{"id":"https://openalex.org/W4283204561","doi":"https://doi.org/10.22270/jddt.v12i3-s.5356","title":"In-vitro antibacterial activity of Fosfomycin and Nitrofurantoin against Pseudomonas aeruginosa and Acinetobacter baumannii against clinical isolates collected from Indian tertiary care hospitals","display_name":"In-vitro antibacterial activity of Fosfomycin and Nitrofurantoin against Pseudomonas aeruginosa and Acinetobacter baumannii against clinical isolates collected from Indian tertiary care hospitals","publication_year":2022,"publication_date":"2022-06-15","ids":{"openalex":"https://openalex.org/W4283204561","doi":"https://doi.org/10.22270/jddt.v12i3-s.5356"},"language":"en","primary_location":{"id":"doi:10.22270/jddt.v12i3-s.5356","doi":"https://doi.org/10.22270/jddt.v12i3-s.5356","is_oa":true,"landing_page_url":"https://doi.org/10.22270/jddt.v12i3-s.5356","pdf_url":"https://jddtonline.info/index.php/jddt/article/download/5356/4685","source":{"id":"https://openalex.org/S2764977280","display_name":"Journal of Drug Delivery and Therapeutics","issn_l":"2250-1177","issn":["2250-1177"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4323972972","host_organization_name":"Society of Pharmaceutical Tecnocrats","host_organization_lineage":["https://openalex.org/P4323972972"],"host_organization_lineage_names":["Society of Pharmaceutical Tecnocrats"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Drug Delivery and Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://jddtonline.info/index.php/jddt/article/download/5356/4685","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089607480","display_name":"Rajesh P. Chavan","orcid":"https://orcid.org/0000-0001-5611-5251","observed_orcids":["https://orcid.org/0000-0001-5611-5251"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rajesh Chavan","raw_affiliation_strings":["Department of Microbiology, Badrinarayan Barwale College, Jalna, Maharashtra, 431203, India"],"raw_orcid":"https://orcid.org/0000-0001-5611-5251","affiliations":[{"raw_affiliation_string":"Department of Microbiology, Badrinarayan Barwale College, Jalna, Maharashtra, 431203, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014244496","display_name":"Bhushan Naphade","orcid":"https://orcid.org/0000-0001-7732-3957","observed_orcids":["https://orcid.org/0000-0001-7732-3957"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bhushan Naphade","raw_affiliation_strings":["Department of Microbiology, Badrinarayan Barwale College, Jalna, Maharashtra, 431203, India"],"raw_orcid":"https://orcid.org/0000-0001-7732-3957","affiliations":[{"raw_affiliation_string":"Department of Microbiology, Badrinarayan Barwale College, Jalna, Maharashtra, 431203, India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007411973","display_name":"Bhalchandra Baburao Waykar","orcid":"https://orcid.org/0000-0001-8454-9567","observed_orcids":["https://orcid.org/0000-0001-8454-9567"]},"institutions":[{"id":"https://openalex.org/I165259314","display_name":"Dr. Babasaheb Ambedkar Marathwada University","ror":"https://ror.org/033pfj584","country_code":"IN","type":"education","lineage":["https://openalex.org/I165259314"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Bhalchandra Waykar","raw_affiliation_strings":["Department of Zoology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, 431001, India"],"raw_orcid":"https://orcid.org/0000-0001-8454-9567","affiliations":[{"raw_affiliation_string":"Department of Zoology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, 431001, India","institution_ids":["https://openalex.org/I165259314"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.238,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.37246216,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"12","issue":"3-S","first_page":"26","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fosfomycin","display_name":"fosfomycin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nitrofurantoin","display_name":"nitrofurantoin","score":1.0},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.9879999756813049},{"id":"https://openalex.org/keywords/acinetobacter-baumannii","display_name":"Acinetobacter baumannii","score":1.0},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.9760000109672546},{"id":"https://openalex.org/keywords/gram-negative-bacteria","display_name":"Gram-negative