{"id":"https://openalex.org/W4282977699","doi":"https://doi.org/10.1158/1538-7445.am2022-5371","title":"Abstract 5371: Repurposing erbb2 (HER2/neu) as a neoantigen target for neu-negative tumors using a novel erbb2-encoding lentivirus","display_name":"Abstract 5371: Repurposing erbb2 (HER2/neu) as a neoantigen target for neu-negative tumors using a novel erbb2-encoding lentivirus","publication_year":2022,"publication_date":"2022-06-15","ids":{"openalex":"https://openalex.org/W4282977699","doi":"https://doi.org/10.1158/1538-7445.am2022-5371"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2022-5371","doi":"https://doi.org/10.1158/1538-7445.am2022-5371","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2022-5371","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074761882","display_name":"Emmanuel M Gabriel","orcid":"https://orcid.org/0000-0001-8570-4784","observed_orcids":["https://orcid.org/0000-0001-8570-4784"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emmanuel M. Gabriel","raw_affiliation_strings":["1Mayo Clinic Jacksonville, Jacksonville, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mayo Clinic Jacksonville, Jacksonville, FL;","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038191637","display_name":"Brian M. Necela","orcid":"https://orcid.org/0000-0002-4409-1245","observed_orcids":["https://orcid.org/0000-0002-4409-1245"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Necela","raw_affiliation_strings":["1Mayo Clinic Jacksonville, Jacksonville, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mayo Clinic Jacksonville, Jacksonville, FL;","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054396510","display_name":"Deborah A. Bahr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deborah Bahr","raw_affiliation_strings":["1Mayo Clinic Jacksonville, Jacksonville, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mayo Clinic Jacksonville, Jacksonville, FL;","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072428874","display_name":"Jamie L. Kaplan","orcid":"https://orcid.org/0000-0002-3511-0467","observed_orcids":["https://orcid.org/0000-0002-3511-0467"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jamie Kaplan","raw_affiliation_strings":["1Mayo Clinic Jacksonville, Jacksonville, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mayo Clinic Jacksonville, Jacksonville, FL;","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011054139","display_name":"Kristopher M. Attwood","orcid":"https://orcid.org/0000-0002-7229-5472","observed_orcids":["https://orcid.org/0000-0002-7229-5472","https://orcid.org/0009-0003-3874-1293"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristopher Attwood","raw_affiliation_strings":["2Roswell Park Comprehensive Cancer Center, Buffalo, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Roswell Park Comprehensive Cancer Center, Buffalo, NY","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031005364","display_name":"Keith L. Knutson","orcid":"https://orcid.org/0000-0001-9932-4467","observed_orcids":["https://orcid.org/0000-0001-9932-4467"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith Knutson","raw_affiliation_strings":["1Mayo Clinic Jacksonville, Jacksonville, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mayo Clinic Jacksonville, Jacksonville, FL;","institution_ids":["https://openalex.org/I4210146710"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"82","issue":"12_Supplement","first_page":"5371","last_page":"5371"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.48730000853538513,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.48730000853538513,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.3131999969482422,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.0731000006198883,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/her2-neu","display_name":"HER2/neu","score":0.9750000238418579},{"id":"https://openalex.org/keywords/erbb2","display_name":"ERBB2","score":0.9089999794960022},{"id":"https://openalex.org/keywords/neoantigens","display_name":"neoantigens","score":0.8299999833106995},{"id":"https://openalex.org/keywords/b16-melanoma","display_name":"B16 melanoma","score":0.8379999995231628},{"id":"https://openalex.org/keywords/anti-her2-antibody","display_name":"anti-HER2 antibody","score":0.6710000038146973},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.7310000061988831},{"id":"https://openalex.org/keywords/immune-recognition","display_name":"immune recognition","score":0.38999998569488525}],"concepts":[{"id":"https://openalex.org/C2776872082","wikidata":"https://www.wikidata.org/wiki/Q181874","display_name":"HER2/neu","level":4,"score":0.8824869394302368},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5885626077651978},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5078371167182922},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5025539398193359},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.46562880277633667},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.46474167704582214},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.4622279107570648},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4259960353374481},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.41235268115997314},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4019060432910919},