{"id":"https://openalex.org/W4283078735","doi":"https://doi.org/10.1111/jnc.15657","title":"Beyond monoamines: II. Novel applications for PET imaging in psychiatric disorders","display_name":"Beyond monoamines: II. Novel applications for PET imaging in psychiatric disorders","publication_year":2022,"publication_date":"2022-06-18","ids":{"openalex":"https://openalex.org/W4283078735","doi":"https://doi.org/10.1111/jnc.15657","pmid":"https://pubmed.ncbi.nlm.nih.gov/35716057"},"language":"en","primary_location":{"id":"doi:10.1111/jnc.15657","doi":"https://doi.org/10.1111/jnc.15657","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jnc.15657","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050516079","display_name":"Sarah K. Royse","orcid":"https://orcid.org/0000-0003-4846-0180","observed_orcids":["https://orcid.org/0000-0003-4846-0180"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah K. Royse","raw_affiliation_strings":["Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA"],"raw_orcid":"https://orcid.org/0000-0003-4846-0180","affiliations":[{"raw_affiliation_string":"Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068192630","display_name":"Brian J. Lopresti","orcid":"https://orcid.org/0000-0002-0595-0203","observed_orcids":["https://orcid.org/0000-0002-0595-0203"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Brian J. Lopresti","raw_affiliation_strings":["Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA"],"raw_orcid":"https://orcid.org/0000-0002-0595-0203","affiliations":[{"raw_affiliation_string":"Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029440312","display_name":"Chester A. Mathis","orcid":"https://orcid.org/0000-0001-9811-0950","observed_orcids":["https://orcid.org/0000-0001-9811-0950"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chester A. Mathis","raw_affiliation_strings":["Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA"],"raw_orcid":"https://orcid.org/0000-0001-9811-0950","affiliations":[{"raw_affiliation_string":"Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029666400","display_name":"Savannah Tollefson","orcid":"https://orcid.org/0000-0002-2581-1083","observed_orcids":["https://orcid.org/0000-0002-2581-1083"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Savannah Tollefson","raw_affiliation_strings":["Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA"],"raw_orcid":"https://orcid.org/0000-0002-2581-1083","affiliations":[{"raw_affiliation_string":"Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007496748","display_name":"Rajesh Narendran","orcid":"https://orcid.org/0000-0002-4292-2850","observed_orcids":["https://orcid.org/0000-0002-4292-2850"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajesh Narendran","raw_affiliation_strings":["Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA","Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA"],"raw_orcid":"https://orcid.org/0000-0002-4292-2850","affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5068192630"],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":{"value":4700,"currency":"USD","value_usd":4700},"apc_paid":null,"fwci":0.2525,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.20387597,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"164","issue":"3","first_page":"401","last_page":"443"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.5185999870300293,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.5185999870300293,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.1687999963760376,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.04490000009536743,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pet-radiotracer","display_name":"PET radiotracer","score":0.7509999871253967},{"id":"https://openalex.org/keywords/mental-disorders","display_name":"mental illness","score":0.8240000009536743},{"id":"https://openalex.org/keywords/substance-use-disorders","display_name":"substance use disorders","score":0.7609999775886536},{"id":"https://openalex.org/keywords/anxiety-disorders","display_name":"anxiety disorders","score":0.9990000128746033},{"id":"https://openalex.org/keywords/eating-disorders","display_name":"eating disorders","score":1.0},{"id":"https://openalex.org/keywords/personality-disorders","display_name":"personality disorders","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mood-disorders","display_name":"mood disorders","score":1.0},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":1.0},{"id":"https://openalex.org/keywords/neurochemical-imaging","display_name":"neurochemical imaging","score":0.6940000057220459},{"id":"https://openalex.org/keywords/drug-development","display_name":"drug development","score":0.414000004529953},{"id":"https://openalex.org/keywords/radiopharmaceutical-development","display_name":"radiopharmaceutical