{"id":"https://openalex.org/W4283069360","doi":"https://doi.org/10.1186/s13054-022-04055-4","title":"Effect of intravenous clarithromycin in patients with sepsis, respiratory and multiple organ dysfunction syndrome: a randomized clinical trial","display_name":"Effect of intravenous clarithromycin in patients with sepsis, respiratory and multiple organ dysfunction syndrome: a randomized clinical trial","publication_year":2022,"publication_date":"2022-06-18","ids":{"openalex":"https://openalex.org/W4283069360","doi":"https://doi.org/10.1186/s13054-022-04055-4","pmid":"https://pubmed.ncbi.nlm.nih.gov/35717241","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9206755"},"language":"en","primary_location":{"id":"doi:10.1186/s13054-022-04055-4","doi":"https://doi.org/10.1186/s13054-022-04055-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13054-022-04055-4","pdf_url":"https://ccforum.biomedcentral.com/counter/pdf/10.1186/s13054-022-04055-4","source":{"id":"https://openalex.org/S191417626","display_name":"Critical Care","issn_l":"1364-8535","issn":["1364-8535","1466-609X","1574-4280","1875-7081"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ccforum.biomedcentral.com/counter/pdf/10.1186/s13054-022-04055-4","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016776205","display_name":"Eleni Karakike","orcid":"https://orcid.org/0000-0002-0187-512X","observed_orcids":["https://orcid.org/0000-0002-0187-512X"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Eleni Karakike","raw_affiliation_strings":["4th Department of Internal Medicine, National and Kapodistrian University of Athens, 1 Rimini Street, 124 62, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4th Department of Internal Medicine, National and Kapodistrian University of Athens, 1 Rimini Street, 124 62, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083823258","display_name":"Brendon P. Scicluna","orcid":"https://orcid.org/0000-0003-2826-0341","observed_orcids":["https://orcid.org/0000-0003-2826-0341"]},"institutions":[{"id":"https://openalex.org/I197854408","display_name":"University of Malta","ror":"https://ror.org/03a62bv60","country_code":"MT","type":"education","lineage":["https://openalex.org/I197854408"]},{"id":"https://openalex.org/I2801220772","display_name":"Mater Dei Hospital","ror":"https://ror.org/05a01hn31","country_code":"MT","type":"healthcare","lineage":["https://openalex.org/I2801220772"]},{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["MT","NL"],"is_corresponding":false,"raw_author_name":"Brendon P. Scicluna","raw_affiliation_strings":["Centre for Molecular Medicine and Biobanking, University of Malta, Msida, Malta","Department of Applied Biomedical Science, Faculty of Health Sciences, Mater Dei Hospital, University of Malta, Msida, Malta","Division of Infectious Diseases, Center for Experimental Molecular Medicine, Amsterdam University Medical Centers, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Molecular Medicine and Biobanking, University of Malta, Msida, Malta","institution_ids":["https://openalex.org/I197854408"]},{"raw_affiliation_string":"Department of Applied Biomedical Science, Faculty of Health Sciences, Mater Dei Hospital, University of Malta, Msida, Malta","institution_ids":["https://openalex.org/I197854408","https://openalex.org/I2801220772"]},{"raw_affiliation_string":"Division of Infectious Diseases, Center for Experimental Molecular Medicine, Amsterdam University Medical Centers, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I4210151833","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024183034","display_name":"Maria Roumpoutsou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Maria Roumpoutsou","raw_affiliation_strings":["4th Department of Internal Medicine, National and Kapodistrian University of Athens, 1 Rimini Street, 124 62, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4th Department of Internal Medicine, National and Kapodistrian University of Athens, 1 Rimini Street, 124 62, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087164805","display_name":"Ioannis Mitrou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Ioannis Mitrou","raw_affiliation_strings":["4th Department of Internal Medicine, National and Kapodistrian University of Athens, 1 Rimini Street, 124 62, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4th Department of Internal Medicine, National and Kapodistrian University of Athens, 1 Rimini Street, 124 62, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029131333","display_name":"Niki