{"id":"https://openalex.org/W4283018830","doi":"https://doi.org/10.1126/sciadv.abo2658","title":"Amphotericin B assembles into seven-molecule ion channels: An NMR and molecular dynamics study","display_name":"Amphotericin B assembles into seven-molecule ion channels: An NMR and molecular dynamics study","publication_year":2022,"publication_date":"2022-06-17","ids":{"openalex":"https://openalex.org/W4283018830","doi":"https://doi.org/10.1126/sciadv.abo2658","pmid":"https://pubmed.ncbi.nlm.nih.gov/35714188","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9205587"},"language":"en","primary_location":{"id":"doi:10.1126/sciadv.abo2658","doi":"https://doi.org/10.1126/sciadv.abo2658","is_oa":true,"landing_page_url":"https://doi.org/10.1126/sciadv.abo2658","pdf_url":null,"source":{"id":"https://openalex.org/S2737427234","display_name":"Science Advances","issn_l":"2375-2548","issn":["2375-2548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Advances","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1126/sciadv.abo2658","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086411845","display_name":"Yuichi Umegawa","orcid":"https://orcid.org/0000-0002-1057-8119","observed_orcids":["https://orcid.org/0000-0002-1057-8119"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yuichi Umegawa","raw_affiliation_strings":["Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan","Project Research Center for Fundamental Sciences, Osaka University, Toyonaka, Osaka 560-0043, Japan"],"raw_orcid":"https://orcid.org/0000-0002-1057-8119","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Project Research Center for Fundamental Sciences, Osaka University, Toyonaka, Osaka 560-0043, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052787558","display_name":"Tomoya Yamamoto","orcid":"https://orcid.org/0000-0002-3284-5388","observed_orcids":["https://orcid.org/0000-0002-3284-5388"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Tomoya Yamamoto","raw_affiliation_strings":["Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan"],"raw_orcid":"https://orcid.org/0000-0002-3284-5388","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017399157","display_name":"Mayank Kumar Dixit","orcid":"https://orcid.org/0000-0003-2956-6756","observed_orcids":["https://orcid.org/0000-0003-2956-6756"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Mayank Dixit","raw_affiliation_strings":["Department of Materials Chemistry, Graduate School of Engineering, Nagoya University, Nagoya 464-8603, Japan"],"raw_orcid":"https://orcid.org/0000-0003-2956-6756","affiliations":[{"raw_affiliation_string":"Department of Materials Chemistry, Graduate School of Engineering, Nagoya University, Nagoya 464-8603, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002712487","display_name":"Kosuke Funahashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kosuke Funahashi","raw_affiliation_strings":["Department of Materials Chemistry, Graduate School of Engineering, Nagoya University, Nagoya 464-8603, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materials Chemistry, Graduate School of Engineering, Nagoya University, Nagoya 464-8603, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087119267","display_name":"Sangjae Seo","orcid":"https://orcid.org/0000-0002-3555-6223","observed_orcids":["https://orcid.org/0000-0002-3555-6223"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sangjae Seo","raw_affiliation_strings":["Department of Materials Chemistry, Graduate School of Engineering, Nagoya University, Nagoya 464-8603, Japan"],"raw_orcid":"https://orcid.org/0000-0002-3555-6223","affiliations":[{"raw_affiliation_string":"Department of Materials Chemistry, Graduate School of Engineering, Nagoya University, Nagoya 464-8603, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yasuo Nakagawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuo Nakagawa","raw_affiliation_strings":["Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105369056","display_name":"Taiga Suzuki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taiga Suzuki","raw_affiliation_strings":["Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084868806","display_name":"Shigeru Matsuoka","orcid":"https://orcid.org/0000-0002-4422-5389","observed_orcids":["https://orcid.org/0000-0002-4422-5389"]},"institutions":[{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeru Matsuoka","raw_affiliation_strings":["Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan","Japan Science and Technology Agency, ERATO, Lipid Active Structure Project, Osaka University, Toyonaka, Osaka 560-0043, Japan"],"raw_orcid":"https://orcid.org/0000-0002-4422-5389","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Japan Science and Technology Agency, ERATO, Lipid Active Structure Project, Osaka