{"id":"https://openalex.org/W4283319277","doi":"https://doi.org/10.3390/ijms23136935","title":"Seventy-Two-Hour LRRK2 Kinase Activity Inhibition Increases Lysosomal GBA Expression in H4, a Human Neuroglioma Cell Line","display_name":"Seventy-Two-Hour LRRK2 Kinase Activity Inhibition Increases Lysosomal GBA Expression in H4, a Human Neuroglioma Cell Line","publication_year":2022,"publication_date":"2022-06-22","ids":{"openalex":"https://openalex.org/W4283319277","doi":"https://doi.org/10.3390/ijms23136935","pmid":"https://pubmed.ncbi.nlm.nih.gov/35805938","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9266636"},"language":"en","primary_location":{"id":"doi:10.3390/ijms23136935","doi":"https://doi.org/10.3390/ijms23136935","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms23136935","pdf_url":"https://www.mdpi.com/1422-0067/23/13/6935/pdf?version=1655974569","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/23/13/6935/pdf?version=1655974569","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023250528","display_name":"Clara Ruz","orcid":"https://orcid.org/0000-0003-1846-3962","observed_orcids":["https://orcid.org/0000-0003-1846-3962"]},"institutions":[{"id":"https://openalex.org/I173304897","display_name":"Universidad de Granada","ror":"https://ror.org/04njjy449","country_code":"ES","type":"education","lineage":["https://openalex.org/I173304897"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Clara Ruz","raw_affiliation_strings":["Department of Physiology, Faculty of Medicine, Universidad de Granada, 18016 Granada, Spain","Institute of Neurosciences \u201cFederico Ol\u00f3riz\u201d, Centro de Investigaci\u00f3n Biom\u00e9dica (CIBM), Universidad de Granada, 18016 Granada, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Faculty of Medicine, Universidad de Granada, 18016 Granada, Spain","institution_ids":["https://openalex.org/I173304897"]},{"raw_affiliation_string":"Institute of Neurosciences \u201cFederico Ol\u00f3riz\u201d, Centro de Investigaci\u00f3n Biom\u00e9dica (CIBM), Universidad de Granada, 18016 Granada, Spain","institution_ids":["https://openalex.org/I173304897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022474167","display_name":"Jos\u00e9 Luis Alcantud","orcid":"https://orcid.org/0000-0002-4389-5313","observed_orcids":["https://orcid.org/0000-0002-4389-5313"]},"institutions":[{"id":"https://openalex.org/I173304897","display_name":"Universidad de Granada","ror":"https://ror.org/04njjy449","country_code":"ES","type":"education","lineage":["https://openalex.org/I173304897"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Luis Alcantud","raw_affiliation_strings":["Institute of Neurosciences \u201cFederico Ol\u00f3riz\u201d, Centro de Investigaci\u00f3n Biom\u00e9dica (CIBM), Universidad de Granada, 18016 Granada, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neurosciences \u201cFederico Ol\u00f3riz\u201d, Centro de Investigaci\u00f3n Biom\u00e9dica (CIBM), Universidad de Granada, 18016 Granada, Spain","institution_ids":["https://openalex.org/I173304897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013949505","display_name":"Francisco Vives","orcid":"https://orcid.org/0000-0003-2061-1004","observed_orcids":["https://orcid.org/0000-0003-2061-1004"]},"institutions":[{"id":"https://openalex.org/I173304897","display_name":"Universidad de Granada","ror":"https://ror.org/04njjy449","country_code":"ES","type":"education","lineage":["https://openalex.org/I173304897"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Francisco Vives","raw_affiliation_strings":["Department of Physiology, Faculty of Medicine, Universidad de Granada, 18016 Granada, Spain","Institute of Neurosciences \u201cFederico Ol\u00f3riz\u201d, Centro de Investigaci\u00f3n Biom\u00e9dica (CIBM), Universidad de Granada, 18016 Granada, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Faculty of Medicine, Universidad de Granada, 18016 Granada, Spain","institution_ids":["https://openalex.org/I173304897"]},{"raw_affiliation_string":"Institute of Neurosciences \u201cFederico Ol\u00f3riz\u201d, Centro de Investigaci\u00f3n Biom\u00e9dica (CIBM), Universidad de Granada, 18016 Granada, Spain","institution_ids":["https://openalex.org/I173304897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102949296","display_name":"Francisco