{"id":"https://openalex.org/W4283079369","doi":"https://doi.org/10.1002/cpt.2631","title":"Quantitative Clinical Pharmacology of CAR T\u2010Cell Therapy","display_name":"Quantitative Clinical Pharmacology of CAR T\u2010Cell Therapy","publication_year":2022,"publication_date":"2022-06-18","ids":{"openalex":"https://openalex.org/W4283079369","doi":"https://doi.org/10.1002/cpt.2631","pmid":"https://pubmed.ncbi.nlm.nih.gov/35716389"},"language":"en","primary_location":{"id":"doi:10.1002/cpt.2631","doi":"https://doi.org/10.1002/cpt.2631","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cpt.2631","pdf_url":null,"source":{"id":"https://openalex.org/S159852663","display_name":"Clinical Pharmacology & Therapeutics","issn_l":"0009-9236","issn":["0009-9236","1085-8733","1532-6535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacology & Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/1887/3512378","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005732386","display_name":"Sarah A. Holstein","orcid":"https://orcid.org/0000-0002-9342-5635","observed_orcids":["https://orcid.org/0000-0002-9342-5635"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sarah A. Holstein","raw_affiliation_strings":["Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044490765","display_name":"Karthik Venkatakrishnan","orcid":"https://orcid.org/0000-0003-4039-9813","observed_orcids":["https://orcid.org/0000-0003-4039-9813"]},"institutions":[{"id":"https://openalex.org/I4210111614","display_name":"EMD Serono, Inc. (United States)","ror":"https://ror.org/027zrs220","country_code":"US","type":"company","lineage":["https://openalex.org/I164928964","https://openalex.org/I4210111614"]},{"id":"https://openalex.org/I4405266695","display_name":"Merck Healthcare KGaA, Darmstadt (Germany)","ror":"https://ror.org/04vpzfb52","country_code":"DE","type":"company","lineage":["https://openalex.org/I164928964","https://openalex.org/I4405266695"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Karthik Venkatakrishnan","raw_affiliation_strings":["EMD Serono Research and Development Institute, Inc., Billerica, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMD Serono Research and Development Institute, Inc., Billerica, Massachusetts, USA","institution_ids":["https://openalex.org/I4210111614","https://openalex.org/I4405266695"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077172862","display_name":"Piet H. van der Graaf","orcid":"https://orcid.org/0000-0003-1314-3484","observed_orcids":["https://orcid.org/0000-0003-1314-3484"]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Piet H. van der Graaf","raw_affiliation_strings":["Certera QSP, Certara UK Ltd., Sheffield, UK","Leiden University, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Certera QSP, Certara UK Ltd., Sheffield, UK","institution_ids":[]},{"raw_affiliation_string":"Leiden University, Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5005732386"],"corresponding_institution_ids":["https://openalex.org/I59130452"],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":null,"fwci":0.4609,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.59673273,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"112","issue":"1","first_page":"11","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/car-t-cell-therapy","display_name":"CAR T-cell therapy","score":0.9300000071525574},{"id":"https://openalex.org/keywords/car-t-cell-kinetics","display_name":"CAR T-cell kinetics","score":0.8460000157356262},{"id":"https://openalex.org/keywords/cd19-car-t-cell-therapy","display_name":"CD19 CAR T-cell therapy","score":0.6480000019073486},{"id":"https://openalex.org/keywords/b-cell-acute-lymphoblastic-leukemia","display_name":"B-cell acute lymphoblastic