bacteria","score":0.7459999918937683},{"id":"https://openalex.org/keywords/antimicrobial-susceptibility","display_name":"antimicrobial susceptibility","score":0.7929999828338623},{"id":"https://openalex.org/keywords/minimum-inhibitory-concentration","display_name":"minimum inhibitory concentration","score":0.8880000114440918},{"id":"https://openalex.org/keywords/imipenem","display_name":"imipenem","score":0.7310000061988831},{"id":"https://openalex.org/keywords/meropenem","display_name":"meropenem","score":0.9990000128746033},{"id":"https://openalex.org/keywords/clinical-isolates","display_name":"clinical isolates","score":0.6679999828338623},{"id":"https://openalex.org/keywords/trimethoprim-sulfamethoxazole","display_name":"trimethoprim-sulfamethoxazole","score":0.8339999914169312}],"concepts":[{"id":"https://openalex.org/C2778897966","wikidata":"https://www.wikidata.org/wiki/Q183554","display_name":"Fosfomycin","level":3,"score":0.9719558358192444},{"id":"https://openalex.org/C2777629877","wikidata":"https://www.wikidata.org/wiki/Q422669","display_name":"Nitrofurantoin","level":4,"score":0.8346483707427979},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7995360493659973},{"id":"https://openalex.org/C2776315533","wikidata":"https://www.wikidata.org/wiki/Q3241189","display_name":"Acinetobacter baumannii","level":4,"score":0.7690231800079346},{"id":"https://openalex.org/C2778523567","wikidata":"https://www.wikidata.org/wiki/Q310457","display_name":"Acinetobacter","level":3,"score":0.7005339860916138},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.6900511980056763},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.5072288513183594},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.439129501581192},{"id":"https://openalex.org/C2781463711","wikidata":"https://www.wikidata.org/wiki/Q131143","display_name":"Pseudomonas","level":3,"score":0.41178545355796814},{"id":"https://openalex.org/C2779631663","wikidata":"https://www.wikidata.org/wiki/Q425152","display_name":"Imipenem","level":4,"score":0.4102970361709595},{"id":"https://openalex.org/C2778512257","wikidata":"https://www.wikidata.org/wiki/Q256602","display_name":"Ciprofloxacin","level":3,"score":0.32229578495025635},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.2695769965648651},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.20517176389694214},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.22270/jddt.v12i3-s.5356","doi":"https://doi.org/10.22270/jddt.v12i3-s.5356","is_oa":true,"landing_page_url":"https://doi.org/10.22270/jddt.v12i3-s.5356","pdf_url":"https://jddtonline.info/index.php/jddt/article/download/5356/4685","source":{"id":"https://openalex.org/S2764977280","display_name":"Journal of Drug Delivery and Therapeutics","issn_l":"2250-1177","issn":["2250-1177"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4323972972","host_organization_name":"Society of Pharmaceutical Tecnocrats","host_organization_lineage":["https://openalex.org/P4323972972"],"host_organization_lineage_names":["Society of Pharmaceutical Tecnocrats"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Drug Delivery and Therapeutics","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.22270/jddt.v12i3-s.5356","doi":"https://doi.org/10.22270/jddt.v12i3-s.5356","is_oa":true,"landing_page_url":"https://doi.org/10.22270/jddt.v12i3-s.5356","pdf_url":"https://jddtonline.info/index.php/jddt/article/download/5356/4685","source":{"id":"https://openalex.org/S2764977280","display_name":"Journal of Drug Delivery and Therapeutics","issn_l":"2250-1177","issn":["2250-1177"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4323972972","host_organization_name":"Society of Pharmaceutical Tecnocrats","host_organization_lineage":["https://openalex.org/P4323972972"],"host_organization_lineage_names":["Society of Pharmaceutical Tecnocrats"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Drug Delivery and Therapeutics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320329004","display_name":"Wockhardt","ror":"https://ror.org/01djxaj77"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4283204561.pdf","grobid_xml":"https://content.openalex.org/works/W4283204561.