{"id":"https://openalex.org/W4283210386","doi":"https://doi.org/10.1002/cncr.34348","title":"Differential prognostic effect of systemic inflammation in patients with non\u2013small cell lung cancer treated with immunotherapy or chemotherapy: A post hoc analysis of the phase 3 OAK trial","display_name":"Differential prognostic effect of systemic inflammation in patients with non\u2013small cell lung cancer treated with immunotherapy or chemotherapy: A post hoc analysis of the phase 3 OAK trial","publication_year":2022,"publication_date":"2022-06-21","ids":{"openalex":"https://openalex.org/W4283210386","doi":"https://doi.org/10.1002/cncr.34348","pmid":"https://pubmed.ncbi.nlm.nih.gov/35727053","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11497250"},"language":"en","primary_location":{"id":"doi:10.1002/cncr.34348","doi":"https://doi.org/10.1002/cncr.34348","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cncr.34348","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.34348","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.34348","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060954139","display_name":"Alessio Cortellini","orcid":"https://orcid.org/0000-0002-1209-5735","observed_orcids":["https://orcid.org/0000-0002-1209-5735"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Alessio Cortellini","raw_affiliation_strings":["Division of Cancer, Department of Surgery and Cancer, Imperial College London, London, UK"],"raw_orcid":"https://orcid.org/0000-0002-1209-5735","affiliations":[{"raw_affiliation_string":"Division of Cancer, Department of Surgery and Cancer, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030450694","display_name":"Biagio Ricciuti","orcid":"https://orcid.org/0000-0002-0651-2678","observed_orcids":["https://orcid.org/0000-0002-0651-2678"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210134579","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Biagio Ricciuti","raw_affiliation_strings":["Lowe Center for Thoracic Oncology, Dana\u2013Farber Cancer Institute Harvard Medical School Boston Massachusetts USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lowe Center for Thoracic Oncology, Dana\u2013Farber Cancer Institute Harvard Medical School Boston Massachusetts USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012061864","display_name":"Hossein Borghaei","orcid":"https://orcid.org/0000-0002-2577-4454","observed_orcids":["https://orcid.org/0000-0002-2577-4454"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I4210122924","display_name":"Temple University Health System","ror":"https://ror.org/02fhvxj45","country_code":"US","type":"education","lineage":["https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hossein Borghaei","raw_affiliation_strings":["Department of Hematology\u2013Oncology, Fox Chase Cancer Center Temple University Health System Philadelphia Pennsylvania USA"],"raw_orcid":"https://orcid.org/0000-0002-2577-4454","affiliations":[{"raw_affiliation_string":"Department of Hematology\u2013Oncology, Fox Chase Cancer Center Temple University Health System Philadelphia Pennsylvania USA","institution_ids":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090621600","display_name":"Abdul Rafeh Naqash","orcid":"https://orcid.org/0000-0001-7622-720X","observed_orcids":["https://orcid.org/0000-0001-7622-720X"]},"institutions":[{"id":"https://openalex.org/I4390039380","display_name":"OU Health Stephenson Cancer Center","ror":"https://ror.org/02bmcqd02","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039271","https://openalex.org/I4390039380"]},{"id":"https://openalex.org/I8692664","display_name":"University of Oklahoma","ror":"https://ror.org/02aqsxs83","country_code":"US","type":"education","lineage":["https://openalex.org/I8692664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abdul Rafeh Naqash","raw_affiliation_strings":["Medical Oncology/TSET Phase 1 Program, Stephenson Cancer Center, University of Oklahoma, Oklahoma City, Oklahoma, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology/TSET Phase 1 Program, Stephenson Cancer Center, University of Oklahoma, Oklahoma City, Oklahoma, USA","institution_ids":["https://openalex.org/I4390039380","https://openalex.org/I8692664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023635260","display_name":"Antonio