leukemia","score":0.8029999732971191},{"id":"https://openalex.org/keywords/b-cell-non-hodgkin-lymphoma","display_name":"B-cell non-Hodgkin lymphoma","score":0.9290000200271606},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9490000009536743},{"id":"https://openalex.org/keywords/b-cell-maturation-antigen","display_name":"BCMA","score":0.4659999907016754},{"id":"https://openalex.org/keywords/lisocabtagene-maraleucel","display_name":"lisocabtagene maraleucel","score":0.8799999952316284},{"id":"https://openalex.org/keywords/cytokine-release-syndrome","display_name":"cytokine release syndrome","score":0.6850000023841858},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.8090000152587891},{"id":"https://openalex.org/keywords/antitumor-efficacy","display_name":"antitumor efficacy","score":0.6039999723434448}],"concepts":[{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.8618783950805664},{"id":"https://openalex.org/C2780850621","wikidata":"https://www.wikidata.org/wiki/Q3961647","display_name":"Cytokine release syndrome","level":5,"score":0.8269311189651489},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6816133856773376},{"id":"https://openalex.org/C2778020697","wikidata":"https://www.wikidata.org/wiki/Q410189","display_name":"Blinatumomab","level":4,"score":0.5554835200309753},{"id":"https://openalex.org/C2778957590","wikidata":"https://www.wikidata.org/wiki/Q798033","display_name":"CD19","level":3,"score":0.5105630159378052},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.4618785083293915},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4581540822982788},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.4536539614200592},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.4486456513404846},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.4298287630081177},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4235355854034424},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.41852957010269165},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.40695059299468994},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.3737296462059021},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36357805132865906},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2781168222427368},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20459383726119995},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16578468680381775},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.1480368673801422},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.14747300744056702},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016219","descriptor_name":"Immunotherapy, Adoptive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1002/cpt.2631","doi":"https://doi.org/10.1002/cpt.2631","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cpt.2631","pdf_url":null,"source":{"id":"https://openalex.org/S159852663","display_name":"Clinical Pharmacology & Therapeutics","issn_l":"0009-9236","issn":["0009-9236","1085-8733","1532-6535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacology & Therapeutics","raw_type":"journal-article"},{"id":"pmid:35716389","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35716389","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical pharmacology and therapeutics","raw_type":"Editorial"},{"id":"pmh:oai:alma.31UKB_LEU:9940744679102711","doi":null,"is_oa":false,"landing_page_url":"https://scholarlypublications.universiteitleiden.nl/handle/1887/3512378","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical Pharmacology & Therapeutics, Vol. 112, no. 1, p. 11-15","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:scholarlypublications.universiteitleiden.nl:item_3512378","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1887/3512378","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical Pharmacology & Therapeutics","raw_type":"Article / Letter to editor"},{"id":"pmh:ul:oai:scholarlypublications.universiteitleiden.nl:item_3512378","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1887/3512378","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical Pharmacology & Therapeutics, 112(1), 11 - 15. Wiley","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:ul:oai:scholarlypublications.universiteitleiden.nl:item_3512378","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1887/3512378","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical Pharmacology & Therapeutics, 112(1), 11 - 15. Wiley","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W2760653955","https://openalex.org/W2773804840","https://openalex.org/W2787301955","https://openalex.org/W2801641802","https://openalex.org/W2891902322","https://openalex.org/W2906581363","https://openalex.org/W2913143854","https://openalex.org/W2921490864","https://openalex.org/W2943335541","https://openalex.org/W2980455452","https://openalex.org/W2980542859","https://openalex.org/W2989866811","https://openalex.org/W3004644443","https://openalex.org/W3006233208","https://openalex.org/W3082855561","https://openalex.org/W3091273267","https://openalex.org/W3126231081","https://openalex.org/W3128956257","https://openalex.org/W3133229959","https://openalex.org/W3146763078","https://openalex.org/W3166894073","https://openalex.org/W3176532045","https://openalex.org/W3181045823","https://openalex.org/W3186991133","https://openalex.org/W3214550499","https://openalex.org/W3217557393","https://openalex.org/W4213026615","https://openalex.org/W4220662097"],"related_works":["https://openalex.org/W4293215085","https://openalex.org/W3216084716","https://openalex.org/W4402272868","https://openalex.org/W4319337581","https://openalex.org/W2417137551","https://openalex.org/W2986148091","https://openalex.org/W2475572178","https://openalex.org/W2515536126","https://openalex.org/W2983214991","https://openalex.org/W4404024270"],"abstract_inverted_index":{"One":[0],"of":[1,18,51,101,149,175,197,210,219,225,248,262,277,307,424,430,442,473,514,559,574,600,637,670,676,690,693,777,797,827,830,836,839,875,878,887,890,905,912,929,944,954,976,997,1023,1027,1057,1071,1083,1090,1098,1130,1147,1157,1200,1222,1240,1254,1258,1272,1290,1298,1343,1356,1369,1375,1392,1396,1412,1423,1433,1463,1505,1526,1532,1546,1571,1583,1589,1628,1641,1658,1668,1686,1716,1737,1765,1787,1802,1824,1839,1897,1924,1967,2020],"the":[2,11,16,49,81,99,143,164,170,195,208,259,263,284,301,308,320,341,414,425,440,448,471,491,498,512,527,618,688,701,709,792,804,837,863,876,885,903,923,926,933,945,959,980,1004,1024,1064,1069,1102,1123,1128,1143,1148,1158,1170,1173,1177,1183,1187,1195,1201,1205,1209,1236,1248,1270,1273,1287,1357,1384,1390,1397,1407,1464,1497,1542,1587,1598,1603,1623,1656,1659,1664,1669,1692,1701,1710,1717,1724,1754,1785,1849,1919,1954,1992,2007,2012,2033],"most":[3],"significant":[4],"innovations":[5],"in":[6,25,220,266,283,377,459,515,531,539,582,603,703,791,816,884,917,956,1035,1139,1144,1235,1243,1329,1467,1515,1591,1655,1720,1903,1957,1964,2001,2032],"personalized":[7],"cancer":[8],"medicine":[9],"over":[10,1107,1458,1481,1653],"past":[12],"decade":[13],"has":[14,47,166,189,228,728,1303,1477,1501,1866],"been":[15,71,78,137,190,229,488,729,766,1478],"development":[17,148,919,1786],"chimeric":[19],"antigen":[20,120,1766],"receptor":[21,314],"(CAR)":[22],"T-cell":[23,45,74,134,269,503,696,1150,1192,1231,1327,1470,1509,1534,1630,1676,1731,1748,1830,1898,1905],"therapy,":[24,1259],"which":[26,1388],"a":[27,211,216,421,431,460,467,549,645,720,740,771,780,913,930,1091,1252,1261,1284,1323,1340,1363,1400,1450,1557,1561,1608,1683,1965,2025],"patient's":[28,144],"own":[29,145],"cells":[30,1398,1886],"are":