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W426143053","https://openalex.org/W611976593","https://openalex.org/W1560155743","https://openalex.org/W1608202677","https://openalex.org/W1894757789","https://openalex.org/W1968252808","https://openalex.org/W2002116702","https://openalex.org/W2016751193","https://openalex.org/W2019288208","https://openalex.org/W2025782712","https://openalex.org/W2035673076","https://openalex.org/W2035799236","https://openalex.org/W2067595614","https://openalex.org/W2068897689","https://openalex.org/W2070833213","https://openalex.org/W2081148559","https://openalex.org/W2091058499","https://openalex.org/W2092879181","https://openalex.org/W2101273146","https://openalex.org/W2103958498","https://openalex.org/W2111300853","https://openalex.org/W2115486016","https://openalex.org/W2122167024","https://openalex.org/W2125021870","https://openalex.org/W2128480475","https://openalex.org/W2129842338","https://openalex.org/W2136942615","https://openalex.org/W2142754694","https://openalex.org/W2151188223","https://openalex.org/W2155057224","https://openalex.org/W2172196696","https://openalex.org/W2470176545","https://openalex.org/W2977386011"],"related_works":["https://openalex.org/W3115667807","https://openalex.org/W2321089192","https://openalex.org/W1597814999","https://openalex.org/W1978737638","https://openalex.org/W2085900850","https://openalex.org/W2019288208","https://openalex.org/W289974723","https://openalex.org/W2147966396","https://openalex.org/W2022079465","https://openalex.org/W1560155743"],"abstract_inverted_index":{"The":[0,66,97,204],"remarkable":[1],"increase":[2],"in":[3,24,64,130],"resistance":[4],"to":[5,9],"currently":[6],"available":[7,63],"antibiotics":[8,31,109],"Gram-negative":[10],"pathogens":[11,80],"particularly":[12],"multidrug":[13],"resistant":[14],"(MDR)":[15],"Pseudomonas":[16,57,77,82,128,136,160,193,213],"aeruginosa":[17],"and":[18,36,54,59,74,78,84,104,114,139,162,167,182,195,222,249],"Acinetobacter":[19,60,79,86,147,163,196],"baumannii,":[20],"This":[21],"has":[22],"resulted":[23],"increasing":[25],"use":[26],"of":[27,41,72,102,157,177,190,207],"older":[28],"under":[29],"evaluated":[30],"such":[32],"as":[33],"fosfomycin,":[34],"nitrofurantoin,":[35],"Trimethoprime-Sulfamethoxazole":[37],"for":[38,52,159,192,212],"the":[39,154,174,234],"treatment":[40],"infections":[42],"caused":[43],"by":[44],"MDR":[45],"pathogens.":[46],"However,":[47],"limited":[48],"in-vitro":[49,70,125],"pharmacodynamic":[50],"data":[51],"fosfomycin":[53,73,103,158,208],"nitrofurantoin":[55,75,105,131,140,191],"against":[56,76,127,135,146,232],"Spp.,":[58,61,83,87,161,164,194,197,235],"is":[62,219],"literature.":[65],"current":[67],"study":[68],"demonstrates":[69],"activities":[71,145],"(425":[81],"352":[85],"Total:":[88],"777":[89],"Strains),":[90],"isolated":[91],"from":[92],"Indian":[93],"tertiary":[94],"care":[95],"hospitals.":[96],"minimum":[98],"inhibitory":[99],"concentration":[100],"(MIC50/90)":[101],"along":[106],"with":[107,236],"comparator":[108,178],"were":[110,165,184],"determined":[111],"using":[112],"Clinical":[113],"Laboratory":[115],"Standards":[116],"Institute":[117],"recommended":[118],"agar":[119],"dilution":[120],"method.":[121],"Fosfomycin":[122,138],"demonstrated":[123,132],"excellent":[124],"activity":[126,134,231],"while":[129],"poor":[133,202],"Spp.,.":[137,148],"did":[141,228],"not":[142,229],"show":[143,230],"promising":[144],"By":[149,170],"applying":[150,171],"E.":[151],"coli":[152],"breakpoints,":[153,173],"susceptibility":[155,175,205,237],"rates":[156,176,238],"72.4%,":[166],"14.8%,":[168],"respectively.":[169],"respective":[172],"drugs,":[179],"including":[180,215],"imipenem":[181],"meropenem,":[183],"lower":[185],"than":[186],"fosfomycin.":[187],"Susceptibility":[188],"rate":[189,206],"was":[198,209],"<1.2%":[199],"suggesting":[200],"its":[201,224],"activity.":[203],">":[210],"70%":[211],"isolates,":[214],"strains":[216],"expressing":[217],"carbapenemases":[218],"encouraging":[220],"finding":[221],"supports":[223],"potential":[225],"use.":[226],"Nitrofurantoin":[227,242],"both":[233],"<1.2%.":[239],"Keywords:":[240],"Fosfomycin,":[241],"Gram-negative,":[243],"Multi":[244],"Drug":[245],"Resistant,":[246],"A.":[247],"baumannii":[248],"P.":[250],"aeruginosa.":[251]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-06-22T00:00:00"}