{"id":"https://openalex.org/W4283019937","doi":"https://doi.org/10.1016/s0016-5085(22)60658-9","title":"1164: METAGENOMIC INTERROGATION OF RESPIRATORY AND GUT MICROBIAL COMMUNITIES, HOST IMMUNE RESPONSE, AND RISK OF SEVERE COVID-19","display_name":"1164: METAGENOMIC INTERROGATION OF RESPIRATORY AND GUT MICROBIAL COMMUNITIES, HOST IMMUNE RESPONSE, AND RISK OF SEVERE COVID-19","publication_year":2022,"publication_date":"2022-05-01","ids":{"openalex":"https://openalex.org/W4283019937","doi":"https://doi.org/10.1016/s0016-5085(22)60658-9"},"language":"en","primary_location":{"id":"doi:10.1016/s0016-5085(22)60658-9","doi":"https://doi.org/10.1016/s0016-5085(22)60658-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0016-5085(22)60658-9","pdf_url":null,"source":{"id":"https://openalex.org/S143352558","display_name":"Gastroenterology","issn_l":"0016-5085","issn":["0016-5085","1528-0012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9212339","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100623040","display_name":"Long Hoang Nguyen","orcid":"https://orcid.org/0000-0002-5436-4219","observed_orcids":["https://orcid.org/0000-0002-5436-4219"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Long H. Nguyen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085764848","display_name":"Daniel A. Okin","orcid":"https://orcid.org/0000-0002-3802-4695","observed_orcids":["https://orcid.org/0000-0002-3802-4695"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel Okin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048731424","display_name":"David A. Drew","orcid":"https://orcid.org/0000-0002-8813-0816","observed_orcids":["https://orcid.org/0000-0002-8813-0816"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David A. Drew","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027093750","display_name":"Vincent M. Battista","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vincent M. Battista","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002258308","display_name":"Trenton Reinicke","orcid":"https://orcid.org/0000-0002-0160-4901","observed_orcids":["https://orcid.org/0000-0002-0160-4901"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Trenton Reinicke","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024951589","display_name":"Chun\u2010Han Lo","orcid":"https://orcid.org/0000-0001-8202-4513","observed_orcids":["https://orcid.org/0000-0001-8202-4513"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chun-Han Lo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089490032","display_name":"Jacqueline Elise Woo","orcid":"https://orcid.org/0009-0001-0118-1830","observed_orcids":["https://orcid.org/0009-0001-0118-1830"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jacqueline Woo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084946057","display_name":"Alexander Caraballo","orcid":"https://orcid.org/0009-0001-2385-9913","observed_orcids":["https://orcid.org/0009-0001-2385-9913"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexander Caraballo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060334262","display_name":"Mehdi Benamar","orcid":"https://orcid.org/0000-0003-1532-8642","observed_orcids":["https://orcid.org/0000-0003-1532-8642"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mehdi Benamar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079746187","display_name":"Lorenzo M. Berra","orcid":"https://orcid.org/0000-0003-2702-2093","observed_orcids":["https://orcid.org/0000-0003-2702-2093"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lorenzo Berra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046992774","display_name":"Jacob Vieira","orcid":"https://orcid.org/0000-0002-7627-4943","observed_orcids":["https://orcid.org/0000-0002-7627-4943"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jacob M. Vieira","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037899909","display_name":"Ching\u2010Ying Huang","orcid":"https://orcid.org/0009-0006-9890-4789","observed_orcids":["https://orcid.org/0009-0006-9890-4789"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ching-Ying Huang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Qian Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qian Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077708867","display_name":"Marina V. Magicheva-Gupta","orcid":"https://orcid.org/0009-0003-4117-7283","observed_orcids":["https://orcid.org/0009-0003-4117-7283"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marina V. Magicheva-Gupta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074508362","display_name":"Talal A. Chatila","orcid":"https://orcid.org/0000-0001-7439-2762","observed_orcids":["https://orcid.org/0000-0001-7439-2762"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Talal Chatila","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008844345","display_name":"Curtis Huttenhower","orcid":"https://orcid.org/0000-0002-1110-0096","observed_orcids":["https://orcid.org/0000-0002-1110-0096"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Curtis Huttenhower","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068835941","display_name":"Andrew Tan Chan","orcid":"https://orcid.org/0000-0001-7284-6767","observed_orcids":["https://orcid.org/0000-0001-7284-6767","https://orcid.org/0000-0002-3662-5964","https://orcid.org/0000-0002-5436-4219"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew Chan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5080386133","display_name":"Peggy S. Lai","orcid":"https://orcid.org/0000-0001-9501-8606","observed_orcids":["https://orcid.org/0000-0001-9501-8606"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peggy Lai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3200,"currency":"USD","value_usd":3200},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.05458106,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"162","issue":"7","first_page":"S","last_page":"278"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.8511000275611877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.8511000275611877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.08460000157356262,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.02459999918937683,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.8709999918937683},{"id":"https://openalex.org/keywords/sars-cov-2-antibodies","display_name":"SARS-CoV-2 antibodies","score":0.9440000057220459},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.9800000190734863},{"id":"https://openalex.org/keywords/convalescent-patients","display_name":"convalescent patients","score":0.7689999938011169},{"id":"https://openalex.org/keywords/single-cell-rna-sequencing","display_name":"single-cell RNA sequencing","score":0.7070000171661377},{"id":"https://openalex.org/keywords/hla-dqa1","display_name":"HLA-DQA1","score":0.9520000219345093},{"id":"https://openalex.org/keywords/gpr183","display_name":"GPR183","score":0.9940000176429749},{"id":"https://openalex.org/keywords/host-immune-response","display_name":"host immune response","score":0.6980000138282776},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.6710000038146973},{"id":"https://openalex.org/keywords/respiratory-microbiome","display_name":"airway microbiome","score":0.9810000061988831},{"id":"https://openalex.org/keywords/severe-covid-19-risk","display_name":"severe COVID-19 risk","score":0.9160000085830688}],"concepts":[{"id":"https://openalex.org/C15151743","wikidata":"https://www.wikidata.org/wiki/Q903778","display_name":"Metagenomics","level":3,"score":0.8201075792312622},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6567528247833252},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.5788187980651855},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.4990983009338379},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4709637761116028},{"id":"https://openalex.org/C2776240099","wikidata":"https://www.wikidata.org/wiki/Q327018","display_name":"Interrogation","level":2,"score":0.46866974234580994},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.45740464329719543},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.43928173184394836},{"id":"https://openalex.org/C2994443828","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Host response","level":3,"score":0.43887633085250854},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3959771692752838},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3155839443206787},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.16811993718147278},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.09486597776412964},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08869209885597229},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07563778758049011},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.05547213554382324},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.05481943488121033},{"id":"https://openalex.org/C166957645","wikidata":"https://www.wikidata.org/wiki/Q23498","display_name":"Archaeology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/s0016-5085(22)60658-9","doi":"https://doi.org/10.1016/s0016-5085(22)60658-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0016-5085(22)60658-9","pdf_url":null,"source":{"id":"https://openalex.org/S143352558","display_name":"Gastroenterology","issn_l":"0016-5085","issn":["0016-5085","1528-0012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9212339","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9212339","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9212339","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9212339","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4282968163","https://openalex.org/W4315928854","https://openalex.org/W3117070727","https://openalex.org/W3093238428","https://openalex.org/W4283171743","https://openalex.org/W4283023721","https://openalex.org/W3081471161","https://openalex.org/W4319160733","https://openalex.org/W3169566748","https://openalex.org/W3095441943"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2022-06-18T00:00:00"}