{"id":"https://openalex.org/W4282974465","doi":"https://doi.org/10.1158/1538-7445.am2022-4014","title":"Abstract 4014: Pathway based analysis of glioblastoma by multi-omics with applications in targeted therapy, prognosis and probabilistic classification","display_name":"Abstract 4014: Pathway based analysis of glioblastoma by multi-omics with applications in targeted therapy, prognosis and probabilistic classification","publication_year":2022,"publication_date":"2022-06-15","ids":{"openalex":"https://openalex.org/W4282974465","doi":"https://doi.org/10.1158/1538-7445.am2022-4014"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2022-4014","doi":"https://doi.org/10.1158/1538-7445.am2022-4014","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2022-4014","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005772200","display_name":"Simona Migliozzi","orcid":"https://orcid.org/0000-0002-4870-8943","observed_orcids":["https://orcid.org/0000-0002-4870-8943"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Simona Migliozzi","raw_affiliation_strings":["1Columbia University, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Columbia University, New York, NY;","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063710053","display_name":"Young Taek Oh","orcid":"https://orcid.org/0000-0001-8356-2428","observed_orcids":["https://orcid.org/0000-0001-8356-2428"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Young Taek Oh","raw_affiliation_strings":["1Columbia University, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Columbia University, New York, NY;","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014041205","display_name":"Luciano Garofano","orcid":"https://orcid.org/0000-0001-8582-0865","observed_orcids":["https://orcid.org/0000-0001-8582-0865"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luciano Garofano","raw_affiliation_strings":["1Columbia University, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Columbia University, New York, NY;","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031360420","display_name":"Mohammad Hasanain","orcid":"https://orcid.org/0000-0001-5207-101X","observed_orcids":["https://orcid.org/0000-0001-5207-101X"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hasanain Mohammad","raw_affiliation_strings":["1Columbia University, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Columbia University, New York, NY;","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025088765","display_name":"Fulvio D\u2019Angelo","orcid":"https://orcid.org/0000-0002-4940-4693","observed_orcids":["https://orcid.org/0000-0002-4940-4693"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fulvio D'Angelo","raw_affiliation_strings":["1Columbia University, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Columbia University, New York, NY;","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075302770","display_name":"Ryan D. Najac","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan D. Najac","raw_affiliation_strings":["1Columbia University, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Columbia University, New York, NY;","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039402966","display_name":"Franck Bielle","orcid":"https://orcid.org/0000-0001-6564-6388","observed_orcids":["https://orcid.org/0000-0001-6564-6388"]},"institutions":[{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Franck Bielle","raw_affiliation_strings":["2Sorbonne Universit\u00e9, Paris, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Sorbonne Universit\u00e9, Paris, France;","institution_ids":["https://openalex.org/I39804081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075595989","display_name":"Karima Mokhtari","orcid":"https://orcid.org/0000-0002-4777-7584","observed_orcids":["https://orcid.org/0000-0002-4777-7584"]},"institutions":[{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Karima Mokhtari","raw_affiliation_strings":["3H\u00f4pital La Piti\u00e9 Salp\u00eatri\u00e8re, Paris, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3H\u00f4pital La Piti\u00e9 Salp\u00eatri\u00e8re, Paris, France;","institution_ids":["https://openalex.org/I4210121705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015247761","display_name":"Jann Nagina Sarkaria","orcid":"https://orcid.org/0000-0001-7489-4885","observed_orcids":["https://orcid.org/0000-0001-7489-4885"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jann N. Sarkaria","raw_affiliation_strings":["4Mayo Clinic, Rochester, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Mayo Clinic, Rochester, MN;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085527072","display_name":"Michele Ceccarelli","orcid":"https://orcid.org/0000-0002-4702-6617","observed_orcids":["https://orcid.org/0000-0002-4702-6617"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Michele Ceccarelli","raw_affiliation_strings":["5University of Naples Federico II, Napoli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5University of Naples Federico II, Napoli, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072780405","display_name":"Marc