University, Toyonaka, Osaka 560-0043, Japan","institution_ids":["https://openalex.org/I4210086780","https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024878798","display_name":"Hiroshi Tsuchikawa","orcid":"https://orcid.org/0000-0003-0554-2303","observed_orcids":["https://orcid.org/0000-0003-0554-2303"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Tsuchikawa","raw_affiliation_strings":["Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan"],"raw_orcid":"https://orcid.org/0000-0003-0554-2303","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065965638","display_name":"Shinya Hanashima","orcid":"https://orcid.org/0000-0003-3102-7890","observed_orcids":["https://orcid.org/0000-0003-3102-7890"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinya Hanashima","raw_affiliation_strings":["Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan"],"raw_orcid":"https://orcid.org/0000-0003-3102-7890","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011094769","display_name":"Tohru Oishi","orcid":"https://orcid.org/0000-0002-3057-9354","observed_orcids":["https://orcid.org/0000-0002-3057-9354"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tohru Oishi","raw_affiliation_strings":["Department of Chemistry, Graduate School of Science, Kyushu University, Fukuoka 819-0395, Japan","Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan"],"raw_orcid":"https://orcid.org/0000-0002-3057-9354","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Graduate School of Science, Kyushu University, Fukuoka 819-0395, Japan","institution_ids":["https://openalex.org/I135598925"]},{"raw_affiliation_string":"Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020924412","display_name":"Nobuaki Matsumori","orcid":"https://orcid.org/0000-0003-0495-2044","observed_orcids":["https://orcid.org/0000-0003-0495-2044"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuaki Matsumori","raw_affiliation_strings":["Department of Chemistry, Graduate School of Science, Kyushu University, Fukuoka 819-0395, Japan","Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan"],"raw_orcid":"https://orcid.org/0000-0003-0495-2044","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Graduate School of Science, Kyushu University, Fukuoka 819-0395, Japan","institution_ids":["https://openalex.org/I135598925"]},{"raw_affiliation_string":"Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013051927","display_name":"Wataru Shinoda","orcid":"https://orcid.org/0000-0002-3388-9227","observed_orcids":["https://orcid.org/0000-0002-3388-9227"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]},{"id":"https://openalex.org/I4405287422","display_name":"Research Institute for Interdisciplinary Science, Okayama University","ror":"https://ror.org/053qc0g03","country_code":"JP","type":"facility","lineage":["https://openalex.org/I163770644","https://openalex.org/I4405287422"]},{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Wataru Shinoda","raw_affiliation_strings":["Department of Chemistry, Faculty of Science, Okayama University, Okayama 700-8530, Japan","Department of Materials Chemistry, Graduate School of Engineering, Nagoya University, Nagoya 464-8603, Japan","Research Institute for Interdisciplinary Science, Okayama University, Okayama 700-8530, Japan"],"raw_orcid":"https://orcid.org/0000-0002-3388-9227","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Science, Okayama University, Okayama 700-8530, Japan","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Department of Materials Chemistry, Graduate School of Engineering, Nagoya University, Nagoya 464-8603, Japan","institution_ids":["https://openalex.org/I60134161"]},{"raw_affiliation_string":"Research Institute for Interdisciplinary Science, Okayama University, Okayama 700-8530, Japan","institution_ids":["https://openalex.org/I163770644","https://openalex.org/I4405287422"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040082917","display_name":"Michio Murata","orcid":"https://orcid.org/0000-0002-1600-145X","observed_orcids":["https://orcid.org/0000-0002-1600-145X"]},"institutions":[{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Michio Murata","raw_affiliation_strings":["Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan","Japan Science and Technology Agency, ERATO, Lipid Active Structure Project, Osaka University, Toyonaka, Osaka 560-0043, Japan","Project Research Center for Fundamental Sciences, Osaka University, Toyonaka, Osaka 560-0043, Japan"],"raw_orcid":"https://orcid.org/0000-0002-1600-145X","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Japan Science and Technology Agency, ERATO, Lipid Active Structure Project, Osaka University, Toyonaka, Osaka 560-0043, Japan","institution_ids":["https://openalex.org/I4210086780","https://openalex.org/I98285908"]},{"raw_affiliation_string":"Project