{"id":"https://openalex.org/W4283259971","doi":"https://doi.org/10.1097/cp9.0000000000000004","title":"Serum N-terminal-pro-B-type natriuretic peptide is dependent on age and sex: a cross-sectional analysis in healthy adults from Northeast China","display_name":"Serum N-terminal-pro-B-type natriuretic peptide is dependent on age and sex: a cross-sectional analysis in healthy adults from Northeast China","publication_year":2022,"publication_date":"2022-03-01","ids":{"openalex":"https://openalex.org/W4283259971","doi":"https://doi.org/10.1097/cp9.0000000000000004"},"language":"en","primary_location":{"id":"doi:10.1097/cp9.0000000000000004","doi":"https://doi.org/10.1097/cp9.0000000000000004","is_oa":true,"landing_page_url":"https://doi.org/10.1097/cp9.0000000000000004","pdf_url":null,"source":{"id":"https://openalex.org/S4210203274","display_name":"Cardiology Plus","issn_l":"2470-7511","issn":["2470-7511","2470-752X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiology Plus","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1097/cp9.0000000000000004","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103109907","display_name":"Bing He","orcid":"https://orcid.org/0000-0003-1476-0986","observed_orcids":["https://orcid.org/0000-0003-1476-0986"]},"institutions":[{"id":"https://openalex.org/I4210125137","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125137"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bing He","raw_affiliation_strings":["Department of Laboratory Medicine, First Hospital of Jilin University, Changchun, Jilin 130499, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, First Hospital of Jilin University, Changchun, Jilin 130499, China","institution_ids":["https://openalex.org/I4210125137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008540593","display_name":"Panyang Xu","orcid":"https://orcid.org/0000-0002-2895-9112","observed_orcids":["https://orcid.org/0000-0002-2895-9112"]},"institutions":[{"id":"https://openalex.org/I4210125137","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125137"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pan-Yang Xu","raw_affiliation_strings":["Department of Laboratory Medicine, First Hospital of Jilin University, Changchun, Jilin 130499, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, First Hospital of Jilin University, Changchun, Jilin 130499, China","institution_ids":["https://openalex.org/I4210125137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067414470","display_name":"Qi Zhou","orcid":"https://orcid.org/0000-0002-5084-8697","observed_orcids":["https://orcid.org/0000-0002-5084-8697"]},"institutions":[{"id":"https://openalex.org/I4210125137","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125137"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi Zhou","raw_affiliation_strings":["Department of Pediatrics, First Hospital of Jilin University, Changchun, Jilin 130499, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, First Hospital of Jilin University, Changchun, Jilin 130499, China","institution_ids":["https://openalex.org/I4210125137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020022966","display_name":"Jiancheng Xu","orcid":"https://orcid.org/0000-0001-8796-271X","observed_orcids":["https://orcid.org/0000-0001-8796-271X"]},"institutions":[{"id":"https://openalex.org/I4210125137","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125137"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jian-Cheng Xu","raw_affiliation_strings":["Department of Laboratory Medicine, First Hospital of Jilin University, Changchun, Jilin 130499, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, First Hospital of Jilin University, Changchun, Jilin 130499, China","institution_ids":["https://openalex.org/I4210125137"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017873319","display_name":"Lu Cai","orcid":"https://orcid.org/0000-0003-3048-1135","observed_orcids":["https://orcid.org/0000-0003-3048-1135"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lu Cai","raw_affiliation_strings":["Department of Pediatrics, Pediatric Research Institute, The University of Louisville, Louisville, KY 40292, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Pediatric Research Institute, The University of Louisville, Louisville, KY 