{"id":"https://openalex.org/W4283074261","doi":"https://doi.org/10.1016/j.jtocrr.2022.100361","title":"Two Uncomplicated Pregnancies on Alectinib in a Woman With Metastatic ALK-Rearranged NSCLC: A Case Report","display_name":"Two Uncomplicated Pregnancies on Alectinib in a Woman With Metastatic ALK-Rearranged NSCLC: A Case Report","publication_year":2022,"publication_date":"2022-06-17","ids":{"openalex":"https://openalex.org/W4283074261","doi":"https://doi.org/10.1016/j.jtocrr.2022.100361","pmid":"https://pubmed.ncbi.nlm.nih.gov/35814861","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9264015"},"language":"en","primary_location":{"id":"doi:10.1016/j.jtocrr.2022.100361","doi":"https://doi.org/10.1016/j.jtocrr.2022.100361","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jtocrr.2022.100361","pdf_url":"http://www.jtocrr.org/article/S2666364322000856/pdf","source":{"id":"https://openalex.org/S4210220242","display_name":"JTO Clinical and Research Reports","issn_l":"2666-3643","issn":["2666-3643"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JTO Clinical and Research Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.jtocrr.org/article/S2666364322000856/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072940838","display_name":"Chloe Weidenbaum","orcid":"https://orcid.org/0000-0003-4246-9192","observed_orcids":["https://orcid.org/0000-0003-4246-9192"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chloe Weidenbaum","raw_affiliation_strings":["Department of Medicine, University of Tennessee Health Science Center, Nashville, Tennessee"],"raw_orcid":"https://orcid.org/0000-0003-4246-9192","affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Tennessee Health Science Center, Nashville, Tennessee","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014140299","display_name":"Christopher Cann","orcid":"https://orcid.org/0000-0002-6960-6460","observed_orcids":["https://orcid.org/0000-0002-6960-6460"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher G. Cann","raw_affiliation_strings":["Division of Hematology-Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology-Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023408319","display_name":"Sarah S. Osmundson","orcid":"https://orcid.org/0000-0002-7626-9992","observed_orcids":["https://orcid.org/0000-0002-7626-9992"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Osmundson","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018378822","display_name":"Wade Thomas Iams","orcid":"https://orcid.org/0000-0003-2109-298X","observed_orcids":["https://orcid.org/0000-0003-2109-298X"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wade T. Iams","raw_affiliation_strings":["Division of Hematology-Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee","Vanderbilt-Ingram Cancer Center, Nashville, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology-Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Vanderbilt-Ingram Cancer Center, Nashville, Tennessee","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049126384","display_name":"Travis John Osterman","orcid":"https://orcid.org/0000-0002-2841-8121","observed_orcids":["https://orcid.org/0000-0002-2841-8121"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Travis Osterman","raw_affiliation_strings":["Division of Hematology-Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee","Vanderbilt-Ingram Cancer Center, Nashville, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology-Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Vanderbilt-Ingram Cancer Center, Nashville, Tennessee","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5018378822"],"corresponding_institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299","https://openalex.org/I901861585"],"apc_list":{"value":2000,"currency":"USD","value_usd":2000},"apc_paid":{"value":2000,"currency":"USD","value_usd":2000},"fwci":1.7876,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.82483805,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":97},"biblio":{"volume":"3","issue":"8","first_page":"100361","last_page":"100361"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11964","display_name":"Pregnancy and Medication Impact","score":0.7523999810218811,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11964","display_name":"Pregnancy and Medication Impact","score":0.7523999810218811,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.22450000047683716,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12230","display_name":"Cardiovascular Issues in Pregnancy","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alectinib","display_name":"alectinib","score":0.9990000128746033},{"id":"https://openalex.org/keywords/alk-rearrangement","display_name":"ALK rearrangement","score":0.8690000176429749},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.875},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.9309999942779541},{"id":"https://openalex.org/keywords/metastatic-lung-cancer","display_name":"metastatic lung cancer","score":0.8259999752044678},{"id":"https://openalex.org/keywords/pregnancy","display_name":"pregnancy","score":0.9520000219345093},{"id":"https://openalex.org/keywords/medication-safety-in-pregnancy","display_name":"drug safety in pregnancy","score":0.859000027179718},{"id":"https://openalex.org/keywords/fetal-development","display_name":"fetal development","score":0.7099999785423279},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.7739999890327454}],"concepts":[{"id":"https://openalex.org/C2779220645","wikidata":"https://www.wikidata.org/wiki/Q21099132","display_name":"Alectinib","level":5,"score":0.9960342645645142},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.763062596321106},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.6663343906402588},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5814892053604126},{"id":"https://openalex.org/C117643217","wikidata":"https://www.wikidata.org/wiki/Q17824987","display_name":"Anaplastic