{"id":"https://openalex.org/W4283220174","doi":"https://doi.org/10.1055/a-1835-1690","title":"Statins Increase the Bioavailability of Fixed-Dose Combination of Sofosbuvir/Ledipasvir by Inhibition of P-glycoprotein","display_name":"Statins Increase the Bioavailability of Fixed-Dose Combination of Sofosbuvir/Ledipasvir by Inhibition of P-glycoprotein","publication_year":2022,"publication_date":"2022-06-20","ids":{"openalex":"https://openalex.org/W4283220174","doi":"https://doi.org/10.1055/a-1835-1690","pmid":"https://pubmed.ncbi.nlm.nih.gov/35724670"},"language":"en","primary_location":{"id":"doi:10.1055/a-1835-1690","doi":"https://doi.org/10.1055/a-1835-1690","is_oa":false,"landing_page_url":"https://doi.org/10.1055/a-1835-1690","pdf_url":null,"source":{"id":"https://openalex.org/S4210226141","display_name":"Drug Research","issn_l":"2194-9379","issn":["2194-9379","2194-9387"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","medline","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081358454","display_name":"Khaled Sobhy Abdelkawy","orcid":"https://orcid.org/0009-0007-0710-9868","observed_orcids":["https://orcid.org/0009-0007-0710-9868"]},"institutions":[{"id":"https://openalex.org/I130309236","display_name":"Kafrelsheikh University","ror":"https://ror.org/04a97mm30","country_code":"EG","type":"education","lineage":["https://openalex.org/I130309236"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"K.S. Abdelkawy","raw_affiliation_strings":["Department of Clinical Pharmacy, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt","institution_ids":["https://openalex.org/I130309236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078544916","display_name":"Fathalla F. Belal","orcid":"https://orcid.org/0000-0001-6242-2178","observed_orcids":["https://orcid.org/0000-0001-6242-2178"]},"institutions":[{"id":"https://openalex.org/I159247623","display_name":"Mansoura University","ror":"https://ror.org/01k8vtd75","country_code":"EG","type":"education","lineage":["https://openalex.org/I159247623"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Fathalla Belal","raw_affiliation_strings":["Department of Analytical Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Analytical Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura, Egypt","institution_ids":["https://openalex.org/I159247623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076351397","display_name":"AbdelazizE Abdelaziz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130309236","display_name":"Kafrelsheikh University","ror":"https://ror.org/04a97mm30","country_code":"EG","type":"education","lineage":["https://openalex.org/I130309236"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"AbdelazizE Abdelaziz","raw_affiliation_strings":["Department of Pharmaceutical Technology, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Technology, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt","institution_ids":["https://openalex.org/I130309236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033781325","display_name":"H. A. Elmekawy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130309236","display_name":"Kafrelsheikh University","ror":"https://ror.org/04a97mm30","country_code":"EG","type":"education","lineage":["https://openalex.org/I130309236"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"H. A. Elmekawy","raw_affiliation_strings":["Department of Clinical Pharmacy, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt","institution_ids":["https://openalex.org/I130309236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090058518","display_name":"Mohamed Y. Abdelgaied","orcid":"https://orcid.org/0000-0002-0990-954X","observed_orcids":["https://orcid.org/0000-0002-0990-954X"]},"institutions":[{"id":"https://openalex.org/I96823368","display_name":"German University in Cairo","ror":"https://ror.org/03rjt0z37","country_code":"EG","type":"education","lineage":["https://openalex.org/I96823368"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"M. Y. Abdelgaied","raw_affiliation_strings":["Department of Pharmacology, Toxicology and Clinical Pharmacy, Faculty of Pharmacy and Biotechnology, German University in Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Toxicology and Clinical Pharmacy, Faculty of Pharmacy and Biotechnology, German University in Cairo, Egypt","institution_ids":["https://openalex.org/I96823368"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020773984","display_name":"Noha Mahmoud El-Khodary","orcid":"https://orcid.org/0000-0003-3303-0399","observed_orcids":["https://orcid.org/0000-0003-3303-0399"]},"institutions":[{"id":"https://openalex.org/I130309236","display_name":"Kafrelsheikh University","ror":"https://ror.org/04a97mm30","country_code":"EG","type":"education","lineage":["https://openalex.org/I130309236"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"N. M. El-Khodary","raw_affiliation_strings":["Department of Clinical