[31,201,1120,1887,1952],"engineered":[32,141,1202,1885],"to":[33,168,192,206,258,299,335,497,657,662,735,806,854,894,921,982,993,1000,1011,1047,1066,1114,1133,1153,1218,1226,1265,1279,1436,1485,1499,1673,1729,1744,1780,1784,1811,1846,1917,1975,1987,1989,2010,2017],"becoming":[34],"cancer-fighting":[35],"weapons":[36],"(Figure":[37],"1).":[38],"Blending":[39],"oncology,":[40],"biotechnology,":[41],"and":[42,63,84,104,111,114,126,177,186,204,255,273,303,338,347,353,362,381,387,391,394,404,518,544,572,596,611,629,652,668,715,726,744,761,932,948,951,967,973,1039,1194,1220,1293,1307,1311,1349,1372,1455,1472,1493,1564,1597,1626,1666,1706,1709,1739,1827,1852,1913,1921,1935,1949,1959,1977,1983,1998,2024],"immunology,":[43],"CAR":[44,73,133,158,171,226,268,322,502,695,801,1149,1191,1326,1425,1447,1469,1487,1533,1629,1649,1675,1730,1747,1793,1804,1808,1818,1825,1829,1904],"therapy":[46,438,812,1328,1451,1507,1631,1705,1732,1777,1831,1865,1940],"revolutionized":[48],"management":[50],"relapsed/refractory":[52,89,1246],"B-cell":[53,59,102,118,534],"acute":[54],"lymphoblastic":[55],"leukemia":[56,589],"(B-ALL),":[57],"various":[58,694],"non-Hodgkin's":[60],"lymphomas":[61],"(NHLs),":[62],"multiple":[64,831],"myeloma":[65],"(MM).":[66],"Since":[67],"2017,":[68],"there":[69,547,562,660],"have":[70,77,136,506,764,1607],"six":[72,1255],"therapies":[75,135,844,991,1062,1483],"that":[76,231,315,401,447,479,505,746,855,979,1160,1336,1416,1452,1503,1524,1602,1671,1682,1873,2005],"approved":[79,132],"by":[80,242,868],"US":[82],"Food":[83],"Drug":[85],"Administration":[86],"(FDA)":[87],"for":[88,98,122,344,784,842,857,1014,1060,1112,1309,1712,1726,1863,1996,2027],"hematological":[90],"malignancies.":[91],"These":[92,444],"include":[93,1063,1169],"four":[94],"products":[95,116,139,152,160,697],"targeting":[96,117],"CD19":[97,1648],"treatment":[100,1528,1549,1969],"NHL":[103,286],"B-ALL":[105,585],"(tisagenlecleucel,":[106],"axicabtagene":[107,601],"ciloleucel,":[108],"brexucabtagene":[109],"autoleucel,":[110],"lisocabtagene":[112,278,778,846,1301,1547,1612,1687],"maraleucel)":[113],"two":[115,292],"maturation":[119],"(BCMA)":[121],"MM":[123,619,640],"(idecabtagene":[124],"vicleucel":[125,622,1242],"ciltacabtagene":[127,642],"autoleucel).":[128],"To":[129,2004],"date,":[130],"all":[131,675],"autologous":[138],"(i.e.,":[140],"using":[142,291,1094],"T-cells);":[146],"however,":[147],"\"off-the-shelf\"":[150],"allogeneic":[151,157,1817],"(derived":[153],"from":[154,280,323,417,500,511,523,818,1042,1263,1406],"donors),":[155],"including":[156],"NK":[159],"is":[161,316,679,685,732,749,813,920,986,1380,1474,1594,1632,1740,1778,1871],"underway.":[162],"As":[163,635,1446],"field":[165,1838],"grappled":[167],"optimize":[169,1048],"constructs,":[172],"prolong":[173],"duration":[174,558,1082,1135,1432],"response,":[176,646],"minimize":[178],"toxicities,":[179],"such":[180,707,1032,1366,1762,1790,1946],"as":[181,428,436,698,700,708,822,824,910,969,1031,1101,1367,1556,1568,1661,1663,1757,1759,1763,1791,1854,1947,1991],"cytokine":[182],"release":[183],"syndrome":[184],"(CRS)":[185],"neurotoxicity,1":[187],"it":[188,1333,1870],"fascinating":[191],"observe":[193],"how":[194,1883],"principles":[196],"quantitative":[198,295,892],"clinical":[199,828,882,914,935,974,1007,1840,1973],"pharmacology":[200,820,915,1029,1841],"being":[202,554,737,1125,1381],"adapted":[203],"applied":[205],"understand":[207],"behaviors":[209],"living":[212,1926],"drug.":[213],"For":[214,1233],"example,":[215,1234],"general":[217],"model":[218,1545],"vivo":[221,267,378,516,1145,1394,1468,1516,1721],"cellular":[222,379,785,1099,1704,1776,1864,1914,1939],"kinetics":[223,689,702],"(CKs)":[224],"T-cells":[227,1211,1275,1295,1338,1345,1358,1371,1426,1448,1650,1660,1794,1796,1809],"proposed":[