D\u2019Alessio","orcid":"https://orcid.org/0000-0002-9164-3671","observed_orcids":["https://orcid.org/0000-0002-9164-3671"]},"institutions":[{"id":"https://openalex.org/I1339471597","display_name":"Humanitas University","ror":"https://ror.org/020dggs04","country_code":"IT","type":"education","lineage":["https://openalex.org/I1339471597"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB","IT"],"is_corresponding":false,"raw_author_name":"Antonio D'Alessio","raw_affiliation_strings":["Department of Biomedical Sciences, Humanitas University, Pieve Emanuele (Milan), Italy","Division of Cancer, Department of Surgery and Cancer, Imperial College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele (Milan), Italy","institution_ids":["https://openalex.org/I1339471597"]},{"raw_affiliation_string":"Division of Cancer, Department of Surgery and Cancer, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051093023","display_name":"Claudia Angela Maria Fulgenzi","orcid":"https://orcid.org/0000-0002-5654-9225","observed_orcids":["https://orcid.org/0000-0002-5654-9225"]},"institutions":[{"id":"https://openalex.org/I155125353","display_name":"Universit\u00e0 Campus Bio-Medico","ror":"https://ror.org/04gqx4x78","country_code":"IT","type":"education","lineage":["https://openalex.org/I155125353"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB","IT"],"is_corresponding":false,"raw_author_name":"Claudia A. M. Fulgenzi","raw_affiliation_strings":["Department of Medical Oncology, University Campus Bio-Medico of Rome, Rome, Italy","Division of Cancer, Department of Surgery and Cancer, Imperial College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, University Campus Bio-Medico of Rome, Rome, Italy","institution_ids":["https://openalex.org/I155125353"]},{"raw_affiliation_string":"Division of Cancer, Department of Surgery and Cancer, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064542874","display_name":"Alfredo Addeo","orcid":"https://orcid.org/0000-0003-0988-0828","observed_orcids":["https://orcid.org/0000-0003-0988-0828","https://orcid.org/0000-0002-7086-7174"]},"institutions":[{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Alfredo Addeo","raw_affiliation_strings":["Oncology Department, University Hospital of Geneva, Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Department, University Hospital of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I4210106256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033351253","display_name":"Giuseppe Luigi Banna","orcid":"https://orcid.org/0000-0003-0764-3650","observed_orcids":["https://orcid.org/0000-0003-0764-3650"]},"institutions":[{"id":"https://openalex.org/I4210090003","display_name":"Portsmouth Hospitals NHS Trust","ror":"https://ror.org/009fk3b63","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210090003"]},{"id":"https://openalex.org/I4210151091","display_name":"Candiolo Cancer Institute","ror":"https://ror.org/04wadq306","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210151091","https://openalex.org/I4210153126","https://openalex.org/I4210167100"]}],"countries":["GB","IT"],"is_corresponding":false,"raw_author_name":"Giuseppe L. Banna","raw_affiliation_strings":["Candiolo Cancer Institute, FPO-IRCCS, Turin, Italy","Portsmouth Hospitals University NHS Trust, Portsmouth, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Candiolo Cancer Institute, FPO-IRCCS, Turin, Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Portsmouth Hospitals University NHS Trust, Portsmouth, UK","institution_ids":["https://openalex.org/I4210090003"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001343667","display_name":"David James Pinato","orcid":"https://orcid.org/0000-0002-3529-0103","observed_orcids":["https://orcid.org/0000-0002-3529-0103"]},"institutions":[{"id":"https://openalex.org/I123338534","display_name":"Universit\u00e0 degli Studi del Piemonte Orientale \u201cAmedeo Avogadro\u201d","ror":"https://ror.org/04387x656","country_code":"IT","type":"education","lineage":["https://openalex.org/I123338534"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB","IT"],"is_corresponding":false,"raw_author_name":"David James Pinato","raw_affiliation_strings":["Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale \u201cA. Avogadro,\u201d