{"id":"https://openalex.org/W4282984166","doi":"https://doi.org/10.1158/1538-7445.am2022-5205","title":"Abstract 5205: VG2025: Transcriptional and translational dually regulated (TTDR) oncolytic virus for cancer immunotherapy","display_name":"Abstract 5205: VG2025: Transcriptional and translational dually regulated (TTDR) oncolytic virus for cancer immunotherapy","publication_year":2022,"publication_date":"2022-06-15","ids":{"openalex":"https://openalex.org/W4282984166","doi":"https://doi.org/10.1158/1538-7445.am2022-5205"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2022-5205","doi":"https://doi.org/10.1158/1538-7445.am2022-5205","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2022-5205","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074390824","display_name":"Yanal M. Murad","orcid":"https://orcid.org/0000-0003-2792-3932","observed_orcids":["https://orcid.org/0000-0003-2792-3932"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yanal Murad","raw_affiliation_strings":["1Virogin Biotech, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Virogin Biotech, Vancouver, British Columbia, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039857323","display_name":"Guoyu Liu","orcid":"https://orcid.org/0009-0006-3548-7834","observed_orcids":["https://orcid.org/0009-0006-3548-7834","https://orcid.org/0009-0005-8581-156X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guoyu Liu","raw_affiliation_strings":["1Virogin Biotech, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Virogin Biotech, Vancouver, British Columbia, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"I-Fang Lee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I-Fang Lee","raw_affiliation_strings":["1Virogin Biotech, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Virogin Biotech, Vancouver, British Columbia, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044115415","display_name":"Zahid M. Delwar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zahid Delwar","raw_affiliation_strings":["1Virogin Biotech, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Virogin Biotech, Vancouver, British Columbia, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043887016","display_name":"Dmitry V. Chouljenko","orcid":"https://orcid.org/0000-0001-8524-2102","observed_orcids":["https://orcid.org/0000-0001-8524-2102"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dmitry Chouljenko","raw_affiliation_strings":["1Virogin Biotech, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Virogin Biotech, Vancouver, British Columbia, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089767518","display_name":"Will Liu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Will Liu","raw_affiliation_strings":["1Virogin Biotech, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Virogin Biotech, Vancouver, British Columbia, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112531090","display_name":"Jun Ding","orcid":"https://orcid.org/0000-0002-5923-3621","observed_orcids":["https://orcid.org/0000-0002-5923-3621"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jun Ding","raw_affiliation_strings":["1Virogin Biotech, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Virogin Biotech, Vancouver, British Columbia, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110024934","display_name":"Luke Bu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luke Bu","raw_affiliation_strings":["1Virogin Biotech, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Virogin Biotech, Vancouver, British Columbia, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101518661","display_name":"Ronghua Zhao","orcid":"https://orcid.org/0000-0002-2208-1505","observed_orcids":["https://orcid.org/0000-0002-2208-1505"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ronghua Zhao","raw_affiliation_strings":["1Virogin Biotech, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Virogin Biotech, Vancouver, British Columbia, Canada","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090771104","display_name":"William W.