Research Center for Fundamental Sciences, Osaka University, Toyonaka, Osaka 560-0043, Japan","institution_ids":["https://openalex.org/I98285908"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5013051927","https://openalex.org/A5017399157","https://openalex.org/A5040082917","https://openalex.org/A5052787558","https://openalex.org/A5086411845"],"corresponding_institution_ids":["https://openalex.org/I163770644","https://openalex.org/I4210086780","https://openalex.org/I4405287422","https://openalex.org/I60134161","https://openalex.org/I98285908"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":3.8236,"has_fulltext":true,"cited_by_count":66,"citation_normalized_percentile":{"value":0.95889192,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"8","issue":"24","first_page":"eabo2658","last_page":"eabo2658"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9193999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9193999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.016899999231100082,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.01119999960064888,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amphotericin-b","display_name":"amphotericin B","score":1.0},{"id":"https://openalex.org/keywords/ion-channels","display_name":"ion channels","score":0.7440000176429749},{"id":"https://openalex.org/keywords/ergosterol","display_name":"ergosterol","score":0.8360000252723694},{"id":"https://openalex.org/keywords/antifungal-agents","display_name":"antifungal agents","score":0.7639999985694885},{"id":"https://openalex.org/keywords/fungal-sterols","display_name":"fungal sterols","score":0.5320000052452087},{"id":"https://openalex.org/keywords/channel-aggregation","display_name":"channel aggregation","score":0.5619999766349792},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.7950000166893005},{"id":"https://openalex.org/keywords/membrane-permeation","display_name":"membrane permeation","score":0.41200000047683716}],"concepts":[{"id":"https://openalex.org/C2777910421","wikidata":"https://www.wikidata.org/wiki/Q143263","display_name":"Ergosterol","level":2,"score":0.7715842723846436},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.6516506671905518},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.6074100732803345},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.5602002739906311},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.54648357629776},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.5386251211166382},{"id":"https://openalex.org/C2991737395","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal drug","level":3,"score":0.5069973468780518},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.48828864097595215},{"id":"https://openalex.org/C2778718757","wikidata":"https://www.wikidata.org/wiki/Q143623","display_name":"Sterol","level":3,"score":0.4777733087539673},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46481093764305115},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4246929883956909},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.40236321091651917},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3205562233924866},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.3141288161277771},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.18489482998847961},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1690702736377716},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1472727656364441},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.146560400724411},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.10558316111564636},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.07724472880363464},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":9,"locations":[{"id":"doi:10.1126/sciadv.abo2658","doi":"https://doi.org/10.1126/sciadv.abo2658","is_oa":true,"landing_page_url":"https://doi.org/10.1126/sciadv.abo2658","pdf_url":null,"source":{"id":"https://openalex.org/S2737427234","display_name":"Science Advances","issn_l":"2375-2548","issn":["2375-2548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Advances","raw_type":"journal-article"},{"id":"doi:10.26434/chemrxiv-2021-46790","doi":"https://doi.org/10.26434/chemrxiv-2021-46790","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv-2021-46790","pdf_url":null,"source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"doi:10.26434/chemrxiv-2021-46790-v2","doi":"https://doi.org/10.26434/chemrxiv-2021-46790-v2","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv-2021-46790-v2","pdf_url":null,"source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"doi:10.33774/chemrxiv-2021-46790-v2","doi":"https://doi.org/10.33774/chemrxiv-2021-46790-v2","is_oa":true,"landing_page_url":"https://doi.org/10.33774/chemrxiv-2021-46790-