Arrebola","orcid":"https://orcid.org/0000-0002-5030-3339","observed_orcids":["https://orcid.org/0000-0002-5030-3339"]},"institutions":[{"id":"https://openalex.org/I173304897","display_name":"Universidad de Granada","ror":"https://ror.org/04njjy449","country_code":"ES","type":"education","lineage":["https://openalex.org/I173304897"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Francisco Arrebola","raw_affiliation_strings":["Department of Histology, Faculty of Medicine, Universidad de Granada, 18016 Granada, Spain","Institute of Neurosciences \u201cFederico Ol\u00f3riz\u201d, Centro de Investigaci\u00f3n Biom\u00e9dica (CIBM), Universidad de Granada, 18016 Granada, Spain"],"raw_orcid":"https://orcid.org/0000-0002-5030-3339","affiliations":[{"raw_affiliation_string":"Department of Histology, Faculty of Medicine, Universidad de Granada, 18016 Granada, Spain","institution_ids":["https://openalex.org/I173304897"]},{"raw_affiliation_string":"Institute of Neurosciences \u201cFederico Ol\u00f3riz\u201d, Centro de Investigaci\u00f3n Biom\u00e9dica (CIBM), Universidad de Granada, 18016 Granada, Spain","institution_ids":["https://openalex.org/I173304897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020514779","display_name":"John Hardy","orcid":"https://orcid.org/0000-0002-3122-0423","observed_orcids":["https://orcid.org/0000-0002-3122-0423"]},"institutions":[{"id":"https://openalex.org/I4405260083","display_name":"UCL Queen Square Institute of Neurology","ror":"https://ror.org/0370htr03","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John Hardy","raw_affiliation_strings":["Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK","institution_ids":["https://openalex.org/I4405260083","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000831279","display_name":"Patrick Alfryn Lewis","orcid":"https://orcid.org/0000-0003-4537-0489","observed_orcids":["https://orcid.org/0000-0003-4537-0489","https://orcid.org/0000-0002-2192-9543"]},"institutions":[{"id":"https://openalex.org/I133836048","display_name":"Royal Veterinary College","ror":"https://ror.org/01wka8n18","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I133836048"]},{"id":"https://openalex.org/I4405260083","display_name":"UCL Queen Square Institute of Neurology","ror":"https://ror.org/0370htr03","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Patrick A. Lewis","raw_affiliation_strings":["Department of Comparative Biomedical Science, Royal Veterinary College, Royal College Street, London NW1 0TU, UK","Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK"],"raw_orcid":"https://orcid.org/0000-0003-4537-0489","affiliations":[{"raw_affiliation_string":"Department of Comparative Biomedical Science, Royal Veterinary College, Royal College Street, London NW1 0TU, UK","institution_ids":["https://openalex.org/I133836048"]},{"raw_affiliation_string":"Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK","institution_ids":["https://openalex.org/I4405260083","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005572028","display_name":"Claudia Manzoni","orcid":"https://orcid.org/0000-0001-5367-4023","observed_orcids":["https://orcid.org/0000-0001-5367-4023","https://orcid.org/0000-0003-3799-1832"]},"institutions":[{"id":"https://openalex.org/I4405283614","display_name":"UCL School of Pharmacy","ror":"https://ror.org/01zna6t55","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405283614","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Claudia Manzoni","raw_affiliation_strings":["Department of Pharmacology, UCL School of Pharmacy, London WC1N 1AX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, UCL School of Pharmacy, London WC1N 1AX, UK","institution_ids":["https://openalex.org/I4405283614","https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054872097","display_name":"Raquel Dur\u00e1n","orcid":"https://orcid.org/0000-0002-5749-8968","observed_orcids":["https://orcid.org/0000-0002-5749-8968"]},"institutions":[{"id":"https://openalex.org/I173304897","display_name":"Universidad de Granada","ror":"https://ror.org/04njjy449","country_code":"ES","type":"education","lineage":["https://openalex.org/I173304897"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Raquel Duran","raw_affiliation_strings":["Department