{"id":"https://openalex.org/W4282980281","doi":"https://doi.org/10.3389/fped.2022.923010","title":"Aerosol Delivery of Lung Surfactant and Nasal CPAP in the Treatment of Neonatal Respiratory Distress Syndrome","display_name":"Aerosol Delivery of Lung Surfactant and Nasal CPAP in the Treatment of Neonatal Respiratory Distress Syndrome","publication_year":2022,"publication_date":"2022-06-15","ids":{"openalex":"https://openalex.org/W4282980281","doi":"https://doi.org/10.3389/fped.2022.923010","pmid":"https://pubmed.ncbi.nlm.nih.gov/35783301","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9240419"},"language":"en","primary_location":{"id":"doi:10.3389/fped.2022.923010","doi":"https://doi.org/10.3389/fped.2022.923010","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fped.2022.923010","pdf_url":"https://www.frontiersin.org/articles/10.3389/fped.2022.923010/pdf","source":{"id":"https://openalex.org/S2596117549","display_name":"Frontiers in Pediatrics","issn_l":"2296-2360","issn":["2296-2360"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pediatrics","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fped.2022.923010/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012020338","display_name":"Frans J. Walther","orcid":"https://orcid.org/0000-0003-1931-159X","observed_orcids":["https://orcid.org/0000-0003-1931-159X","https://orcid.org/0000-0002-1395-1433"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I177607063","display_name":"The Lundquist Institute","ror":"https://ror.org/025j2nd68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I177607063"]},{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Frans J. Walther","raw_affiliation_strings":["Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States","Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, United States","institution_ids":["https://openalex.org/I177607063","https://openalex.org/I4210165985"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087075708","display_name":"Alan J. Waring","orcid":"https://orcid.org/0000-0002-0151-2695","observed_orcids":["https://orcid.org/0000-0002-0151-2695"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I177607063","display_name":"The Lundquist Institute","ror":"https://ror.org/025j2nd68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I177607063"]},{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan J. Waring","raw_affiliation_strings":["Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States","Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, United States","institution_ids":["https://openalex.org/I177607063","https://openalex.org/I4210165985"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5012020338"],"corresponding_institution_ids":["https://openalex.org/I161318765","https://openalex.org/I177607063","https://openalex.org/I4210165985"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2777,"currency":"EUR","value_usd":2994},"fwci":0.6435,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.59477883,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"10","issue":null,"first_page":"923010","last_page":"923010"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neonatal-respiratory-distress-syndrome","display_name":"neonatal respiratory distress syndrome","score":0.8349999785423279},{"id":"https://openalex.org/keywords/nasal-cpap","display_name":"nasal continuous positive airway pressure","score":0.8579999804496765},{"id":"https://openalex.org/keywords/preterm-infants","display_name":"preterm infants","score":0.7609999775886536},{"id":"https://openalex.org/keywords/bronchopulmonary-dysplasia-prevention","display_name":"bronchopulmonary dysplasia prevention","score":0.9649999737739563},{"id":"https://openalex.org/keywords/nasal-interface","display_name":"nasal interface","score":0.7889999747276306}],"concepts":[{"id":"https://openalex.org/C58226133","wikidata":"https://www.wikidata.org/wiki/Q1324199","display_name":"Pulmonary surfactant","level":2,"score":0.8448964357376099},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8438141345977783},{"id":"https://openalex.org/C141983124","wikidata":"https://www.wikidata.org/wiki/Q188008","display_name":"Respiratory distress","level":2,"score":0.7319419384002686},{"id":"https://openalex.org/C2778721537","wikidata":"https://www.wikidata.org/wiki/Q922640","display_name":"Bronchopulmonary