development","score":0.6449999809265137}],"concepts":[{"id":"https://openalex.org/C187714386","wikidata":"https://www.wikidata.org/wiki/Q420225","display_name":"Monoamine neurotransmitter","level":4,"score":0.7547589540481567},{"id":"https://openalex.org/C42251903","wikidata":"https://www.wikidata.org/wiki/Q18391002","display_name":"Monoaminergic","level":4,"score":0.7230268716812134},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.5634161829948425},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.5581153035163879},{"id":"https://openalex.org/C25876315","wikidata":"https://www.wikidata.org/wiki/Q15197465","display_name":"Neurochemical","level":2,"score":0.5498703122138977},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.48348337411880493},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45495596528053284},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.44831138849258423},{"id":"https://openalex.org/C2777308609","wikidata":"https://www.wikidata.org/wiki/Q270673","display_name":"Personality disorders","level":3,"score":0.44312241673469543},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.43718278408050537},{"id":"https://openalex.org/C2777134132","wikidata":"https://www.wikidata.org/wiki/Q188638","display_name":"Mood disorders","level":3,"score":0.42794692516326904},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.42709100246429443},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.4250425398349762},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.3651517629623413},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33324912190437317},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.32294392585754395},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.25330936908721924},{"id":"https://openalex.org/C187288502","wikidata":"https://www.wikidata.org/wiki/Q641118","display_name":"Personality","level":2,"score":0.1835567057132721},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.13435596227645874},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12222340703010559},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11373597383499146},{"id":"https://openalex.org/C77805123","wikidata":"https://www.wikidata.org/wiki/Q161272","display_name":"Social psychology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000588","descriptor_name":"Amines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000588","descriptor_name":"Amines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001523","descriptor_name":"Mental Disorders","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011954","descriptor_name":"Receptors, Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/jnc.15657","doi":"https://doi.org/10.1111/jnc.15657","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jnc.15657","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},{"id":"pmid:35716057","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35716057","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":384,"referenced_works":["https://openalex.org/W179673099","https://openalex.org/W205485714","https://openalex.org/W766527749","https://openalex.org/W1160137332","https://openalex.org/W1483260266","https://openalex.org/W1506913170","https://openalex.org/W1507810325","https://openalex.org/W1512847190","https://openalex.org/W1520021447","https://openalex.org/W1521733187","https://openalex.org/W1523031842","https://openalex.org/W1543912755","https://openalex.org/W1685180105","https://openalex.org/W1756714365","https://openalex.org/W1783343300","https://openalex.org/W1785252265","https://openalex.org/W1834156980","https://openalex.org/W1853120840","https://openalex.org/W1864738837","https://openalex.org/W1865865724","https://openalex.org/W1896248600","https://openalex.org/W1927796084","https://openalex.org/W1956747963","https://openalex.org/W1964179714","https://openalex.org/W1964347513","https://openalex.org/W1964684181","https://openalex.org/W1965030220","https://openalex.org/W1965191651","https://openalex.org/W1967041207","https://openalex.org/W1967207691","https://openalex.org/W1967267265","https://openalex.org/W1968677614","https://openalex.org/W1968763887","https://openalex.org/W1968831909","https://openalex.org/W1971002170","https://openalex.org/W1975952150","https://openalex.org/W1976630512","https://openalex.org/W1977081760","https://openalex.org/W1977410909","https://openalex.org/W1978238793","https://openalex.org/W1978456505","https://openalex.org/W1978716021","https://openalex.org/W1978885695","https://openalex.org/W1979308736","https://openalex.org/W1981964004","https://openalex.org/W1983611759","https://openalex.org/W1983924090","https://openalex.org/W1983982251","https://openalex.org/W1984005161","https://openalex.org/W1984006673","https://openalex.org/W1984247449","https://openalex.org/W1985836432","https://openalex.org/W1986068242","https://openalex.org/W1987065152","https://openalex.org/W1989155012","https