40292, USA","institution_ids":["https://openalex.org/I142740786"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5020022966"],"corresponding_institution_ids":["https://openalex.org/I4210125137"],"apc_list":null,"apc_paid":null,"fwci":0.1556,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.43660556,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"7","issue":"1","first_page":"48","last_page":"55"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.5166000127792358,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.5166000127792358,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.4738999903202057,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/n-terminal-pro-b-type-natriuretic-peptide","display_name":"N-terminal pro-brain natriuretic peptide","score":0.9369999766349792},{"id":"https://openalex.org/keywords/nt-probnp","display_name":"NT-proBNP","score":0.8999999761581421},{"id":"https://openalex.org/keywords/reference-values","display_name":"reference values","score":0.9129999876022339},{"id":"https://openalex.org/keywords/age-related-variation","display_name":"age-related variation","score":0.6150000095367432},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9950000047683716},{"id":"https://openalex.org/keywords/healthy-adults","display_name":"healthy adults","score":0.9919999837875366},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.7710000276565552},{"id":"https://openalex.org/keywords/serum-creatinine","display_name":"serum creatinine","score":0.5870000123977661},{"id":"https://openalex.org/keywords/urea-nitrogen","display_name":"urea nitrogen","score":0.8190000057220459},{"id":"https://openalex.org/keywords/uric-acid","display_name":"uric acid","score":0.9079999923706055},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.8450000286102295},{"id":"https://openalex.org/keywords/northeast-china","display_name":"Northeast China","score":0.7070000171661377}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8204354643821716},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.7294379472732544},{"id":"https://openalex.org/C2775915353","wikidata":"https://www.wikidata.org/wiki/Q1571529","display_name":"Natriuretic peptide","level":3,"score":0.6299757957458496},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.5424067378044128},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.5284702181816101},{"id":"https://openalex.org/C142052008","wikidata":"https://www.wikidata.org/wiki/Q954027","display_name":"Cross-sectional study","level":2,"score":0.5261126160621643},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5189692378044128},{"id":"https://openalex.org/C2778176769","wikidata":"https://www.wikidata.org/wiki/Q764079","display_name":"Blood urea nitrogen","level":3,"score":0.44734689593315125},{"id":"https://openalex.org/C2779881121","wikidata":"https://www.wikidata.org/wiki/Q105522","display_name":"Uric acid","level":2,"score":0.43816810846328735},{"id":"https://openalex.org/C2986834420","wikidata":"https://www.wikidata.org/wiki/Q5932254","display_name":"Age groups","level":2,"score":0.4237307012081146},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3501177430152893},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.3217007517814636},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.17228174209594727},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.1235610842704773},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1097/cp9.0000000000000004","doi":"https://doi.org/10.1097/cp9.0000000000000004","is_oa":true,"landing_page_url":"https://doi.org/10.1097/cp9.0000000000000004","pdf_url":null,"source":{"id":"https://openalex.org/S4210203274","display_name":"Cardiology Plus","issn_l":"2470-7511","issn":["2470-7511","2470-752X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiology Plus","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:a2635dc9a615483ba782bab072ce0182","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a2635dc9a615483ba782bab072ce0182","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cardiology Plus, Vol 7, Iss 1, Pp 48-55 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1097/cp9.0000000000000004","doi":"https://doi.org/10.1097/cp9.0000000000000004","is_oa":true,"landing_page_url":"https://doi.org/10.1097/cp9.0000000000000004","pdf_url":null,"source":{"id":"https://openalex.org/S4210203274","display_name":"Cardiology