dysplasia","level":4,"score":0.626409649848938},{"id":"https://openalex.org/C2780352487","wikidata":"https://www.wikidata.org/wiki/Q2281580","display_name":"Nebulizer","level":2,"score":0.620904266834259},{"id":"https://openalex.org/C2779547634","wikidata":"https://www.wikidata.org/wiki/Q5165502","display_name":"Continuous positive airway pressure","level":3,"score":0.5810286998748779},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5728880167007446},{"id":"https://openalex.org/C536800656","wikidata":"https://www.wikidata.org/wiki/Q898674","display_name":"Neonatology","level":3,"score":0.5378984212875366},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4963076710700989},{"id":"https://openalex.org/C200457457","wikidata":"https://www.wikidata.org/wiki/Q584049","display_name":"Ventilation (architecture)","level":2,"score":0.45542922616004944},{"id":"https://openalex.org/C2780395437","wikidata":"https://www.wikidata.org/wiki/Q754348","display_name":"Neonatal respiratory distress syndrome","level":4,"score":0.4233993589878082},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3619709014892578},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13234087824821472},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.07053151726722717},{"id":"https://openalex.org/C2778376644","wikidata":"https://www.wikidata.org/wiki/Q2253111","display_name":"Gestational age","level":3,"score":0.06078985333442688},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C2776006263","wikidata":"https://www.wikidata.org/wiki/Q16606552","display_name":"Obstructive sleep apnea","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fped.2022.923010","doi":"https://doi.org/10.3389/fped.2022.923010","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fped.2022.923010","pdf_url":"https://www.frontiersin.org/articles/10.3389/fped.2022.923010/pdf","source":{"id":"https://openalex.org/S2596117549","display_name":"Frontiers in Pediatrics","issn_l":"2296-2360","issn":["2296-2360"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pediatrics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9240419","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9240419","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Pediatr","raw_type":"Text"},{"id":"pmid:35783301","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35783301","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pediatrics","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:bc973d5021d04dad9871c24aedf955dd","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/bc973d5021d04dad9871c24aedf955dd","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pediatrics, Vol 10 (2022)","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt1344q7n2","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/1344q7n2","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pediatrics, vol 10","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fped.2022.923010","doi":"https://doi.org/10.3389/fped.2022.923010","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fped.2022.923010","pdf_url":"https://www.frontiersin.org/articles/10.3389/fped.2022.923010/pdf","source":{"id":"https://openalex.org/S2596117549","display_name":"Frontiers in Pediatrics","issn_l":"2296-2360","issn":["2296-2360"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pediatrics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1226448701","display_name":"Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center - to develop synthetic aerosolized lung surfactant and non-invasive delivery device for use in respiratory distress syndrome (RDS) a significant caus...","funder_award_id":"INV-040846","funder_id":"https://openalex.org/F4320306137","funder_display_name":"Bill and Melinda Gates Foundation"},{"id":"https://openalex.org/G7791485084","display_name":"Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center - to expedite the necessary preclinical testing of multiple candidate drug formulations to determine the best drug formulation to use in future human...","funder_award_id":"INV-001227","funder_id":"https://openalex.org/F4320306137","funder_display_name":"Bill and Melinda Gates Foundation"}],"funders":[{"id":"https://openalex.org/F4320306137","display_name":"Bill and Melinda Gates Foundation","ror":"https://ror.org/0456r8d26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4282980281.pdf","grobid_xml":"https://content.openalex.org/works/W4282980281.