{"id":"https://openalex.org/W4282983265","doi":"https://doi.org/10.1158/1538-7445.am2022-1429","title":"Abstract 1429: DDT induces intergenerational epigenetic inheritance of cancer predisposition in a mouse model","display_name":"Abstract 1429: DDT induces intergenerational epigenetic inheritance of cancer predisposition in a mouse model","publication_year":2022,"publication_date":"2022-06-15","ids":{"openalex":"https://openalex.org/W4282983265","doi":"https://doi.org/10.1158/1538-7445.am2022-1429"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2022-1429","doi":"https://doi.org/10.1158/1538-7445.am2022-1429","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2022-1429","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061174868","display_name":"Raquel Santana da Cruz","orcid":"https://orcid.org/0000-0002-9369-2733","observed_orcids":["https://orcid.org/0000-0002-9369-2733"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raquel Santana Da Cruz","raw_affiliation_strings":["1Georgetown University, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Georgetown University, Washington, DC","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085341947","display_name":"Odalys Dominguez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Odalys Dominguez","raw_affiliation_strings":["1Georgetown University, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Georgetown University, Washington, DC","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018024948","display_name":"Apsra Nasir","orcid":"https://orcid.org/0000-0003-3644-911X","observed_orcids":["https://orcid.org/0000-0003-3644-911X"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Apsra Nasir","raw_affiliation_strings":["1Georgetown University, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Georgetown University, Washington, DC","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050368935","display_name":"Alexandra K. Gonsiewski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandra K. Gonsiewski","raw_affiliation_strings":["1Georgetown University, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Georgetown University, Washington, DC","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111802528","display_name":"Maria Idalia Cruz","orcid":"https://orcid.org/0009-0006-5530-2876","observed_orcids":["https://orcid.org/0009-0006-5530-2876"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Idalia Cruz","raw_affiliation_strings":["1Georgetown University, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Georgetown University, Washington, DC","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101765266","display_name":"Jin Lu","orcid":"https://orcid.org/0000-0001-7933-0309","observed_orcids":["https://orcid.org/0000-0001-7933-0309"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lu Jin","raw_affiliation_strings":["1Georgetown University, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Georgetown University, Washington, DC","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063138179","display_name":"Matthew McCoy","orcid":"https://orcid.org/0000-0001-7601-6963","observed_orcids":["https://orcid.org/0000-0001-7601-6963"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew McCoy","raw_affiliation_strings":["1Georgetown University, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Georgetown University, Washington, DC","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020391084","display_name":"S\u00f4nia de Assis","orcid":"https://orcid.org/0000-0001-5053-0614","observed_orcids":["https://orcid.org/0000-0001-5053-0614"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sonia de Assis","raw_affiliation_strings":["1Georgetown University, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Georgetown University, Washington, DC","institution_ids":["https://openalex.org/I184565670"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I184565670"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"82","issue":"12_Supplement","first_page":"1429","last_page":"1429"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.018400000408291817,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.009499999694526196,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ddt","display_name":"DDT","score":0.9850000143051147},{"id":"https://openalex.org/keywords/intergenerational-epigenetic-inheritance","display_name":"intergenerational epigenetic inheritance","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cancer-susceptibility","display_name":"cancer susceptibility","score":0.8370000123977661},{"id":"https://openalex.org/keywords/paternal-exposure","display_name":"paternal exposure","score":0.5540000200271606},{"id":"https://openalex.org/keywords/sperm-rna","display_name":"sperm RNA","score":0.7200000286102295},{"id":"https://openalex.org/keywords/microrna-10b","display_name":"microRNA-10b","score":0.8899999856948853},{"id":"https://openalex.org/keywords/small-rna","display_name":"small RNA","score":0.8320000171661377},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8019999861717224},{"id":"https://openalex.org/keywords/missing-heritability","display_name":"missing heritability","score":0.871999979019165},{"id":"https://openalex.org/keywords/endocrine-disruptors","display_name":"endocrine disruptors","score":0.7279999852180481},{"id":"https://openalex.org/keywords/environmental-toxicants","display_name":"environmental