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4008922874927521},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3862530589103699},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3544599115848541},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.26172858476638794},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22947534918785095},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.11350920796394348},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2022-5371","doi":"https://doi.org/10.1158/1538-7445.am2022-5371","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2022-5371","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4403569889","https://openalex.org/W56052896","https://openalex.org/W2160344066","https://openalex.org/W2046485878","https://openalex.org/W2374453472","https://openalex.org/W1971977282","https://openalex.org/W1993562783","https://openalex.org/W1168628786","https://openalex.org/W2334296208","https://openalex.org/W2352542858"],"abstract_inverted_index":{"Abstract":[0],"INTRODUCTION:":[1],"HER2/neu":[2,41,312],"is":[3],"a":[4,46,58,206,247,290,298,352,359],"potent":[5],"biomarker":[6],"for":[7,49,120,301,321,355,370],"which":[8,81],"anti-HER2/neu":[9],"antibodies":[10,320],"offer":[11],"significant":[12],"responses.":[13],"However,":[14],"many":[15],"cancers,":[16],"such":[17],"as":[18,45,246,297,351],"melanoma,":[19],"have":[20],"less":[21,83],"than":[22,84],"5%":[23,85],"expression":[24,37,87,166,171,282,313],"of":[25,29,38,88,126,184,192,202,211,240,260,269,331,366],"HER2/neu.":[26,332],"The":[27,90,147],"purpose":[28],"this":[30,128],"study":[31,306],"was":[32,54,70,96,102,135,144,172,286],"to":[33,56,104,163,216,230,317],"determine":[34],"whether":[35],"induced":[36,311],"erbb2":[39,155,241,281,295,349],"(mouse":[40],"analogue)":[42],"could":[43],"function":[44],"neoantigen":[47,248,299,353],"target":[48,300,354],"anti-erbb2":[50,302],"antibody.":[51,303],"METHODS:":[52],"RT-PCR":[53],"used":[55,103],"construct":[57],"rat":[59],"erbb2-encoding":[60,68,261,292,361],"vector":[61],"using":[62,289,358],"the":[63,75,182,189,367],"live,":[64],"non-replicating":[65],"lentivirus":[66,362],"pLenti6.3.":[67],"pLenti6.3":[69,262],"transfected":[71,272],"in":[72,139,156,167,186,199,242,263,270],"vitro":[73,157],"into":[74],"B16":[76,93,232,265,284],"mouse":[77],"melanoma":[78,285],"cell":[79,94,142,150],"line,":[80],"has":[82],"endogenous":[86],"erbb2.":[89],"generated":[91],"erbb2+":[92],"line":[95,151],"designated":[97],"B16/neu.":[98],"Anti-erbb2":[99,178],"antibody":[100,129,179],"(7.16.4)":[101,180],"treat":[105],"C57Bl/6":[106,244],"male":[107],"and":[108,141,205,267],"female":[109],"mice":[110,245],"bearing":[111],"B16/neu":[112,138,149,185,223,273],"(200":[113],"ug":[114,131],"intraperitoneally":[115],"three":[116],"times":[117],"per":[118,132],"week":[119],"3":[121],"weeks).":[122],"To":[123],"confirm":[124],"activity":[125],"7.16.4,":[127],"(100":[130],"T75":[133],"flask)":[134],"co-cultured":[136],"with":[137,255,275],"vitro,":[140,187],"growth/confluence":[143],"measured.":[145],"RESULTS:":[146],"novel":[148,291,360],"expressed":[152],"approximately":[153],"50%":[154],"on":[158,174,283],"flow":[159],"cytometry":[160],"analysis,":[161],"compared":[162,215,229],"2%":[164],"errb2":[165],"na\u00efve":[168,231,243,264],"B16.":[169],"Erbb2/neu":[170],"confirmed":[173],"fluorescent":[175],"Western":[176],"blot.":[177],"slowed":[181],"growth":[183,204,227],"confirming":[188],"suppressive":[190],"effects":[191],"7.16.4.":[193,256],"In":[194,257],"B16/neu-bearing":[195],"mice,":[196],"7.16.4":[197,276],"resulted":[198],"effective":[200],"control":[201],"tumor":[203,208],"complete":[207],"response":[209],"rate":[210],"35.7%,":[212],"(5/14":[213],"mice)":[214],"placebo":[217],"controls":[218],"(p":[219,234],"<":[220],"0.01).":[221],"Interestingly,":[222],"tumors":[224,233,266,274,357],"demonstrated":[225],"slower":[226],"kinetics":[228],"=":[235],"0.013),":[236],"suggesting":[237],"immune":[238],"recognition":[239],"target.":[249],"No":[250],"adverse":[251],"reactions":[252],"were":[253],"observed":[254],"vivo":[258,271],"inoculation":[259],"treatment":[268],"comprise":[277],"ongoing":[278],"experiments.":[279],"CONCLUSIONS:":[280],"successfully":[287],"achieved":[288],"lentivirus.":[293],"Induced":[294],"served":[296],"This":[304],"preclinical":[305],"provides":[307],"translational":[308],"evidence":[309],"that":[310,324],"may":[314],"be":[315],"utilized":[316],"repurpose":[318],"anti-HER2":[319],"human":[322],"malignancies":[323],"do":[325],"not":[326],"normally":[327],"express":[328],"high":[329],"levels":[330],"Citation":[333],"Format:":[334],"Emmanuel":[335],"M.":[336],"Gabriel,":[337],"Brian":[338],"Necela,":[339],"Deborah":[340],"Bahr,":[341],"Jamie":[342],"Kaplan,":[343],"Kristopher":[344],"Attwood,":[345],"Keith":[346],"Knutson.":[347],"Repurposing":[348],"(HER2/neu)":[350],"neu-negative":[356],"[abstract].":[363],"In:":[364],"Proceedings":[365],"American":[368],"Association":[369],"Cancer":[371,382],"Research":[372],"Annual":[373],"Meeting":[374],"2022;":[375],"2022":[376],"Apr":[377],"8-13.":[378],"Philadelphia":[379],"(PA):":[380],"AACR;":[381],"Res":[383],"2022;82(12_Suppl):Abstract":[384],"nr":[385],"5371.":[386]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2022-06-17T00:00:00"}