Plus","issn_l":"2470-7511","issn":["2470-7511","2470-752X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiology Plus","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6700000166893005}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1507701463","https://openalex.org/W1592734136","https://openalex.org/W1978798002","https://openalex.org/W1987580585","https://openalex.org/W1988916724","https://openalex.org/W1989196423","https://openalex.org/W2003616272","https://openalex.org/W2025583699","https://openalex.org/W2030717682","https://openalex.org/W2061686707","https://openalex.org/W2072567352","https://openalex.org/W2100053387","https://openalex.org/W2122935216","https://openalex.org/W2140046463","https://openalex.org/W2140732936","https://openalex.org/W2325967199","https://openalex.org/W2432508435","https://openalex.org/W2558417454","https://openalex.org/W2585235989","https://openalex.org/W2608226954","https://openalex.org/W2807208240","https://openalex.org/W2946465773","https://openalex.org/W2965711424","https://openalex.org/W2998317890","https://openalex.org/W3146699994","https://openalex.org/W4236374402","https://openalex.org/W4293860347"],"related_works":["https://openalex.org/W2390494251","https://openalex.org/W2383457339","https://openalex.org/W3146699994","https://openalex.org/W2432508435","https://openalex.org/W4295484284","https://openalex.org/W2399160443","https://openalex.org/W2153845023","https://openalex.org/W2369374126","https://openalex.org/W7212015097","https://openalex.org/W7161999665"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Previous":[2],"studies":[3],"suggested":[4],"higher":[5,170,199,202],"serum":[6,49],"N-terminal-pro-B-type":[7],"natriuretic":[8],"peptide":[9],"(NT-proBNP)":[10],"level":[11,150,186,229],"with":[12,97,127,152,176,189,219,233,243],"older":[13,193,248],"age":[14,143,154,182],"and":[15,45,112,139,164,167,207,237,247],"in":[16,51,171,174],"women,":[17,141],"but":[18],"the":[19,69,92,106,110,177,180,190,220,244],"reference":[20],"intervals":[21],"(RIs)":[22],"recommended":[23],"by":[24,109,224],"assay":[25],"manufacturers":[26],"do":[27],"not":[28],"fully":[29],"recognize":[30],"such":[31],"pattern.":[32],"Aims:":[33],"In":[34],"this":[35],"study,":[36],"we":[37],"aimed":[38],"to":[39,62,83,122,156,159,162],"establish":[40],"a":[41,74,78,98],"set":[42],"of":[43,179,235],"age-":[44],"sex-specific":[46],"RIs":[47,101],"for":[48,213],"NT-proBNP":[50,87,128,149,185,228,240],"healthy":[52],"adults":[53],"from":[54,68,80],"Northeast":[55],"China.":[56],"Methods:":[57],"Healthy":[58],"adult":[59],"subjects":[60,136],"(20":[61,155],"\u226495":[63],"years":[64],"old)":[65],"were":[66,102,125],"recruited":[67],"physical":[70],"examination":[71],"center":[72],"at":[73],"teaching":[75],"hospital":[76],"during":[77],"period":[79],"March":[81],"2020":[82],"July":[84],"2020.":[85],"Serum":[86,148,227],"concentration":[88],"was":[89,120,168,187,218],"measured":[90],"using":[91],"VITROS":[93],"5600":[94],"Integrated":[95],"System":[96],"chemiluminescence":[99],"method.":[100],"calculated":[103],"based":[104],"on":[105],"EP28-A3c":[107],"guidelines":[108],"Clinical":[111],"Laboratory":[113],"Standards":[114],"Institute.":[115],"A":[116],"generalized":[117],"linear":[118],"model":[119],"performed":[121],"factors":[123],"that":[124],"associated":[126,188,242],"level.":[129],"Results:":[130],"The":[131,215],"final":[132],"analysis":[133],"included":[134],"2,183":[135],"(1,074":[137],"men":[138,175],"1,109":[140],"mean":[142],"54.2":[144],"\u00b1":[145],"19.5":[146],"years).":[147],"increased":[151],"advancing":[153],"<50,":[157],"50":[158],"<60,":[160],"60":[161],"<75":[163],"\u226575":[165,181],"years),":[166],"significantly":[169],"women":[172],"than":[173],"exception":[178],"group.":[183],"Higher":[184,239],"female":[191,221,245],"sex,":[192,222],"age,":[194],"lower":[195,204,208],"body":[196],"mass":[197],"index,":[198],"urea":[200],"nitrogen,":[201],"creatinine,":[203],"uric":[205],"acid,":[206],"triglyceride":[209],"(P":[210],"<":[211],"0.05":[212],"all).":[214],"strongest":[216],"association":[217],"followed":[223],"age.":[225,238,249],"Conclusions:":[226],"must":[230],"be":[231],"interpreted":[232],"consideration":[234],"sex":[236,246],"is":[241]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2022-06-23T00:00:00"}