Pharmacy, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt","institution_ids":["https://openalex.org/I130309236"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.05509089,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"72","issue":"06","first_page":"319","last_page":"326"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.3869999945163727,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.3869999945163727,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.2883000075817108,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.27390000224113464,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.9010000228881836},{"id":"https://openalex.org/keywords/sofosbuvir","display_name":"sofosbuvir","score":0.8270000219345093},{"id":"https://openalex.org/keywords/ledipasvir","display_name":"ledipasvir","score":1.0},{"id":"https://openalex.org/keywords/p-glycoprotein-inhibition","display_name":"P-glycoprotein inhibition","score":0.9110000133514404},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.8730000257492065},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.7279999852180481},{"id":"https://openalex.org/keywords/atorvastatin","display_name":"atorvastatin","score":0.8989999890327454},{"id":"https://openalex.org/keywords/lovastatin","display_name":"lovastatin","score":1.0},{"id":"https://openalex.org/keywords/direct-acting-antivirals","display_name":"direct-acting antivirals","score":0.8119999766349792},{"id":"https://openalex.org/keywords/hepatitis-c","display_name":"hepatitis C","score":0.5649999976158142},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9150000214576721},{"id":"https://openalex.org/keywords/hepatic-elimination","display_name":"hepatic elimination","score":0.656000018119812},{"id":"https://openalex.org/keywords/fixed-dose-combination","display_name":"fixed-dose combination","score":0.6639999747276306}],"concepts":[{"id":"https://openalex.org/C22979827","wikidata":"https://www.wikidata.org/wiki/Q5137311","display_name":"Cmax","level":3,"score":0.8825857639312744},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.8507072925567627},{"id":"https://openalex.org/C2777482532","wikidata":"https://www.wikidata.org/wiki/Q668093","display_name":"Atorvastatin","level":2,"score":0.7743468284606934},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.7684212923049927},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7279893755912781},{"id":"https://openalex.org/C2780940807","wikidata":"https://www.wikidata.org/wiki/Q417740","display_name":"Lovastatin","level":3,"score":0.6929721832275391},{"id":"https://openalex.org/C2775999097","wikidata":"https://www.wikidata.org/wiki/Q15409409","display_name":"Ledipasvir","level":5,"score":0.6426569819450378},{"id":"https://openalex.org/C2778390639","wikidata":"https://www.wikidata.org/wiki/Q2502747","display_name":"Sofosbuvir","level":5,"score":0.6308283805847168},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.5045202970504761},{"id":"https://openalex.org/C87813604","wikidata":"https://www.wikidata.org/wiki/Q1242899","display_name":"Crossover study","level":4,"score":0.5040673017501831},{"id":"https://openalex.org/C42404028","wikidata":"https://www.wikidata.org/wiki/Q864940","display_name":"Bioequivalence","level":3,"score":0.4744490385055542},{"id":"https://openalex.org/C2776839432","wikidata":"https://www.wikidata.org/wiki/Q954845","display_name":"Statin","level":2,"score":0.4502262473106384},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44467759132385254},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4281960427761078},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21808123588562012},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.21198183298110962},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.18054687976837158},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12195295095443726},{"id":"https://openalex.org/C2780040827","wikidata":"https://www.wikidata.org/wiki/Q421862","display_name":"Ribavirin","level":4,"score":0.052403002977371216},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069059","descriptor_name":"Atorvastatin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069474","descriptor_name":"Sofosbuvir","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005449","descriptor_name":"Fluorenes","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008148","descriptor_name":"Lovastatin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018435","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D018592","descriptor_name":"Cross-Over Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020168","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B, Member 1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1055/a-1835-1690","doi":"https://doi.org/10.1055/a-1835-1690","is_oa":false,"landing_page_url":"https://doi.org/10.1055/a-1835-1690","pdf_url":null,"source":{"id":"https://openalex.org/S4210226141","display_name":"Drug Research","issn_l":"2194-9379","issn":["2194-9379","2194-9387"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","medline","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Research","raw_type":"journal-article"},{"id":"pmid:35724670","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35724670","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320317358","display_name":"Kafrelsheikh