{"id":"https://openalex.org/W4283069909","doi":"https://doi.org/10.1007/s10753-022-01694-1","title":"ALDH2 Hampers Immune Escape in Liver Hepatocellular Carcinoma through ROS/Nrf2-mediated Autophagy","display_name":"ALDH2 Hampers Immune Escape in Liver Hepatocellular Carcinoma through ROS/Nrf2-mediated Autophagy","publication_year":2022,"publication_date":"2022-06-17","ids":{"openalex":"https://openalex.org/W4283069909","doi":"https://doi.org/10.1007/s10753-022-01694-1","pmid":"https://pubmed.ncbi.nlm.nih.gov/35715591"},"language":"en","primary_location":{"id":"doi:10.1007/s10753-022-01694-1","doi":"https://doi.org/10.1007/s10753-022-01694-1","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10753-022-01694-1","pdf_url":null,"source":{"id":"https://openalex.org/S127393932","display_name":"Inflammation","issn_l":"0360-3997","issn":["0360-3997","1573-2576"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064170452","display_name":"Jingyao Hu","orcid":"https://orcid.org/0000-0002-6799-3620","observed_orcids":["https://orcid.org/0000-0002-6799-3620"]},"institutions":[{"id":"https://openalex.org/I4210099028","display_name":"Fourth Affiliated Hospital of China Medical University","ror":"https://ror.org/012sz4c50","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099028"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jingyao Hu","raw_affiliation_strings":["The Fourth Department of General Surgery, The Fourth Affiliated Hospital of China Medical University, Huanggu District, No. 4, Chongshan East Road, 110000, Liaoning, People's Republic of China. jyhu@cmu.edu.cn","The Fourth Department of General Surgery, The Fourth Affiliated Hospital of China Medical University, Huanggu District, No. 4, Chongshan East Road, 110000, Liaoning, People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0002-6799-3620","affiliations":[{"raw_affiliation_string":"The Fourth Department of General Surgery, The Fourth Affiliated Hospital of China Medical University, Huanggu District, No. 4, Chongshan East Road, 110000, Liaoning, People's Republic of China. jyhu@cmu.edu.cn","institution_ids":["https://openalex.org/I4210099028"]},{"raw_affiliation_string":"The Fourth Department of General Surgery, The Fourth Affiliated Hospital of China Medical University, Huanggu District, No. 4, Chongshan East Road, 110000, Liaoning, People's Republic of China","institution_ids":["https://openalex.org/I4210099028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101503415","display_name":"Liang Yang","orcid":"https://orcid.org/0000-0002-1173-1859","observed_orcids":["https://orcid.org/0000-0002-1173-1859"]},"institutions":[{"id":"https://openalex.org/I4210099028","display_name":"Fourth Affiliated Hospital of China Medical University","ror":"https://ror.org/012sz4c50","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099028"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liang Yang","raw_affiliation_strings":["The Third Department of General Surgery, The Fourth Affiliated Hospital of China Medical University, 110000, Liaoning, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third Department of General Surgery, The Fourth Affiliated Hospital of China Medical University, 110000, Liaoning, People's Republic of China","institution_ids":["https://openalex.org/I4210099028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030986536","display_name":"Xueqiang Peng","orcid":"https://orcid.org/0000-0003-3522-0348","observed_orcids":["https://orcid.org/0000-0003-3522-0348"]},"institutions":[{"id":"https://openalex.org/I4210099028","display_name":"Fourth Affiliated Hospital of China Medical University","ror":"https://ror.org/012sz4c50","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099028"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xueqiang Peng","raw_affiliation_strings":["The Third Department of General Surgery, The Fourth Affiliated Hospital of China Medical University, 110000, Liaoning, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third Department of General Surgery, The Fourth Affiliated Hospital of China Medical University, 110000, Liaoning, People's Republic of China","institution_ids":["https://openalex.org/I4210099028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058571125","display_name":"Minghuan Mao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099028","display_name":"Fourth Affiliated Hospital of China Medical University","ror":"https://ror.org/012sz4c50","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099028"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Minghuan Mao","raw_affiliation_strings":["The Fourth Department of General Surgery, The Fourth Affiliated Hospital of China Medical University, Huanggu District, No. 4, Chongshan East Road, 110000, Liaoning, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Fourth Department of General Surgery, The Fourth Affiliated Hospital of China Medical University, Huanggu District, No. 4, Chongshan East Road, 110000, Liaoning, People's Republic of China","institution_ids":["https://openalex.org/I4210099028"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xiaodan Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099028","display_name":"Fourth Affiliated Hospital of China Medical University","ror":"https://ror.org/012sz4c50","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099028"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaodan Liu","raw_affiliation_strings":["The Fifth Department of General Surgery, The Fourth Affiliated Hospital of China Medical University, 110000, Liaoning, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Fifth Department of General Surgery, The Fourth Affiliated Hospital of China Medical University, 110000, Liaoning, People's Republic of China","institution_ids":["https://openalex.org/I4210099028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037014147","display_name":"Jianbo Song","orcid":"https://orcid.org/0000-0002-4040-0792","observed_orcids":["https://orcid.org/0000-0002-4040-0792","https://orcid.org/0000-0001-6648-0367"]},"institutions":[{"id":"https://openalex.org/I4210099028","display_name":"Fourth Affiliated Hospital of China Medical University","ror":"https://ror.org/012sz4c50","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099028"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianbo Song","raw_affiliation_strings":["Interventional Department, The Fourth Affiliated Hospital of China Medical University, 110000, Liaoning, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interventional Department, The