{"id":"https://openalex.org/W4283220554","doi":"https://doi.org/10.1038/s41598-022-14392-7","title":"CD73 downregulation by EGFR-targeted liposomal CD73 siRNA potentiates antitumor effect of liposomal doxorubicin in 4T1 tumor-bearing mice","display_name":"CD73 downregulation by EGFR-targeted liposomal CD73 siRNA potentiates antitumor effect of liposomal doxorubicin in 4T1 tumor-bearing mice","publication_year":2022,"publication_date":"2022-06-21","ids":{"openalex":"https://openalex.org/W4283220554","doi":"https://doi.org/10.1038/s41598-022-14392-7","pmid":"https://pubmed.ncbi.nlm.nih.gov/35729230","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9213518"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-022-14392-7","doi":"https://doi.org/10.1038/s41598-022-14392-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-022-14392-7","pdf_url":"https://www.nature.com/articles/s41598-022-14392-7.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-022-14392-7.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020842779","display_name":"Anvar Soleimani","orcid":"https://orcid.org/0000-0003-1091-0537","observed_orcids":["https://orcid.org/0000-0003-1091-0537"]},"institutions":[{"id":"https://openalex.org/I165560825","display_name":"Mashhad University of Medical Sciences","ror":"https://ror.org/04sfka033","country_code":"IR","type":"education","lineage":["https://openalex.org/I165560825"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Anvar Soleimani","raw_affiliation_strings":["Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran","institution_ids":["https://openalex.org/I165560825"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050253847","display_name":"Farshad Mirzavi","orcid":"https://orcid.org/0000-0003-4686-1511","observed_orcids":["https://orcid.org/0000-0003-4686-1511"]},"institutions":[{"id":"https://openalex.org/I165560825","display_name":"Mashhad University of Medical Sciences","ror":"https://ror.org/04sfka033","country_code":"IR","type":"education","lineage":["https://openalex.org/I165560825"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Farshad Mirzavi","raw_affiliation_strings":["Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran","institution_ids":["https://openalex.org/I165560825"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045230308","display_name":"Sara Nikoofal\u2010Sahlabadi","orcid":"https://orcid.org/0000-0001-8619-654X","observed_orcids":["https://orcid.org/0000-0001-8619-654X"]},"institutions":[{"id":"https://openalex.org/I4210128695","display_name":"Hormozgan University of Medical Sciences","ror":"https://ror.org/037wqsr57","country_code":"IR","type":"education","lineage":["https://openalex.org/I4210128695"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Sara Nikoofal-Sahlabadi","raw_affiliation_strings":["Department of Pharmaceutics, Faculty of Pharmacy, Hormozgan University of Medical Sciences, Bandar Abbas, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Faculty of Pharmacy, Hormozgan University of Medical Sciences, Bandar Abbas, Iran","institution_ids":["https://openalex.org/I4210128695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017947632","display_name":"Amin Reza Nikpoor","orcid":"https://orcid.org/0000-0001-5619-8771","observed_orcids":["https://orcid.org/0000-0001-5619-8771"]},"institutions":[{"id":"https://openalex.org/I4210128695","display_name":"Hormozgan University of Medical Sciences","ror":"https://ror.org/037wqsr57","country_code":"IR","type":"education","lineage":["https://openalex.org/I4210128695"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Amin Reza Nikpoor","raw_affiliation_strings":["Molecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran","institution_ids":["https://openalex.org/I4210128695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050909191","display_name":"Bita Taghizadeh","orcid":"https://orcid.org/0000-0003-4056-1446","observed_orcids":["https://orcid.org/0000-0003-4056-1446"]},"institutions":[{"id":"https://openalex.org/I163205636","display_name":"Tabriz University of Medical Sciences","ror":"https://ror.org/04krpx645","country_code":"IR","type":"education","lineage":["https://openalex.org/I163205636"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Bita Taghizadeh","raw_affiliation_strings":["Department of Medical Biotechnology, School of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biotechnology, School of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran","institution_ids":["https://openalex.org/I163205636"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084551363","display_name":"Mehdi