of Physiology, Faculty of Medicine, Universidad de Granada, 18016 Granada, Spain","Institute of Neurosciences \u201cFederico Ol\u00f3riz\u201d, Centro de Investigaci\u00f3n Biom\u00e9dica (CIBM), Universidad de Granada, 18016 Granada, Spain"],"raw_orcid":"https://orcid.org/0000-0002-5749-8968","affiliations":[{"raw_affiliation_string":"Department of Physiology, Faculty of Medicine, Universidad de Granada, 18016 Granada, Spain","institution_ids":["https://openalex.org/I173304897"]},{"raw_affiliation_string":"Institute of Neurosciences \u201cFederico Ol\u00f3riz\u201d, Centro de Investigaci\u00f3n Biom\u00e9dica (CIBM), Universidad de Granada, 18016 Granada, Spain","institution_ids":["https://openalex.org/I173304897"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5054872097"],"corresponding_institution_ids":["https://openalex.org/I173304897"],"apc_list":{"value":2300,"currency":"CHF","value_usd":2408},"apc_paid":{"value":2300,"currency":"CHF","value_usd":2408},"fwci":0.3913,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.57951065,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"23","issue":"13","first_page":"6935","last_page":"6935"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.5884000062942505,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.5884000062942505,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":0.3928000032901764,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lrrk2-kinase-inhibition","display_name":"LRRK2 kinase inhibition","score":0.8629999756813049},{"id":"https://openalex.org/keywords/gba1","display_name":"GBA1","score":0.6759999990463257},{"id":"https://openalex.org/keywords/beta-glucocerebrosidase","display_name":"beta-glucocerebrosidase","score":0.8880000114440918},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9390000104904175},{"id":"https://openalex.org/keywords/lysosomal-dysfunction","display_name":"lysosomal dysfunction","score":0.875},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.8690000176429749},{"id":"https://openalex.org/keywords/mli-2","display_name":"MLi-2","score":0.9959999918937683},{"id":"https://openalex.org/keywords/lc3-ii","display_name":"LC3-II","score":0.8109999895095825},{"id":"https://openalex.org/keywords/protein-metabolism","display_name":"protein metabolism","score":0.37700000405311584}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5313397645950317},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5255968570709229},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5248066186904907},{"id":"https://openalex.org/C2780427247","wikidata":"https://www.wikidata.org/wiki/Q409961","display_name":"LRRK2","level":4,"score":0.5036577582359314},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4055701494216919},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.182131826877594},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11435699462890625},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.060578495264053345},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.04126235842704773}],"mesh":[{"descriptor_ui":"D000071158","descriptor_name":"Leucine-Rich Repeat Serine-Threonine Protein Kinase-2","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000071158","descriptor_name":"Leucine-Rich Repeat Serine-Threonine Protein Kinase-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000071158","descriptor_name":"Leucine-Rich Repeat Serine-Threonine Protein Kinase-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005962","descriptor_name":"Glucosylceramidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005962","descriptor_name":"Glucosylceramidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007294","descriptor_name":"Inositol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D007294","descriptor_name":"Inositol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.3390/ijms23136935","doi":"https://doi.org/10.3390/ijms23136935","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms23136935","pdf_url":"https://www.mdpi.com/1422-0067/23/13/6935/pdf?version=1655974569","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9266636","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9266636","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:35805938","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35805938","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:digibug.ugr.es:10481/76497","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10481/76497","pdf_url":null,"source":{"id":"https://openalex.org/S4306400567","display_name":"Institutional