://openalex.org/W1989435867","https://openalex.org/W1989501319","https://openalex.org/W1990151307","https://openalex.org/W1992379299","https://openalex.org/W1992600467","https://openalex.org/W1993210323","https://openalex.org/W1993675061","https://openalex.org/W1994034477","https://openalex.org/W1995180357","https://openalex.org/W1995649260","https://openalex.org/W1996278273","https://openalex.org/W1996605747","https://openalex.org/W1997343602","https://openalex.org/W1998628114","https://openalex.org/W2002660165","https://openalex.org/W2003241187","https://openalex.org/W2004136146","https://openalex.org/W2005019035","https://openalex.org/W2006715508","https://openalex.org/W2006801926","https://openalex.org/W2007856779","https://openalex.org/W2008915714","https://openalex.org/W2010755056","https://openalex.org/W2011269223","https://openalex.org/W2011302013","https://openalex.org/W2014496017","https://openalex.org/W2015382915","https://openalex.org/W2016560067","https://openalex.org/W2018035697","https://openalex.org/W2020358225","https://openalex.org/W2021211846","https://openalex.org/W2023081218","https://openalex.org/W2023630999","https://openalex.org/W2024256650","https://openalex.org/W2025011978","https://openalex.org/W2025782867","https://openalex.org/W2026408490","https://openalex.org/W2028056198","https://openalex.org/W2028643731","https://openalex.org/W2033310095","https://openalex.org/W2033892527","https://openalex.org/W2035940581","https://openalex.org/W2041781351","https://openalex.org/W2042018182","https://openalex.org/W2043664792","https://openalex.org/W2044710410","https://openalex.org/W2045175240","https://openalex.org/W2048246008","https://openalex.org/W2049756310","https://openalex.org/W2050264833","https://openalex.org/W2050449932","https://openalex.org/W2051455839","https://openalex.org/W2052158272","https://openalex.org/W2053177007","https://openalex.org/W2054230322","https://openalex.org/W2054684724","https://openalex.org/W2056127364","https://openalex.org/W2057349855","https://openalex.org/W2057475206","https://openalex.org/W2058804254","https://openalex.org/W2059154494","https://openalex.org/W2059469137","https://openalex.org/W2060312436","https://openalex.org/W2060935518","https://openalex.org/W2061976085","https://openalex.org/W2062875322","https://openalex.org/W2063614714","https://openalex.org/W2064739541","https://openalex.org/W2066735646","https://openalex.org/W2067166581","https://openalex.org/W2067464985","https://openalex.org/W2067591041","https://openalex.org/W2069024265","https://openalex.org/W2069747847","https://openalex.org/W2070100701","https://openalex.org/W2071528273","https://openalex.org/W2072069319","https://openalex.org/W2073304163","https://openalex.org/W2074106622","https://openalex.org/W2075785597","https://openalex.org/W2076109356","https://openalex.org/W2078867001","https://openalex.org/W2079847735","https://openalex.org/W2080245026","https://openalex.org/W2080549100","https://openalex.org/W2080849892","https://openalex.org/W2081629269","https://openalex.org/W2083176947","https://openalex.org/W2083210219","https://openalex.org/W2084772141","https://openalex.org/W2085340375","https://openalex.org/W2086234880","https://openalex.org/W2087276569","https://openalex.org/W2088851718","https://openalex.org/W2089121016","https://openalex.org/W2089159998","https://openalex.org/W2090203522","https://openalex.org/W2090306035","https://openalex.org/W2091416980","https://openalex.org/W2092601979","https://openalex.org/W2093344454","https://openalex.org/W2094381755","https://openalex.org/W2095549182","https://openalex.org/W2097016719","https://openalex.org/W2099676413","https://openalex.org/W2100115596","https://openalex.org/W2100653148","https://openalex.org/W2101357408","https://openalex.org/W2102924425","https://openalex.org/W2102988446","https://openalex.org/W2106194191","https://openalex.org/W2108598556","https://openalex.org/W2110456238","https://openalex.org/W2112222692","https://openalex.org/W2113964999","https://openalex.org/W2117124193","https://openalex.org/W2119106378","https://openalex.org/W2119224914","https://openalex.org/W2119396394","https://openalex.org/W2120064419","https://openalex.org/W2120431726","https://openalex.org/W2120711072","https://openalex.org/W2121887890","https://openalex.org/W2123699076","https://openalex.org/W2123907272","https://openalex.org/W2127865535","https://openalex.org/W2129771952","https://openalex.org/W2132911807","https://openalex.org/W2133902497","https://openalex.org/W2133942268","https://openalex.org/W2135267943","https://openalex.org/W2136160086","https://openalex.org/W2136619214","https://openalex.org/W2138566108","https://openalex.org/W2139725823","https://openalex.org/W2147293981","https://openalex.org/W2147949752","https://openalex.org/W2148239264","https://openalex.org/W2148360918","https://openalex.org/W2149199906","https://openalex.org/W2149413054","https://openalex.org/W2149984162","https://openalex.org/W2153347457","https://openalex.org/W2154039789","https://openalex.org/W2154094039","https://openalex.org/W2154178137","https://openalex.org/W2154855551","https://openalex.org/W2156443184","https://openalex.org/W2160730205","https://openalex.org/W2163854332","https://openalex.org/W2164805406","https://openalex.org/W2165028799","https://openalex.org/W2165143086","https://openalex.org/W2165398609","https://openalex.org/W2167317773","https://openalex.org/W2167561374","https://openalex.org/W2169142949","https://openalex.org/W2169146450","https://openalex.org/W2170388379","https://openalex.org/W2170652634","https://openalex.org/W2171390740","https://openalex.org/W2174050801","https://openalex.org/W2190964405","https://openalex.org/W2201607793","https://openalex.org/W2224961198","https://openalex.org/W2235703329","https://openalex.org/W2255138985","https://openalex.org/W2263665616","https://openalex.org/W2280580658","https://openalex.org/W2292774225","https://openalex.org/W2296042795","https://openalex.org/W2298338128","https://openalex.org/W2333481795","https://openalex.org/W2334516706","https://openalex.org/W2341083729","https://openalex.org/W2404811412","https://openalex.org/W2409433773","https://openalex.org/W2409613380","https://openalex.org/W2410113231","https://openalex.org/W2410910353","https://openalex.org/W2411778514","https://openalex.org/W2411812154","https://openalex.org/W2412925494","https://openalex.org/W2415963701","https://openalex.org/W2416532744","https://openalex.org/W2420643468","https://openalex.org/W2425309345","https://openalex.org/W2428350633","https://openalex.org/W2460053986","https://openalex.org/W2460172330","https://openalex.org/W2461326626","https://openalex.org/W2495904677","https://openalex.org/W2499012016","https://openalex.org/W2503767557","https://openalex.org/W2512806904","https://openalex.org/W2514007471","https://openalex.org/W2516454076","https://openalex.org/W2524197207","https://openalex.org/W2525236957","https://openalex.org/W2528666032","https://openalex.org/W2529229840","https://openalex.org/W2545969880","https://openalex.org/W2550807593","https://openalex.org/W2556294351","https://openalex.org/W2556709183","https://openalex.org/W2557472215","https://openalex.org/W2577715742","https://openalex.org/W2593649648","https://openalex.org/W2600498303","https://openalex.org/W2604485039","https://openalex.org/W2607127847","https://openalex.org/W2607180956","https://openalex.org/W2620551182","https://openalex.org/W2688630157","https://openalex.org/W2701605098","https://openalex.org/W2734859381","https://openalex.org/W2737301914","https://openalex.org/W2743887053","https://openalex.org/W2750655618","https://openalex.org/W2754837151","https://openalex.org/W2757408013","https://openalex.org/W2762942735","https://openalex.org/W2766540017","https://openalex.org/W2767998289","https://openalex.org/W2769429014","https://openalex.org/W2774837788","https://openalex.org/W2780020557","https://openalex.org/W2782662916","https://openalex.org/W2783590820","https://openalex.org/W2783781439","https://openalex.org/W2787368117","https://openalex.org/W2787897432","https://openalex.org/W2789276845","https://openalex.org/W2789585735","https://openalex.org/W2789902292","https://openalex.org/W2790353451","https://openalex.org/W2792047311","https://openalex.org/W2795144781","https://openalex.org/W2798004100","https://openalex.org/W2803719513","https://openalex.org/W2808009711","https://openalex.org/W2809991606","https://openalex.org/W2810096032","https://openalex.org/W2885580638","https://openalex.org/W2888416545","https://openalex.org/W2889703975","https://openalex.org/W2895594228","https://openalex.org/W2898554771","https://openalex.org/W2902311239","https://openalex.org/W2904008600","https://openalex.org/W2907647716","https://openalex.org/W2911413360","https://openalex.org/W2916149580","https://openalex.org/W2922855419","https://openalex.org/W2933363539","https://openalex.org/W2934202128","https://openalex.org/W2936612831","https://openalex.org/W2943224465","https://openalex.org/W2944252253","https://openalex.org/W2945144988","https://openalex.org/W2945294004","https://openalex.org/W2945545318","https://openalex.org/W2946960983","https://openalex.org/W2949765872","https://openalex.org/W2950455447","https://openalex.org/W2952123642","https://openalex.org/W2955122068","https://openalex.org/W2964427901","https://openalex.org/W2966662913","https://openalex.org/W2972170675","https://openalex.org/W2974247326","https://openalex.org/W2976822772","https://openalex.org/W2982685163","https://openalex.org/W2983986276","https://openalex.org/W2984443530","https://openalex.org/W2987141237","https://openalex.org/W2988853192","https://openalex.org/W2997938254","https://openalex.org