230],"involves":[232,1127,1389],"initial":[233,492],"rapid":[234],"distribution":[235],"following":[236,1110,1907],"infusion,":[237],"then":[238],"subsequent":[239,762],"expansion":[240,332,380,517,651,667,763,786,880,1002,1100,1146,1471,1492,1517,1572],"followed":[241],"biexponential":[243],"decline.2":[244],"In":[245,617,754,770,1322,1495,1541],"this":[246,731,1413,2002],"issue":[247,2016],"Clinical":[249],"Pharmacology":[250,2019],"&":[251],"Therapeutics":[252],"(CPT)":[253],"Ogasawara":[254,869,1678],"colleagues":[256],"contribute":[257],"growing":[260],"understanding":[261,874,943,1462,1874],"relationship":[264,721,783,924,947,1129],"between":[265,359,376,542,566,594,650,666,722,758,925,1703],"expansion,":[270],"antitumor":[271,383],"efficacy,":[272],"toxicity.3":[274],"The":[275,834,1773,1837,1894],"CKs":[276],"maraleucel":[279,847,1302,1613,1688],"patients":[281,418,524,583,604,638,1244,1330,1417,1437,1643],"treated":[282,525],"TRANSCEND":[285],"001":[287],"trial4":[288],"were":[289,407,413,480,1350,1573],"evaluated":[290,1382],"bioanalytical":[293],"methods:":[294],"polymerase":[296],"chain":[297],"reaction":[298],"measure":[300],"transgene":[302],"flow":[304],"cytometric":[305],"detection":[306],"nonfunctional":[309],"truncated":[310],"epidermal":[311],"growth":[312],"factor":[313],"co-expressed":[317],"along":[318],"with":[319,556,580,584,605,609,626,639,810,941,989,1054,1077,1245,1260,1331,1339,1352,1383,1399,1418,1438,1538,1550,1560,1576,1644,1746,1832,1901,1929],"CD19-specific":[321],"peripheral":[324],"blood":[325],"samples.3":[326],"Reported":[327],"CK":[328,521,540,775,829,1544],"parameters":[329,541],"included":[330],"maximum":[331],"(Cmax),":[333],"time":[334,441,472,1073,1654],"Cmax":[336,363,553,568,623,1563],"(Tmax),":[337],"area":[339,1736],"under":[340,1634],"curve":[342],"(AUC)":[343],"both":[345,382],"0\u201328":[346],"0\u201390":[348],"days":[349,352,361,366,477,1109,1531],"post-infusion":[350],"(AUC0\u201328":[351],"AUC0\u201390":[354,365],"days).":[355],"A":[356,520,672],"high":[357,680],"correlation":[358,649],"AUC0\u201328":[360,570],"or":[364,435,483,586,860,938,1085,1136,1518,1578,1768,1814,1834],"was":[367,548,563,607,624,654,1334,1536,1554],"observed.":[368],"Multivariable":[369],"logistic":[370],"regression":[371],"analysis":[372,398,522,776,908],"revealed":[373,446],"an":[374,564,592,664,906,942,1460,1734],"association":[375,565,593,665],"efficacy":[384,1078],"(overall":[385],"response":[386,389,610,628,653,727,1084,1115,1134,1434],"complete":[388],"rates)":[390],"toxicity":[392],"(CRS":[393],"neurologic":[395],"events).":[396],"This":[397,494,1018,1378,1971],"further":[399,1699],"demonstrated":[400,591,1651],"patient":[402,1249],"age":[403],"tumor":[405,1727,1755],"burden":[406],"confounding":[408],"variables.":[409],"Of":[410],"particular":[411],"interest":[412],"data":[415,1933],"obtained":[416],"who":[419,465,1646],"received":[420,466,1189,1647],"second":[422,450,468,1684],"infusion":[423,469,1535,1908],"product,":[426,1387],"either":[427,481],"part":[429,911],"planned":[432,449],"two-dose":[433],"schedule":[434],"salvage":[437],"at":[439,470,1889],"relapse.":[443],"studies":[445,579,678],"dose":[451,724,742,759,795,895,962,1016,1185,1694],"administered":[452,725,760,794,1005,1484],"on":[453,526,739,881,1611,1938],"day":[454],"15":[455],"did":[456,1605,1695],"not":[457,615,655,750,765,788,850,899,987,1512,1595,1606,1696],"result":[458],"higher":[461,567,1341,1419,1562],"Cmax,":[462],"whereas":[463],"those":[464],"relapse":[474],"achieved":[475,489,644],"Cmax/AUC0\u201328":[476],"values":[478,1442],"equivalent":[482],"lower":[484,1439],"than":[485,1003,1420,1440,1880],"what":[486],"had":[487,1251,1346,1429],"after":[490,1190,1691],"infusion.":[493],"work":[495],"adds":[496],"findings