-G. Jia","orcid":"https://orcid.org/0000-0002-2755-6821","observed_orcids":["https://orcid.org/0000-0002-2755-6821"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William Jia","raw_affiliation_strings":["1Virogin Biotech, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Virogin Biotech, Vancouver, British Columbia, Canada","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"82","issue":"12_Supplement","first_page":"5205","last_page":"5205"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oncolytic-herpesvirus","display_name":"oncolytic herpesvirus","score":0.7900000214576721},{"id":"https://openalex.org/keywords/herpes-simplex-virus-type-1","display_name":"herpes simplex virus type 1","score":0.9729999899864197},{"id":"https://openalex.org/keywords/icp27","display_name":"ICP27","score":0.7670000195503235},{"id":"https://openalex.org/keywords/icp34-5","display_name":"ICP34.5","score":0.9139999747276306},{"id":"https://openalex.org/keywords/mir-124","display_name":"miR-124","score":0.8169999718666077},{"id":"https://openalex.org/keywords/mir-143","display_name":"miR-143","score":1.0},{"id":"https://openalex.org/keywords/il-12","display_name":"IL-12","score":0.9430000185966492},{"id":"https://openalex.org/keywords/cytokine-expression","display_name":"cytokine expression","score":0.5260000228881836},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.5139999985694885},{"id":"https://openalex.org/keywords/abscopal-effect","display_name":"abscopal effect","score":0.8679999709129333},{"id":"https://openalex.org/keywords/neurovirulence","display_name":"neurovirulence","score":0.4869999885559082}],"concepts":[{"id":"https://openalex.org/C82210918","wikidata":"https://www.wikidata.org/wiki/Q1560099","display_name":"Oncolytic virus","level":3,"score":0.9175713062286377},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.6016721725463867},{"id":"https://openalex.org/C77430603","wikidata":"https://www.wikidata.org/wiki/Q166992","display_name":"Internal ribosome entry site","level":5,"score":0.5425710082054138},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5258023142814636},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.5135088562965393},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4839104115962982},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.4799007177352905},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.424255907535553},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4137926697731018},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.39620208740234375},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3273639678955078},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.3127894997596741},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.3022937476634979},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11319014430046082}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2022-5205","doi":"https://doi.org/10.1158/1538-7445.am2022-5205","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2022-5205","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4319915108","https://openalex.org/W4379283180","https://openalex.org/W2015645387","https://openalex.org/W2525561336","https://openalex.org/W4242349280","https://openalex.org/W4389279879","https://openalex.org/W2954272689","https://openalex.org/W3028599473","https://openalex.org/W3047821107","https://openalex.org/W2885498560"],"abstract_inverted_index":{"Abstract":[0],"VG2025":[1,99,144,208,244,287,384,426],"is":[2,38,280],"a":[3,51,105,151,160,193,214,239,266,300,311,319,349,387,393],"genetically":[4],"modified":[5],"HSV-1":[6,46,334],"oncolytic":[7,463],"virus":[8,23,29,145,209,464],"(OV)":[9],"wherein":[10],"the":[11,33,44,61,123,197,204,258,304,331,375,399,407,472],"transcription":[12],"and":[13,25,78,94,110,120,136,159,182,221,227,231,257,273,343,377,404,412,458],"translation":[14],"of":[15,43,60,72,98,107,143,153,162,171,199,216,255,260,286,294,306,333,362,371,383,471],"critical":[16],"viral":[17,200],"genes":[18],"are":[19,81,100,114],"regulated":[20,461],"to":[21,138,299,330,335,341,417],"enhance":[22],"safety":[24,345,350],"promote":[26],"tumor":[27,52,124,163,218,270],"specific":[28,53,125,284],"replication":[30,210],"without":[31],"attenuating":[32],"virus.":[34],"The":[35,92,128,251,381],"TTDR":[36],"design":[37],"based":[39],"on":[40,315],"transcriptional":[41],"control":[42,59],"essential":[45],"immediate-early":[47],"protein":[48],"ICP27":[49],"using":[50,277],"CEA":[54,148,167],"promoter,":[55],"coupled":[56],"with":[57,147,165,180,188,324,359,414,429],"translational":[58,459],"key":[62],"neurovirulence":[63],"factor":[64],"ICP34.5":[65,172,201],"accomplished":[66],"by":[67,103,116,122,176,186,353,367,378],"introducing":[68],"multiple":[69],"tandem":[70],"copies":[71],"miRNA":[73,205],"binding":[74],"sites":[75],"for":[76,236,465,475],"miR-124":[77,181],"miR-143":[79,183],"which":[80,279,338],"downregulated":[82],"in":[83,88,134,150,196,213,238,247,265,292,303,392,398],"tumors":[84],"but":[85],"abundantly":[86],"expressed":[87,261],"normal":[89,157],"brain":[90],"tissues.":[91],"anti-tumor":[93,249,321],"immune":[95,252,322,326],"stimulatory":[96,253],"properties":[97],"also":[101],"enhanced":[102],"expressing":[104],"pair":[106],"cytokines":[108],"(IL-12":[109],"IL-15/IL-15R\u03b1":[111],"complex)":[112],"that":[113,288,425],"linked":[115],"2A":[117],"cleavage":[118],"peptides":[119],"controlled":[121],"promoter":[126],"CXCR4.":[127],"dual":[129],"regulation":[130,170],"strategy":[131],"was":[132,174,206,211,364,390,401,427],"verified":[133,366],"vitro":[135],"shown":[137],"be":[139],"highly":[140],"selective.":[141],"Growth":[142],"correlated":[146],"expression":[149,173],"panel":[152],"cell":[154,219,223],"lines":[155,224],"including":[156,373],"cells":[158,164,179,416],"selection":[161],"varying":[166],"levels.":[168],"miRNA-mediated":[169],"validated":[175],"transfecting":[177],"HEK293t":[178],"precursors,":[184],"followed":[185],"infection":[187,397],"VG2025.":[189,360],"RT-qPCR":[190],"testing":[191,237],"revealed":[192],"significant":[194,301],"decrease":[195],"levels":[198],"mRNA":[202],"when":[203],"present.":[207],"evaluated":[212,391],"variety":[215],"human":[217,295],"lines,":[220],"two":[222],"representing":[225],"NSCLC":[226],"pancreatic":[228],"cancer":[229,466],"(A549":[230],"BxPC3,":[232],"respectively)":[233],"were":[234,263,410],"selected":[235],"humanized":[240],"mouse":[241,268,283],"model,":[242],"where":[243],"displayed":[245],"strong":[246],"vivo":[248],"efficacy.":[250],"characteristics":[254],"VG2025,":[256],"bioactivity":[259],"cytokines,":[262],"demonstrated":[264],"syngeneic":[267],"colorectal":[269],"model":[271,275],"(CT26)":[272],"lymphoma":[274],"(A20)":[276],"VG2026,":[278],"an":[281,325],"identical":[282],"variant":[285],"expresses":[289],"murine":[290],"IL-12":[291],"place":[293],"IL-12.":[296],"In":[297],"addition":[298],"reduction":[302],"growth":[305],"injected":[307],"tumors,":[308,317],"we":[309,347],"observed":[310],"clear":[312],"abscopal":[313],"effect":[314],"contralateral":[316],"indicating":[318],"robust":[320],"response":[323],"memory":[327],"effect.":[328],"Due":[329],"tendency":[332],"establish":[336],"latency":[337],"may":[339],"lead":[340],"neurotoxicity":[342,363],"potential":[344],"concerns,":[346],"performed":[348],"pharmacology":[351],"study":[352],"subcutaneously":[354],"inoculating":[355],"immunocompetent":[356],"DBA":[357],"mice":[358],"Absence":[361],"further":[365],"more":[368],"aggressive":[369],"routes":[370],"administration,":[372],"via":[374],"nose":[376],"corneal":[379],"scarification.":[380],"risk":[382],"reactivation":[385,431],"from":[386],"latent":[388,396],"state":[389],"two-step":[394],"study:":[395],"CNS":[400],"first":[402],"established":[403],"confirmed,":[405],"then":[406],"trigeminal":[408],"ganglia":[409],"removed":[411],"co-cultured":[413],"Vero":[415],"detect":[418],"reactivation-related":[419],"cytopathic":[420],"effects.":[421],"All":[422],"studies":[423],"showed":[424],"safe":[428],"no":[430],"events":[432],"detected.":[433],"Citation":[434],"Format:":[435],"Yanal":[436],"Murad,":[437],"Guoyu":[438],"Liu,":[439,447],"I-Fang":[440],"Lee,":[441],"Zahid":[442],"Delwar,":[443],"Dmitry":[444],"Chouljenko,":[445],"Will":[446],"Jun":[448],"Ding,":[449],"Luke":[450],"Bu,":[451],"Ronghua":[452],"Zhao,":[453],"William":[454],"Jia.":[455],"VG2025:":[456],"Transcriptional":[457],"dually":[460],"(TTDR)":[462],"immunotherapy":[467],"[abstract].":[468],"In:":[469],"Proceedings":[470],"American":[473],"Association":[474],"Cancer":[476,487],"Research":[477],"Annual":[478],"Meeting":[479],"2022;":[480],"2022":[481],"Apr":[482],"8-13.":[483],"Philadelphia":[484],"(PA):":[485],"AACR;":[486],"Res":[488],"2022;82(12_Suppl):Abstract":[489],"nr":[490],"5205.":[491]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-06-17T00:00:00"}