Sanson","orcid":"https://orcid.org/0000-0002-1813-8476","observed_orcids":["https://orcid.org/0000-0002-1813-8476"]},"institutions":[{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marc Sanson","raw_affiliation_strings":["2Sorbonne Universit\u00e9, Paris, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Sorbonne Universit\u00e9, Paris, France;","institution_ids":["https://openalex.org/I39804081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053349450","display_name":"Anna Lasorella","orcid":"https://orcid.org/0000-0002-1839-5421","observed_orcids":["https://orcid.org/0000-0002-1839-5421"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Lasorella","raw_affiliation_strings":["1Columbia University, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Columbia University, New York, NY;","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078024735","display_name":"Antonio Iavarone","orcid":"https://orcid.org/0000-0002-0683-4634","observed_orcids":["https://orcid.org/0000-0002-0683-4634"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Antonio Iavarone","raw_affiliation_strings":["1Columbia University, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Columbia University, New York, NY;","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"82","issue":"12_Supplement","first_page":"4014","last_page":"4014"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9860000014305115},{"id":"https://openalex.org/keywords/tumor-subtypes","display_name":"tumor subtypes","score":0.7889999747276306},{"id":"https://openalex.org/keywords/proteogenomics","display_name":"proteogenomics","score":0.9229999780654907},{"id":"https://openalex.org/keywords/multi-omics","display_name":"multi-omics","score":0.7699999809265137},{"id":"https://openalex.org/keywords/pathway-analysis","display_name":"pathway analysis","score":0.531000018119812},{"id":"https://openalex.org/keywords/actionable-therapeutic-targets","display_name":"actionable targets","score":0.6880000233650208},{"id":"https://openalex.org/keywords/patient-derived-organoids","display_name":"patient-derived organoids","score":0.7720000147819519},{"id":"https://openalex.org/keywords/dna-pk-inhibition","display_name":"DNA-PK inhibition","score":0.8790000081062317},{"id":"https://openalex.org/keywords/pkcdelta","display_name":"PKC\u03b4","score":0.7730000019073486},{"id":"https://openalex.org/keywords/oxidative-phosphorylation","display_name":"oxidative phosphorylation","score":0.6690000295639038},{"id":"https://openalex.org/keywords/probabilistic-classification","display_name":"probabilistic classification","score":0.5799999833106995},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"precision medicine","score":0.6359999775886536},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.7009999752044678},{"id":"https://openalex.org/keywords/treatment-resistance","display_name":"treatment resistance","score":0.4830000102519989}],"concepts":[{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.5728217363357544},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5456737279891968},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5380496382713318},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47768598794937134},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.47597402334213257},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.4432443082332611},{"id":"https://openalex.org/C6675166","wikidata":"https://www.wikidata.org/wiki/Q7187538","display_name":"Phosphoproteomics","level":5,"score":0.41270214319229126},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4042419195175171},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.38900989294052124},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.28575897216796875},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15523749589920044},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14648941159248352},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.11834061145782471},{"id":"https://openalex.org/C87325107","wikidata":"https://www.wikidata.org/wiki/Q7251493","display_name":"Protein phosphorylation","level":4,"score":0.10606107115745544}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2022-4014","doi":"https://doi.org/10.1158/1538-7445.am2022-4014","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2022-4014","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4309013950","https://openalex.org/W4318979782","https://openalex.org/W4308977931","https://openalex.org/W3180984932","https://openalex.org/W3174987561","https://openalex.org/W3178343214","https://openalex.org/W2140301591","https://openalex.org/W3126609356","https://openalex.org/W2963461072","https://openalex.org/W4205895734"],"abstract_inverted_index":{"Abstract":[0],"The":[1,57,144,233,362],"proteogenomic":[2,67],"characterization":[3],"of":[4,22,31,48,59,66,79,102,127,137,146,178,189,224,239,249,292,314,339,378,428,444],"human":[5,103],"tumors":[6,179],"has":[7,159],"begun":[8],"to":[9,69,105,135,195,337,374],"uncover":[10],"molecular":[11,162],"attributes":[12],"enriched":[13],"in":[14,34,180,201,210,229,266,320,371,390,434],"different":[15],"tumor":[16,41,82,90],"subtypes":[17,114,200,342,