Repository of the University of Granada (University of Granada)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173304897","host_organization_name":"Universidad de Granada","host_organization_lineage":["https://openalex.org/I173304897"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:doaj.org/article:76c384a670744734a1775f258021b7f1","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/76c384a670744734a1775f258021b7f1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 23, Iss 6935, p 6935 (2022)","raw_type":"article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10151785","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10151785/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences , 23 (13) , Article 6935. (2022)","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.3390/ijms23136935","doi":"https://doi.org/10.3390/ijms23136935","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms23136935","pdf_url":"https://www.mdpi.com/1422-0067/23/13/6935/pdf?version=1655974569","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1022342702","display_name":null,"funder_award_id":"FPU14/03473","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G1197136394","display_name":null,"funder_award_id":"MR/L010933/1","funder_id":"https://openalex.org/F4320321764","funder_display_name":"Ministerio de Educaci\u00f3n, Cultura y Deporte"},{"id":"https://openalex.org/G1367246866","display_name":"Dissecting the role of LRRK2 in the regulation of autophagy","funder_award_id":"MR/L010933/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G1439425407","display_name":null,"funder_award_id":"FPU14/03473","funder_id":"https://openalex.org/F4320336383","funder_display_name":"Fundaci\u00f3n P\u00fablica Andaluza Progreso y Salud"},{"id":"https://openalex.org/G1904212243","display_name":null,"funder_award_id":"B-CTS-702-UGR20","funder_id":"https://openalex.org/F4320336383","funder_display_name":"Fundaci\u00f3n P\u00fablica Andaluza Progreso y Salud"},{"id":"https://openalex.org/G2192894781","display_name":null,"funder_award_id":"PI-0424-2014","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G2695804304","display_name":null,"funder_award_id":"MR/N026004/1","funder_id":"https://openalex.org/F4320321764","funder_display_name":"Ministerio de Educaci\u00f3n, Cultura y Deporte"},{"id":"https://openalex.org/G3091155051","display_name":null,"funder_award_id":"EST16/00809","funder_id":"https://openalex.org/F4320321764","funder_display_name":"Ministerio de Educaci\u00f3n, Cultura y Deporte"},{"id":"https://openalex.org/G3154129639","display_name":null,"funder_award_id":"EST16/00809","funder_id":"https://openalex.org/F4320336383","funder_display_name":"Fundaci\u00f3n P\u00fablica Andaluza Progreso y Salud"},{"id":"https://openalex.org/G355417461","display_name":null,"funder_award_id":"PI-0424-2014","funder_id":"https://openalex.org/F4320321764","funder_display_name":"Ministerio de Educaci\u00f3n, Cultura y Deporte"},{"id":"https://openalex.org/G3626853939","display_name":null,"funder_award_id":"MR/N026004/1","funder_id":"https://openalex.org/F4320336383","funder_display_name":"Fundaci\u00f3n P\u00fablica Andaluza Progreso y Salud"},{"id":"https://openalex.org/G4263727114","display_name":null,"funder_award_id":"FPU14/03473","funder_id":"https://openalex.org/F4320321764","funder_display_name":"Ministerio de Educaci\u00f3n, Cultura y Deporte"},{"id":"https://openalex.org/G589339204","display_name":"Understanding the genes for Parkinson's disease","funder_award_id":"MR/N026004/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G610685162","display_name":null,"funder_award_id":"MR/L010933/1","funder_id":"https://openalex.org/F4320336383","funder_display_name":"Fundaci\u00f3n P\u00fablica Andaluza Progreso y Salud"},{"id":"https://openalex.org/G6182281273","display_name":null,"funder_award_id":"B-CTS-702-UGR20","funder_id":"https://openalex.org/F4320321764","funder_display_name":"Ministerio de Educaci\u00f3n, Cultura y