v2","pdf_url":"https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/6196dfb962372e3729be423d/original/amphotericin-b-assembles-into-seven-molecule-ion-channels-in-membrane-domain.pdf","source":null,"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"doi:10.33774/chemrxiv-2021-46790","doi":"https://doi.org/10.33774/chemrxiv-2021-46790","is_oa":true,"landing_page_url":"https://doi.org/10.33774/chemrxiv-2021-46790","pdf_url":"https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/616bcb078b620dbefe524f62/original/amphotericin-b-assembles-into-seven-molecule-ion-channels-an-nmr-and-molecular-dynamics-study.pdf","source":null,"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmid:35714188","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35714188","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science advances","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9205587","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9205587/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Adv","raw_type":"Text"},{"id":"pmh:oai:irdb.nii.ac.jp:01081:0005904871","doi":null,"is_oa":true,"landing_page_url":"https://ousar.lib.okayama-u.ac.jp/65915","pdf_url":"https://ousar.lib.okayama-u.ac.jp/files/public/6/65915/20230928092601414970/fulltext.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Science Advances","raw_type":"journal article"},{"id":"pmh:oai:EPrintsOUDIR.lib.okayama-u.ac.jp:65915","doi":null,"is_oa":false,"landing_page_url":"https://ousar.lib.okayama-u.ac.jp/65915","pdf_url":null,"source":{"id":"https://openalex.org/S4377196325","display_name":"Okayama University Scientific Achievement Repository (Okayama University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I163770644","host_organization_name":"Okayama University","host_organization_lineage":["https://openalex.org/I163770644"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Science Advances","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1126/sciadv.abo2658","doi":"https://doi.org/10.1126/sciadv.abo2658","is_oa":true,"landing_page_url":"https://doi.org/10.1126/sciadv.abo2658","pdf_url":null,"source":{"id":"https://openalex.org/S2737427234","display_name":"Science Advances","issn_l":"2375-2548","issn":["2375-2548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Advances","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2712646973","display_name":null,"funder_award_id":"17H06406","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3141836182","display_name":"Dynamic conformation and domain structure of lipid molecules in model biomembranes","funder_award_id":"16H06315","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4243712418","display_name":"Protein function control starting from the pharmacophore skeleton of natural products for the development of new bioactive compounds","funder_award_id":"20K05730","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4427610599","display_name":"Establishment of research base for lipid chemical biology","funder_award_id":"20H00405","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4786538180","display_name":"Challenges to create natural product-drug conjugate starting from screening of natural products that bind to membrane proteins","funder_award_id":"22K19115","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5462346855","display_name":null,"funder_award_id":"JPMJER1005","funder_id":"https://openalex.org/F4320338112","funder_display_name":"Exploratory Research for Advanced Technology"},{"id":"https://openalex.org/G665593669","display_name":"Chemical study on dynamics of model lipid bilayers reproducing biomembrane under non-equilibrium conditions","funder_award_id":"21H04707","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8124272165","display_name":"\u6751\u7530\u8102\u8cea\u6d3b\u6027\u69cb\u9020\u30d7\u30ed\u30b8\u30a7\u30af\u30c8","funder_award_id":"JPMJER1005","funder_id":"https://openalex.org/F4320334789","funder_display_name":"Japan Science and Technology Agency"}],"funders":[{"id":"https://openalex.org/F4320322832","display_name":"University of Tokyo","ror":"https://ror.org/057zh3y96"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320334789","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19"},{"id":"https://openalex.org/F4320338112","display_name":"Exploratory Research for Advanced