383],"and":[18,72,92,151,169,203,272,347,358,384,438],"proposed":[19,50],"a":[20,99,160,186,237,324,333],"panoply":[21],"subtype-specific":[23],"targets.":[24],"As":[25],"these":[26],"studies":[27,373],"lacked":[28],"experimental":[29,234],"testing":[30],"potential":[32],"targets":[33,51,209,305],"high-quality":[35],"cell":[36,120],"models":[37],"accurately":[38],"reflecting":[39],"individual":[40],"subtypes,":[42],"it":[43],"remains":[44],"unclear":[45],"whether":[46],"any":[47],"the":[49,77,80,107,141,166,198,222,252,281,290,298,315,330,340,376,445],"retained":[52],"value":[53],"for":[54,140,221,280,306,317,387,448],"precision":[55,318],"medicine.":[56],"absence":[58],"clinically":[60,253],"useful":[61],"classifiers":[62],"further":[63],"hampered":[64],"translation":[65,313],"information":[68],"better":[70],"diagnose":[71],"treat":[73],"cancer":[74],"patients.":[75],"In":[76],"case":[78],"brain":[81],"glioblastoma":[83,429],"(GBM),":[84],"such":[85],"challenges":[86],"are":[87],"exacerbated":[88],"by":[89,173,260,430],"heterogeneity":[91],"broad":[93],"therapeutic":[94,379],"resistance.":[95],"Here,":[96],"we":[97,115,192,212,322],"analyzed":[98],"large":[100],"dataset":[101],"GBM":[104,113,157,190,211,231,241,268,285,294,308,335,382],"determine":[106],"multi-omics":[108,431],"features":[109,346],"that":[110,155,164,247,332],"characterize":[111],"four":[112,181,341],"recently":[116],"identified":[117],"through":[118],"single":[119],"RNAseq":[121],"analysis.":[122],"Each":[123],"subtype":[124,158],"exhibits":[125,348],"activation":[126],"unique":[128],"hallmark":[129],"functional":[130,182,299],"traits":[131],"including":[132],"distinct":[133],"sensitivity":[134],"inhibitors":[136],"mitochondrial":[138,142,293],"respiration":[139],"subtype.":[143,232,269,286],"inspection":[145],"proteomics,":[147],"phosphoproteomics,":[148],"metabolomics,":[149],"lipidomics":[150],"acetylomics":[152],"data":[153],"revealed":[154],"each":[156,174,230],"coherent":[161],"structure":[163],"drives":[165],"dominant":[167],"function":[168],"can":[170,368],"be":[171,369],"extracted":[172,354],"analytical":[175],"platform.":[176],"Stratification":[177],"classes":[183],"is":[184,364],"not":[185],"specific":[187],"attribute":[188],"as":[191,277,385],"were":[193],"able":[194],"unbiasedly":[196],"identify":[197,207],"same":[199],"breast":[202],"lung":[204],"cancer.":[205],"To":[206,310],"actionable":[208,304],"developed":[213,323],"an":[214],"unbiased":[215],"protein":[216],"kinase":[217],"signaling":[218],"network":[219],"approach":[220],"selection":[223,388],"master":[225],"kinases":[226],"aberrantly":[227],"activated":[228],"follow-up":[235],"using":[236,352],"library":[238],"annotated":[240],"patient":[242],"derived":[243],"organoids":[244],"(PDOs)":[245],"established":[246],"inhibition":[248],"DNA-PK":[250],"with":[251,289,295,381,432],"tested":[254],"compound":[255],"nedisertib":[256],"radiosensitizes":[257],"proliferative/progenitor":[258],"PDOs":[259],"exacerbating":[261],"replication":[262],"stress-induced":[263],"DNA":[264],"damage":[265],"this":[267],"Furthermore,":[270],"genetic":[271],"pharmacological":[273],"tools":[274],"qualified":[275],"PKC\u03b4":[276],"vulnerable":[278],"target":[279],"broadly":[282],"resistant":[283],"glycolytic/plurimetabolic":[284],"Thus,":[287],"together":[288],"targeting":[291],"OXPHOS":[296],"inhibitors,":[297],"classification":[300,326,440],"delivers":[301],"experimentally":[302],"validated":[303],"three":[307],"subtypes.":[309],"provide":[311],"rapid":[312],"classifier":[316],"medicine":[319],"GBM,":[321],"probabilistic":[325,439],"tool":[327,386],"which":[328],"determines":[329],"probability":[331],"patient\u2019s":[334],"belongs":[336],"one":[338],"based":[343,426],"on":[344],"transcriptomic":[345],"optimal":[349],"performance":[350],"when":[351],"RNA":[353],"from":[355],"either":[356],"frozen":[357],"paraffin":[359],"embedded":[360],"tissues.":[361],"algorithm":[363],"publicly":[365],"accessible.":[366],"It":[367],"used":[370],"retrospective":[372],"evaluate":[375],"association":[377],"response":[380],"criteria":[389],"prospective":[391],"clinical":[392],"trials.":[393],"Citation":[394],"Format:":[395],"Simona":[396],"Migliozzi,":[397],"Young":[398],"Taek":[399],"Oh,":[400],"Luciano":[401],"Garofano,":[402],"Hasanain":[403],"Mohammad,":[404],"Fulvio":[405],"D'Angelo,":[406],"Ryan":[407],"D.":[408],"Najac,":[409],"Franck":[410],"Bielle,":[411],"Karima":[412],"Mokhtari,":[413],"Jann":[414],"N.":[415],"Sarkaria,":[416],"Michele":[417],"Ceccarelli,":[418],"Marc":[419],"Sanson,":[420],"Anna":[421],"Lasorella,":[422],"Antonio":[423],"Iavarone.":[424],"Pathway":[425],"analysis":[427],"applications":[433],"targeted":[435],"therapy,":[436],"prognosis":[437],"[abstract].":[441],"In:":[442],"Proceedings":[443],"American":[446],"Association":[447],"Cancer":[449,460],"Research":[450],"Annual":[451],"Meeting":[452],"2022;":[453],"2022":[454],"Apr":[455],"8-13.":[456],"Philadelphia":[457],"(PA):":[458],"AACR;":[459],"Res":[461],"2022;82(12_Suppl):Abstract":[462],"nr":[463],"4014.":[464]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-06-17T00:00:00"}