University","ror":"https://ror.org/04a97mm30"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W74649421","https://openalex.org/W921429692","https://openalex.org/W1484112502","https://openalex.org/W1510298788","https://openalex.org/W1581747141","https://openalex.org/W1586789942","https://openalex.org/W1841839642","https://openalex.org/W1975192364","https://openalex.org/W1994499694","https://openalex.org/W2012152582","https://openalex.org/W2015283800","https://openalex.org/W2021844025","https://openalex.org/W2028538270","https://openalex.org/W2032332568","https://openalex.org/W2037557484","https://openalex.org/W2042049257","https://openalex.org/W2053009244","https://openalex.org/W2053895073","https://openalex.org/W2057318017","https://openalex.org/W2061864878","https://openalex.org/W2068062063","https://openalex.org/W2070645257","https://openalex.org/W2071124826","https://openalex.org/W2074041396","https://openalex.org/W2080083635","https://openalex.org/W2082911977","https://openalex.org/W2089691623","https://openalex.org/W2092767297","https://openalex.org/W2106642167","https://openalex.org/W2109457390","https://openalex.org/W2117816931","https://openalex.org/W2118276142","https://openalex.org/W2119371081","https://openalex.org/W2120165528","https://openalex.org/W2121703474","https://openalex.org/W2122267139","https://openalex.org/W2124094927","https://openalex.org/W2127303295","https://openalex.org/W2151554611","https://openalex.org/W2155820299","https://openalex.org/W2156031384","https://openalex.org/W2340968307","https://openalex.org/W2394689692","https://openalex.org/W2484875770","https://openalex.org/W2524098531","https://openalex.org/W2742581645","https://openalex.org/W2782023682","https://openalex.org/W2797062806","https://openalex.org/W2797355482","https://openalex.org/W2894210232","https://openalex.org/W3004129163","https://openalex.org/W3005619165","https://openalex.org/W3015742464","https://openalex.org/W3032964979","https://openalex.org/W3033563729","https://openalex.org/W3038275517","https://openalex.org/W3154390833"],"related_works":["https://openalex.org/W3147054939","https://openalex.org/W2023146232","https://openalex.org/W3127732578","https://openalex.org/W2153930779","https://openalex.org/W2614817248","https://openalex.org/W1991204820","https://openalex.org/W2797355482","https://openalex.org/W1480085725","https://openalex.org/W2118964190","https://openalex.org/W35427688"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Coadministration":[2],"of":[3,18,25,29,87,127,141,148,197,210,227,246],"statins":[4],"and":[5,21,43,90,94,115,119,125,133,158,195,200,206,212,248],"direct":[6],"acting":[7],"antiviral":[8],"agents":[9],"is":[10,223,242],"frequently":[11],"used.":[12],"This":[13],"study":[14],"explored":[15],"the":[16,146,224],"effects":[17],"both":[19,198],"atorvastatin":[20,48,137,167,189,205,238,247],"lovastatin":[22,60,142,169,207],"on":[23],"pharmacokinetics":[24],"a":[26,38,46,58,103,171],"fixed-dose":[27],"combination":[28],"sofosbuvir/ledipasvir":[30],"\u201cFDCSL\u201d.":[31],"Methods":[32],"12":[33],"healthy":[34],"volunteers":[35],"participated":[36],"in":[37,106,113,173,193,231],"randomized,":[39],"three-phase":[40],"crossover":[41],"trial":[42],"were":[44,98,129],"administered":[45],"single":[47,59],"dose":[49,61],"80":[50],"mg":[51,56,63,68,74],"plus":[52,64],"tablet":[53,65],"containing":[54,66,72],"400/90":[55,67,73],"FDCSL,":[57,69],"40":[62],"or":[70],"tablets":[71],"FDCSL":[75,144],"alone.":[76],"Liquid":[77],"chromatography-tandem":[78],"mass":[79],"spectrometry":[80],"was":[81,178,234],"used":[82],"to":[83,187],"analyze":[84],"plasma":[85],"samples":[86],"sofosbuvir,":[88,149],"ledipasvir":[89,174],"sofosbuvir":[91,107,199,211,232],"metabolite":[92,151,214],"\u201cGS-331007\u201d":[93],"their":[95],"pharmacokinetic":[96],"parameters":[97],"determined.":[99],"Results":[100],"Atorvastatin":[101],"caused":[102],"significant":[104,191],"rise":[105],"bioavailability":[108,147,233],"as":[109],"explained":[110],"by":[111,117,131,154,161],"increasing":[112],"AUC0\u2212\u221e":[114],"Cmax":[116,126,159,196],"34.36%":[118],"11.97%,":[120],"respectively.":[121],"In":[122],"addition,":[123],"AUC0-\u221e":[124,194],"GS-331007":[128],"increased":[130,145,208],"73.73%":[132],"67.86%,":[134],"respectively":[135],"after":[136,181,215,237,244],"intake.":[138,239],"Similarly,":[139],"co-administration":[140,245],"with":[143,184,218],"its":[150,201,213],"(AUC0-\u221e":[152],"increase":[153,160,192,230],"17.2%,":[155],"17.38%,":[156],"respectively,":[157],"12.03%,":[162],"22.24%,":[163],"respectively).":[164],"However,":[165],"neither":[166],"nor":[168],"showed":[170,190],"change":[172],"bioavailability.":[175],"Hepatic":[176],"elimination":[177],"not":[179],"affected":[180],"statin":[182],"intake":[183],"FDCSL.":[185,219,249],"Compared":[186],"lovastatin,":[188],"metabolite.":[202],"Conclusions":[203],"Both":[204],"AUC":[209],"concurrent":[216],"administration":[217],"Statins\u2019":[220],"P-glycoprotein":[221],"inhibition":[222],"attributed":[225],"mechanism":[226],"interaction.":[228],"The":[229],"more":[235],"pronounced":[236],"Close":[240],"monitoring":[241],"needed":[243]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-06-22T00:00:00"}