Novara Italy","Division of Cancer, Department of Surgery and Cancer, Imperial College London, London, UK"],"raw_orcid":"https://orcid.org/0000-0002-3529-0103","affiliations":[{"raw_affiliation_string":"Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale \u201cA. Avogadro,\u201d Novara Italy","institution_ids":["https://openalex.org/I123338534"]},{"raw_affiliation_string":"Division of Cancer, Department of Surgery and Cancer, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":14,"corresponding_author_ids":["https://openalex.org/A5060954139"],"corresponding_institution_ids":["https://openalex.org/I47508984"],"apc_list":{"value":4600,"currency":"USD","value_usd":4600},"apc_paid":{"value":4600,"currency":"USD","value_usd":4600},"fwci":3.3413,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.94694607,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"128","issue":"16","first_page":"3067","last_page":"3079"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9570000171661377},{"id":"https://openalex.org/keywords/neutrophil-to-lymphocyte-ratio","display_name":"neutrophil-to-lymphocyte ratio","score":0.9120000004768372},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/atezolizumab","display_name":"atezolizumab","score":0.9100000262260437},{"id":"https://openalex.org/keywords/docetaxel","display_name":"docetaxel","score":0.984000027179718},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.6610000133514404},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.9810000061988831},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7329999804496765},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8600000143051147},{"id":"https://openalex.org/keywords/cell-free-dna","display_name":"cell-free DNA","score":0.6140000224113464},{"id":"https://openalex.org/keywords/kras-mutation","display_name":"KRAS mutation","score":0.7239999771118164},{"id":"https://openalex.org/keywords/pd-l1-expression","display_name":"PD-L1 expression","score":0.8949999809265137},{"id":"https://openalex.org/keywords/smoking-status","display_name":"smoking status","score":0.48100000619888306},{"id":"https://openalex.org/keywords/oak-trial","display_name":"OAK trial","score":0.597000002861023}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8935887813568115},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7327330112457275},{"id":"https://openalex.org/C2775949291","wikidata":"https://www.wikidata.org/wiki/Q20707748","display_name":"Atezolizumab","level":5,"score":0.6800854802131653},{"id":"https://openalex.org/C2781190966","wikidata":"https://www.wikidata.org/wiki/Q420436","display_name":"Docetaxel","level":3,"score":0.67902672290802},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5954635739326477},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.5601224899291992},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5335951447486877},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.509678840637207},{"id":"https://openalex.org/C119060515","wikidata":"https://www.wikidata.org/wiki/Q1916617","display_name":"Interquartile range","level":2,"score":0.49658018350601196},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.39213699102401733},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.35876935720443726},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.24233081936836243},{"id":"https://openalex.org/C2780030458","wikidata":"https://www.wikidata.org/wiki/Q7041828","display_name":"Nivolumab","level":4,"score":0.19716385006904602},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.13280856609344482},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072019","descriptor_name":"Kelch-Like ECH-Associated Protein 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000073888","descriptor_name":"Cell-Free Nucleic Acids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077143","descriptor_name":"Docetaxel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004265","descriptor_name":"DNA Helicases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060890","descriptor_name":"B7-H1 Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1002/cncr.34348","doi":"https://doi.org/10.1002/cncr.34348","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cncr.34348","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.34348","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11497250","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11497250","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Text"},{"id":"pmid:35727053","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35727053","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Clinical Trial, Phase III"},{"id":"pmh:oai:unige.ch:unige:167313","doi":null,"is_oa":true,"landing_page_url":"https://archive-ouverte.unige.ch/unige:167313","pdf_url":null,"source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ISSN: 0008-543X","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:unige.ch:aou:unige:167313","doi":null,"is_oa":true,"landing_page_url":"https://archive-ouverte.unige.ch/unige:167313","pdf_url":null,"source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 0008-543X","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1002/cncr.34348","doi":"https://doi.org/10.1002/cncr.34348","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cncr.34348","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.34348","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2306499702","display_name":null,"funder_award_id":"25697","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"},{"id":"https://openalex.org/G2921181837","display_name":null,"funder_award_id":"PS3416","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320320283","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10"},{"id":"https://openalex.org/F4320320284","display_name":"Imperial College Healthcare NHS Trust","ror":"https://ror.org/056ffv270"},{"id":"https://openalex.org/F4320323054","display_name":"Associazione Italiana per la Ricerca sul Cancro","ror":"https://ror.org/02g2x7380"},{"id":"https://openalex.org/F4320325678","display_name":"European Association for the Study of the Liver","ror":"https://ror.org/01s2mxg92"},{"id":"https://openalex.org/F4320333939","display_name":"Imperial Experimental Cancer Medicine Centre","ror":null},{"id":"https://openalex.org/F4320336039","display_name":"NIHR Imperial Biomedical Research Centre","ror":"https://ror.org/01kmhx639"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4283210386.pdf","grobid_xml":"https://content.openalex.org/works/W4283210386.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W625329317","https://openalex.org/W1516195360","https://openalex.org/W2001137830","https://openalex.org/W2014229457","https://openalex.org/W2037754934","https://openalex.org/W2073557332","https://openalex.org/W2117692326","https://openalex.org/W2118278569","https://openalex.org/W2293531514","https://openalex.org/W2322998534","https://openalex.org/W2407074776","https://openalex.org/W2411767313","https://openalex.org/W2511052658","https://openalex.org/W2534193912","https://openalex.org/W2538232731","https://openalex.org/W2567564314","https://openalex.org/W2737656823","https://openalex.org/W2762602728","https://openalex.org/W2784283849","https://openalex.org/W2789677706","https://openalex.org/W2800476967","https://openalex.org/W2803847828","https://openalex.org/W2883160489","https://openalex.org/W2886963239","https://openalex.org/W2911557337","https://openalex.org/W2912418732","https://openalex.org/W2948132055","https://openalex.org/W2950387289","https://openalex.org/W2959497269","https://openalex.org/W2965881487","https://openalex.org/W2972655397","https://openalex.org/W2985170860","https://openalex.org/W3003949123","https://openalex.org/W3010041910","https://openalex.org/W3010344840","https://openalex.org/W3020255857","https://openalex.org/W3045548086","https://openalex.org/W3095297211","https://openalex.org/W3127371144","https://openalex.org/W3136094932","https://openalex.org/W3161297204","https://openalex.org/W3206266376","https://openalex.org/W3212177864","https://openalex.org/W3217012599"],"related_works":["https://openalex.org/W4281788152","https://openalex.org/W2898470963","https://openalex.org/W4379281239","https://openalex.org/W3190307045","https://openalex.org/W2895924482","https://openalex.org/W2980793254","https://openalex.org/W2718452821","https://openalex.org/W4417274251","https://openalex.org/W2768086146","https://openalex.org/W4321768390"],"abstract_inverted_index":{"BACKGROUND:":[0],"A":[1,208,358],"proinflammatory":[2],"diathesis,":[3],"as":[4],"measured":[5],