":[499],"other":[501,704,888,1616,1960],"trials":[504],"explored":[507],"potential":[508,648,1167],"dose/exposure-response":[509],"relationships":[510,809,866,985,1046,1059,1113,1876],"perspective":[513],"CKs.":[519],"JULIET":[528],"study":[529,1239,1324,1411,1522],"(tisagenlecleucel":[530],"diffuse":[532],"large":[533],"lymphoma),":[535],"showed":[536],"no":[537],"difference":[538],"responders":[543],"nonresponders;":[545],"although,":[546,659,1520],"trend":[550],"toward":[551],"higher-than-median":[552],"associated":[555,608,625,934,949,1351,1537,1559,1575],"longer":[557,630,1431],"response.5":[560],"However,":[561,1567],"(or":[569],"days)":[571],"rates":[573],"grade":[575],"3/4":[576],"CRS.5":[577],"Similar":[578],"tisagenlecleucel":[581],"chronic":[587],"lymphocytic":[588],"(CLL)":[590],"Cmax/AUC":[595],"response.6,":[597],"7":[598,1530],"Expansion":[599],"ciloleucel":[602],"B-NHL":[606],"neurological":[612,1579],"events":[613,1580],"but":[614,1314],"CRS.8":[616],"setting,":[620],"idecabtagene":[621,1241],"deeper":[627],"progression":[631],"free":[632],"survival":[633,1137],"(PFS).9":[634],"97%":[636],"receiving":[641],"autoleucel":[643],"any":[647,1890],"possible":[656],"discern;":[658],"appeared":[661],"be":[663,789,851,900,965,1154,1277,1280,1297,1319,1942,2030],"severity":[669],"CRS.10":[671],"commonality":[673],"among":[674,1215],"these":[677,1117,1569,1855,1925],"interpatient":[681],"variability.":[682],"Less":[683],"information":[684],"available":[686],"regarding":[687],"long-term":[691,1164,1196,1637,1674,1751],"persistence":[692,1132,1197,1473,1627,1749],"well":[699,815,823,1662,1758],"relevant":[705],"compartments,":[706],"bone":[710],"marrow,":[711],"secondary":[712],"lymphoid":[713],"tissues,":[714],"cerebral":[716],"spinal":[717],"fluid.":[718],"Although":[719,1088],"cell":[723,843,1184,1948],"demonstrated,":[730],"generally":[733],"limited":[734],"responses":[736],"dependent":[738],"certain":[741],"threshold,":[743],"above":[745],"threshold":[747],"dose-dependency":[748],"consistently":[751],"seen.9,":[752],"11-14":[753],"addition,":[755],"consistent":[756],"correlations":[757],"observed.3,":[767],"12,":[768],"13":[769],"previously":[772],"published":[773],"population":[774,1250,1543],"maraleucel,":[779,1548],"discernible":[781],"dose-exposure":[782,808,946,984],"could":[787],"observed":[790,1044],"tested":[793],"range":[796,963,1262],"44\u2013156":[798],"\u00d7":[799],"106":[800],"T-cells.15":[802],"Indeed,":[803],"inability":[805,981],"discern":[807,983],"CAR-T":[811,832,879,990,1001,1049,1061,1131],"reconciled":[814],"simulations":[817],"systems":[819,1028,1931],"models16":[821],"mechanism-informed":[825],"modeling":[826],"products.17":[833],"interpretation":[835,1588],"results":[838,1405],"exposure-response":[840,865,907,1045,1058,1875],"analyses":[841,1056,1593],"like":[845,1081],"may":[848,898,1212,1296,1318,1361],"thus":[849],"entirely":[852],"analogous":[853],"applicable":[856],"small":[858],"molecules":[859],"biologics.":[861],"Whereas":[862,1861],"multivariable":[864],"described":[867],"et":[870,1679],"al.3":[871],"advance":[872],"our":[873],"importance":[877,1299],"outcomes":[883,936,1138],"context":[886],"sources":[889,953],"variability,":[891],"translation":[893],"selection":[896],"decisions":[897],"straightforward.":[901],"Typically,":[902],"purpose":[904],"conducted":[909],"plan":[916],"drug":[918],"quantify":[922],"systemic":[927,957],"exposure":[928,1103],"therapeutic":[931,961,1955],"(efficacy":[937],"toxicity).":[939],"Together":[940],"intrinsic":[950],"extrinsic":[952],"variability":[955,999],"exposures,":[958],"desired":[960],"can":[964,1453,1490,1621],"inferred":[966],"tailored":[968],"appropriate":[970],"across":[971],"populations":[972],"contexts":[975],"use.":[977],"Given":[978