Karampela","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Niki Karampela","raw_affiliation_strings":["Intensive Care Unit, Korgialeneio Benakeio General Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Unit, Korgialeneio Benakeio General Hospital, Athens, Greece","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Athanasios Karageorgos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Athanasios Karageorgos","raw_affiliation_strings":["4th Department of Internal Medicine, National and Kapodistrian University of Athens, 1 Rimini Street, 124 62, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4th Department of Internal Medicine, National and Kapodistrian University of Athens, 1 Rimini Street, 124 62, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085542738","display_name":"Konstantinos Psaroulis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Konstantinos Psaroulis","raw_affiliation_strings":["Intensive Care Unit, Aghios Dimitrios General Hospital, Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Unit, Aghios Dimitrios General Hospital, Thessaloniki, Greece","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015751415","display_name":"Eleni Massa","orcid":"https://orcid.org/0000-0003-4594-3259","observed_orcids":["https://orcid.org/0000-0003-4594-3259"]},"institutions":[{"id":"https://openalex.org/I4210165841","display_name":"Hippocration General Hospital","ror":"https://ror.org/05v5wwy67","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210165841"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Eleni Massa","raw_affiliation_strings":["Intensive Care Unit, Hippokration General Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Unit, Hippokration General Hospital, Athens, Greece","institution_ids":["https://openalex.org/I4210165841"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060428819","display_name":"Achillefs Pitsoulis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Achillefs Pitsoulis","raw_affiliation_strings":["Intensive Care Unit, G. Gennimatas General Hospital, Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Unit, G. Gennimatas General Hospital, Thessaloniki, Greece","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061425195","display_name":"Panagiotis Chaloulis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087568","display_name":"Theageneio General Hospital","ror":"https://ror.org/004hfxk38","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210087568"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Panagiotis Chaloulis","raw_affiliation_strings":["Intensive Care Unit, Theageneion General Hospital, Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Unit, Theageneion General Hospital, Thessaloniki, Greece","institution_ids":["https://openalex.org/I4210087568"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050917394","display_name":"Evanthia Pappa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114623","display_name":"Laiko General Hospital of Athens","ror":"https://ror.org/02dvs1389","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210114623"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Evanthia Pappa","raw_affiliation_strings":["Intensive Care Unit, Laiko General Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Unit, Laiko General Hospital, Athens, Greece","institution_ids":["https://openalex.org/I4210114623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056016950","display_name":"Irene T. Schrijver","orcid":"https://orcid.org/0000-0002-3904-5893","observed_orcids":["https://orcid.org/0000-0002-3904-5893"]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]},{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Irene T. Schrijver","raw_affiliation_strings":["Infectious Diseases Service, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases Service, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882","https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080287202","display_name":"Frantzeska G. Frantzeskaki","orcid":"https://orcid.org/0000-0002-3897-6282","observed_orcids":["https://orcid.org/0000-0002-3897-6282"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Frantzeska Frantzeskaki","raw_affiliation_strings":["2nd Department of Critical Care Medicine, National and Kapodistrian University of Athens, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2nd Department of Critical Care Medicine, National and Kapodistrian University of Athens, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002694006","display_name":"Malvina