"by":[6],"the":[7,32,54,58,66,104,120,197,264,279,283,331,355,380],"neutrophil":[8],"to":[9,45,65,77],"lymphocyte":[10],"ratio":[11,222],"(NLR),":[12],"heralds":[13],"an":[14,246],"adverse":[15],"disease":[16],"course":[17],"for":[18,119,245,251,326],"non-small":[19],"cell":[20],"lung":[21],"cancer":[22],"(NSCLC).":[23],"METHODS:":[24],"This":[25],"post":[26],"hoc":[27],"analysis":[28],"used":[29],"data":[30,100,297],"from":[31,298,372],"phase":[33],"3":[34],"OAK":[35],"trial":[36],"(NCT02008227),":[37],"which":[38],"randomized":[39],"previously":[40],"treated":[41],"patients":[42,97,254,276,302,363],"with":[43,81,98,110,128,189,216,256,303,354,364,376],"NSCLC":[44,365],"atezolizumab":[46,105,219,265,289,373],"or":[47,196],"docetaxel.":[48],"The":[49,243,272,383],"main":[50],"objective":[51],"was":[52,126,212,260],"assessing":[53],"differential":[55],"impact":[56],"of":[57,114,160,249,274,282,288,330,334],"pretreatment":[59,209],"NLR":[60,99,113,124,210,285,317,361,384],"on":[61],"overall":[62],"survival":[63,370],"according":[64,76],"treatment":[67,391],"modality.":[68],"In":[69,92],"addition,":[70],"patients'":[71],"genomic":[72],"characteristics":[73],"were":[74,101,351],"assessed":[75],"their":[78],"inflammatory":[79],"status":[80,132,150],"a":[82,111,129,147,157,304,314,368],"circulating":[83],"free":[84],"DNA":[85,345],"(cfDNA)":[86],"next-generation":[87],"sequencing":[88],"(NGS)":[89],"analysis.":[90],"RESULTS:":[91],"all,":[93],"600":[94],"and":[95,106,177,343,348],"575":[96],"included":[102],"in":[103,263,286,374,379,389,392],"docetaxel":[107,231,381],"cohorts,":[108],"respectively,":[109],"median":[112,316],"4":[115],"(interquartile":[116],"range,":[117],"2.6-6.7)":[118],"pooled":[121],"population.":[122],"An":[123],"\u22654":[125,211,253],"associated":[127,215,353],"positive":[130],"smoking":[131],"(88.6%":[133],"vs.":[134,142,152,164,172,182,319],"78.1%;":[135],"p":[136,144,154,166,174,184,240,269,292,321],"<":[137,155,175],".01),":[138,146,156,168,176],"male":[139],"sex":[140],"(66.4%":[141],"57.6%;":[143],"=":[145,167,185,241,270,293,322],"worse":[148],"performance":[149],"(71.3%":[151],"55.2%;":[153],"higher":[158,262,315],"number":[159],"metastatic":[161],"sites":[162],"(63.2%":[163],"51.6%;":[165],"squamous":[169],"histology":[170],"(32.1%":[171],"21.4%;":[173],"tissue":[178,198],"KRAS":[179],"mutations":[180],"(30%":[181],"18.7%;":[183],".02)":[186],"but":[187],"not":[188],"programmed":[190],"death":[191,250],"ligand":[192],"1":[193],"(PD-L1)":[194],"expression":[195,388],"epidermal":[199],"growth":[200],"factor":[201],"receptor":[202],"(EGFR)/anaplastic":[203],"lymphoma":[204],"kinase":[205],"(ALK)":[206],"status.":[207],"more":[213],"strongly":[214],"mortality":[217],"after":[218],"(adjusted":[220],"hazard":[221],"[HR],":[223],"1.64;":[224],"95%":[225,234],"confidence":[226],"interval":[227],"[CI],":[228],"1.35-2.01)":[229],"versus":[230],"(HR,":[232],"1.32;":[233],"CI,":[235],"1.08-1.60;":[236],"multivariable":[237],"[MVA]":[238],"interaction":[239,268,291],".08).":[242],"HR":[244],"increased":[247,278],"risk":[248],"PD-L1-negative/NLR":[252],"(compared":[255],"PD-L1-positive/NLR":[257],"<4":[258],"patients)":[259],"significantly":[261,352],"cohort":[266],"(MVA":[267,290],".01).":[271,323],"exclusion":[273],"EGFR/ALK-positive":[275],"further":[277],"prognostic":[280],"ability":[281],"baseline":[284,360],"favor":[287],".02).":[294],"Pretreatment":[295],"cfDNA":[296],"NGS":[299],"showed":[300],"that":[301],"high":[305],"blood":[306],"tumor":[307],"mutation":[308],"burden":[309],"(cutoff,":[310],"16":[311],"mut/Mb)":[312],"had":[313],"(4.6":[318],"3.7;":[320],"After":[324],"adjustments":[325],"multiple":[327],"comparisons,":[328],"none":[329],"selected":[332],"variants":[333],"interest":[335],"(EGFR,":[336],"KRAS,":[337],"TP53,":[338],"KEAP1,":[339],"STK11,":[340],"SMARCA4,":[341],"ARID1A,":[342],"targeted":[344],"damage":[346],"response":[347],"repair":[349],"genes)":[350],"NLR.":[356],"CONCLUSIONS:":[357],"low":[359],"identified":[362,378],"who":[366],"derived":[367],"greater":[369],"benefit":[371],"comparison":[375],"those":[377],"cohort.":[382],"could":[385],"complement":[386],"PD-L1":[387],"tailoring":[390],"this":[393],"setting.":[394]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-06-22T00:00:00"}