],"uncommon":[988],"owing":[992],"far":[994],"greater":[995],"contribution":[996],"biological":[998],"dose,":[1006],"pharmacologists":[1008,1974],"will":[1009,1019,1842,1877,1909,1941,2029],"need":[1010,1065,1711],"rethink":[1012],"strategies":[1013,1916],"informing":[1015],"optimization.":[1017],"require":[1020,1878,1910],"continued":[1021],"evaluation":[1022],"translational":[1025],"fidelity":[1026],"models":[1030,1033],"should":[1034],"principle":[1036],"help":[1037],"explain":[1038],"extend":[1040],"inference":[1041],"clinically":[1043],"precision":[1050],"therapy.":[1051],"Additional":[1052],"challenges":[1053,1845],"pharmacometric":[1055],"carefully":[1067],"consider":[1068],"impact":[1070,1610],"immortal":[1072],"bias18":[1074],"when":[1075,1093],"dealing":[1076],"end":[1079],"points":[1080],"overall":[1086],"survival.":[1087],"less":[1089],"concern":[1092],"early":[1095],"\"landmark\"":[1096],"measures":[1097],"metric":[1104],"(e.g.,":[1105,1619],"AUC":[1106],"28":[1108],"infusion)":[1111],"rates,":[1116],"pharmacostatistical":[1118],"considerations":[1119],"important":[1121],"if":[1122],"question":[1124],"asked":[1126],"time-to-event":[1140],"analyses.":[1141],"Ultimately":[1142],"product":[1151,1414],"appears":[1152],"just":[1155],"one":[1156,1521],"factors":[1159,1718],"influences":[1161],"short-":[1162],"and/or":[1163,1229,1552,1585,1750],"efficacy.":[1165,1494],"Other":[1166],"contributors":[1168],"starting":[1171,1206],"substrate,":[1172],"phenotypes":[1174,1657,1906],"produced":[1175],"during":[1176,1359],"manufacturing":[1178,1305,1360],"process,":[1179],"pretreatment":[1180],"lymphodepletion":[1181],"regimens,":[1182],"administered,":[1186],"medications":[1188],"administration,":[1193],"(and":[1198,1300],"phenotype)":[1199],"cells.":[1203,1377],"From":[1204],"substrate":[1207],"perspective,":[1208],"collected":[1210,1274,1337],"vary":[1213],"widely":[1214],"individuals":[1216],"due":[1217],"numbers":[1219,1289,1665],"types":[1221],"prior":[1223,1256,1267],"therapies,":[1224,1951],"contributing":[1225],"prolonged":[1227],"lymphopenia":[1228],"suppressed":[1230],"function.":[1232],"phase":[1237,1409],"II":[1238],"MM,":[1247],"median":[1253,1421,1441],"lines":[1257],"3":[1264],"16":[1266],"lines.9":[1268],"Thus,":[1269],"quality":[1271],"would":[1276],"expected":[1278],"very":[1281],"heterogeneous.":[1282],"On":[1283],"broader":[1285],"level,":[1286],"relative":[1288,1373],"transduced":[1291],"CD4+":[1292,1310],"CD8+":[1294,1312,1424],"separate":[1304],"processes":[1306],"infusions":[1308],"T-cells),":[1313],"more":[1315,1320,1713,1879],"sophisticated":[1316,1911],"immunophenotyping":[1317],"informative.":[1321],"involving":[1325],"CLL,":[1332],"found":[1335,1523],"frequency":[1342],"CD27+CD45RO-CD8+":[1344],"memory-like":[1347,1370],"characteristics":[1348,1923],"sustained":[1353],"remission.19":[1354],"Manipulation":[1355],"elicit":[1362],"superior":[1364],"phenotype,":[1365],"enrichment":[1368],"depletion":[1374],"senescent":[1376],"approach":[1379],"bb21217":[1385],"anti-BCMA":[1386],"use":[1391,1525],"ex":[1393],"culture":[1395],"phosphoinositide":[1401],"3-kinase":[1402],"inhibitor.":[1403],"Preliminary":[1404],"ongoing":[1408],"I":[1410],"suggest":[1415],"number":[1422],"expressing":[1427],"CD27/CD28":[1428],"significantly":[1430],"compared":[1435],"(P":[1443],"=":[1444],"0.0024).20":[1445],"represent":[1449],"replicate":[1454],"sustain":[1456],"itself":[1457],"time,":[1459],"improved":[1461],"mechanisms":[1465,1725],"driving":[1466],"needed.":[1475],"There":[1476],"much":[1479],"scrutiny":[1480],"whether":[1482],"manage":[1486],"T-cell-induced":[1488],"CRS":[1489,1577],"abrogate":[1491],"general,":[1496],"literature":[1498],"date":[1500],"suggested":[1502],"receipt":[1504],"corticosteroid":[1506