Lada","orcid":"https://orcid.org/0000-0001-9979-1495","observed_orcids":["https://orcid.org/0000-0001-9979-1495"]},"institutions":[{"id":"https://openalex.org/I2800888565","display_name":"Sismanoglio General Hospital","ror":"https://ror.org/057cm0m66","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I2800888565"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Malvina Lada","raw_affiliation_strings":["2nd Department of Internal Medicine, Sismanogleion General Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2nd Department of Internal Medicine, Sismanogleion General Hospital, Athens, Greece","institution_ids":["https://openalex.org/I2800888565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067019998","display_name":"Nicol\u00e1s Dauby","orcid":"https://orcid.org/0000-0002-7697-6849","observed_orcids":["https://orcid.org/0000-0002-7697-6849"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I4210154425","display_name":"Centre Hospitalier Universitaire de Saint-Pierre","ror":"https://ror.org/05cmp5q80","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210154425"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Nicolas Dauby","raw_affiliation_strings":["Department of Infectious Diseases, Centre Hospitalier Universitaire Saint-Pierre, Universit\u00e9 Libre de Bruxelles (ULB), Brussels, Belgium","Institute for Medical Immunology, Universit\u00e9 Libre de Bruxelles (ULB), Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Centre Hospitalier Universitaire Saint-Pierre, Universit\u00e9 Libre de Bruxelles (ULB), Brussels, Belgium","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I4210154425"]},{"raw_affiliation_string":"Institute for Medical Immunology, Universit\u00e9 Libre de Bruxelles (ULB), Brussels, Belgium","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052970110","display_name":"David De Bels","orcid":"https://orcid.org/0000-0001-9324-5768","observed_orcids":["https://orcid.org/0000-0001-9324-5768"]},"institutions":[{"id":"https://openalex.org/I4210102955","display_name":"Centre Hospitalier Universitaire Brugmann","ror":"https://ror.org/011apjk30","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210102955"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"David De Bels","raw_affiliation_strings":["Department of Intensive Care, Centre Hospitalier Universitaire Brugmann, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Intensive Care, Centre Hospitalier Universitaire Brugmann, Brussels, Belgium","institution_ids":["https://openalex.org/I4210102955"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ioannis Floros","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114623","display_name":"Laiko General Hospital of Athens","ror":"https://ror.org/02dvs1389","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210114623"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Ioannis Floros","raw_affiliation_strings":["Intensive Care Unit, Laiko General Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Unit, Laiko General Hospital, Athens, Greece","institution_ids":["https://openalex.org/I4210114623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005343190","display_name":"Souzana Anisoglou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087568","display_name":"Theageneio General Hospital","ror":"https://ror.org/004hfxk38","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210087568"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Souzana Anisoglou","raw_affiliation_strings":["Intensive Care Unit, Theageneion General Hospital, Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Unit, Theageneion General Hospital, Thessaloniki, Greece","institution_ids":["https://openalex.org/I4210087568"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051477764","display_name":"Eleni Antoniadou","orcid":"https://orcid.org/0009-0000-9916-8118","observed_orcids":["https://orcid.org/0009-0000-9916-8118"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eleni Antoniadou","raw_affiliation_strings":["Intensive Care Unit, G. Gennimatas General Hospital, Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Unit, G. Gennimatas General Hospital, Thessaloniki, Greece","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085504317","display_name":"Maria Patrani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Patrani","raw_affiliation_strings":["Intensive Care Unit, Korgialeneio Benakeio General Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Unit, Korgialeneio Benakeio General Hospital, Athens, Greece","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113988399","display_name":"Glykeria