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W1418104844","https://openalex.org/W1582987089","https://openalex.org/W1857797615","https://openalex.org/W1890260689","https://openalex.org/W1967018645","https://openalex.org/W1970568537","https://openalex.org/W1975132504","https://openalex.org/W1980455634","https://openalex.org/W2011301883","https://openalex.org/W2025616773","https://openalex.org/W2029582676","https://openalex.org/W2059373814","https://openalex.org/W2073672268","https://openalex.org/W2074913484","https://openalex.org/W2081757816","https://openalex.org/W2089104007","https://openalex.org/W2090237499","https://openalex.org/W2110023782","https://openalex.org/W2125663105","https://openalex.org/W2129596517","https://openalex.org/W2132321035","https://openalex.org/W2153409356","https://openalex.org/W2154030833","https://openalex.org/W2208478899","https://openalex.org/W2255415998","https://openalex.org/W2271960768","https://openalex.org/W2466926643","https://openalex.org/W2487756862","https://openalex.org/W2521731765","https://openalex.org/W2556479848","https://openalex.org/W2556862721","https://openalex.org/W2559274231","https://openalex.org/W2571552301","https://openalex.org/W2611614566","https://openalex.org/W2736885904","https://openalex.org/W2750707260","https://openalex.org/W2787961050","https://openalex.org/W2884059194","https://openalex.org/W2918434396","https://openalex.org/W2938937438","https://openalex.org/W2944885168","https://openalex.org/W2955052806","https://openalex.org/W2960398430","https://openalex.org/W2969601660","https://openalex.org/W2991525889","https://openalex.org/W2996231905","https://openalex.org/W3010827775","https://openalex.org/W3014413257","https://openalex.org/W3016622983","https://openalex.org/W3034297253","https://openalex.org/W3039524702","https://openalex.org/W3092672479","https://openalex.org/W3110330187","https://openalex.org/W3111401041","https://openalex.org/W3113379136","https://openalex.org/W3129358485","https://openalex.org/W3131350653","https://openalex.org/W3153276891","https://openalex.org/W3157472730","https://openalex.org/W3172358300","https://openalex.org/W3179300535","https://openalex.org/W3202426378","https://openalex.org/W3207198683","https://openalex.org/W4200234572","https://openalex.org/W4213070486","https://openalex.org/W4221110713","https://openalex.org/W4224284698","https://openalex.org/W4225933227","https://openalex.org/W4242183124"],"related_works":["https://openalex.org/W2005053299","https://openalex.org/W2909947704","https://openalex.org/W2955052806","https://openalex.org/W2130070034","https://openalex.org/W4403426957","https://openalex.org/W2996231905","https://openalex.org/W4389521924","https://openalex.org/W3159996371","https://openalex.org/W1973542004","https://openalex.org/W3166835189"],"abstract_inverted_index":{"After":[0],"shifting":[1],"away":[2],"from":[3],"invasive":[4,20],"mechanical":[5],"ventilation":[6,14],"and":[7,18,55,61,72,83,90,116,123],"intratracheal":[8],"instillation":[9],"of":[10,52,74,92,104,113,118],"surfactant":[11,21,38,77,94,107,135],"toward":[12],"non-invasive":[13,37,75,93,132],"with":[15,32],"nasal":[16,119,124],"CPAP":[17],"less":[19],"administration":[22],"in":[23,29,45,63,80,140],"order":[24],"to":[25,67,137],"prevent":[26],"bronchopulmonary":[27],"dysplasia":[28],"preterm":[30,84,138],"infants":[31,85,139],"respiratory":[33],"distress":[34],"syndrome,":[35],"fully":[36],"nebulization":[39,64,115,127],"is":[40],"the":[41,50,88,102,141],"next":[42],"Holy":[43],"Grail":[44],"neonatology.":[46],"Here":[47],"we":[48],"review":[49],"characteristics":[51],"animal-derived":[53],"(clinical)":[54],"new":[56,99],"advanced":[57],"synthetic":[58,105],"lung":[59,70,76,106],"surfactants":[60],"improvements":[62],"technology":[65],"required":[66],"secure":[68],"optimal":[69],"deposition":[71],"effectivity":[73],"administration.":[78],"Studies":[79],"surfactant-deficient":[81],"animals":[82],"have":[86],"demonstrated":[87],"safety":[89],"potential":[91],"administration,":[95],"but":[96],"also":[97],"provide":[98],"directions":[100],"for":[101,109,134],"development":[103],"destined":[108],"aerosol":[110],"delivery,":[111],"implementation":[112],"breath-actuated":[114],"optimization":[117],"CPAP,":[120],"nebulizer":[121],"circuit":[122],"interface.":[125],"Surfactant":[126],"may":[128],"offer":[129],"a":[130],"truly":[131],"option":[133],"delivery":[136],"near":[142],"future.":[143]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-06-17T00:00:00"}