Barati","orcid":"https://orcid.org/0000-0002-5715-1948","observed_orcids":["https://orcid.org/0000-0002-5715-1948"]},"institutions":[{"id":"https://openalex.org/I165560825","display_name":"Mashhad University of Medical Sciences","ror":"https://ror.org/04sfka033","country_code":"IR","type":"education","lineage":["https://openalex.org/I165560825"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mehdi Barati","raw_affiliation_strings":["Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran","institution_ids":["https://openalex.org/I165560825"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050273143","display_name":"Mohammad Soukhtanloo","orcid":"https://orcid.org/0000-0003-2145-125X","observed_orcids":["https://orcid.org/0000-0003-2145-125X"]},"institutions":[{"id":"https://openalex.org/I165560825","display_name":"Mashhad University of Medical Sciences","ror":"https://ror.org/04sfka033","country_code":"IR","type":"education","lineage":["https://openalex.org/I165560825"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Mohammad Soukhtanloo","raw_affiliation_strings":["Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. soukhtanloom@mums.ac.ir","Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. soukhtanloom@mums.ac.ir","institution_ids":["https://openalex.org/I165560825"]},{"raw_affiliation_string":"Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran","institution_ids":["https://openalex.org/I165560825"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048139853","display_name":"Mahmoud Reza Jaafari","orcid":"https://orcid.org/0000-0003-3908-6828","observed_orcids":["https://orcid.org/0000-0003-3908-6828"]},"institutions":[{"id":"https://openalex.org/I165560825","display_name":"Mashhad University of Medical Sciences","ror":"https://ror.org/04sfka033","country_code":"IR","type":"education","lineage":["https://openalex.org/I165560825"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Mahmoud Reza Jaafari","raw_affiliation_strings":["Department of Pharmaceutical Nanotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. jafariMR@mums.ac.ir","Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. jafariMR@mums.ac.ir","Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Nanotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. jafariMR@mums.ac.ir","institution_ids":["https://openalex.org/I165560825"]},{"raw_affiliation_string":"Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. jafariMR@mums.ac.ir","institution_ids":["https://openalex.org/I165560825"]},{"raw_affiliation_string":"Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran","institution_ids":["https://openalex.org/I165560825"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5048139853","https://openalex.org/A5050273143"],"corresponding_institution_ids":["https://openalex.org/I165560825"],"apc_list":{"value":2190,"currency":"USD","value_usd":2190},"apc_paid":{"value":2190,"currency":"USD","value_usd":2190},"fwci":1.0221,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.7174458,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"12","issue":"1","first_page":"10423","last_page":"10423"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.7324000000953674,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.7324000000953674,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.2605000138282776,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd73","display_name":"CD73","score":0.9890000224113464},{"id":"https://openalex.org/keywords/sirna-delivery","display_name":"siRNA delivery","score":0.800000011920929},{"id":"https://openalex.org/keywords/liposomal-doxorubicin","display_name":"liposomal doxorubicin","score":0.9810000061988831},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8519999980926514},{"id":"https://openalex.org/keywords/4t1-breast-cancer-model","display_name":"4T1 breast cancer","score":0.8659999966621399},{"id":"https://openalex.org/keywords/ge11-peptide","display_name":"GE11 peptide","score":0.7850000262260437},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.6029999852180481},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.6990000009536743},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.4490000009536743},{"id":"https://openalex.org/keywords/nanoparticle-toxicity","display_name":"nanoparticle toxicity","score":0.4449999928474426},{"id":"https://openalex.org/keywords/encapsulation-efficiency","display_name":"encapsulation efficiency","score":0.6159999966621399},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.6100000143051147},{"id":"https://openalex.org/keywords/metastatic-breast-cancer","display_name":"metastatic