Vlachogianni","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Glykeria Vlachogianni","raw_affiliation_strings":["Intensive Care Unit, Aghios Dimitrios General Hospital, Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Unit, Aghios Dimitrios General Hospital, Thessaloniki, Greece","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088298881","display_name":"Eleni K Mouloudi","orcid":"https://orcid.org/0000-0003-0079-2012","observed_orcids":["https://orcid.org/0000-0003-0079-2012"]},"institutions":[{"id":"https://openalex.org/I4210165841","display_name":"Hippocration General Hospital","ror":"https://ror.org/05v5wwy67","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210165841"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Eleni Mouloudi","raw_affiliation_strings":["Intensive Care Unit, Hippokration General Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Unit, Hippokration General Hospital, Athens, Greece","institution_ids":["https://openalex.org/I4210165841"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064861218","display_name":"Anastasia Antoniadou","orcid":"https://orcid.org/0000-0003-0991-9198","observed_orcids":["https://orcid.org/0000-0003-0991-9198"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Anastasia Antoniadou","raw_affiliation_strings":["4th Department of Internal Medicine, National and Kapodistrian University of Athens, 1 Rimini Street, 124 62, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4th Department of Internal Medicine, National and Kapodistrian University of Athens, 1 Rimini Street, 124 62, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015902606","display_name":"David Grimaldi","orcid":"https://orcid.org/0000-0001-8428-065X","observed_orcids":["https://orcid.org/0000-0001-8428-065X"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"David Grimaldi","raw_affiliation_strings":["Department of Intensive Care, CUB-Erasme, Universit\u00e9 Libre de Bruxelles (ULB), Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Intensive Care, CUB-Erasme, Universit\u00e9 Libre de Bruxelles (ULB), Brussels, Belgium","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053283797","display_name":"Thierry Roger","orcid":"https://orcid.org/0000-0002-9358-0109","observed_orcids":["https://orcid.org/0000-0002-9358-0109"]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]},{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Thierry Roger","raw_affiliation_strings":["Infectious Diseases Service, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases Service, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882","https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030071794","display_name":"Willem Joost Wiersinga","orcid":"https://orcid.org/0000-0003-2277-1343","observed_orcids":["https://orcid.org/0000-0003-2277-1343"]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"W. Joost Wiersinga","raw_affiliation_strings":["Division of Infectious Diseases, Center for Experimental Molecular Medicine, Amsterdam University Medical Centers, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Center for Experimental Molecular Medicine, Amsterdam University Medical Centers, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I4210151833","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066582790","display_name":"Iraklis Tsangaris","orcid":"https://orcid.org/0000-0003-4395-0471","observed_orcids":["https://orcid.org/0000-0003-4395-0471"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Iraklis Tsangaris","raw_affiliation_strings":["2nd Department of Critical Care Medicine, National and Kapodistrian University of Athens, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2nd Department of Critical Care Medicine, National and Kapodistrian University of Athens, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011316933","display_name":"Evangelos J. Giamarellos\u2010Bourboulis","orcid":"https://orcid.org/0000-0003-4713-3911","observed_orcids":["https://orcid.org/0000-0003-4713-3911"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Evangelos J. Giamarellos-Bourboulis","raw_affiliation_strings":["4th Department of Internal Medicine, National and Kapodistrian University of Athens, 1 Rimini Street, 124 62, Athens, Greece. egiamarel@med.uoa.gr","4th Department of Internal Medicine, National and Kapodistrian University of Athens, 1 Rimini Street, 124 62, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4th Department of Internal Medicine, National and Kapodistrian University of Athens, 1 Rimini Street, 