Fourth Affiliated Hospital of China Medical University, 110000, Liaoning, People's Republic of China","institution_ids":["https://openalex.org/I4210099028"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100724753","display_name":"Hangyu Li","orcid":"https://orcid.org/0000-0002-2570-1642","observed_orcids":["https://orcid.org/0000-0002-2570-1642"]},"institutions":[{"id":"https://openalex.org/I4210099028","display_name":"Fourth Affiliated Hospital of China Medical University","ror":"https://ror.org/012sz4c50","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099028"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hangyu Li","raw_affiliation_strings":["The Third Department of General Surgery, The Fourth Affiliated Hospital of China Medical University, 110000, Liaoning, People's Republic of China. sj_li_hangyu@sina.com","The Third Department of General Surgery, The Fourth Affiliated Hospital of China Medical University, 110000, Liaoning, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third Department of General Surgery, The Fourth Affiliated Hospital of China Medical University, 110000, Liaoning, People's Republic of China. sj_li_hangyu@sina.com","institution_ids":["https://openalex.org/I4210099028"]},{"raw_affiliation_string":"The Third Department of General Surgery, The Fourth Affiliated Hospital of China Medical University, 110000, Liaoning, People's Republic of China","institution_ids":["https://openalex.org/I4210099028"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5064170452","https://openalex.org/A5100724753"],"corresponding_institution_ids":["https://openalex.org/I4210099028"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":null,"fwci":1.6177,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.8409262,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"45","issue":"6","first_page":"2309","last_page":"2324"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.5088000297546387,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.5088000297546387,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.1429000049829483,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.10809999704360962,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aldh2","display_name":"ALDH2","score":0.8700000047683716},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9819999933242798},{"id":"https://openalex.org/keywords/tumor-immune-evasion","display_name":"tumor immune evasion","score":0.9259999990463257},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.8080000281333923},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9990000128746033},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8859999775886536},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8299999833106995},{"id":"https://openalex.org/keywords/t-cell-accumulation","display_name":"T cell accumulation","score":0.7979999780654907},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.5429999828338623},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.4950000047683716}],"concepts":[{"id":"https://openalex.org/C3175096","wikidata":"https://www.wikidata.org/wiki/Q2640417","display_name":"ALDH2","level":4,"score":0.9087177515029907},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6557924747467041},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.6208018660545349},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6134147644042969},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.5975131392478943},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5316271185874939},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.5056583881378174},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.44910264015197754},{"id":"https://openalex.org/C25747580","wikidata":"https://www.wikidata.org/wiki/Q423792","display_name":"Aldehyde dehydrogenase","level":3,"score":0.3698459267616272},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35246315598487854},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3178004026412964},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.18653789162635803},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12940755486488342},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10494381189346313},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08403173089027405}],"mesh":[{"descriptor_ui":"D000071396","descriptor_name":"Aldehyde Dehydrogenase, Mitochondrial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000071396","descriptor_name":"Aldehyde Dehydrogenase, Mitochondrial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019139","descriptor_name":"Tumor Escape","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s10753-022-01694-1","doi":"https://doi.org/10.1007/s10753-022-01694-1","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10753-022-01694-1","pdf_url":null,"source":{"id":"https://openalex.org/S127393932","display_name":"Inflammation","issn_l":"0360-3997","issn":["0360-3997","1573-2576"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammation","raw_type":"journal-article"},{"id":"pmid:35715591","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35715591","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1985124617","https://openalex.org/W2160618318","https://openalex.org/W2272984102","https://openalex.org/W2744206077","https://openalex.org/W2884737578","https://openalex.org/W2898314774","https://openalex.org/W2900447455","https://openalex.org/W2910750468","https://openalex.org/W2913162269","https://openalex.org/W2946528223","https://openalex.org/W2954123950","https://openalex.org/W2982670491","https://openalex.org/W3018219660","https://openalex.org/W3036796178","https://openalex.org/W3046160590","https://openalex.org/W3094426756","https://openalex.org/W3126794039","https://openalex.org/W3128252230","https://openalex.org/W3134273384","https://openalex.org/W3139398025","https://openalex.org/W3176679646","https://openalex.org/W3180440119","https://openalex.org/W3195441296","https://openalex.org/W3197292161","https://openalex.org/W3197504514","https://openalex.org/W3198306371","https://openalex.org/W3217183894","https://openalex.org/W4211073619"],"related_works":["https://openalex.org/W4389485108","https://openalex.org/W4402489433","https://openalex.org/W2561827514","https://openalex.org/W4396738807","https://openalex.org/W4212957158","https://openalex.org/W3203158130","https://openalex.org/W4206856020","https://openalex.org/W2944499075","https://openalex.org/W3128252230","https://openalex.org/W4407002989"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2022-06-19T00:00:00"}