toxins","score":0.6259999871253967},{"id":"https://openalex.org/keywords/germline","display_name":"germline","score":0.5139999985694885}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7429425716400146},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6973587870597839},{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.6945151686668396},{"id":"https://openalex.org/C2780473477","wikidata":"https://www.wikidata.org/wiki/Q3072135","display_name":"Toxicant","level":3,"score":0.6469818353652954},{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.6355421543121338},{"id":"https://openalex.org/C2781087480","wikidata":"https://www.wikidata.org/wiki/Q17145","display_name":"Sperm","level":2,"score":0.5756259560585022},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5444018840789795},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5290611982345581},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4728567600250244},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.44616737961769104},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.425266295671463},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3041383624076843},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.20014819502830505},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.19150537252426147},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1881369948387146},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14227214455604553}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2022-1429","doi":"https://doi.org/10.1158/1538-7445.am2022-1429","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2022-1429","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.979200005531311,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3179669348","https://openalex.org/W3101951167","https://openalex.org/W2788384886","https://openalex.org/W3116578897","https://openalex.org/W2048130534","https://openalex.org/W2947286447","https://openalex.org/W2902372981","https://openalex.org/W6921311995","https://openalex.org/W4391386702","https://openalex.org/W7096644778"],"abstract_inverted_index":{"Abstract":[0],"DNA":[1],"sequence":[2],"accounts":[3],"for":[4,122,285,353],"the":[5,35,58,93,98,102,132,190,199,244,256,289,299,350],"majority":[6],"of":[7,95,152,193,205,214,218,224,243,249,291,298,302,339,349],"disease":[8],"heritability,":[9],"including":[10,65],"cancer.":[11,216],"Yet,":[12],"not":[13],"all":[14],"familial":[15],"cancer":[16,63,88,181,292,340],"cases":[17],"can":[18,38],"be":[19,39],"explained":[20],"by":[21,41],"genetic":[22],"factors.":[23],"There":[24],"is":[25],"mounting":[26],"evidence":[27],"that":[28,34,189,266],"environmentally-induced":[29],"epigenetic":[30,337],"inheritance":[31,290,338],"occurs":[32],"and":[33,53,67,101,120,233,294,304],"progeny\u2019s":[36],"traits":[37],"shaped":[40],"parental":[42],"environmental":[43,54],"experiences.":[44],"In":[45,137],"humans,":[46],"epidemiologic":[47],"studies":[48],"have":[49,202,272],"implicated":[50],"endocrine":[51],"disruptors":[52],"toxicants":[55],"such":[56],"as":[57],"pesticide":[59],"DDT":[60,78,96,113,133,153,170,197,261,334],"in":[61,82,86,198,209,231,237,260,288,309,342],"intergenerational":[62,84,105,336],"development,":[64],"breast":[66,87,180,215,303],"childhood":[68],"tumors.":[69],"Using":[70],"a":[71,116,234,282,343],"mouse":[72,141,212,344],"model,":[73],"we":[74],"investigated":[75,92],"whether":[76],"paternal":[77,99],"exposure":[79],"may":[80],"result":[81],"an":[83,229],"increase":[85,230],"development.":[89],"We":[90,187,263],"also":[91,264],"effects":[94],"on":[97],"germline":[100],"mechanisms":[103],"underlying":[104],"transmission.":[106],"Male":[107],"mice":[108],"(c57bl/6)":[109],"were":[110,145,162,176],"exposed":[111,195],"to":[112,115,130,167,178,196,277],"or":[114,125,134,154,157,172,184,252],"control-vehicle":[117],"(CO)":[118],"solution":[119],"used":[121,177],"sperm":[123,151,246,286],"collection":[124],"mating":[126],"with":[127,147,228,270],"unexposed":[128],"females":[129,175],"produce":[131,168],"CO":[135,155],"daughters.":[136,262],"another":[138],"experiment,":[139],"normal":[140],"embryos":[142,268],"(zygote":[143],"stage)":[144],"injected":[146,174,269],"RNA":[148,173,247],"purified":[149],"from":[150],"males":[156,194,220,251],"miRNA":[158],"mimic.":[159],"Resulting":[160],"zygotes":[161],"implanted":[163],"into":[164],"surrogate":[165],"mothers":[166],"offspring.":[169],"daughters":[171],"study":[179],"development":[182],"(carcinogen-induced":[183],"orthotopic":[185],"models).":[186],"found":[188,265],"female":[191],"progeny":[192],"pre-conception":[200],"period":[201],"higher":[203],"susceptibility":[204],"developing":[206],"aggressive":[207],"tumors":[208],"two":[210],"different":[211],"models":[213],"Sperm":[217],"DDT-exposed":[219,250],"exhibited":[221],"distinct":[222],"patterns":[223],"small":[225],"non-coding":[226],"RNAs,":[227],"miRNAs":[232],"specific":[235],"surge":[236],"miRNA-10b":[238,254],"levels.":[239],"Remarkably,":[240],"embryonic":[241],"injection":[242],"entire":[245],"load":[248],"synthetic":[253],"recapitulated":[255],"tumor":[257],"phenotypes":[258],"observed":[259],"E3.5":[267],"miR-10b":[271],"altered":[273],"transcriptional":[274],"profile":[275],"compared":[276],"controls.":[278],"Our":[279],"findings":[280],"reveal":[281],"causal":[283],"role":[284],"RNAs":[287],"predisposition":[293,341],"could":[295],"explain":[296],"some":[297],"\u201cmissing":[300],"heritability\u201d":[301],"other":[305],"malignancies,":[306],"if":[307],"confirmed":[308],"humans.":[310],"Citation":[311],"Format:":[312],"Raquel":[313],"Santana":[314],"Da":[315],"Cruz,":[316,326],"Odalys":[317],"Dominguez,":[318],"Apsra":[319],"Nasir,":[320],"Alexandra":[321],"K.":[322],"Gonsiewski,":[323],"Maria":[324],"Idalia":[325],"Lu":[327],"Jin,":[328],"Matthew":[329],"McCoy,":[330],"Sonia":[331],"de":[332],"Assis.":[333],"induces":[335],"model":[345],"[abstract].":[346],"In:":[347],"Proceedings":[348],"American":[351],"Association":[352],"Cancer":[354,365],"Research":[355],"Annual":[356],"Meeting":[357],"2022;":[358],"2022":[359],"Apr":[360],"8-13.":[361],"Philadelphia":[362],"(PA):":[363],"AACR;":[364],"Res":[366],"2022;82(12_Suppl):Abstract":[367],"nr":[368],"1429.":[369]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2022-06-17T00:00:00"}