124 62, Athens, Greece. egiamarel@med.uoa.gr","institution_ids":["https://openalex.org/I200777214"]},{"raw_affiliation_string":"4th Department of Internal Medicine, National and Kapodistrian University of Athens, 1 Rimini Street, 124 62, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":15,"corresponding_author_ids":["https://openalex.org/A5011316933"],"corresponding_institution_ids":["https://openalex.org/I200777214"],"apc_list":{"value":3690,"currency":"USD","value_usd":3690},"apc_paid":{"value":3690,"currency":"USD","value_usd":3690},"fwci":6.8346,"has_fulltext":true,"cited_by_count":44,"citation_normalized_percentile":{"value":0.98139429,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"26","issue":"1","first_page":"183","last_page":"183"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clarithromycin","display_name":"clarithromycin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.996999979019165},{"id":"https://openalex.org/keywords/acute-respiratory-distress-syndrome","display_name":"acute respiratory distress syndrome","score":0.8080000281333923},{"id":"https://openalex.org/keywords/multiple-organ-failure","display_name":"multiple organ failure","score":0.9750000238418579},{"id":"https://openalex.org/keywords/28-day-mortality","display_name":"28-day mortality","score":0.9129999876022339},{"id":"https://openalex.org/keywords/sepsis-recurrence","display_name":"sepsis recurrence","score":0.9779999852180481},{"id":"https://openalex.org/keywords/immune-restoration","display_name":"immune restoration","score":0.6660000085830688},{"id":"https://openalex.org/keywords/monocyte-hla-dr-expression","display_name":"monocyte HLA-DR expression","score":0.8880000114440918},{"id":"https://openalex.org/keywords/nonclassical-monocytes","display_name":"non-classical monocytes","score":0.9850000143051147},{"id":"https://openalex.org/keywords/cholesterol-homeostasis","display_name":"cholesterol homeostasis","score":0.9210000038146973},{"id":"https://openalex.org/keywords/sofa-score","display_name":"SOFA score","score":0.7829999923706055},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.5590000152587891},{"id":"https://openalex.org/keywords/macrolide-antibiotics","display_name":"macrolide antibiotics","score":0.6819999814033508},{"id":"https://openalex.org/keywords/critically-ill-patients","display_name":"critically ill patients","score":0.6110000014305115}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9266701936721802},{"id":"https://openalex.org/C2776962512","wikidata":"https://www.wikidata.org/wiki/Q118551","display_name":"Clarithromycin","level":3,"score":0.7432444095611572},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.722941517829895},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.6524388790130615},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6295597553253174},{"id":"https://openalex.org/C2778426790","wikidata":"https://www.wikidata.org/wiki/Q1649580","display_name":"Organ dysfunction","level":3,"score":0.5854916572570801},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5046223402023315},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.46581602096557617},{"id":"https://openalex.org/C2777465075","wikidata":"https://www.wikidata.org/wiki/Q7392039","display_name":"SOFA score","level":3,"score":0.4371156692504883},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10133010149002075},{"id":"https://openalex.org/C2776409635","wikidata":"https://www.wikidata.org/wiki/Q180556","display_name":"Helicobacter pylori","level":2,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009102","descriptor_name":"Multiple Organ Failure","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D009102","descriptor_name":"Multiple Organ Failure","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017291","descriptor_name":"Clarithromycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017291","descriptor_name":"Clarithromycin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D061605","descriptor_name":"Administration, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":10,"locations":[{"id":"doi:10.1186/s13054-022-04055-4","doi":"https://doi.org/10.1186/s13054-022-04055-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13054-022-04055-4","pdf_url":"https://ccforum.biomedcentral.com/counter/pdf/10.1186/s13054-022-04055-4","source":{"id":"https://openalex.org/S191417626","display_name":"Critical Care","issn_l":"1364-8535","issn":["1364-8535","1466-609X","1574-4280","1875-7081"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9206755","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9206755","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Crit