,1527],"post-CAR":[1508],"administration":[1510,1582,1685],"does":[1511],"negatively":[1513],"impair":[1514],"efficacy;":[1519],"within":[1529],"shorter":[1539],"PFS.21-24":[1540],"tocilizumab":[1551,1584],"corticosteroids":[1553],"identified":[1555],"covariate":[1558,1592],"AUC0-28":[1565],"days.15":[1566],"metrics":[1570],"also":[1574],"necessitating":[1581],"corticosteroids,":[1586],"causality":[1590],"straightforward,":[1596],"authors":[1599],"ultimately":[1600],"concluded":[1601],"covariates":[1604],"meaningful":[1609],"CKs.15":[1614],"Whether":[1615],"immunomodulatory":[1617],"agents":[1618],"lenalidomide)":[1620],"enhance":[1622],"cytolytic":[1624],"activity":[1625],"currently":[1633],"investigation.":[1635],"Finally,":[1636],"follow-up":[1638],"(7":[1639],"years)":[1640],"2":[1642,1689],"CLL":[1645],"changes":[1652],"identities":[1667],"clones":[1670],"contributed":[1672],"persistence.25":[1677],"al.'s":[1680],"finding":[1681],"weeks":[1690],"first":[1693],"alter":[1697],"Cmax3":[1698],"highlights":[1700],"differences":[1702],"traditional":[1707],"therapeutics":[1708],"extensive":[1714],"exploration":[1715],"controlling":[1719],"expansion.":[1722],"Determining":[1723],"resistance":[1728],"remains":[1733],"active":[1735],"investigation":[1738],"likely":[1741],"multifactorial,":[1742],"related":[1743],"problems":[1745],"cytotoxic":[1752],"activity,":[1753],"microenvironment":[1756],"tumor-intrinsic":[1760],"mechanisms,":[1761],"loss":[1764],"expression":[1767],"aberrant":[1769],"apoptotic":[1770],"machinery.26,":[1771],"27":[1772],"science":[1774],"behind":[1775],"continuing":[1779],"rapidly":[1781],"evolve,":[1782],"leading":[1783],"novel":[1788,1856,1968],"approaches,":[1789],"dual-targeting":[1792],"(including":[1795],"co-expressing":[1797],"different":[1798,1803],"CARs":[1799],"vs.":[1800],"mixtures":[1801],"T":[1805],"products),":[1806],"armored":[1807],"(engineered":[1810],"secrete":[1812],"cytokines":[1813],"antibody-like":[1815],"proteins),":[1816],"T-cells,":[1819,1826],"CAR-NK":[1820],"cells,":[1821],"regional":[1822],"delivery":[1823],"combining":[1828],"chemotherapeutic":[1833],"immunotherapeutic":[1835],"agents.":[1836],"face":[1843],"new":[1844,1979],"fully":[1847],"delineate":[1848],"pharmacokinetics,":[1850],"pharmacodynamics,":[1851],"pharmacometrics":[1853],"approaches":[1857],"reach":[1858],"human":[1859],"testing.":[1860],"pharmacokinetics":[1862],"evolved":[1867],"into":[1868],"CK,":[1869],"evident":[1872],"simply":[1881],"counting":[1882],"many":[1884],"present":[1888],"given":[1891],"timepoint":[1892],"post-infusion.":[1893],"inherent":[1895],"complexity":[1896],"biology":[1899],"coupled":[1900],"alterations":[1902],"molecular":[1912],"interrogation":[1915],"capture":[1918],"phenotypic":[1920],"functional":[1922],"drugs.":[1927],"Collaboration":[1928],"immunologists,":[1930],"pharmacologists,":[1932],"scientists,":[1934],"others":[1936],"working":[1937],"critical.":[1943],"Innovative":[1944],"modalities,":[1945],"gene":[1950],"transforming":[1953],"landscape":[1956],"oncology":[1958],"disease":[1961],"areas,":[1962],"resulting":[1963],"spectrum":[1966],"options.":[1970],"requires":[1972],"adapt":[1976],"develop":[1978,1990],"skill":[1980],"sets,":[1981],"knowledge,":[1982],"expertise.":[1984],"CPT":[1985],"aspires":[1986],"continue":[1988],"pre-eminent":[1993],"destination":[1994],"journal":[1995,2008],"research":[1997],"educational":[1999],"publications":[2000],"area.":[2003],"end,":[2006],"plans":[2009],"devote":[2011],"September":[2013],"2023":[2014],"themed":[2015],"\"Clinical":[2018],"Novel":[2021],"Therapeutic":[2022],"Modalities\"":[2023],"Call":[2026],"Papers":[2028],"issued":[2031],"coming":[2034],"months.":[2035]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-06-19T00:00:00"}