.org/W6939584299","https://openalex.org/W7105747766","https://openalex.org/W2605651569","https://openalex.org/W4388721885"],"abstract_inverted_index":{"The":[0,76,259,273],"vaginal":[1,147,181,224,282],"microbiome":[2,14],"influences":[3],"a":[4,13,70,97,174,188],"wide":[5],"range":[6],"of":[7,27,32,40,49,58,80,86,100,103,123,138,179,213,223,228,234,240,245,253,261,276,311,315,324],"health":[8],"outcomes":[9],"in":[10,93,134,159,196,256,284,295],"women,":[11],"where":[12],"dominated":[15,153],"by":[16,42,217,271],"Lactobacillus":[17],"spp.":[18],"is":[19,53,69],"considered":[20],"optimal":[21],"and":[22,30,73,110,207,242,292,303,321],"associated":[23,54,249],"with":[24,55,151,161,165,226,250],"reduced":[25,208],"risk":[26,57,252],"pre-term":[28],"birth":[29],"acquisition":[31,255],"sexually":[33],"transmitted":[34],"infections":[35],"including":[36,127,237],"HIV.":[37],"Conversely,":[38],"replacement":[39],"lactobacilli":[41],"non-optimal":[43],"bacteria":[44],"leads":[45],"to":[46,204,328],"the":[47,63,84,94,101,107,121,135,139,180,229,232,262,280,309,313,319,325],"development":[48,85],"bacterial":[50],"vaginosis,":[51],"which":[52,68,247,298],"increased":[56],"these":[59,104,277],"outcomes.":[60],"Lactobacilli":[61],"produce":[62],"metabolite":[64],"lactic":[65],"acid":[66],"(LA)":[67],"potent":[71],"antibacterial":[72],"antiviral":[74],"agent.":[75],"potential":[77],"therapeutic":[78],"benefits":[79],"LA":[81],"have":[82],"prompted":[83],"numerous":[87],"over-the-counter":[88,125],"LA-containing":[89],"gels":[90,141,167,186,230,264,278],"for":[91,132,301],"use":[92,133],"vagina,":[95],"although":[96],"comprehensive":[98],"analysis":[99],"impact":[102,190,314],"formulations":[105],"on":[106,191,279,318],"cervicovaginal":[108],"epithelium":[109,283,327],"pro-inflammatory":[111,235],"cytokine/chemokine":[112],"responses,":[113],"has":[114,299],"not":[115],"been":[116],"assessed.":[117],"Here,":[118],"we":[119,183],"evaluated":[120],"properties":[122],"11":[124,140],"gels,":[126],"9":[128],"containing":[129],"LA,":[130],"marketed":[131],"vagina.":[136],"Ten":[137],"had":[142,187],"an":[143],"osmolality":[144],"greater":[145],"than":[146],"fluid":[148],"from":[149],"women":[150,160],"Lactobacillus-":[152],"microbiota":[154],"(370":[155],"\u00b1":[156],"40":[157],"mOsmol/kg":[158],"Nugent":[162],"score":[163],"0\u20133),":[164],"six":[166],"that":[168],"were":[169],"hyperosmolal":[170,185],">2,000":[171],"mOsmol/kg.":[172],"Using":[173],"reconstructed":[175],"primary":[176],"cell":[177],"model":[178],"epithelium,":[182],"found":[184],"detrimental":[189,274],"epithelial":[192,209,289],"barrier":[193,210,290],"integrity,":[194],"resulting":[195],"substantial":[197],"cellular":[198],"toxicity":[199],"(<10%":[200],"viability":[201],"as":[202,269],"compared":[203],"untreated":[205,214],"cells)":[206],"integrity":[211,291,320],"[\u224830%":[212],"cells,":[215],"assessed":[216],"transepithelial":[218],"electrical":[219],"resistance":[220],"(TEER)].":[221],"Treatment":[222],"tissues":[225],"most":[227],"elicited":[231,265],"production":[233],"factors":[236],"IL-1\u03b1":[238],"(8":[239],"11)":[241,246],"IL-1\u03b2":[243],"(10":[244],"are":[248],"heightened":[251],"HIV":[254],"vivo":[257,296],".":[258],"majority":[260],"OTC":[263],"moderate":[266],"tissue":[267],"damage":[268],"determined":[270],"histology.":[272],"effects":[275],"human":[281],"vitro":[285],"may":[286],"predict":[287],"compromised":[288],"genital":[293],"inflammation":[294],",":[297],"implications":[300],"sexual":[302],"reproductive":[304],"health.":[305],"This":[306],"study":[307],"highlights":[308],"importance":[310],"evaluating":[312],"intravaginal":[316],"products":[317],"inflammatory":[322],"status":[323],"mucosal":[326],"avoid":[329],"unfavorable":[330],"off":[331],"target":[332],"effects.":[333]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":7}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2022-06-24T00:00:00"}