lymphoma kinase","level":4,"score":0.5082051753997803},{"id":"https://openalex.org/C2778347629","wikidata":"https://www.wikidata.org/wiki/Q4652380","display_name":"ALK inhibitor","level":5,"score":0.4897449016571045},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4695069491863251},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.41279205679893494},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3467063307762146},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.26586484909057617},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06762611865997314},{"id":"https://openalex.org/C2776232967","wikidata":"https://www.wikidata.org/wiki/Q6743514","display_name":"Malignant pleural effusion","level":3,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.jtocrr.2022.100361","doi":"https://doi.org/10.1016/j.jtocrr.2022.100361","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jtocrr.2022.100361","pdf_url":"http://www.jtocrr.org/article/S2666364322000856/pdf","source":{"id":"https://openalex.org/S4210220242","display_name":"JTO Clinical and Research Reports","issn_l":"2666-3643","issn":["2666-3643"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JTO Clinical and Research Reports","raw_type":"journal-article"},{"id":"pmid:35814861","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35814861","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JTO clinical and research reports","raw_type":"Case Reports"},{"id":"pmh:oai:pubmedcentral.nih.gov:9264015","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9264015/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JTO Clin Res Rep","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:e0ab1a9c91e04b6db186ffa06e744fb8","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e0ab1a9c91e04b6db186ffa06e744fb8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JTO Clinical and Research Reports, Vol 3, Iss 8, Pp 100361- (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.jtocrr.2022.100361","doi":"https://doi.org/10.1016/j.jtocrr.2022.100361","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jtocrr.2022.100361","pdf_url":"http://www.jtocrr.org/article/S2666364322000856/pdf","source":{"id":"https://openalex.org/S4210220242","display_name":"JTO Clinical and Research Reports","issn_l":"2666-3643","issn":["2666-3643"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JTO Clinical and Research Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[{"id":"https://openalex.org/G4773283923","display_name":null,"funder_award_id":"030763","funder_id":"https://openalex.org/F4320314458","funder_display_name":"National Comprehensive Cancer Network"},{"id":"https://openalex.org/G4955288667","display_name":null,"funder_award_id":"211702","funder_id":"https://openalex.org/F4320314458","funder_display_name":"National Comprehensive Cancer Network"},{"id":"https://openalex.org/G9000083166","display_name":"Vanderbilt Clinical Oncology Research Career Development Award","funder_award_id":"K12CA090625","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320314458","display_name":"National Comprehensive Cancer Network","ror":"https://ror.org/0465x5x63"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4283074261.pdf","grobid_xml":"https://content.openalex.org/works/W4283074261.grobid-xml"},"referenced_works_count":5,"referenced_works":["https://openalex.org/W2120335312","https://openalex.org/W2412693322","https://openalex.org/W2800047395","https://openalex.org/W2887485646","https://openalex.org/W3148813812"],"related_works":["https://openalex.org/W4312840493","https://openalex.org/W4388766514","https://openalex.org/W4410260786","https://openalex.org/W4311951883","https://openalex.org/W4393182883","https://openalex.org/W4400198140","https://openalex.org/W3148813812","https://openalex.org/W4365814751","https://openalex.org/W4416441459","https://openalex.org/W7129692580"],"abstract_inverted_index":{"Lung":[0],"cancer":[1],"incidence":[2],"is":[3],"increasing":[4],"in":[5,8],"pregnancy":[6,21,49],"due":[7],"part":[9],"to":[10,36,93,114],"advanced":[11],"maternal":[12],"age.":[13],"A":[14],"subset":[15],"of":[16,59,119],"patients":[17],"with":[18,62,69,80],"NSCLC":[19],"during":[20,48,122],"harbor":[22],"an":[23],"ALK":[24,28,38,64],"gene":[25],"rearrangement.":[26],"Although":[27],"inhibitors,":[29],"such":[30],"as":[31],"alectinib,":[32],"are":[33,42,112],"routinely":[34],"used":[35],"treat":[37],"-rearranged":[39,65],"NSCLC,":[40],"there":[41],"limited":[43],"safety":[44,118],"data":[45],"regarding":[46],"use":[47],"and":[50,83,109],"fetal":[51],"effects.":[52],"Here,":[53],"we":[54],"report":[55],"the":[56,74,117],"second":[57],"case":[58],"a":[60],"patient":[61,75],"metastatic":[63],"lung":[66],"adenocarcinoma":[67],"treated":[68],"alectinib":[70,89,120],"throughout":[71],"pregnancy.":[72,123],"Notably,":[73],"had":[76],"two":[77],"uncomplicated":[78],"pregnancies":[79],"routine":[81],"obstetrical":[82],"postnatal":[84],"courses.":[85],"In":[86],"this":[87],"case,":[88],"did":[90],"not":[91,102],"seem":[92],"affect":[94],"embryofetal":[95],"or":[96,105],"early":[97],"childhood":[98],"development.":[99],"This":[100],"does":[101],"exclude":[103],"undetectable":[104],"delayed":[106],"toxic":[107],"effects,":[108],"additional":[110],"studies":[111],"needed":[113],"further":[115],"reveal":[116],"treatment":[121]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2022-06-19T00:00:00"}