/W2999023794","https://openalex.org/W3005891013","https://openalex.org/W3005984347","https://openalex.org/W3007031421","https://openalex.org/W3016244411","https://openalex.org/W3020973073","https://openalex.org/W3022579363","https://openalex.org/W3024855275","https://openalex.org/W3033044767","https://openalex.org/W3036711860","https://openalex.org/W3037072862","https://openalex.org/W3038929040","https://openalex.org/W3041483244","https://openalex.org/W3046119666","https://openalex.org/W3046566500","https://openalex.org/W3090511974","https://openalex.org/W3093249185","https://openalex.org/W3095768911","https://openalex.org/W3105701481","https://openalex.org/W3112912573","https://openalex.org/W3113386492","https://openalex.org/W3121673660","https://openalex.org/W3135964742","https://openalex.org/W3137327477","https://openalex.org/W3143302253","https://openalex.org/W3153669168","https://openalex.org/W3158465868","https://openalex.org/W3162518855","https://openalex.org/W3165007551","https://openalex.org/W3168748807","https://openalex.org/W3171272486","https://openalex.org/W3183696218","https://openalex.org/W3189411429","https://openalex.org/W3191456044","https://openalex.org/W3193708544","https://openalex.org/W3193943478","https://openalex.org/W3201969358","https://openalex.org/W4210956615","https://openalex.org/W4238106785","https://openalex.org/W4247665917","https://openalex.org/W4252300900","https://openalex.org/W4294730249","https://openalex.org/W6651966000","https://openalex.org/W6673523290","https://openalex.org/W6682545412","https://openalex.org/W6682834088","https://openalex.org/W6780463754","https://openalex.org/W6781228390","https://openalex.org/W6825936576","https://openalex.org/W7073701707","https://openalex.org/W7075734684"],"related_works":["https://openalex.org/W4280558335","https://openalex.org/W1594393078","https://openalex.org/W2000021187","https://openalex.org/W2623826449","https://openalex.org/W4409268646","https://openalex.org/W3012609924","https://openalex.org/W4282842198","https://openalex.org/W2428228247","https://openalex.org/W2045353436","https://openalex.org/W3217494956"],"abstract_inverted_index":{"Abstract":[0],"Early":[1],"applications":[2],"of":[3,14,38,40,57,66,69,112,118,140,151,191,210],"positron":[4],"emission":[5],"tomography":[6],"(PET)":[7],"in":[8,60,79,87,110,137,166],"psychiatry":[9],"sought":[10],"to":[11,204,214],"identify":[12],"derangements":[13],"cerebral":[15],"blood":[16],"flow":[17],"and":[18,31,46,73,89,98,163,187,207],"metabolism.":[19],"The":[20],"need":[21],"for":[22,94,145,218],"more":[23],"specific":[24],"neurochemical":[25],"imaging":[26,74,143],"probes":[27,33],"was":[28],"soon":[29],"evident,":[30],"these":[32,216],"initially":[34],"targeted":[35],"the":[36,55,64,116,138,160,192,205,208],"sites":[37],"action":[39],"neuroleptic":[41],"(dopamine":[42],"D":[43],"2":[44],"receptors)":[45,49],"psychoactive":[47],"(serotonin":[48],"drugs.":[50],"For":[51],"nearly":[52],"30":[53],"years,":[54],"centrality":[56],"monoamine":[58],"dysfunction":[59],"psychiatric":[61,100,171],"disorders":[62],"drove":[63],"development":[65,82,104,129,134,139],"an":[67],"armamentarium":[68],"monoaminergic":[70],"PET":[71,127,142],"radiopharmaceuticals":[72],"methodologies.":[75],"However,":[76],"continued":[77],"investments":[78],"monoamine\u2010enhancing":[80],"drug":[81,103,133],"realized":[83],"only":[84],"modest":[85],"gains":[86],"efficacy":[88],"tolerability.":[90],"As":[91],"patent":[92],"protection":[93],"many":[95],"widely":[96],"prescribed":[97],"profitable":[99],"drugs":[101],"lapsed,":[102],"pipelines":[105],"shifted":[106],"away":[107],"from":[108],"monoamines":[109],"search":[111],"novel":[113,161,219],"targets":[114,162,217],"with":[115],"promises":[117],"improved":[119],"efficacy,":[120],"or":[121],"abandoned":[122],"altogether.":[123],"Over":[124],"this":[125,152],"period,":[126],"radiopharmaceutical":[128],"activities":[130],"closely":[131],"parallelled":[132],"priorities,":[135],"resulting":[136],"new":[141],"agents":[144],"non\u2010monoamine":[146],"targets.":[147],"In":[148],"part":[149,167],"two":[150],"review,":[153],"we":[154],"survey":[155],"clinical":[156,211],"research":[157],"studies":[158,193],"using":[159],"radiotracers":[164],"described":[165,194],"one":[168],"across":[169],"major":[170],"application":[172],"areas":[173],"such":[174],"as":[175,197,199],"substance":[176],"use":[177],"disorders,":[178,180,182,184,186],"anxiety":[179],"eating":[181],"personality":[183],"mood":[185],"schizophrenia.":[188],"Important":[189],"limitations":[190],"are":[195],"discussed,":[196],"well":[198],"key":[200],"methodologic":[201],"issues,":[202],"challenges":[203],"field,":[206],"status":[209],"trials":[212],"seeking":[213],"exploit":[215],"therapeutics.":[220],"image":[221]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-06-19T00:00:00"}