breast cancer","score":0.7049999833106995},{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.4000000059604645}],"concepts":[{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.8908623456954956},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.7205332517623901},{"id":"https://openalex.org/C2777807558","wikidata":"https://www.wikidata.org/wiki/Q4914764","display_name":"Biodistribution","level":3,"score":0.6600028872489929},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6313384175300598},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.5903542041778564},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.5526689291000366},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5351857542991638},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4658551812171936},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3763432800769806},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3150922656059265},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2636401355266571},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.20109325647354126},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14815232157707214},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.14506486058235168},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1333252489566803},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07753372192382812},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015720","descriptor_name":"5'-Nucleotidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058851","descriptor_name":"GPI-Linked Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41598-022-14392-7","doi":"https://doi.org/10.1038/s41598-022-14392-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-022-14392-7","pdf_url":"https://www.nature.com/articles/s41598-022-14392-7.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-1008064/v1","doi":"https://doi.org/10.21203/rs.3.rs-1008064/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-1008064/v1","pdf_url":"https://www.researchsquare.com/article/rs-1008064/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmid:35729230","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35729230","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9213518","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9213518/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:23777b5dd4a34641ab009b693c32ead9","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/23777b5dd4a34641ab009b693c32ead9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-022-14392-7","doi":"https://doi.org/10.1038/s41598-022-14392-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-022-14392-7","pdf_url":"https://www.nature.com/articles/s41598-022-14392-7.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G535350460","display_name":null,"funder_award_id":"951111","funder_id":"https://openalex.org/F4320322855","funder_display_name":"Mashhad University of Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320322855","display_name":"Mashhad University of Medical Sciences","ror":"https://ror.org/04sfka033"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4283220554.pdf","grobid_xml":"https://content.openalex.org/works/W4283220554.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W758305415","https://openalex.org/W1970013864","https://openalex.org/W2002978200","https://openalex.org/W2028897202","https://openalex.org/W2040329251","https://openalex.org/W2055532721","https://openalex.org/W2066188228","https://openalex.org/W2083232571","https://openalex.org/W2113661022","https://openalex.org/W2159945718","https://openalex.org/W2176599934","https://openalex.org/W2222718468","https://openalex.org/W2296497547","https://openalex.org/W2413021648","https://openalex.org/W2421622109","https://openalex.org/W2474535137","https://openalex.org/W2565450071","https://openalex.org/W2588451912","https://openalex.org/W2765132620","https://openalex.org/W2769890142","https://openalex.org/W2771197204","https://openalex.org/W2784379952","https://openalex.org/W2785041354","https://openalex.org/W2785399752","https://openalex.org/W2800676430","https://openalex.org/W2809650769","https://openalex.org/W2883139684","https://openalex.org/W2885900642","https://openalex.org/W2888899523","https://openalex.org/W2889393188","https://openalex.org/W2890392576","https://openalex.org/W2911986483","https://openalex.org/W2913272230","https://openalex.org/W2937318865","https://openalex.org/W2945311898","https://openalex.org/W2946119619","https://openalex.org/W2946193244","https://openalex.org/W2946529095","https://openalex.org/W2954610786","https://openalex.org