Technology","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4283018830.pdf","grobid_xml":"https://content.openalex.org/works/W4283018830.grobid-xml"},"referenced_works_count":87,"referenced_works":["https://openalex.org/W1031578623","https://openalex.org/W1481998649","https://openalex.org/W1605166042","https://openalex.org/W1835618335","https://openalex.org/W1963873138","https://openalex.org/W1965757829","https://openalex.org/W1966482878","https://openalex.org/W1969049043","https://openalex.org/W1971258070","https://openalex.org/W1974403030","https://openalex.org/W1976499671","https://openalex.org/W1977865696","https://openalex.org/W1989880817","https://openalex.org/W1990771438","https://openalex.org/W1991794210","https://openalex.org/W1997772366","https://openalex.org/W1999077168","https://openalex.org/W1999558853","https://openalex.org/W2006509814","https://openalex.org/W2007298400","https://openalex.org/W2013892132","https://openalex.org/W2013899608","https://openalex.org/W2015951207","https://openalex.org/W2017196167","https://openalex.org/W2018305634","https://openalex.org/W2021520922","https://openalex.org/W2026877196","https://openalex.org/W2027146079","https://openalex.org/W2029262543","https://openalex.org/W2031280181","https://openalex.org/W2031427361","https://openalex.org/W2032638339","https://openalex.org/W2034332162","https://openalex.org/W2035687084","https://openalex.org/W2036519717","https://openalex.org/W2037472715","https://openalex.org/W2039268281","https://openalex.org/W2040448714","https://openalex.org/W2043901383","https://openalex.org/W2044671580","https://openalex.org/W2057206378","https://openalex.org/W2060433756","https://openalex.org/W2066414494","https://openalex.org/W2067174909","https://openalex.org/W2070753604","https://openalex.org/W2072250256","https://openalex.org/W2073894126","https://openalex.org/W2075629818","https://openalex.org/W2081693079","https://openalex.org/W2082579144","https://openalex.org/W2086627262","https://openalex.org/W2094383126","https://openalex.org/W2097163260","https://openalex.org/W2106826842","https://openalex.org/W2121842516","https://openalex.org/W2125021125","https://openalex.org/W2125156271","https://openalex.org/W2128572087","https://openalex.org/W2130529613","https://openalex.org/W2139472183","https://openalex.org/W2150886462","https://openalex.org/W2158870821","https://openalex.org/W2159442951","https://openalex.org/W2168269595","https://openalex.org/W2176296025","https://openalex.org/W2206954826","https://openalex.org/W2315722001","https://openalex.org/W2330260612","https://openalex.org/W2331250947","https://openalex.org/W2331907103","https://openalex.org/W2345460617","https://openalex.org/W2402130404","https://openalex.org/W2408449184","https://openalex.org/W2444060841","https://openalex.org/W2615549939","https://openalex.org/W2936166313","https://openalex.org/W2952945846","https://openalex.org/W2980032979","https://openalex.org/W2993882026","https://openalex.org/W3107020639","https://openalex.org/W3114277239","https://openalex.org/W3120665294","https://openalex.org/W4200065590","https://openalex.org/W4232686413","https://openalex.org/W4235577607","https://openalex.org/W4247011483","https://openalex.org/W4252366653"],"related_works":["https://openalex.org/W3215534893","https://openalex.org/W3114277239","https://openalex.org/W4403980555","https://openalex.org/W2337246996","https://openalex.org/W2044671580","https://openalex.org/W2234897181","https://openalex.org/W2993882026","https://openalex.org/W1986825268","https://openalex.org/W2899777196","https://openalex.org/W1984021073"],"abstract_inverted_index":{"Amphotericin":[0],"B,":[1],"an":[2,64],"antifungal":[3],"drug":[4,41,58,116],"with":[5],"a":[6],"long":[7],"history":[8],"of":[9,34,47,56,77,91,107],"use,":[10],"forms":[11],"fungicidal":[12],"ion-permeable":[13],"channels":[14],"across":[15],"cell":[16],"membranes.":[17],"Using":[18],"solid-state":[19],"nuclear":[20],"magnetic":[21],"resonance":[22],"spectroscopy":[23],"and":[24,93,118],"molecular":[25,36],"dynamics":[26],"simulations,":[27],"we":[28],"experimentally":[29],"elucidated":[30],"the":[31,35,45,48,74,78,83,89,108],"three-dimensional":[32],"structure":[33,69,99],"assemblies":[37],"formed":[38],"by":[39],"this":[40],"in":[42,44,82,88,94],"membranes":[43],"presence":[46],"fungal":[49],"sterol":[50],"ergosterol.":[51],"A":[52],"stable":[53],"assembly":[54],"consisting":[55],"seven":[57],"molecules":[59,92],"was":[60],"observed":[61],"to":[62,73],"form":[63],"ion":[65],"conductive":[66],"channel.":[67],"The":[68,97],"is":[70],"somewhat":[71],"similar":[72],"upper":[75],"half":[76],"barrel-stave":[79],"model":[80],"proposed":[81],"1970s":[84],"but":[85],"substantially":[86],"different":[87],"number":[90],"their":[95],"arrangement.":[96],"present":[98],"explains":[100],"many":[101],"previous":[102],"findings,":[103],"including":[104],"structure-activity":[105],"relationships":[106],"drug,":[109],"which":[110],"will":[111],"be":[112],"useful":[113],"for":[114],"improving":[115],"efficacy":[117],"reducing":[119],"adverse":[120],"effects.":[121]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":20},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2022-06-18T00:00:00"}