Care","raw_type":"Text"},{"id":"pmid:35717241","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35717241","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical care (London, England)","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unil.ch:iris/222264","doi":null,"is_oa":true,"landing_page_url":"https://iris.unil.ch/handle/iris/222264","pdf_url":"https://iris.unil.ch/bitstreams/082e2ff7-30b7-4fd0-b5fd-90b404ff92ef/download","source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:www.um.edu.mt:123456789/98561","doi":null,"is_oa":true,"landing_page_url":"https://www.um.edu.mt/library/oar/handle/123456789/98561","pdf_url":null,"source":{"id":"https://openalex.org/S4306400782","display_name":"OAR@UM (University of Malta)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I197854408","host_organization_name":"University of Malta","host_organization_lineage":["https://openalex.org/I197854408"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/657c4b7a-7218-43e7-b68d-c0eca413b39a","doi":null,"is_oa":true,"landing_page_url":"https://pure.amc.nl/en/publications/effect-of-intravenous-clarithromycin-in-patients-with-sepsis-respiratory-and-multiple-organ-dysfunction-syndrome(657c4b7a-7218-43e7-b68d-c0eca413b39a).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Critical Care, 26(1):183. Springer Science + Business Media","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dipot.ulb.ac.be:2013/345114","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/345114","pdf_url":null,"source":{"id":"https://openalex.org/S4306401063","display_name":"D\u00e9p\u00f4t institutionnel de l'Universit\u00e9 libre de Bruxelles (Universit\u00e9 Libre de Bruxelles)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132053463","host_organization_name":"Universit\u00e9 Libre de Bruxelles","host_organization_lineage":["https://openalex.org/I132053463"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Critical care, 26 (1","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:3fb6358b3e844d6284ce50b1283067ca","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3fb6358b3e844d6284ce50b1283067ca","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Critical Care, Vol 26, Iss 1, Pp 1-11 (2022)","raw_type":"article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire/5eb6ab90-3ec5-48ee-ab57-2bd2fa16ab48","doi":null,"is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/5eb6ab90-3ec5-48ee-ab57-2bd2fa16ab48","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:serval.unil.ch:BIB_AD06BCD240B9","doi":null,"is_oa":true,"landing_page_url":"https://serval.unil.ch/notice/serval:BIB_AD06BCD240B9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401797","display_name":"SERVAL (Universit\u00e9 de Lausanne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210093590","host_organization_name":"Swiss School of Archaeology in Greece","host_organization_lineage":["https://openalex.org/I4210093590"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Critical care, vol. 26, no. 1, pp. 183","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/s13054-022-04055-4","doi":"https://doi.org/10.1186/s13054-022-04055-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13054-022-04055-4","pdf_url":"https://ccforum.biomedcentral.com/counter/pdf/10.1186/s13054-022-04055-4","source":{"id":"https://openalex.org/S191417626","display_name":"Critical Care","issn_l":"1364-8535","issn":["1364-8535","1466-609X","1574-4280","1875-7081"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G8609360947","display_name":null,"funder_award_id":"676129","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"}],"funders":[{"id":"https://openalex.org/F4320323149","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42"},{"id":"https://openalex.org/F4320332999","display_name":"Horizon 2020 Framework Programme","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F5188751197","display_name":"Hellenic Institute for the Study of Sepsis","ror":"https://ror.org/02n4vr545"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4283069360.pdf","grobid_xml":"https://content.openalex.org/works/W4283069360.