/W3037289028","https://openalex.org/W3107885361","https://openalex.org/W3124907925","https://openalex.org/W3134796986","https://openalex.org/W3181127299","https://openalex.org/W3189490217","https://openalex.org/W6721220291"],"related_works":["https://openalex.org/W3211341821","https://openalex.org/W3189490217","https://openalex.org/W2565450071","https://openalex.org/W2222718468","https://openalex.org/W1992817854","https://openalex.org/W2387285990","https://openalex.org/W4283215200","https://openalex.org/W4249483011","https://openalex.org/W4238771231","https://openalex.org/W2888654018"],"abstract_inverted_index":{"Abstract":[0],"Blocking":[1],"CD73":[2,29,43,89,164,168,245,262,267,276,282,353,379,385,400],"ectonucleotidase":[3],"has":[4],"been":[5],"proposed":[6],"as":[7],"a":[8,25,145],"potential":[9],"therapeutic":[10],"approach":[11],"for":[12,96,161,288],"cancer":[13,122],"treatment.":[14],"The":[15,85,151,182,197,232,301],"present":[16],"study":[17],"aimed":[18],"to":[19,273,293,313,374],"investigate":[20],"the":[21,39,50,63,75,81,103,125,141,162,205,218,235,242,248,289,294,314,318,322,334,343,356,367,370,375,388,397],"antitumor":[22,104],"effect":[23],"of":[24,61,74,106,127,130,144,148,153,234,241,331,358,390,399],"novel":[26],"EGFR-Targeted":[27],"liposomal":[28,36,76,86,112,136,155,163,391],"siRNA":[30,44,90,165,169,246,263,380],"formulation":[31,87,296,381],"in":[32,38,97,109,116,132,140,222,230,279,321,333,342,369],"combination":[33,110,302,344],"therapy":[34,345],"with":[35,93,111,135,308],"doxorubicin":[37,113,137,392],"4T1":[40,82,119],"mouse":[41,146],"model.":[42],"was":[45,65,91,114,138,185,193,210,285,340],"encapsulated":[46],"into":[47],"nanoliposomes":[48],"by":[49,67],"ethanol":[51],"injection":[52],"method.":[53],"After":[54],"preparation,":[55],"characterization,":[56],"morphology,":[57],"and":[58,72,166,176,189,224,254,363],"stability":[59],"evaluation":[60],"formulations,":[62],"toxicity":[64,240],"measured":[66],"MTT":[68,236],"assay.":[69],"Uptake":[70],"assay":[71,237],"efficiency":[73,208,284],"formulations":[77,108,131,156,270],"were":[78,171,220,225,271],"investigated":[79],"on":[80],"cell":[83,250],"line.":[84],"containing":[88,244,261],"targeted":[92,290],"GE11":[94],"peptide":[95],"vivo":[98],"evaluations.":[99],"Following":[100],"biodistribution":[101],"analysis,":[102],"activity":[105,357],"prepared":[107,154],"studied":[115],"mice":[117],"bearing":[118],"metastatic":[120],"breast":[121,149],"cells.":[123],"Finally,":[124,347],"induction":[126],"immune":[128,319],"response":[129],"concomitant":[133],"treatment":[134,323],"evaluated":[139],"tumor":[142,305,335],"microenvironment":[143],"model":[147],"cancer.":[150],"size":[152],"at":[157],"N/P":[158,201],"=":[159,202],"16":[160,203],"GE11-liposomal":[167],"groups":[170,324],"89":[172],"nm":[173,178,229],"\u00b1":[174,179,212],"4.4":[175],"95":[177],"6.6,":[180],"respectively.":[181],"nanoparticle\u2019s":[183],"PDI":[184],"less":[186,226],"than":[187,227],"0.3":[188],"their":[190],"surface":[191],"charge":[192],"below":[194],"10":[195],"mV.":[196],"results":[198,215,233,257,349],"demonstrated":[199],"that":[200,217,259,352],"yielded":[204],"best":[206],"encapsulation":[207],"which":[209,325],"94%":[211],"3.3.":[213],"AFM":[214],"showed":[216,238,258,303,328,351],"liposomes":[219,243,260],"spherical":[221],"shape":[223],"100":[228],"size.":[231],"significant":[239],"during":[247],"48-h":[249],"culture.":[251],"Real-time":[252],"PCR":[253],"flow":[255],"cytometry":[256],"could":[264],"effectively":[265],"downregulate":[266,275],"expression.":[268],"Liposomal":[269],"able":[272],"significantly":[274,286,365,394],"gene":[277],"expression,":[278],"vivo.":[280],"However,":[281,337],"downregulation":[283,354,398],"higher":[287],"form":[291],"compared":[292,312,373],"non-targeted":[295],"(P":[297],"value":[298],"<":[299],"0.01).":[300],"maximum":[304],"growth":[306],"delay":[307],"remarkable":[309],"survival":[310],"improvement":[311],"control":[315,376],"group.":[316,346,377],"Studying":[317],"responses":[320],"received":[326],"doxorubicin,":[327],"decreased":[329],"number":[330],"lymphocytes":[332,360,372],"environment.":[336],"this":[338],"decrease":[339],"lower":[341],"our":[348],"clearly":[350],"increases":[355],"CD8+":[359],"(IFN-\u213d":[361],"production)":[362],"also":[364],"decreases":[366],"Foxp3":[368],"CD25+":[371],"GE11-Lipo":[378],"can":[382],"efficiently":[383],"knockdown":[384],"ectonucleotidase.":[386,401],"Also,":[387],"efficacy":[389],"is":[393],"enhanced":[395],"via":[396]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2022-06-22T00:00:00"}
