{"id":"https://openalex.org/W4282972016","doi":"https://doi.org/10.1158/1538-7445.am2022-3642","title":"Abstract 3642: The aged lung promotes reactivation from metastatic melanoma dormancy","display_name":"Abstract 3642: The aged lung promotes reactivation from metastatic melanoma dormancy","publication_year":2022,"publication_date":"2022-06-15","ids":{"openalex":"https://openalex.org/W4282972016","doi":"https://doi.org/10.1158/1538-7445.am2022-3642"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2022-3642","doi":"https://doi.org/10.1158/1538-7445.am2022-3642","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2022-3642","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054709370","display_name":"Mitchell E. Fane","orcid":"https://orcid.org/0000-0001-6163-5753","observed_orcids":["https://orcid.org/0000-0001-6163-5753"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mitchell Fane","raw_affiliation_strings":["1Johns Hopkins School of Public Health, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Johns Hopkins School of Public Health, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085589424","display_name":"Ashani T. Weeraratna","orcid":"https://orcid.org/0000-0003-0448-6952","observed_orcids":["https://orcid.org/0000-0003-0448-6952"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashani Weeraratna","raw_affiliation_strings":["1Johns Hopkins School of Public Health, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Johns Hopkins School of Public Health, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"82","issue":"12_Supplement","first_page":"3642","last_page":"3642"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.7529000043869019,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.7529000043869019,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.05290000140666962,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.031700000166893005,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metastatic-melanoma","display_name":"metastatic melanoma","score":0.9049999713897705},{"id":"https://openalex.org/keywords/tumor-dormancy","display_name":"tumor dormancy","score":0.9070000052452087},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.503000020980835},{"id":"https://openalex.org/keywords/lung-microenvironment","display_name":"lung microenvironment","score":0.8730000257492065},{"id":"https://openalex.org/keywords/lung-fibroblasts","display_name":"lung fibroblasts","score":0.8759999871253967},{"id":"https://openalex.org/keywords/mer-receptor","display_name":"Mer receptor","score":0.7039999961853027},{"id":"https://openalex.org/keywords/protein-s","display_name":"protein S","score":0.9850000143051147},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.9160000085830688},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.5860000252723694},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.8980000019073486},{"id":"https://openalex.org/keywords/myeloid-derived-suppressor-cells","display_name":"myeloid-derived suppressor cells","score":0.9359999895095825},{"id":"https://openalex.org/keywords/immune-infiltration","display_name":"immune cell infiltration","score":0.4490000009536743},{"id":"https://openalex.org/keywords/paracrine-signaling","display_name":"paracrine signaling","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.6972998380661011},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6401054263114929},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.5504794716835022},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.5498851537704468},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4903697967529297},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.41628071665763855},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40556347370147705},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.23134192824363708},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.22644653916358948},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2022-3642","doi":"https://doi.org/10.1158/1538-7445.am2022-3642","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2022-3642","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3082314559","https://openalex.org/W4316372768","https://openalex.org/W4281725021","https://openalex.org/W4281943257","https://openalex.org/W4317104869","https://openalex.org/W4283388920","https://openalex.org/W4393085423","https://openalex.org/W4286268768","https://openalex.org/W1764226931","https://openalex.org/W2402090796"],"abstract_inverted_index":{"Abstract":[0],"Our":[1,38],"previous":[2],"data":[3,39],"have":[4],"indicated":[5],"that":[6,30,41,50,71,148,178,186,222],"while":[7],"tumors":[8],"grow":[9],"more":[10,18,92],"slowly":[11],"in":[12,100,112,146,175],"aged":[13,273],"mouse":[14],"skin,":[15],"they":[16],"form":[17],"lung":[19,25,45,80,132,137,156,234,274],"metastases.":[20],"We":[21],"queried":[22],"whether":[23],"the":[24,59,79,113,125,195,233,285],"microenvironment":[26,81,261],"undergoes":[27],"age-related":[28],"changes":[29,77],"provide":[31],"a":[32,91,101,176,229,237,258],"permissive":[33,93,260],"niche":[34,94],"for":[35,95,262,288],"metastatic":[36,189,255,278],"outgrowth.":[37],"showed":[40],"secreted":[42],"factors":[43],"by":[44,120],"fibroblasts":[46,138,157],"changed":[47],"during":[48],"aging":[49],"promoted":[51],"proliferation":[52,106],"of":[53,58,66,84,107,118,127,155,191,197,207,225,284],"melanoma":[54,73,110,121,152,163,181,192,226,264,279],"cells":[55,74,111,122,164,193,211,227],"via":[56,82],"expression":[57],"tyrosine":[60],"kinase":[61],"receptor":[62],"MER.":[63],"Further":[64],"investigation":[65],"this":[67],"MER-high":[68,230],"phenotype":[69,239],"revealed":[70],"these":[72],"induce":[75,105,236],"dramatic":[76],"to":[78,104,151,250],"secretion":[83,117],"its":[85],"primary":[86],"ligand":[87],"PROS1,":[88],"which":[89,173,240],"creates":[90],"metastasis.":[96],"It":[97],"first":[98],"acts":[99],"paracrine":[102],"manner":[103],"previously":[108],"dormant":[109,263],"lung.":[114],"MER":[115,187],"induced":[116,188],"PROS1":[119],"also":[123],"regulates":[124],"production":[126,245],"extracellular":[128],"matrix":[129],"(ECM)":[130],"from":[131,161,277],"fibroblasts.":[133],"Specifically,":[134],"healthy":[135],"human":[136],"produce":[139],"thick,":[140],"unified":[141],"cellular":[142],"derived":[143],"matrices":[144],"(CDMs)":[145],"vitro":[147],"are":[149],"growth-restrictive":[150],"cells.":[153,265],"Treatment":[154],"with":[158,166],"conditioned":[159],"media":[160],"MER-High":[162],"or":[165],"recombinant-PROS1":[167],"alters":[168,242],"CDM":[169,177],"density":[170],"and":[171,201,208,213,246,253,257],"orientation,":[172],"resulted":[174],"dramatically":[179,241],"increased":[180],"proliferation.":[182],"Finally,":[183],"we":[184,220],"found":[185],"outgrowth":[190,256],"within":[194,232],"lungs":[196],"mice":[198],"decreased":[199],"CD4":[200],"CD8":[202],"T-cells":[203],"whilst":[204],"increasing":[205],"infiltration":[206,249],"immunosuppressive":[209],"T-regulatory":[210],"(Tregs)":[212],"Myeloid":[214],"Derived":[215],"Suppressor":[216],"Cells":[217],"(MDSCs).":[218],"Overall,":[219],"find":[221],"age-induced":[223],"activation":[224],"towards":[228],"state":[231],"can":[235],"cancer":[238],"fibroblast":[243],"ECM":[244],"immune":[247],"cell":[248],"promote":[251],"aggressive":[252],"efficient":[254],"growth":[259],"Citation":[266],"Format:":[267],"Mitchell":[268],"Fane,":[269],"Ashani":[270],"Weeraratna.":[271],"The":[272],"promotes":[275],"reactivation":[276],"dormancy":[280],"[abstract].":[281],"In:":[282],"Proceedings":[283],"American":[286],"Association":[287],"Cancer":[289,300],"Research":[290],"Annual":[291],"Meeting":[292],"2022;":[293],"2022":[294],"Apr":[295],"8-13.":[296],"Philadelphia":[297],"(PA):":[298],"AACR;":[299],"Res":[301],"2022;82(12_Suppl):Abstract":[302],"nr":[303],"3642.":[304]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2022-06-17T00:00:00"}