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W371461304","https://openalex.org/W1941901208","https://openalex.org/W1965929258","https://openalex.org/W2098019283","https://openalex.org/W2100536943","https://openalex.org/W2102856718","https://openalex.org/W2131345386","https://openalex.org/W2144537497","https://openalex.org/W2168456558","https://openalex.org/W2171284117","https://openalex.org/W2177407033","https://openalex.org/W2329772284","https://openalex.org/W2338943353","https://openalex.org/W2557169014","https://openalex.org/W2761004909","https://openalex.org/W2782135811","https://openalex.org/W2792364673","https://openalex.org/W2914455493","https://openalex.org/W2977322360","https://openalex.org/W2977556556","https://openalex.org/W2992739672","https://openalex.org/W2998853022","https://openalex.org/W3012763772","https://openalex.org/W3033872389","https://openalex.org/W3036684707","https://openalex.org/W3082355253","https://openalex.org/W3193838886","https://openalex.org/W3214720083","https://openalex.org/W4233317660"],"related_works":["https://openalex.org/W6958465242","https://openalex.org/W4389043125","https://openalex.org/W2144537497","https://openalex.org/W2100536943","https://openalex.org/W6902073770","https://openalex.org/W1985026341","https://openalex.org/W1990078043","https://openalex.org/W2101682791","https://openalex.org/W2088710272","https://openalex.org/W7128511544"],"abstract_inverted_index":{"BACKGROUND:":[0],"Clarithromycin":[1,200,243,258],"may":[2],"act":[3],"as":[4,119],"immune-regulating":[5],"treatment":[6],"in":[7,46,124,134,156,162,194,218,231],"sepsis":[8,116,130,198,207,251,263],"and":[9,33,65,83,132,139,159,197,226,235,254],"acute":[10],"respiratory":[11,32,76,253],"dysfunction":[12,36],"syndrome.":[13,37],"However,":[14],"clinical":[15,44],"evidence":[16],"remains":[17],"inconclusive.":[18],"We":[19,39],"aimed":[20],"to":[21,57,89,147,176],"evaluate":[22],"whether":[23],"clarithromycin":[24,94,158],"improves":[25],"28-day":[26,108],"mortality":[27,196,247],"among":[28,248],"patients":[29,47,144,155,249],"with":[30,48,51,203,250,252,261],"sepsis,":[31],"multiple":[34,255],"organ":[35,256],"METHODS:":[38],"conducted":[40],"a":[41,267],"multicenter,":[42],"randomized,":[43],"trial":[45,273],"sepsis.":[49],"Participants":[50],"ratio":[52],"of":[53,59,93,206,223,228,269],"partial":[54],"oxygen":[55,61],"pressure":[56],"fraction":[58],"inspired":[60],"less":[62],"than":[63,67,74],"200":[64],"more":[66],"3":[68],"SOFA":[69,125],"points":[70],"from":[71],"systems":[72],"other":[73],"the":[75,157,163],"function":[77],"were":[78,87,113,145,190,239],"enrolled":[79],"between":[80],"December":[81],"2017":[82],"September":[84],"2019.":[85],"Patients":[86],"randomized":[88],"receive":[90],"1":[91],"gr":[92],"or":[95],"placebo":[96,164],"intravenously":[97],"once":[98],"daily":[99],"for":[100],"4":[101],"consecutive":[102],"days.":[103],"The":[104],"primary":[105],"endpoint":[106],"was":[107,201,259],"all-cause":[109],"mortality.":[110],"Secondary":[111],"outcomes":[112],"90-day":[114,195],"mortality;":[115],"response":[117],"(defined":[118],"at":[120],"least":[121],"25%":[122],"decrease":[123],"score":[126],"by":[127],"day":[128,151],"7);":[129],"recurrence;":[131],"differences":[133,193],"peripheral":[135],"blood":[136],"cell":[137],"populations":[138],"leukocyte":[140],"transcriptomics.":[141],"RESULTS:":[142],"Fifty-five":[143],"allocated":[146],"each":[148],"arm.":[149],"By":[150],"28,":[152],"27":[153],"(49.1%)":[154],"25":[160],"(45.5%)":[161],"group":[165],"died":[166],"(risk":[167],"difference":[168],"3.6%":[169],"[95%":[170],"confidence":[171],"interval":[172],"(CI)":[173],"-":[174],"15.7":[175],"22.7];":[177],"P":[178,186,213],"=":[179,187,214],"0.703,":[180],"adjusted":[181],"OR":[182],"1.03":[183],"[95%CI":[184,211],"0.35-3.06];":[185],"0.959).":[188],"There":[189],"no":[191],"statistical":[192],"response.":[199],"associated":[202,260],"lower":[204,262],"incidence":[205],"recurrence":[208],"(OR":[209],"0.21":[210],"0.06-0.68];":[212],"0.012);":[215],"significant":[216],"increase":[217],"monocyte":[219],"HLA-DR":[220],"expression;":[221],"expansion":[222],"non-classical":[224],"monocytes;":[225],"upregulation":[227],"genes":[229],"involved":[230],"cholesterol":[232],"homeostasis.":[233],"Serious":[234],"non-serious":[236],"adverse":[237],"events":[238],"equally":[240],"distributed.":[241],"CONCLUSIONS:":[242],"did":[244],"not":[245],"reduce":[246],"dysfunction.":[257],"recurrence,":[264],"possibly":[265],"through":[266],"mechanism":[268],"immune":[270],"restoration.":[271],"Clinical":[272],"registration":[274],"clinicaltrials.gov":[275],"identifier":[276],"NCT03345992":[277],"registered":[278],"17":[279],"November":[280],"2017;":[281],"EudraCT":[282],"2017-001056-55.":[283]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2022-06-19T00:00:00"}