Deporte"},{"id":"https://openalex.org/G6503179824","display_name":null,"funder_award_id":"PI-0424-2014","funder_id":"https://openalex.org/F4320336383","funder_display_name":"Fundaci\u00f3n P\u00fablica Andaluza Progreso y Salud"},{"id":"https://openalex.org/G661946313","display_name":null,"funder_award_id":"EST16/00809","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G6743250684","display_name":null,"funder_award_id":"B-CTS-702-UGR20","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320321764","display_name":"Ministerio de Educaci\u00f3n, Cultura y Deporte","ror":"https://ror.org/03nc27g21"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320336383","display_name":"Fundaci\u00f3n P\u00fablica Andaluza Progreso y Salud","ror":"https://ror.org/0048t7e91"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4283319277.pdf","grobid_xml":"https://content.openalex.org/works/W4283319277.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1977416735","https://openalex.org/W2075407995","https://openalex.org/W2124681346","https://openalex.org/W2136230100","https://openalex.org/W2136969197","https://openalex.org/W2142746955","https://openalex.org/W2154915523","https://openalex.org/W2272666074","https://openalex.org/W2472421578","https://openalex.org/W2531036469","https://openalex.org/W2771581480","https://openalex.org/W2793540513","https://openalex.org/W2802569747","https://openalex.org/W2891994821","https://openalex.org/W2904738501","https://openalex.org/W2946594245","https://openalex.org/W2947227994","https://openalex.org/W2951564130","https://openalex.org/W2972937106","https://openalex.org/W2986932567","https://openalex.org/W2994242284","https://openalex.org/W3004823952","https://openalex.org/W3004950200","https://openalex.org/W3023068941","https://openalex.org/W3040983129","https://openalex.org/W3132867047","https://openalex.org/W3200383688","https://openalex.org/W4210952882","https://openalex.org/W4285797163"],"related_works":["https://openalex.org/W2994242284","https://openalex.org/W4285797163","https://openalex.org/W4390196329","https://openalex.org/W4415045884","https://openalex.org/W4413955406","https://openalex.org/W6982643254","https://openalex.org/W4315865387","https://openalex.org/W3025912431","https://openalex.org/W4408168063","https://openalex.org/W4415093404"],"abstract_inverted_index":{"Mutations":[0],"in":[1,46,87,173],"LRRK2":[2,19,143,151],"and":[3,25,62,64,73,91,97,119,146,154],"GBA1":[4],"are":[5,159],"key":[6],"contributors":[7],"to":[8,27,85,89],"genetic":[9],"risk":[10],"of":[11,34,38,57,81,128,138,163],"developing":[12],"Parkinson's":[13],"disease":[14],"(PD).":[15],"To":[16],"investigate":[17],"how":[18],"kinase":[20,59,144,152],"activity":[21,37,60,83,153,165],"interacts":[22],"with":[23,31,53,95,108,123],"GBA":[24,100],"contributes":[26],"lysosomal":[28,40,139],"dysfunctions":[29],"associated":[30],"the":[32,39,129,142,161,168],"pathology":[33],"PD.":[35,174],"The":[36],"enzyme":[41],"\u03b2-Glucocerebrosidase":[42],"(GCase)":[43],"was":[44],"assessed":[45],"a":[47,65,135],"human":[48],"neuroglioma":[49],"cell":[50],"model":[51],"treated":[52],"two":[54],"selective":[55],"inhibitors":[56],"LRKK2":[58],"(LRRK2-in-1":[61],"MLi-2)":[63],"GCase":[66,82,164],"irreversible":[67],"inhibitor,":[68],"condutirol-beta-epoxide":[69],"(CBE),":[70],"under":[71],"24":[72,90,118],"72":[74,92,105,120],"h":[75,93,106,121],"experimental":[76],"conditions.":[77],"We":[78],"observed":[79],"levels":[80,102,113],"comparable":[84],"controls":[86],"response":[88],"treatments":[94,122],"LRRK2-in-1":[96],"MLi-2.":[98],"However,":[99],"protein":[101,112,170],"increased":[103,115],"upon":[104],"treatment":[107],"LRRK2-in-1.":[109],"Moreover,":[110],"LC3-II":[111],"were":[114],"after":[116],"both":[117],"LRRK2-in-1,":[124],"suggesting":[125],"an":[126,148],"activation":[127],"autophagic":[130],"pathway.":[131],"These":[132],"results":[133],"highlight":[134],"possible":[136],"regulation":[137],"function":[140],"through":[141],"domain":[145],"suggest":[147],"interplay":[149],"between":[150],"GBA.":[155],"Although":[156],"further":[157],"investigations":[158],"needed,":[160],"enhancement":[162],"might":[166],"restore":[167],"defective":[169],"metabolism":[171],"seen":[172]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-06-24T00:00:00"}